DK4135773T3 - Fremgangsmåde til syntese af et konjugat af hyaluronsyre og paclitaxel - Google Patents
Fremgangsmåde til syntese af et konjugat af hyaluronsyre og paclitaxelInfo
- Publication number
- DK4135773T3 DK4135773T3 DK21724037.3T DK21724037T DK4135773T3 DK 4135773 T3 DK4135773 T3 DK 4135773T3 DK 21724037 T DK21724037 T DK 21724037T DK 4135773 T3 DK4135773 T3 DK 4135773T3
- Authority
- DK
- Denmark
- Prior art keywords
- paclitaxel
- conjugate
- synthesis
- hyaluronic acid
- hyaluronic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102020000008209A IT202000008209A1 (it) | 2020-04-17 | 2020-04-17 | Procedimento di sintesi di un coniugato acido ialuronico-paclitaxel |
| PCT/IB2021/053096 WO2021209935A1 (en) | 2020-04-17 | 2021-04-15 | Process for the synthesis of a conjugate of hyaluronic acid and paclitaxel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK4135773T3 true DK4135773T3 (da) | 2026-02-16 |
Family
ID=71662175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21724037.3T DK4135773T3 (da) | 2020-04-17 | 2021-04-15 | Fremgangsmåde til syntese af et konjugat af hyaluronsyre og paclitaxel |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230148151A1 (da) |
| EP (2) | EP4674908A3 (da) |
| CN (1) | CN115379862B (da) |
| DK (1) | DK4135773T3 (da) |
| ES (1) | ES3062918T3 (da) |
| FI (1) | FI4135773T3 (da) |
| HR (1) | HRP20260205T1 (da) |
| IT (1) | IT202000008209A1 (da) |
| LT (1) | LT4135773T (da) |
| PL (1) | PL4135773T3 (da) |
| PT (1) | PT4135773T (da) |
| SI (1) | SI4135773T1 (da) |
| SM (1) | SMT202600048T1 (da) |
| WO (1) | WO2021209935A1 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000007747A1 (it) * | 2020-04-10 | 2021-10-10 | Fidia Farm Spa | Coniugato acido ialuronico-paclitaxel nel trattamento del mesotelioma |
| WO2024038087A1 (en) * | 2022-08-16 | 2024-02-22 | Synartro Ab | Method for preparing sterile compositions |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN163192B (da) | 1983-10-11 | 1988-08-20 | Fidia Spa | |
| IT1263393B (it) | 1993-07-30 | 1996-08-05 | Fidia Advanced Biopolymers Srl | Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare |
| US5616568A (en) | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
| ITPD20020271A1 (it) | 2002-10-18 | 2004-04-19 | Fidia Farmaceutici | Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati. |
| ITMI20071341A1 (it) * | 2007-07-05 | 2009-01-06 | Fidia Farmaceutici | Derivati di acido ialuronico contenenti gruppi in grado di rilasciare no |
| CA2722376C (en) * | 2008-04-22 | 2017-05-30 | Fidia Farmaceutici S.P.A. | Therapeutic use of new pharmaceutical preparations containing antitumoral drugs bound to hyaluronic acid in the treatment of neoplasias |
| IT1402385B1 (it) | 2010-09-09 | 2013-09-04 | Fidia Farmaceutici | Processo per la produzione di acido ialuronico in escherichia coli o bacillus subtilis |
| IT1402384B1 (it) | 2010-09-09 | 2013-09-04 | Fidia Farmaceutici | Processo per la produzione di acido ialuronico in escherichia coli o bacillus megaterium |
| IT201600079633A1 (it) | 2016-07-28 | 2018-01-28 | Fidia Farm Spa | Procedimento di preparazione e purificazione del sale sodico dell’acido ialuronico |
| IT201800009731A1 (it) * | 2018-10-25 | 2020-04-25 | Fidia Farm Spa | Coniugato paclitaxel - acido ialuronico nel trattamento del carcinoma vescicale non infiltrante |
-
2020
- 2020-04-17 IT IT102020000008209A patent/IT202000008209A1/it unknown
-
2021
- 2021-04-15 LT LTEPPCT/IB2021/053096T patent/LT4135773T/lt unknown
- 2021-04-15 ES ES21724037T patent/ES3062918T3/es active Active
- 2021-04-15 FI FIEP21724037.3T patent/FI4135773T3/fi active
- 2021-04-15 SI SI202130397T patent/SI4135773T1/sl unknown
- 2021-04-15 CN CN202180025688.7A patent/CN115379862B/zh active Active
- 2021-04-15 EP EP25207960.3A patent/EP4674908A3/en active Pending
- 2021-04-15 SM SM20260048T patent/SMT202600048T1/it unknown
- 2021-04-15 US US17/917,653 patent/US20230148151A1/en active Pending
- 2021-04-15 HR HRP20260205TT patent/HRP20260205T1/hr unknown
- 2021-04-15 EP EP21724037.3A patent/EP4135773B1/en active Active
- 2021-04-15 PT PT217240373T patent/PT4135773T/pt unknown
- 2021-04-15 DK DK21724037.3T patent/DK4135773T3/da active
- 2021-04-15 WO PCT/IB2021/053096 patent/WO2021209935A1/en not_active Ceased
- 2021-04-15 PL PL21724037.3T patent/PL4135773T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021209935A1 (en) | 2021-10-21 |
| EP4674908A3 (en) | 2026-01-14 |
| FI4135773T3 (fi) | 2026-02-17 |
| HRP20260205T1 (hr) | 2026-03-27 |
| CN115379862A (zh) | 2022-11-22 |
| EP4135773B1 (en) | 2025-11-19 |
| SMT202600048T1 (it) | 2026-03-09 |
| US20230148151A1 (en) | 2023-05-11 |
| IT202000008209A1 (it) | 2021-10-17 |
| EP4674908A2 (en) | 2026-01-07 |
| EP4135773A1 (en) | 2023-02-22 |
| ES3062918T3 (en) | 2026-04-14 |
| CN115379862B (zh) | 2025-12-16 |
| PL4135773T3 (pl) | 2026-04-13 |
| PT4135773T (pt) | 2026-02-04 |
| SI4135773T1 (sl) | 2026-04-30 |
| LT4135773T (lt) | 2026-02-25 |
| CA3172258A1 (en) | 2021-10-21 |
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