DK399182A - Fremgangsmaader til fremstilling og til isolering eller rensning af dipeptidamid-soedemidler samt i det vaesentlige rene salte af saadanne dipeptidamider med aromatiske sulfonsyrer - Google Patents

Fremgangsmaader til fremstilling og til isolering eller rensning af dipeptidamid-soedemidler samt i det vaesentlige rene salte af saadanne dipeptidamider med aromatiske sulfonsyrer Download PDF

Info

Publication number: DK399182A
Authority: DK; Denmark
Prior art keywords: salts; preparing; dipeptidamides; dipeptidamide; purificating
Prior art date: 1981-09-08

Application number

DK399182A

Other languages

English (en)

Other versions

DK155947C (da

DK155947B (da

Inventor

Constantine Sklavounos

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-09-08

Filing date

1982-09-07

Publication date

1983-03-09

1982-09-07 Application filed by Pfizer filed Critical Pfizer

1983-03-09 Publication of DK399182A publication Critical patent/DK399182A/da

1989-06-05 Publication of DK155947B publication Critical patent/DK155947B/da

1989-11-13 Application granted granted Critical

1989-11-13 Publication of DK155947C publication Critical patent/DK155947C/da

Links

238000000034 method Methods 0.000 title abstract 3
239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
150000001408 amides Chemical class 0.000 abstract 2
238000002425 crystallisation Methods 0.000 abstract 2
230000008025 crystallization Effects 0.000 abstract 2
KNIZBZYMVRWQKN-DMTCNVIQSA-N (3s)-3-amino-4-[[(2r)-1-amino-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical class NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC(O)=O KNIZBZYMVRWQKN-DMTCNVIQSA-N 0.000 abstract 1
VMQCQYRHANDJBP-IUYQGCFVSA-N (3s)-3-amino-4-[[(2r)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical class OC(=O)C[C@H](N)C(=O)N[C@H](CO)C(N)=O VMQCQYRHANDJBP-IUYQGCFVSA-N 0.000 abstract 1
-1 Aromatic sulfonic acid salts Chemical class 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
108010016626 Dipeptides Proteins 0.000 abstract 1
235000003599 food sweetener Nutrition 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000003765 sweetening agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/801—Peptide sweetners

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Seasonings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Apparatus For Radiation Diagnosis (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Joints Allowing Movement (AREA)
Coupling Device And Connection With Printed Circuit (AREA)
Manufacturing Of Electrical Connectors (AREA)
Discharging, Photosensitive Material Shape In Electrophotography (AREA)
Detergent Compositions (AREA)

DK399182A 1981-09-08 1982-09-07 I det vaesentlige rene, vandfrie eller hydratiserede salte af l-aspartyl-d-aminosyre-dipeptid-amider med aromatiske sulfonsyrer og fremgangsmaade til fremstilling deraf DK155947C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/300,366 US4375430A (en)	1981-09-08	1981-09-08	Processes for preparation, isolation and purification of dipeptide sweeteners
US30036681		1981-09-08

Publications (3)

Publication Number	Publication Date
DK399182A true DK399182A (da)	1983-03-09
DK155947B DK155947B (da)	1989-06-05
DK155947C DK155947C (da)	1989-11-13

Family

ID=23158792

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK399182A DK155947C (da)	1981-09-08	1982-09-07	I det vaesentlige rene, vandfrie eller hydratiserede salte af l-aspartyl-d-aminosyre-dipeptid-amider med aromatiske sulfonsyrer og fremgangsmaade til fremstilling deraf

Country Status (19)

Country	Link
US (1)	US4375430A (da)
EP (1)	EP0074249B1 (da)
JP (1)	JPS5857350A (da)
AT (1)	ATE8879T1 (da)
AU (1)	AU534082B2 (da)
CA (1)	CA1238903A (da)
DE (1)	DE3260543D1 (da)
DK (1)	DK155947C (da)
ES (3)	ES8308304A1 (da)
FI (1)	FI76352C (da)
GR (1)	GR76704B (da)
IE (1)	IE53795B1 (da)
IL (1)	IL66739A (da)
MX (1)	MX155762A (da)
NO (1)	NO161123C (da)
NZ (1)	NZ201816A (da)
PT (1)	PT75519B (da)
YU (1)	YU43277B (da)
ZA (1)	ZA826522B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4855454A (en) *	1980-01-21	1989-08-08	Pfizer Inc.	Branched amides of L-aspartyl-D-amino acid dipeptides
US4465626A (en) *	1981-09-08	1984-08-14	Pfizer Inc.	Process for preparation, isolation and purification of dipeptide sweeteners
CA1276394C (en) *	1984-07-13	1990-11-13	John M. Janusz	Alpha-l-aspartyl-d-phenylglycine esters and amides useful as high intensity sweeteners
CA1276395C (en) *	1984-07-13	1990-11-13	John M. Janusz	Oxa-fenchyl esters and amides of alpha-l-aspartyl-d- phenylglycine
US4572799A (en) *	1985-04-15	1986-02-25	General Foods Corporation	L-Aminodicarboxylic acid amides
EP0199257A3 (en) *	1985-04-15	1988-08-10	General Foods Corporation	L-aminodicarboxylic acid esters and an edible composition containing same as sweeteners
US4935355A (en) *	1986-04-15	1990-06-19	Synthetech, Inc.	Preparation of dipeptides
US4758443A (en) *	1986-06-18	1988-07-19	General Foods Corporation	Thietanyl-substituted amides and use thereof as sweeteners
US4855455A (en) *	1988-01-22	1989-08-08	W. R. Grace & Co.-Conn.	Preparation of amino acid derivatives
US5283357A (en) *	1988-03-14	1994-02-01	Mitsui Toatsu Chemicals, Incorporated	Separation method of α-l-aspartyl-l-phenylalanine methyl ester
MX2007004191A (es) *	2004-10-14	2007-06-11	Wilex Ag	Metodo para depurar derivados de 3-hidroxi-amidino-fenilalanina mediante la precipitacion y recristalizacion de una sal con un acido sulfonico aromatico.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA909254A (en) *	1969-12-30	1972-09-05	Ariyoshi Yasuo	METHOD OF PURIFYING LOWER ALKYL OF .alpha.-L-ASPARTYL-L-PHENYLALANINE

