DK4135773T3 - Fremgangsmåde til syntese af et konjugat af hyaluronsyre og paclitaxel - Google Patents

Fremgangsmåde til syntese af et konjugat af hyaluronsyre og paclitaxel

Info

Publication number
DK4135773T3
DK4135773T3 DK21724037.3T DK21724037T DK4135773T3 DK 4135773 T3 DK4135773 T3 DK 4135773T3 DK 21724037 T DK21724037 T DK 21724037T DK 4135773 T3 DK4135773 T3 DK 4135773T3
Authority
DK
Denmark
Prior art keywords
paclitaxel
conjugate
synthesis
hyaluronic acid
hyaluronic
Prior art date
Application number
DK21724037.3T
Other languages
English (en)
Inventor
Monica Campisi
Cristian Guarise
Carlo Pizzocaro
Original Assignee
Fidia Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Farm Spa filed Critical Fidia Farm Spa
Application granted granted Critical
Publication of DK4135773T3 publication Critical patent/DK4135773T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK21724037.3T 2020-04-17 2021-04-15 Fremgangsmåde til syntese af et konjugat af hyaluronsyre og paclitaxel DK4135773T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102020000008209A IT202000008209A1 (it) 2020-04-17 2020-04-17 Procedimento di sintesi di un coniugato acido ialuronico-paclitaxel
PCT/IB2021/053096 WO2021209935A1 (en) 2020-04-17 2021-04-15 Process for the synthesis of a conjugate of hyaluronic acid and paclitaxel

Publications (1)

Publication Number Publication Date
DK4135773T3 true DK4135773T3 (da) 2026-02-16

Family

ID=71662175

Family Applications (1)

Application Number Title Priority Date Filing Date
DK21724037.3T DK4135773T3 (da) 2020-04-17 2021-04-15 Fremgangsmåde til syntese af et konjugat af hyaluronsyre og paclitaxel

Country Status (14)

Country Link
US (1) US20230148151A1 (da)
EP (2) EP4674908A3 (da)
CN (1) CN115379862B (da)
DK (1) DK4135773T3 (da)
ES (1) ES3062918T3 (da)
FI (1) FI4135773T3 (da)
HR (1) HRP20260205T1 (da)
IT (1) IT202000008209A1 (da)
LT (1) LT4135773T (da)
PL (1) PL4135773T3 (da)
PT (1) PT4135773T (da)
SI (1) SI4135773T1 (da)
SM (1) SMT202600048T1 (da)
WO (1) WO2021209935A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000007747A1 (it) * 2020-04-10 2021-10-10 Fidia Farm Spa Coniugato acido ialuronico-paclitaxel nel trattamento del mesotelioma
WO2024038087A1 (en) * 2022-08-16 2024-02-22 Synartro Ab Method for preparing sterile compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN163192B (da) 1983-10-11 1988-08-20 Fidia Spa
IT1263393B (it) 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
ITPD20020271A1 (it) 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
ITMI20071341A1 (it) * 2007-07-05 2009-01-06 Fidia Farmaceutici Derivati di acido ialuronico contenenti gruppi in grado di rilasciare no
CA2722376C (en) * 2008-04-22 2017-05-30 Fidia Farmaceutici S.P.A. Therapeutic use of new pharmaceutical preparations containing antitumoral drugs bound to hyaluronic acid in the treatment of neoplasias
IT1402385B1 (it) 2010-09-09 2013-09-04 Fidia Farmaceutici Processo per la produzione di acido ialuronico in escherichia coli o bacillus subtilis
IT1402384B1 (it) 2010-09-09 2013-09-04 Fidia Farmaceutici Processo per la produzione di acido ialuronico in escherichia coli o bacillus megaterium
IT201600079633A1 (it) 2016-07-28 2018-01-28 Fidia Farm Spa Procedimento di preparazione e purificazione del sale sodico dell’acido ialuronico
IT201800009731A1 (it) * 2018-10-25 2020-04-25 Fidia Farm Spa Coniugato paclitaxel - acido ialuronico nel trattamento del carcinoma vescicale non infiltrante

Also Published As

Publication number Publication date
WO2021209935A1 (en) 2021-10-21
EP4674908A3 (en) 2026-01-14
FI4135773T3 (fi) 2026-02-17
HRP20260205T1 (hr) 2026-03-27
CN115379862A (zh) 2022-11-22
EP4135773B1 (en) 2025-11-19
SMT202600048T1 (it) 2026-03-09
US20230148151A1 (en) 2023-05-11
IT202000008209A1 (it) 2021-10-17
EP4674908A2 (en) 2026-01-07
EP4135773A1 (en) 2023-02-22
ES3062918T3 (en) 2026-04-14
CN115379862B (zh) 2025-12-16
PL4135773T3 (pl) 2026-04-13
PT4135773T (pt) 2026-02-04
SI4135773T1 (sl) 2026-04-30
LT4135773T (lt) 2026-02-25
CA3172258A1 (en) 2021-10-21

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