DK397687A - Substituerede pyrido oe2,3-baaoe1,4aabenzodiazepin-6-oner samt laegemidler med indhold af saadanne forbindelser - Google Patents

Substituerede pyrido oe2,3-baaoe1,4aabenzodiazepin-6-oner samt laegemidler med indhold af saadanne forbindelser

Info

Publication number: DK397687A
Authority: DK; Denmark
Prior art keywords: atom; group; atoms; hydrogen atom; compounds
Prior art date: 1986-07-31

Application number

DK397687A

Other languages

English (en)

Other versions

DK397687D0 (da

DK169722B1 (da

Inventor

Wolfhard Engel

Wolfgang Eberlein

Guenter Trummlitz

Gerhard Mihm

Norbert Mayer

Jonge Adriaan De

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-31

Filing date

1987-07-30

Publication date

1988-02-01

1987-07-30 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1987-07-30 Publication of DK397687D0 publication Critical patent/DK397687D0/da

1988-02-01 Publication of DK397687A publication Critical patent/DK397687A/da

1995-01-23 Application granted granted Critical

1995-01-23 Publication of DK169722B1 publication Critical patent/DK169722B1/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000003814 drug Substances 0.000 title abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
208000006218 bradycardia Diseases 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
-1 1,2- ethylene group Chemical group 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
206010039424 Salivary hypersecretion Diseases 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
230000036471 bradycardia Effects 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
230000002349 favourable effect Effects 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
210000004211 gastric acid Anatomy 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
230000002911 mydriatic effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
QYETZOYLEWPRIX-UHFFFAOYSA-N pyrido[2,3-b][1,4]benzodiazepin-6-one Chemical class O=C1N=C2C=CC=NC2=NC2=CC=CC=C12 QYETZOYLEWPRIX-UHFFFAOYSA-N 0.000 abstract 1
208000026451 salivation Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
230000001515 vagal effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Adhesives Or Adhesive Processes (AREA)
Lubricants (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK397687A 1986-07-31 1987-07-30 Substituerede pyrido [2,3-b][1,4]benzodiazepin-6-oner, lægemidler med indhold af forbindelserne, forbindelserne til anvendelse ved behandling af bradycardi og bradyarrhytmi samt fremgangsmåde til fremstilling af forbindelserne DK169722B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3626095		1986-07-31
DE19863626095 DE3626095A1 (de)	1986-07-31	1986-07-31	Neue substituierte pyrido(2,3-b)(1,4)benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (3)

Publication Number	Publication Date
DK397687D0 DK397687D0 (da)	1987-07-30
DK397687A true DK397687A (da)	1988-02-01
DK169722B1 DK169722B1 (da)	1995-01-23

Family

ID=6306503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK397687A DK169722B1 (da)	1986-07-31	1987-07-30	Substituerede pyrido [2,3-b][1,4]benzodiazepin-6-oner, lægemidler med indhold af forbindelserne, forbindelserne til anvendelse ved behandling af bradycardi og bradyarrhytmi samt fremgangsmåde til fremstilling af forbindelserne

Country Status (21)

