DK390689A - Fremgangsmaade til fremstilling af des-b30-insuliner og des-b30-insulinderivater - Google Patents

Fremgangsmaade til fremstilling af des-b30-insuliner og des-b30-insulinderivater Download PDF

Info

Publication number: DK390689A
Authority: DK; Denmark
Prior art keywords: des; insulin derivatives; insulin; insulines; procedure
Prior art date: 1988-08-10

Application number

DK390689A

Other languages

Danish (da)

English (en)

Other versions

DK390689D0 (da

Inventor

Wolfgang Gruenwald

Juergen Mueller-Lehar

Manfred Worm

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-10

Filing date

1989-08-09

Publication date

1990-02-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6360583&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK390689(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-08-09 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-08-09 Publication of DK390689D0 publication Critical patent/DK390689D0/da

1990-02-11 Publication of DK390689A publication Critical patent/DK390689A/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
102000004877 Insulin Human genes 0.000 abstract 3
108090001061 Insulin Proteins 0.000 abstract 3
229940125396 insulin Drugs 0.000 abstract 2
239000004026 insulin derivative Substances 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
-1 ammonium ions Chemical class 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Wood Science & Technology (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Obesity (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Emergency Medicine (AREA)
General Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK390689A 1988-08-10 1989-08-09 Fremgangsmaade til fremstilling af des-b30-insuliner og des-b30-insulinderivater DK390689A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3827121A DE3827121A1 (de)	1988-08-10	1988-08-10	Verfahren zur herstellung von des-b30-insulinen und des-b30-insulinderivaten

Publications (2)

Publication Number	Publication Date
DK390689D0 DK390689D0 (da)	1989-08-09
DK390689A true DK390689A (da)	1990-02-11

Family

ID=6360583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK390689A DK390689A (da)	1988-08-10	1989-08-09	Fremgangsmaade til fremstilling af des-b30-insuliner og des-b30-insulinderivater

Country Status (7)

Country	Link
EP (1)	EP0354507B1 (fr)
JP (1)	JPH02131594A (fr)
KR (1)	KR900003377A (fr)
CN (1)	CN1040222A (fr)
AT (1)	ATE95522T1 (fr)
DE (2)	DE3827121A1 (fr)
DK (1)	DK390689A (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19733651A1 (de) *	1997-08-04	1999-02-18	Boehringer Ingelheim Pharma	Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole
EP2077132A1 (fr)	2008-01-02	2009-07-08	Boehringer Ingelheim Pharma GmbH & Co. KG	Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation
EP2414560B1 (fr)	2009-03-31	2013-10-23	Boehringer Ingelheim International GmbH	Procédé de revêtement d'une surface d'un composant
JP5763053B2 (ja)	2009-05-18	2015-08-12	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	アダプタ、吸入器具及びアトマイザ
BR112012012475B1 (pt)	2009-11-25	2020-03-03	Boehringer Ingelheim International Gmbh	Nebulizador
US10016568B2 (en)	2009-11-25	2018-07-10	Boehringer Ingelheim International Gmbh	Nebulizer
WO2011064163A1 (fr)	2009-11-25	2011-06-03	Boehringer Ingelheim International Gmbh	Nébuliseur
TWI455728B (zh) *	2010-01-14	2014-10-11	Colgate Palmolive Co	牙劑組成物
WO2011160932A1 (fr)	2010-06-24	2011-12-29	Boehringer Ingelheim International Gmbh	Nébuliseur
EP2694220B1 (fr)	2011-04-01	2020-05-06	Boehringer Ingelheim International GmbH	Appareil médical pourvu d'un récipient
US9827384B2 (en)	2011-05-23	2017-11-28	Boehringer Ingelheim International Gmbh	Nebulizer
WO2013152894A1 (fr)	2012-04-13	2013-10-17	Boehringer Ingelheim International Gmbh	Pulvérisateur comprenant des moyens de détrompage
CN102703552B (zh) *	2012-05-15	2014-10-29	山东阿华生物药业有限公司	重组人胰岛素的制备方法及其产品
CN103509775A (zh) *	2012-06-15	2014-01-15	上海抗体药物国家工程研究中心有限公司	无色杆菌蛋白酶ⅰ变体
ES2836977T3 (es)	2013-08-09	2021-06-28	Boehringer Ingelheim Int	Nebulizador
JP6643231B2 (ja)	2013-08-09	2020-02-12	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ネブライザ
CN103467594A (zh) *	2013-09-12	2013-12-25	深圳先进技术研究院	胰岛素修饰物及其制备方法和应用
CN105087724B (zh) *	2014-05-04	2019-12-03	重庆派金生物科技有限公司	酵母重组表达门冬胰岛素的制备方法
CN116036425A (zh)	2014-05-07	2023-05-02	勃林格殷格翰国际有限公司	喷雾器、指示器装置及容器
WO2015169430A1 (fr)	2014-05-07	2015-11-12	Boehringer Ingelheim International Gmbh	Nébuliseur
IL247927B (en)	2014-05-07	2022-09-01	Boehringer Ingelheim Int	Container, a device that turns a liquid into a fine spray and use
CN109735589B (zh) *	2019-01-02	2020-07-10	珠海冀百康生物科技有限公司	一种胰岛素DesB30的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU469686A1 (ru) *	1973-05-15	1975-05-05	Институт Экспериментальной Эндокринологии И Химии Гормонов Амн Ссср	Способ получени дез-аланин-в-30инсулинов

