DK4320112T3 - Pyridinylsubstituerede oxoisoindolinforbindelser - Google Patents

Pyridinylsubstituerede oxoisoindolinforbindelser

Info

Publication number
DK4320112T3
DK4320112T3 DK22718513.9T DK22718513T DK4320112T3 DK 4320112 T3 DK4320112 T3 DK 4320112T3 DK 22718513 T DK22718513 T DK 22718513T DK 4320112 T3 DK4320112 T3 DK 4320112T3
Authority
DK
Denmark
Prior art keywords
oxoisoindoline
subtituted
pyridinyl
compounds
subtituted oxoisoindoline
Prior art date
Application number
DK22718513.9T
Other languages
English (en)
Inventor
Yan Chen
Godwin Kwame Kumi
Audris Huang
Satheesh Kesavan Nair
Bharat Dinkar Shimpukade
Suresh Babu Vishwa Krishna Penmetsa
James Aaron Balog
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK4320112T3 publication Critical patent/DK4320112T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK22718513.9T 2021-04-06 2022-04-05 Pyridinylsubstituerede oxoisoindolinforbindelser DK4320112T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN202111016193 2021-04-06
IN202111022098 2021-05-17
PCT/US2022/023387 WO2022216644A1 (en) 2021-04-06 2022-04-05 Pyridinyl substituted oxoisoindoline compounds

Publications (1)

Publication Number Publication Date
DK4320112T3 true DK4320112T3 (da) 2025-08-18

Family

ID=81385129

Family Applications (1)

Application Number Title Priority Date Filing Date
DK22718513.9T DK4320112T3 (da) 2021-04-06 2022-04-05 Pyridinylsubstituerede oxoisoindolinforbindelser

Country Status (26)

Country Link
US (3) US11718601B2 (da)
EP (1) EP4320112B1 (da)
JP (1) JP7821197B2 (da)
KR (1) KR20230165815A (da)
AR (1) AR125298A1 (da)
AU (1) AU2022253242A1 (da)
BR (1) BR112023020077A2 (da)
CA (1) CA3214244A1 (da)
CL (1) CL2023002966A1 (da)
CO (1) CO2023013321A2 (da)
DK (1) DK4320112T3 (da)
ES (1) ES3035755T3 (da)
FI (1) FI4320112T3 (da)
HR (1) HRP20250796T1 (da)
HU (1) HUE072309T2 (da)
IL (1) IL307343A (da)
LT (1) LT4320112T (da)
MX (1) MX2023011715A (da)
PE (1) PE20231941A1 (da)
PL (1) PL4320112T3 (da)
PT (1) PT4320112T (da)
RS (1) RS66982B1 (da)
SI (1) SI4320112T1 (da)
SM (1) SMT202500281T1 (da)
TW (1) TWI867287B (da)
WO (1) WO2022216644A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3237577A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
EP4493554A1 (en) 2022-03-17 2025-01-22 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
AR131812A1 (es) * 2023-02-08 2025-05-07 Bristol Myers Squibb Co Compuestos y composiciones para la degradación selectiva de proteínas diseñadas
KR102834908B1 (ko) * 2023-09-02 2025-07-16 브리스톨-마이어스 스큅 컴퍼니 치환된 페닐 옥소옥사졸릴 피페리딘 디온 화합물
US20260078119A1 (en) 2024-03-22 2026-03-19 Bristol-Myers Squibb Company Degrader compounds and uses thereof
WO2025226767A1 (en) * 2024-04-24 2025-10-30 Bristol-Myers Squibb Company Substituted 3-(5-(6-aminopyridin-2-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione compounds for use in the treatment of cancer
WO2025234888A1 (en) 2024-05-09 2025-11-13 Captor Therapeutics S.A. Nek7 degraders and methods of use thereof
WO2025234887A1 (en) 2024-05-09 2025-11-13 Captor Therapeutics S.A. Nek7 degraders and methods of use thereof