Country	Link
US (1)	US4971966A (da)
EP (1)	EP0254955B1 (da)
JP (1)	JP2519734B2 (da)
KR (1)	KR950010073B1 (da)
AT (1)	ATE76643T1 (da)
AU (1)	AU594489B2 (da)
CA (1)	CA1311752C (da)
DD (1)	DD265146A5 (da)
DE (2)	DE3626095A1 (da)
DK (1)	DK169722B1 (da)
ES (1)	ES2042523T3 (da)
FI (1)	FI85479C (da)
GR (1)	GR3005157T3 (da)
HU (1)	HU197745B (da)
IE (1)	IE60861B1 (da)
IL (1)	IL83366A (da)
NO (1)	NO165345C (da)
NZ (1)	NZ221278A (da)
PH (1)	PH26406A (da)
PT (1)	PT85455B (da)
ZA (1)	ZA875623B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3726908A1 (de) *	1987-08-13	1989-02-23	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820346A1 (de) *	1988-06-15	1989-12-21	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5179090A (en) *	1989-09-11	1993-01-12	Klaus Rudolf	Condensed diazepinones and medicaments containing these compounds
US5324832A (en) *	1991-07-03	1994-06-28	The United States Of America As Represented By The Department Of Health And Human Services	Muscarinic antagonists
US5716952A (en) *	1992-03-18	1998-02-10	Allergan	Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists
US6531502B1 (en) *	1998-01-21	2003-03-11	Sugen, Inc.	3-Methylidenyl-2-indolinone modulators of protein kinase
JP3875952B2 (ja)	2000-10-20	2007-01-31	昭和電工株式会社	低ソーダアルミナの製造装置及び製造方法
GB0428250D0 (en) *	2004-12-23	2005-01-26	Novartis Ag	Organic compounds
JP2007051037A (ja) *	2005-08-19	2007-03-01	Asahi Kagaku Kogyo Co Ltd	薄片状αアルミナ粒子の製造方法
CN118946564A (zh) *	2022-03-30	2024-11-12	参天制药株式会社	高纯度化合物的制造方法及纯化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1795183B1 (de) *	1968-08-20	1972-07-20	Thomae Gmbh Dr K	5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
US4210648A (en) *	1977-05-31	1980-07-01	Boehringer Ingelheim Gmbh	II-Aminoacyl-5,11-dihydro-6H-pyrido(2,3-B) (1,4)benzodiazepin-6-ones and salts thereof
DE3204403A1 (de) *	1982-02-09	1983-08-11	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4558132A (en) *	1982-07-02	1985-12-10	A. H. Robins Company, Incorporated	Nitro, amino and aroylamino-N-phenylpyridinamines in a process for preparing pyrido[1,4]benzodiazepines
DE3409237A1 (de) *	1984-03-14	1985-09-19	Dr. Karl Thomae Gmbh, 7950 Biberach	Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

1986
- 1986-07-31 DE DE19863626095 patent/DE3626095A1/de not_active Withdrawn
1987
- 1987-07-09 PH PH35517A patent/PH26406A/en unknown
- 1987-07-14 JP JP62175802A patent/JP2519734B2/ja not_active Expired - Lifetime
- 1987-07-15 AT AT87110190T patent/ATE76643T1/de not_active IP Right Cessation
- 1987-07-15 ES ES87110190T patent/ES2042523T3/es not_active Expired - Lifetime
- 1987-07-15 DE DE8787110190T patent/DE3779369D1/de not_active Expired - Lifetime
- 1987-07-15 EP EP87110190A patent/EP0254955B1/de not_active Expired - Lifetime
- 1987-07-29 IL IL83366A patent/IL83366A/xx unknown
- 1987-07-29 CA CA000543258A patent/CA1311752C/en not_active Expired - Lifetime
- 1987-07-29 FI FI873297A patent/FI85479C/fi not_active IP Right Cessation
- 1987-07-29 DD DD87305486A patent/DD265146A5/de not_active IP Right Cessation
- 1987-07-30 NO NO873189A patent/NO165345C/no unknown
- 1987-07-30 NZ NZ221278A patent/NZ221278A/xx unknown
- 1987-07-30 HU HU873522A patent/HU197745B/hu not_active IP Right Cessation
- 1987-07-30 IE IE206287A patent/IE60861B1/en not_active IP Right Cessation
- 1987-07-30 ZA ZA875623A patent/ZA875623B/xx unknown
- 1987-07-30 DK DK397687A patent/DK169722B1/da not_active IP Right Cessation
- 1987-07-30 PT PT85455A patent/PT85455B/pt not_active IP Right Cessation
- 1987-07-31 KR KR1019870008387A patent/KR950010073B1/ko not_active Expired - Fee Related
- 1987-07-31 AU AU76350/87A patent/AU594489B2/en not_active Ceased
- 1987-07-31 US US07/080,716 patent/US4971966A/en not_active Expired - Fee Related
1992
- 1992-07-13 GR GR920401502T patent/GR3005157T3/el unknown

