DK425586A - Fremgangsmaade til bestemmelse af proteaseinhibitorer - Google Patents
Fremgangsmaade til bestemmelse af proteaseinhibitorer Download PDFInfo
- Publication number
- DK425586A DK425586A DK425586A DK425586A DK425586A DK 425586 A DK425586 A DK 425586A DK 425586 A DK425586 A DK 425586A DK 425586 A DK425586 A DK 425586A DK 425586 A DK425586 A DK 425586A
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- protease inhibitors
- protease
- determining protease
- substrate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 abstract 3
- 239000004365 Protease Substances 0.000 abstract 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 3
- 239000000758 substrate Substances 0.000 abstract 3
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8128—Antithrombin III
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96444—Factor X (3.4.21.6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853531778 DE3531778A1 (de) | 1985-09-06 | 1985-09-06 | Verfahren zur bestimmung von proteaseinhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK425586D0 DK425586D0 (da) | 1986-09-05 |
| DK425586A true DK425586A (da) | 1987-03-07 |
Family
ID=6280238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK425586A DK425586A (da) | 1985-09-06 | 1986-09-05 | Fremgangsmaade til bestemmelse af proteaseinhibitorer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4918001A (da) |
| EP (1) | EP0216179B1 (da) |
| JP (1) | JPS6261600A (da) |
| AT (1) | ATE66493T1 (da) |
| AU (1) | AU611847B2 (da) |
| CA (1) | CA1292174C (da) |
| DE (2) | DE3531778A1 (da) |
| DK (1) | DK425586A (da) |
| ES (1) | ES2000974A6 (da) |
| NZ (1) | NZ217459A (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011910A (en) * | 1989-12-28 | 1991-04-30 | Washington University | Reagent and method for determining activity of retroviral protease |
| US5171662A (en) * | 1990-09-13 | 1992-12-15 | The Upjohn Company | Method of detecting HIV protease activity |
| US5292652A (en) * | 1990-10-05 | 1994-03-08 | Athena Neurosciences, Inc. | Amyloidin protease and uses thereof |
| US5235039A (en) * | 1991-06-10 | 1993-08-10 | Eli Lilly And Company | Substrates for hiv protease |
| US5308755A (en) * | 1992-06-08 | 1994-05-03 | Research Corporation Technologies, Inc. | Method for measuring heparin |
| JPH078298A (ja) * | 1993-06-28 | 1995-01-13 | Nippon Shoji Kk | アンチトロンビンｉｉｉ活性の測定方法および該測定用試薬キット |
| JP2968048B2 (ja) * | 1995-05-12 | 1999-10-25 | シェーリング コーポレイション | 表面プラズモン共鳴に基づく酵素アッセイ |
| US5705353A (en) * | 1995-06-07 | 1998-01-06 | Beckman Instruments, Inc. | Method of reducing interferences in assays |
| EP0814167A1 (en) * | 1996-06-21 | 1997-12-29 | Kabushiki Kaisha Kyoto Daiichi Kagaku | A method for measuring the concentration of protease inhibitors, kit for use in such a method and method for dissolving a sunstrate |
| JP3626982B2 (ja) * | 1997-08-29 | 2005-03-09 | アークレイ株式会社 | タンパク質分解酵素阻害物質の測定方法およびそれに用いる測定キット |
| US5985582A (en) * | 1997-12-09 | 1999-11-16 | Sigma-Aldrich Co. | Thrombin-based assay for antithrombin III |
| US7320878B2 (en) * | 2001-11-08 | 2008-01-22 | Tibotec Pharmaceuticals, Ltd. | Protease assay for therapeutic drug monitoring |
| DE102006008613A1 (de) | 2006-02-24 | 2007-08-30 | Dade Behring Marburg Gmbh | Stabilisierte Zubereitungen von Serin-Endopeptidasen, deren Herstellung und Verwendung |
| JP5442781B2 (ja) * | 2011-01-31 | 2014-03-12 | 三洋化成工業株式会社 | プロテアーゼ活性回復方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3912704A (en) * | 1972-05-08 | 1975-10-14 | Ayerst Mckenna & Harrison | Protease inhibitor from horse urine |
| CA1176560A (en) * | 1980-09-30 | 1984-10-23 | Peter C. Harpel | Process for determining inhibitor-enzyme complexes and composition for use therein |
| US4493891A (en) * | 1982-07-27 | 1985-01-15 | University Of Georgia Research Foundation, Inc. | Determination of oxidized α-1-proteinase inhibitor in serum or plasma |
| FI68262C (fi) * | 1982-12-17 | 1985-08-12 | Labsystems Oy | Foerfarande foer konstatering av juverinflammation |
| CA1254119A (en) * | 1984-07-20 | 1989-05-16 | Lloyd A. Schick | Single step protease inhibitor assay |
-
1985
- 1985-09-06 DE DE19853531778 patent/DE3531778A1/de not_active Withdrawn
-
1986
- 1986-08-27 DE DE8686111844T patent/DE3680978D1/de not_active Expired - Lifetime
- 1986-08-27 EP EP86111844A patent/EP0216179B1/de not_active Expired - Lifetime
- 1986-08-27 AT AT86111844T patent/ATE66493T1/de not_active IP Right Cessation
- 1986-09-04 ES ES8601611A patent/ES2000974A6/es not_active Expired
- 1986-09-04 NZ NZ217459A patent/NZ217459A/xx unknown
- 1986-09-04 US US06/903,458 patent/US4918001A/en not_active Expired - Fee Related
- 1986-09-05 CA CA000517638A patent/CA1292174C/en not_active Expired - Lifetime
- 1986-09-05 JP JP61208109A patent/JPS6261600A/ja active Pending
- 1986-09-05 DK DK425586A patent/DK425586A/da not_active Application Discontinuation
- 1986-09-05 AU AU62367/86A patent/AU611847B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2000974A6 (es) | 1988-04-01 |
| JPS6261600A (ja) | 1987-03-18 |
| AU6236786A (en) | 1987-03-12 |
| ATE66493T1 (de) | 1991-09-15 |
| US4918001A (en) | 1990-04-17 |
| DE3531778A1 (de) | 1987-03-12 |
| NZ217459A (en) | 1989-03-29 |
| AU611847B2 (en) | 1991-06-27 |
| EP0216179B1 (de) | 1991-08-21 |
| CA1292174C (en) | 1991-11-19 |
| EP0216179A1 (de) | 1987-04-01 |
| DE3680978D1 (de) | 1991-09-26 |
| DK425586D0 (da) | 1986-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ATS | Application withdrawn |