DK400681A - Isoquinolinderivater fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse forbindelser og deres anvendelse - Google Patents

Isoquinolinderivater fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse forbindelser og deres anvendelse

Info

Publication number
DK400681A
DK400681A DK400681A DK400681A DK400681A DK 400681 A DK400681 A DK 400681A DK 400681 A DK400681 A DK 400681A DK 400681 A DK400681 A DK 400681A DK 400681 A DK400681 A DK 400681A
Authority
DK
Denmark
Prior art keywords
compounds
preparing
isoquinoline derivatives
pharmaceutical preparations
preparations containing
Prior art date
Application number
DK400681A
Other languages
English (en)
Inventor
E Konz
F Hock
J Kaiser
H J Kruse
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK400681A publication Critical patent/DK400681A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK400681A 1980-09-10 1981-09-09 Isoquinolinderivater fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse forbindelser og deres anvendelse DK400681A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803034001 DE3034001A1 (de) 1980-09-10 1980-09-10 Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung

Publications (1)

Publication Number Publication Date
DK400681A true DK400681A (da) 1982-03-11

Family

ID=6111554

Family Applications (1)

Application Number Title Priority Date Filing Date
DK400681A DK400681A (da) 1980-09-10 1981-09-09 Isoquinolinderivater fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse forbindelser og deres anvendelse

Country Status (20)

Country Link
US (1) US4590273A (da)
EP (1) EP0047923B1 (da)
JP (1) JPS5780372A (da)
KR (1) KR830007622A (da)
AT (1) ATE7389T1 (da)
AU (1) AU541976B2 (da)
CA (1) CA1168232A (da)
DE (2) DE3034001A1 (da)
DK (1) DK400681A (da)
ES (3) ES8206511A1 (da)
FI (1) FI71734C (da)
GR (1) GR74978B (da)
HU (1) HU187357B (da)
IE (1) IE51551B1 (da)
IL (1) IL63765A (da)
NO (1) NO813066L (da)
NZ (1) NZ198308A (da)
PH (1) PH19431A (da)
PT (1) PT73629B (da)
ZA (1) ZA816237B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
GR79603B (da) * 1982-07-24 1984-10-31 Pfizer
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
US4544657A (en) * 1983-05-19 1985-10-01 Hoffmann-La Roche Inc. Substituted isoquinolines
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4843077A (en) * 1987-06-09 1989-06-27 Ortho Pharmaceutical Corporation Isoquinoline derivatives having renal vasodilating properties and/or cardiotonic properties and/or phosphodiesterase inhibiting properties
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
US5332733A (en) * 1990-11-24 1994-07-26 Kali-Chemie Pharma Gmbh Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
US6008352A (en) * 1997-04-03 1999-12-28 Neurogen Corporation 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands
US6313141B1 (en) 1997-06-13 2001-11-06 Neurogen Corporation 2-aminoalkylaminoquinolines as dopamine D4 ligands
US5972945A (en) * 1997-06-13 1999-10-26 Neurogen Corporation 2-aminoalkylaminoquinolines; dopamine receptor subtype specific ligands
ATE404539T1 (de) 1997-10-02 2008-08-15 Eisai R&D Man Co Ltd Kondensierte pyridinderivate
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
EE04588B1 (et) 1997-10-27 2006-02-15 Neurosearch A/S Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
US6613901B2 (en) 2000-03-08 2003-09-02 Neurogen Corporation 2-aminoalkylaminoquinolines as dopamine D4 ligands
AU2007271187A1 (en) * 2006-07-03 2008-01-10 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Fused bicyclic compounds interacting with the histamine H4 receptor
EA026115B1 (ru) * 2010-12-17 2017-03-31 Ф. Хоффманн-Ля Рош Аг Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение
EP3601259B1 (en) 2017-03-30 2022-02-23 F. Hoffmann-La Roche AG Isoquinolines as inhibitors of hpk1
TW202019905A (zh) 2018-07-24 2020-06-01 瑞士商赫孚孟拉羅股份公司 異喹啉化合物及其用途
TW202024053A (zh) 2018-10-02 2020-07-01 美商建南德克公司 異喹啉化合物及其用途
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
GB1244501A (en) * 1968-03-09 1971-09-02 Aspro Nicholas Ltd Heterocyclic amines
DE2030675A1 (en) * 1969-06-23 1971-02-11 Arthur D Little, Inc , Cambridge, Mass (V St A) 3-amino-4-phenyl-isoquinoline derivs
US3932412A (en) * 1970-12-07 1976-01-13 Sandoz, Inc. 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates
DE2420012C3 (de) * 1974-04-25 1980-01-10 Dr. Karl Thomae Gmbh, 7950 Biberach Isochinoline
DE2503961C3 (de) * 1975-01-31 1980-02-28 Dr. Karl Thomae Gmbh, 7950 Biberach Isochinoline
AT342057B (de) * 1974-04-25 1978-03-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen
DE2811312A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln
DE2818403A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung
DE2818423A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NZ198308A (en) 1984-03-30
ES506584A0 (es) 1983-03-01
DE3163510D1 (en) 1984-06-14
EP0047923A1 (de) 1982-03-24
JPS5780372A (en) 1982-05-19
FI812783L (fi) 1982-03-11
ES506583A0 (es) 1983-04-01
AU7509181A (en) 1982-03-18
IL63765A (en) 1985-05-31
FI71734B (fi) 1986-10-31
HU187357B (en) 1985-12-28
EP0047923B1 (de) 1984-05-09
GR74978B (da) 1984-07-12
IL63765A0 (en) 1981-12-31
US4590273A (en) 1986-05-20
ES505191A0 (es) 1982-08-16
ES8305351A1 (es) 1983-04-01
ES8304563A1 (es) 1983-03-01
DE3034001A1 (de) 1982-04-22
ZA816237B (en) 1982-08-25
PT73629A (de) 1981-10-01
FI71734C (fi) 1987-02-09
ES8206511A1 (es) 1982-08-16
PT73629B (de) 1983-04-29
CA1168232A (en) 1984-05-29
AU541976B2 (en) 1985-01-31
KR830007622A (ko) 1983-11-04
IE812094L (en) 1982-03-10
PH19431A (en) 1986-04-15
ATE7389T1 (de) 1984-05-15
NO813066L (no) 1982-03-11
IE51551B1 (en) 1987-01-07

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Legal Events

Date Code Title Description
ATS Application withdrawn