Also Published As

Publication number	Publication date
JPS6335573A (ja)	1988-02-16
IL83366A0 (en)	1987-12-31
FI873297A0 (fi)	1987-07-29
FI85479B (fi)	1992-01-15
HUT44549A (en)	1988-03-28
ES2042523T3 (es)	1993-12-16
DK397687D0 (da)	1987-07-30
IE60861B1 (en)	1994-08-24
DE3779369D1 (de)	1992-07-02
ZA875623B (en)	1989-04-26
CA1311752C (en)	1992-12-22
IE872062L (en)	1988-01-31
FI873297A7 (fi)	1988-02-01
KR880001653A (ko)	1988-04-25
FI85479C (fi)	1992-04-27
US4971966A (en)	1990-11-20
PT85455B (pt)	1990-06-29
PT85455A (de)	1987-08-01
AU594489B2 (en)	1990-03-08
DK169722B1 (da)	1995-01-23
NO165345B (no)	1990-10-22
JP2519734B2 (ja)	1996-07-31
PH26406A (en)	1992-07-02
DE3626095A1 (de)	1988-02-11
HU197745B (en)	1989-05-29
EP0254955A3 (en)	1989-08-09
NO873189L (no)	1988-02-01
EP0254955A2 (de)	1988-02-03
IL83366A (en)	1991-05-12
NO873189D0 (no)	1987-07-30
ATE76643T1 (de)	1992-06-15
KR950010073B1 (ko)	1995-09-06
NZ221278A (en)	1990-03-27
DD265146A5 (de)	1989-02-22
GR3005157T3 (da)	1993-05-24
AU7635087A (en)	1988-02-04
NO165345C (no)	1991-01-30
EP0254955B1 (de)	1992-05-27

Legal Events

Date	Code	Title	Description
1995-01-23	B1	Patent granted (law 1993)
1999-05-03	PBP	Patent lapsed

Publication	Publication Date	Title
EP0275888A3 (en)	1989-09-27	Tricyclic benzimidazoles, process for their preparation and use as medicaments
ES2063030T3 (es)	1995-01-01	N-heterociclo-n-(4-piperidil) amidas.
NO167979C (no)	1992-01-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazopyridiner
DK397687D0 (da)	1987-07-30	Substituerede pyrido oe2,3-baaoe1,4aabenzodiazepin-6-oner samt laegemidler med indhold af saadanne forbindelser
NO900425D0 (no)	1990-01-30	Fremgangsmaate og anvendelse av imidazopyridaziner.
FI883745A0 (fi)	1988-08-12	Nya kondenserade diazepinoner, foerfarande foer deras framstaellning och dessa foereningar innehaollande laekemedel.
NO170281C (no)	1992-09-30	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridopyrimidinderivater
DE3060153D1 (en)	1982-03-11	Derivatives of substituted 2-benzoyl glycinanilides, their preparation and their use in anxiolytic medicaments
ATE86993T1 (de)	1993-04-15	Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
ATE5820T1 (de)	1984-01-15	5-substituierte 9-cyanmethylen-dithieno(3,4b:4'.3'-e)-azepine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel.
ES2135383T3 (es)	1999-11-01	Pirido(3,4-b)pirrolo(1,2-e)(1,4,5)oxadiazepinas y compuestos analogos relacionados, un procedimiento para su preparacion y su uso como medicamentos.
BG98448A (bg)	1994-11-15	3-(заместени тетразолил)-4-оксо-4н-пиридо/1,2-а/пиримидини,техни соли,съдържащи ги фармацевтични продукти и метод за получаването им
TH3613A (th)	1986-11-03	สารประกอบเฮเทอโรไซคลิค
TH3063A (th)	1986-02-03	อนุพันธ์ของอิมิตาโซล