DK40192D0 - Imidazolforbindelser, deres fremstilling og anvendelse - Google Patents

Imidazolforbindelser, deres fremstilling og anvendelse

Info

Publication number
DK40192D0
DK40192D0 DK92401A DK40192A DK40192D0 DK 40192 D0 DK40192 D0 DK 40192D0 DK 92401 A DK92401 A DK 92401A DK 40192 A DK40192 A DK 40192A DK 40192 D0 DK40192 D0 DK 40192D0
Authority
DK
Denmark
Prior art keywords
alkyl
amino
alkoxy
nitro
halogen
Prior art date
Application number
DK92401A
Other languages
English (en)
Inventor
Oskar Axelsson
Dan Peters
Elsebet Oestergaard Nielsen
Palle Christophersen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Priority to DK92401A priority Critical patent/DK40192D0/da
Publication of DK40192D0 publication Critical patent/DK40192D0/da
Priority to CA002092211A priority patent/CA2092211C/en
Priority to DK93610022.1T priority patent/DK0563001T3/da
Priority to KR1019930004595A priority patent/KR100286844B1/ko
Priority to ZA932090A priority patent/ZA932090B/xx
Priority to NO931080A priority patent/NO303779B1/no
Priority to NZ247233A priority patent/NZ247233A/en
Priority to ES93610022T priority patent/ES2085133T3/es
Priority to AT93610022T priority patent/ATE134621T1/de
Priority to FI931305A priority patent/FI931305A7/fi
Priority to DE69301618T priority patent/DE69301618T2/de
Priority to JP06568893A priority patent/JP3647051B2/ja
Priority to US08/036,425 priority patent/US5360809A/en
Priority to EP93610022A priority patent/EP0563001B1/en
Priority to AU35406/93A priority patent/AU660219B2/en
Priority to GR960400608T priority patent/GR3019204T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymerization Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK92401A 1992-03-26 1992-03-26 Imidazolforbindelser, deres fremstilling og anvendelse DK40192D0 (da)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DK92401A DK40192D0 (da) 1992-03-26 1992-03-26 Imidazolforbindelser, deres fremstilling og anvendelse
CA002092211A CA2092211C (en) 1992-03-26 1993-03-23 Imidazole compounds, their preparation and use
AU35406/93A AU660219B2 (en) 1992-03-26 1993-03-24 Imidazole compounds, their preparation and use
NZ247233A NZ247233A (en) 1992-03-26 1993-03-24 Phenyl substituted benzimidazole or imidazo-[5,4-b]pyridine derivatives and pharmaceutical compositions thereof
FI931305A FI931305A7 (fi) 1992-03-26 1993-03-24 Imidazolfoereningar, deras framstaellning och bruk
ZA932090A ZA932090B (en) 1992-03-26 1993-03-24 Imidazole compounds, their preparation and use
NO931080A NO303779B1 (no) 1992-03-26 1993-03-24 Imidazolforbindelser, anvendelse derav og farmas°ytisk preparat
DK93610022.1T DK0563001T3 (da) 1992-03-26 1993-03-24 Imidazolforbindelser, deres fremstilling og anvendelse
ES93610022T ES2085133T3 (es) 1992-03-26 1993-03-24 Compuestos de imidazol, su preparacion y su uso.
AT93610022T ATE134621T1 (de) 1992-03-26 1993-03-24 Imidazol-derivate, ihre herstellung und verwendung
KR1019930004595A KR100286844B1 (ko) 1992-03-26 1993-03-24 이미다졸 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물
DE69301618T DE69301618T2 (de) 1992-03-26 1993-03-24 Imidazol-Derivate, ihre Herstellung und Verwendung
JP06568893A JP3647051B2 (ja) 1992-03-26 1993-03-24 イミダゾール化合物、その製造方法及びその使用方法
US08/036,425 US5360809A (en) 1992-03-26 1993-03-24 Imidazole compounds and their use as calcium channel blockers
EP93610022A EP0563001B1 (en) 1992-03-26 1993-03-24 Imidazole compounds, their preparation and use
GR960400608T GR3019204T3 (en) 1992-03-26 1996-03-05 Imidazole compounds, their preparation and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK92401A DK40192D0 (da) 1992-03-26 1992-03-26 Imidazolforbindelser, deres fremstilling og anvendelse

Publications (1)

Publication Number Publication Date
DK40192D0 true DK40192D0 (da) 1992-03-26

Family

ID=8093115

Family Applications (2)