1981
- 1981-09-08 US US06/300,366 patent/US4375430A/en not_active Expired - Lifetime
1982
- 1982-09-02 DE DE8282304608T patent/DE3260543D1/de not_active Expired
- 1982-09-02 EP EP82304608A patent/EP0074249B1/en not_active Expired
- 1982-09-02 AT AT82304608T patent/ATE8879T1/de active
- 1982-09-03 CA CA000410725A patent/CA1238903A/en not_active Expired
- 1982-09-06 NO NO823002A patent/NO161123C/no not_active IP Right Cessation
- 1982-09-06 FI FI823072A patent/FI76352C/fi not_active IP Right Cessation
- 1982-09-06 NZ NZ201816A patent/NZ201816A/en unknown
- 1982-09-06 GR GR69210A patent/GR76704B/el unknown
- 1982-09-07 YU YU2013/82A patent/YU43277B/xx unknown
- 1982-09-07 PT PT75519A patent/PT75519B/pt unknown
- 1982-09-07 MX MX194302A patent/MX155762A/es unknown
- 1982-09-07 DK DK399182A patent/DK155947C/da not_active IP Right Cessation
- 1982-09-07 ZA ZA826522A patent/ZA826522B/xx unknown
- 1982-09-07 IE IE2175/82A patent/IE53795B1/en not_active IP Right Cessation
- 1982-09-07 AU AU88087/82A patent/AU534082B2/en not_active Expired
- 1982-09-07 ES ES515545A patent/ES8308304A1/es not_active Expired
- 1982-09-07 IL IL66739A patent/IL66739A/xx not_active IP Right Cessation
- 1982-09-08 JP JP57156505A patent/JPS5857350A/ja active Granted
1983
- 1983-04-22 ES ES521765A patent/ES8406064A1/es not_active Expired
- 1983-04-22 ES ES521764A patent/ES8406063A1/es not_active Expired

Also Published As

Publication number	Publication date
CA1238903A (en)	1988-07-05
NO161123C (no)	1989-07-05
YU43277B (en)	1989-06-30
NZ201816A (en)	1985-05-31
PT75519B (en)	1985-11-25
DE3260543D1 (en)	1984-09-13
IL66739A0 (en)	1982-12-31
ES515545A0 (es)	1983-08-16
ZA826522B (en)	1983-07-27
FI76352B (fi)	1988-06-30
AU534082B2 (en)	1984-01-05
ES8308304A1 (es)	1983-08-16
US4375430A (en)	1983-03-01
ES521764A0 (es)	1984-07-01
JPS6318959B2 (da)	1988-04-20
JPS5857350A (ja)	1983-04-05
IL66739A (en)	1985-07-31
YU201382A (en)	1985-04-30
ES521765A0 (es)	1984-07-01
IE822175L (en)	1983-03-08
GR76704B (da)	1984-08-29
ES8406064A1 (es)	1984-07-01
PT75519A (en)	1982-10-01
FI823072A0 (fi)	1982-09-06
NO161123B (no)	1989-03-28
EP0074249A1 (en)	1983-03-16
ES8406063A1 (es)	1984-07-01
EP0074249B1 (en)	1984-08-08
AU8808782A (en)	1983-05-05
ATE8879T1 (de)	1984-08-15
FI823072L (fi)	1983-03-09
IE53795B1 (en)	1989-02-15
DK155947C (da)	1989-11-13
DK155947B (da)	1989-06-05
FI76352C (fi)	1988-10-10
NO823002L (no)	1983-03-09
MX155762A (es)	1988-04-25

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Legal Events

Date	Code	Title	Description
2002-09-23	PUP	Patent expired