DK4077695T3 - Fremgangsmåde til fermenteringsproduktion af guanidinoeddikesyre - Google Patents
Fremgangsmåde til fermenteringsproduktion af guanidinoeddikesyre Download PDFInfo
- Publication number
- DK4077695T3 DK4077695T3 DK20823810.5T DK20823810T DK4077695T3 DK 4077695 T3 DK4077695 T3 DK 4077695T3 DK 20823810 T DK20823810 T DK 20823810T DK 4077695 T3 DK4077695 T3 DK 4077695T3
- Authority
- DK
- Denmark
- Prior art keywords
- fermentation production
- guanidinoacetic acid
- guanidinoacetic
- acid
- fermentation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/10—Citrulline; Arginine; Ornithine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01002—Guanidinoacetate N-methyltransferase (2.1.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
- C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/04—Amidinotransferases (2.1.4)
- C12Y201/04001—Glycine amidinotransferase (2.1.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/02—Amidine-lyases (4.3.2)
- C12Y403/02001—Argininosuccinate lyase (4.3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
- C12Y603/04005—Argininosuccinate synthase (6.3.4.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
- C12Y603/04016—Carbamoyl-phosphate synthase (ammonia) (6.3.4.16)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
- C12Y603/05005—Carbamoyl-phosphate synthase (glutamine-hydrolysing) (6.3.5.5)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19218204.6A EP3839051A1 (en) | 2019-12-19 | 2019-12-19 | Method for the fermentative production of guanidinoacetic acid |
| PCT/EP2020/085882 WO2021122400A1 (en) | 2019-12-19 | 2020-12-14 | Method for the fermentative production of guanidinoacetic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK4077695T3 true DK4077695T3 (da) | 2024-10-14 |
Family
ID=69410969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20823810.5T DK4077695T3 (da) | 2019-12-19 | 2020-12-14 | Fremgangsmåde til fermenteringsproduktion af guanidinoeddikesyre |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20250171790A1 (da) |
| EP (2) | EP3839051A1 (da) |
| JP (1) | JP7680454B2 (da) |
| KR (1) | KR20220119026A (da) |
| CN (1) | CN114867861A (da) |
| AR (1) | AR120771A1 (da) |
| AU (1) | AU2020410242B2 (da) |
| BR (1) | BR112022010862A2 (da) |
| DK (1) | DK4077695T3 (da) |
| IL (1) | IL293952A (da) |
| MX (1) | MX2022007250A (da) |
| MY (1) | MY208731A (da) |
| PH (1) | PH12022551505A1 (da) |
| PL (1) | PL4077695T3 (da) |
| TW (1) | TW202136505A (da) |
| WO (1) | WO2021122400A1 (da) |
| ZA (1) | ZA202207792B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2939033T3 (es) | 2019-10-28 | 2023-04-18 | Evonik Operations Gmbh | Mezcla de endurecimiento |
| CN113481139B (zh) * | 2021-07-29 | 2022-11-08 | 江南大学 | 一种产胍基乙酸的重组枯草芽孢杆菌及其构建方法 |
| EP4532739A1 (en) | 2022-06-03 | 2025-04-09 | Evonik Operations GmbH | Method for producing guanidino acetic acid (gaa) |
| CN119325504A (zh) | 2022-06-03 | 2025-01-17 | 赢创运营有限公司 | 通过使用nadh依赖性脱氢酶生产胍基乙酸(gaa)的改良的生物技术方法 |
| EP4612280A1 (en) | 2022-11-03 | 2025-09-10 | Evonik Operations GmbH | Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane exporter protein |
| CN120129742A (zh) | 2022-11-03 | 2025-06-10 | 赢创运营有限公司 | 通过靶向引入或增加属于氨基酸-多胺-有机阳离子超家族的跨膜转运蛋白的活性来产生胍基乙酸(gaa)的改进的生物技术工艺 |
| CN120476204A (zh) | 2023-01-09 | 2025-08-12 | 赢创运营有限公司 | 通过使用具有增强的l-丝氨酸羟甲基转移酶活性的微生物来从丝氨酸发酵产生胍基乙酸（gaa） |
| AU2023423758A1 (en) | 2023-01-09 | 2025-08-21 | Evonik Operations Gmbh | Fermentative production guanidinoacetic acid (gaa) from serine by attenuating l serine ammonia lyase activity in microorganisms |
| JP2026503156A (ja) | 2023-02-01 | 2026-01-27 | エボニック オペレーションズ ゲーエムベーハー | 異種Ｌ－トレオニン３－デヒドロゲナーゼ遺伝子（ｔｄｈ）とグリシンＣ－アセチルトランスフェラーゼ遺伝子（ｋｂｌ）とを含む微生物を使用したグアニジノ酢酸の発酵生産のための方法 |
| WO2024160790A1 (en) | 2023-02-01 | 2024-08-08 | Evonik Operations Gmbh | Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine aldolase gene |