1988
- 1988-08-10 DE DE3827121A patent/DE3827121A1/de not_active Withdrawn
1989
- 1989-08-07 DE DE89114522T patent/DE58905821D1/de not_active Expired - Fee Related
- 1989-08-07 EP EP89114522A patent/EP0354507B1/fr not_active Expired - Lifetime
- 1989-08-07 AT AT89114522T patent/ATE95522T1/de not_active IP Right Cessation
- 1989-08-08 CN CN89105585A patent/CN1040222A/zh active Pending
- 1989-08-09 DK DK390689A patent/DK390689A/da not_active Application Discontinuation
- 1989-08-09 JP JP1204924A patent/JPH02131594A/ja active Pending
- 1989-08-10 KR KR1019890011372A patent/KR900003377A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
DE3827121A1 (de)	1990-02-15
ATE95522T1 (de)	1993-10-15
DE58905821D1 (de)	1993-11-11
CN1040222A (zh)	1990-03-07
KR900003377A (ko)	1990-03-26
JPH02131594A (ja)	1990-05-21
EP0354507B1 (fr)	1993-10-06
EP0354507A2 (fr)	1990-02-14
DK390689D0 (da)	1989-08-09
EP0354507A3 (fr)	1991-06-05

Legal Events

Date	Code	Title	Description
1993-12-13	ATS	Application withdrawn

Publication	Publication Date	Title
DK390689A (da)	1990-02-11	Fremgangsmaade til fremstilling af des-b30-insuliner og des-b30-insulinderivater
ATE80166T1 (de)	1992-09-15	Verfahren zur isolierung rekombinanter polypeptide in biologisch aktiver form.
DE69020794D1 (de)	1995-08-17	Enzymatische Entfernung einer aminoterminalen Proteinsequenz.
DE69429526D1 (de)	2002-01-31	Selbsthärtende calciumphosphatzemente und verfahren zu deren herstellung und verwendung
DE3587873D1 (de)	1994-08-11	Kontrollierte Oxydation von mikrobiell hergestellten Cysteine enthaltenden Proteinen.
IL109448A (en)	1997-03-18	Risperidone pamoate, its preparation and pharmaceutical compositions containing it
HUT47863A (en)	1989-04-28	Process for production of stabilized human protein compositions
NO882207D0 (no)	1988-05-20	Blandingskrystaller av insulin og insulinderivater, fremg. til fremst. av disse blandingskrystaller, farmasoeytiske midler som inneholder disse blandingskrystaller og deres anvendelse til behandling av diabetes mellitus.
DK160806C (da)	1991-10-07	Stabil, vandig syreoploesning af cis-platin egnet til injektion og fremgangsmaade til fremstilling heraf
TW286320B (fr)	1996-09-21
DE3771362D1 (de)	1991-08-22	Verfahren zur herstellung von sehr reinem dermatansulfat und pharmazeutische zusammensetzungen, welche dieses enthalten.
AU568866B2 (en)	1988-01-14	Preparation of insulin derivatives
KR850001287A (ko)	1985-03-18	폴리펩타이드의 제조방법
EP0065286A3 (en)	1984-06-13	Process for the purification or concentration of biologically active proteins, and appropriate means therefor.
AU564269B2 (en)	1987-08-06	Compositions containing s-adenosyl-l methionine
EP0303251A3 (en)	1990-01-31	Modified tpa-containing injection composition
SE8703512D0 (sv)	1987-09-10	Medel for tandbehandling
EP0316725A3 (fr)	1991-01-23	Procédé pour la synthèse enzymatique de peptides, utilisant au moins un acide comme non protéinogène ainsi que les peptides dérivant de cette synthèse
EP0508435A3 (en)	1993-04-07	Pharmaceutical composition of stabilized (leu 13)-motilin-hse
AU586352B2 (en)	1989-07-06	Process for concentration of an aqueous solution of amino acid
ATE62235T1 (de)	1991-04-15	Verfahren zur herstellung von 6-amino-3-hydrazino-pyridazinderivaten.
HU911358D0 (en)	1991-10-28	Grf analogues
KR900007865A (ko)	1990-06-02	융합 단백질의 선택적 절단 방법