Application Number Title Priority Date Filing Date
DK92401A DK40192D0 (da) 1992-03-26 1992-03-26 Imidazolforbindelser, deres fremstilling og anvendelse
DK93610022.1T DK0563001T3 (da) 1992-03-26 1993-03-24 Imidazolforbindelser, deres fremstilling og anvendelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK93610022.1T DK0563001T3 (da) 1992-03-26 1993-03-24 Imidazolforbindelser, deres fremstilling og anvendelse

Country Status (15)

Country Link
US (1) US5360809A (da)
EP (1) EP0563001B1 (da)
JP (1) JP3647051B2 (da)
KR (1) KR100286844B1 (da)
AT (1) ATE134621T1 (da)
AU (1) AU660219B2 (da)
CA (1) CA2092211C (da)
DE (1) DE69301618T2 (da)
DK (2) DK40192D0 (da)
ES (1) ES2085133T3 (da)
FI (1) FI931305A7 (da)
GR (1) GR3019204T3 (da)
NO (1) NO303779B1 (da)
NZ (1) NZ247233A (da)
ZA (1) ZA932090B (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU675484B2 (en) * 1993-03-24 1997-02-06 Neurosearch A/S Benzimidazole compounds, their use and preparation
US5554630A (en) * 1993-03-24 1996-09-10 Neurosearch A/S Benzimidazole compounds
JP3398152B2 (ja) * 1993-10-12 2003-04-21 ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
CA2174080A1 (en) * 1993-10-12 1995-04-20 Paul Edward Aldrich 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
US5552426A (en) * 1994-04-29 1996-09-03 Eli Lilly And Company Methods for treating a physiological disorder associated with β-amyloid peptide
CN1089762C (zh) * 1995-04-21 2002-08-28 纽罗研究公司 苯并咪唑化合物及其用作gabaa受体复合物调节器的用途
US6228871B1 (en) 1995-07-10 2001-05-08 Merck & Co., Inc. Angiogenesis inhibitors
UA49006C2 (uk) * 1996-03-29 2002-09-16 Файзер Інк. Похідні 6-фенілпіридил-2-аміну, фармацевтична композиція, спосіб інгібування синтази оксиду нітрогену у ссавців та спосіб лікування
NZ334868A (en) * 1996-10-21 2001-02-23 Neurosearch As 1-Phenyl-benzimidazole compounds and their use as BAGA-a receptor modulators
GB9702524D0 (en) * 1997-02-07 1997-03-26 Merck Sharp & Dohme Therapeutic agents
US5990146A (en) * 1997-08-20 1999-11-23 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
JP2001518470A (ja) * 1997-09-26 2001-10-16 メルク エンド カムパニー インコーポレーテッド 新規な血管形成阻害剤
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US6541479B1 (en) * 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
EP1109555A4 (en) * 1998-08-31 2001-11-21 Merck & Co Inc Novel angiogenesis inhibitors
AU760250B2 (en) * 1998-12-04 2003-05-08 Neurosearch A/S New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents
JP3270834B2 (ja) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
NZ515543A (en) * 1999-06-22 2003-11-28 Neurosearch As Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
GB9921150D0 (en) 1999-09-07 1999-11-10 Merck Sharp & Dohme Therapeutic agents
EP1294723A1 (en) * 2000-05-24 2003-03-26 MERCK SHARP & DOHME LTD. 3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
US7022480B1 (en) 2001-10-11 2006-04-04 The Regents Of The University Of California Exons of the hSKCa3/KCNN3 gene
GB0208392D0 (en) * 2002-04-11 2002-05-22 Merck Sharp & Dohme Therapeutic compounds
GB0208394D0 (en) * 2002-04-11 2002-05-22 Merck Sharp & Dohme Therapeutic agents
GB0212048D0 (en) * 2002-05-24 2002-07-03 Merck Sharp & Dohme Therapeutic agents
KR101020350B1 (ko) * 2003-03-13 2011-03-08 이데미쓰 고산 가부시키가이샤 신규한 질소 함유 헤테로환 유도체 및 이를 이용한 유기 전기발광 소자
AU2004226179A1 (en) * 2003-04-03 2004-10-14 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABA-a receptor complex
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
WO2005021531A1 (en) * 2003-08-21 2005-03-10 Osi Pharmaceuticals, Inc. N-substituted benzimidazolyl c-kit inhibitors
US7504401B2 (en) 2003-08-29 2009-03-17 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
KR20060115396A (ko) * 2003-10-28 2006-11-08 버텍스 파마슈티칼스 인코포레이티드 이온 채널 조절인자로서 유용한 벤즈이미다졸
DE602006007976D1 (de) * 2005-04-13 2009-09-03 Neurosearch As Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes
WO2006124865A2 (en) * 2005-05-19 2006-11-23 Vertex Pharmaceuticals Incorporated Biaryls derivatives useful as modulators of ion channels
WO2007007463A1 (ja) * 2005-07-11 2007-01-18 Idemitsu Kosan Co., Ltd. 電子吸引性置換基を有する含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
EP1956013B1 (en) * 2005-11-30 2016-04-13 Fujifilm RI Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
DE602006010602D1 (de) * 2005-12-05 2009-12-31 Neurosearch As Benzimidazolderivate und ihre verwendung zur modulierung des gabaa-rezeptorkomplexes
TWI391381B (zh) * 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
CA2694216A1 (en) * 2007-07-24 2009-01-29 Astellas Pharma Inc. Benzimidazole derivative
CN102015691B (zh) * 2008-04-29 2014-01-08 诺华股份有限公司 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物
WO2010055133A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TW201029987A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
WO2010055130A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TW201029986A (en) 2008-11-14 2010-08-16 Neurosearch As Novel compounds
JPWO2010087319A1 (ja) 2009-01-27 2012-08-02 アステラス製薬株式会社 前立腺癌治療剤として有効な物質のスクリーニング方法
WO2011047315A1 (en) 2009-10-15 2011-04-21 Concert Pharmaceuticals, Inc. Subsitituted benzimidazoles
WO2012131501A1 (en) * 2011-03-28 2012-10-04 Glenmark Pharmaceuticals S.A. Substituted benzimidazole compounds as cot kinase inhibitors
US9694005B2 (en) 2013-04-04 2017-07-04 University Of Maryland, Baltimore Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
ES2960987T3 (es) * 2019-04-12 2024-03-07 Riboscience Llc Derivados de heteroarilo bicíclicos como inhibidores de la ectonucleótido pirofosfatasa fosfodiesterasa 1
CN112142622A (zh) * 2020-11-02 2020-12-29 江苏宝众宝达药业有限公司 一种4-氟-3-硝基苯腈的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1570893A (da) * 1968-06-18 1969-06-13
HU190412B (en) * 1981-09-17 1986-09-29 Warner-Lambert Co,Us Process for producing substituted 4,5-dihiydro-6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones and 6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
US4503061A (en) * 1983-07-22 1985-03-05 Warner-Lambert Company Substituted phenyl-pyridinones as cardiotonic agents
JPS59185691A (ja) * 1983-04-06 1984-10-22 Ricoh Co Ltd ジアゾ系感熱記録材料
US4550119A (en) * 1983-05-23 1985-10-29 Warner-Lambert Company 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
MY104933A (en) * 1987-09-30 1994-07-30 Pfizer Ltd Platelet activating factor antagonists
FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
CA2077897A1 (en) * 1990-04-13 1991-10-14 Robert G. Franz Substituted benzimidazoles
GB9010637D0 (en) * 1990-05-11 1990-07-04 Secr Defence A high frequency multichannel diversity differential phase shift(dpsk)communications system
DE4015535A1 (de) * 1990-05-15 1991-11-21 Basf Ag Verfahren zur herstellung von n-substituierten imidazolen
PH31175A (en) * 1990-10-31 1998-03-20 Squibb & Sons Inc Indole and benzimi-dazole-substituted imidazole and benzimidazole derivatives.
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use
EP0520200B1 (en) * 1991-06-24 1998-02-18 Neurosearch A/S Imidazole compounds, their preparation and use

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EP0563001B1 (en) 1996-02-28
NO303779B1 (no) 1998-08-31
NO931080D0 (no) 1993-03-24
AU660219B2 (en) 1995-06-15
EP0563001A1 (en) 1993-09-29
CA2092211A1 (en) 1993-09-27
FI931305A7 (fi) 1993-09-27
JP3647051B2 (ja) 2005-05-11
CA2092211C (en) 2003-08-26
NO931080L (no) 1993-09-27
JPH0649037A (ja) 1994-02-22
KR930019638A (ko) 1993-10-18
US5360809A (en) 1994-11-01
GR3019204T3 (en) 1996-06-30
ZA932090B (en) 1993-10-15
DK0563001T3 (da) 1996-08-05
ES2085133T3 (es) 1996-05-16
DE69301618D1 (de) 1996-04-04
KR100286844B1 (ko) 2001-04-16
FI931305A0 (fi) 1993-03-24
ATE134621T1 (de) 1996-03-15
AU3540693A (en) 1993-09-30
NZ247233A (en) 1995-03-28
DE69301618T2 (de) 1996-08-22

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