| WO2024165344A1 (en) * | 2023-02-06 | 2024-08-15 | Evonik Operations Gmbh | Process for producing free-flowing particles comprising or consisting of an n-guanylamino acid |
| CN120659772A (zh) | 2023-02-06 | 2025-09-16 | 赢创运营有限公司 | 制备n-胍基氨基酸的方法 |
| CN116426497B (zh) * | 2023-03-20 | 2023-10-13 | 江南大学 | 一种l-精氨酸-甘氨酸脒基转移酶及其在生产胍基乙酸中的应用 |
| WO2024208621A1 (en) | 2023-04-03 | 2024-10-10 | Evonik Operations Gmbh | Composition comprising an n-guanylamino acid for drinking water application |
| CN117625503B (zh) * | 2023-11-20 | 2025-08-26 | 江南大学 | 一种利用微生物通过糖质原料发酵生产肌酸的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3849250A (en) | 1971-02-26 | 1974-11-19 | Kyowa Hakko Kogyo Kk | Process for producing l-arginine by fermentation |
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| EP1057893B1 (en) | 1999-06-03 | 2007-05-16 | Ajinomoto Co., Inc. | Method for producing L-arginine |
| US7160705B2 (en) | 2000-04-28 | 2007-01-09 | Ajinomoto Co., Inc. | Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine |
| BRPI0511842B1 (pt) | 2004-06-09 | 2014-08-12 | Alzchem Trostberg Gmbh | Uso de ácido guanidino acético como aditivo para ração animal |
| US20060200870A1 (en) * | 2004-11-24 | 2006-09-07 | Brian Tseng | Methods of treating muscular dystrophy |
| JP4595506B2 (ja) * | 2004-11-25 | 2010-12-08 | 味の素株式会社 | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造方法 |
| MY175283A (en) * | 2008-04-10 | 2020-06-18 | Korea Advanced Inst Sci & Tech | Mutant microorganisms having high ability to produce putrescine and method for producing putrescine using the same |
| KR101835935B1 (ko) | 2014-10-13 | 2018-03-12 | 씨제이제일제당 (주) | L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌의 제조 방법 |
| WO2016200614A2 (en) * | 2015-06-10 | 2016-12-15 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| CN106065411B (zh) | 2016-08-10 | 2021-12-07 | 洛阳华荣生物技术有限公司 | 发酵法生产肌酸 |
| JP2019531759A (ja) * | 2016-10-26 | 2019-11-07 | 味の素株式会社 | 目的物質の製造方法 |
-
2019
- 2019-12-19 EP EP19218204.6A patent/EP3839051A1/en not_active Withdrawn
-
2020
- 2020-12-14 AU AU2020410242A patent/AU2020410242B2/en active Active
- 2020-12-14 JP JP2022537864A patent/JP7680454B2/ja active Active
- 2020-12-14 PL PL20823810.5T patent/PL4077695T3/pl unknown
- 2020-12-14 US US17/757,441 patent/US20250171790A1/en active Pending
- 2020-12-14 KR KR1020227020423A patent/KR20220119026A/ko active Pending
- 2020-12-14 MX MX2022007250A patent/MX2022007250A/es unknown
- 2020-12-14 IL IL293952A patent/IL293952A/en unknown
- 2020-12-14 MY MYPI2022003133A patent/MY208731A/en unknown
- 2020-12-14 EP EP20823810.5A patent/EP4077695B1/en active Active
- 2020-12-14 WO PCT/EP2020/085882 patent/WO2021122400A1/en not_active Ceased
- 2020-12-14 BR BR112022010862A patent/BR112022010862A2/pt unknown
- 2020-12-14 PH PH1/2022/551505A patent/PH12022551505A1/en unknown
- 2020-12-14 DK DK20823810.5T patent/DK4077695T3/da active
- 2020-12-14 CN CN202080087505.XA patent/CN114867861A/zh active Pending
- 2020-12-15 AR ARP200103498A patent/AR120771A1/es not_active Application Discontinuation
- 2020-12-16 TW TW109144374A patent/TW202136505A/zh unknown
-
2022
- 2022-07-13 ZA ZA2022/07792A patent/ZA202207792B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN114867861A (zh) | 2022-08-05 |
| MX2022007250A (es) | 2022-07-13 |
| EP4077695B1 (en) | 2024-07-24 |
| IL293952A (en) | 2022-08-01 |
| AU2020410242A1 (en) | 2022-08-11 |
| PH12022551505A1 (en) | 2023-04-24 |
| US20250171790A1 (en) | 2025-05-29 |
| ZA202207792B (en) | 2023-04-26 |
| EP4077695A1 (en) | 2022-10-26 |
| BR112022010862A2 (pt) | 2022-08-23 |
| EP3839051A1 (en) | 2021-06-23 |
| KR20220119026A (ko) | 2022-08-26 |
| JP7680454B2 (ja) | 2025-05-20 |
| JP2023507482A (ja) | 2023-02-22 |
| PL4077695T3 (pl) | 2024-11-25 |
| AR120771A1 (es) | 2022-03-16 |
| WO2021122400A1 (en) | 2021-06-24 |
| AU2020410242B2 (en) | 2026-04-09 |
| MY208731A (en) | 2025-05-27 |
| TW202136505A (zh) | 2021-10-01 |
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