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2177517E (pt) 1996-07-24 2011-11-10 Celgene Corp 2-(2,6-dioxopiperidin-3-il)-ftalimida amino-substituída para redução dos níveis de tnf-alfa
US20030045552A1 (en) 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
NZ531294A (en) 2001-08-06 2005-11-25 Childrens Medical Center Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
AU2006230099B2 (en) 2005-03-25 2012-04-19 Gitr, Inc. GITR binding molecules and uses therefor
PL2559690T3 (pl) 2005-05-10 2016-09-30 Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
CA2612241C (en) 2005-07-01 2018-11-06 Medarex, Inc. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
TWI382974B (zh) 2005-12-20 2013-01-21 英塞特公司 作為吲哚胺2,3-二氧化酶調節劑之n-羥基甲脒基雜環化物
JP5319532B2 (ja) 2006-09-19 2013-10-16 インサイト・コーポレイション インドールアミン2,3−ジオキシゲナーゼのモジュレーターとしてのn−ヒドロキシアミジノヘテロサイクル
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
CN101801413A (zh) 2007-07-12 2010-08-11 托勒克斯股份有限公司 采用gitr结合分子的联合疗法
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
CN101932325B (zh) 2007-11-30 2014-05-28 新联基因公司 Ido抑制剂
WO2009137095A2 (en) 2008-05-08 2009-11-12 The Johns Hopkins University Compositions and methods for modulating an immune response
US20110176972A1 (en) 2008-05-29 2011-07-21 Saint-Gobain Centre De Recherches et D'Etudes Eur Cellular structure containing aluminium titanate
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
EP4209510B1 (en) 2008-12-09 2024-01-31 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
JP5561577B2 (ja) 2009-07-01 2014-07-30 国立大学法人 名古屋工業大学 光学活性3’−フルオロサリドマイド誘導体の製造方法
PT3023438T (pt) 2009-09-03 2020-05-08 Merck Sharp & Dohme Anticorpos anti-gitr
US8722720B2 (en) 2009-10-28 2014-05-13 Newlink Genetics Corporation Imidazole derivatives as IDO inhibitors
EP2949670B1 (en) 2009-12-10 2019-02-27 F. Hoffmann-La Roche AG Antibodies binding preferentially human csf1r extracellular domain 4 and their use
PH12018501083A1 (en) 2010-03-04 2019-02-18 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
JP5989547B2 (ja) 2010-03-05 2016-09-07 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ヒトcsf−1rに対する抗体及びその使用
KR101656548B1 (ko) 2010-03-05 2016-09-09 에프. 호프만-라 로슈 아게 인간 csf-1r에 대한 항체 및 이의 용도
SMT201900074T1 (it) 2010-05-04 2019-02-28 Five Prime Therapeutics Inc Anticorpi che legano csf1r
SG10201912092VA (en) 2010-09-09 2020-02-27 Pfizer 4-1bb binding molecules
NO2694640T3 (da) 2011-04-15 2018-03-17
SI2699264T1 (en) 2011-04-20 2018-08-31 Medimmune Llc Antibodies and other molecules that bind b7-h1 and pd-1
US9624298B2 (en) 2011-11-28 2017-04-18 Merck Patent Gmbh Anti-PD-L1 antibodies and uses thereof
EP2791174B1 (en) 2011-12-15 2018-02-28 F. Hoffmann-La Roche AG Antibodies against human csf-1r and uses thereof
CN104093740B (zh) 2012-02-06 2018-01-09 弗·哈夫曼-拉罗切有限公司 使用csf1r抑制剂的组合物和方法
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
KR20150018533A (ko) 2012-05-11 2015-02-23 파이브 프라임 테라퓨틱스, 인크. 콜로니 자극 인자 1 수용체(csf1r)에 결속하는 항체들에 의한 질병 상태의 치료 방법
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
CN104684582A (zh) 2012-08-31 2015-06-03 戊瑞治疗有限公司 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法
WO2015107196A1 (en) 2014-01-20 2015-07-23 Institut Curie Use of thalidomide or analogs thereof for preventing neurologic disorders induced by brain irradiation
WO2016191178A1 (en) 2015-05-22 2016-12-01 Biotheryx, Inc. Compounds targeting proteins, compositions, methods, and uses thereof
KR20240119196A (ko) 2015-06-04 2024-08-06 아비나스 오퍼레이션스, 인코포레이티드 단백질분해의 이미드계 조절인자 및 관련된 이용 방법
GB201516243D0 (en) 2015-09-14 2015-10-28 Glaxosmithkline Ip Dev Ltd Novel compounds
US10830762B2 (en) 2015-12-28 2020-11-10 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
CA3017740A1 (en) 2016-03-16 2017-09-21 Pearlie BURNETTE Small molecules against cereblon to enhance effector t cell function
JP7037500B2 (ja) 2016-04-06 2022-03-16 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン Mdm2タンパク質分解剤
JP6921114B2 (ja) 2016-04-22 2021-08-18 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド サイクリン依存性キナーゼ8(cdk8)阻害剤のe3リガーゼリガンドとのコンジュゲーションによるcdk8の分解および使用法
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
WO2017197056A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Bromodomain targeting degronimers for target protein degradation
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
CN110062759B (zh) 2016-09-13 2022-05-24 密执安大学评议会 作为bet蛋白降解剂的稠合的1,4-氧氮杂䓬
LT3660004T (lt) 2016-10-11 2023-06-12 Arvinas Operations, Inc. Junginiai ir metodai, skirti tikslinei androgeno receptoriaus degradacijai
EP3535265A4 (en) 2016-11-01 2020-07-08 Arvinas, Inc. PROTACS TARGETING ON TAU PROTEIN AND RELATED METHODS FOR USE
WO2018102725A1 (en) 2016-12-01 2018-06-07 Arvinas, Inc. Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
AU2017382176A1 (en) 2016-12-21 2019-05-30 Biotheryx, Inc. Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof
EP3559006A4 (en) 2016-12-23 2021-03-03 Arvinas Operations, Inc. COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF F TAL LIVER KINASE POLYPEPTIDES
RU2019121527A (ru) 2016-12-23 2021-01-15 Эрвинэс Оперейшнс, Инк. Химерные молекулы, нацеливающиеся на протеолиз egfr, и связанные с ними способы применения
EP3558994A4 (en) 2016-12-23 2021-05-12 Arvinas Operations, Inc. COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FAST ACCELERATED FIBROSARCOMA POLYPEPTIDES
TWI793151B (zh) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
KR20200086278A (ko) 2017-10-18 2020-07-16 노파르티스 아게 선택적 단백질 분해를 위한 조성물 및 방법
JP2021512153A (ja) 2018-01-26 2021-05-13 イエール ユニバーシティ タンパク質分解のイミド系モジュレーターおよび使用方法
KR20210018199A (ko) * 2018-03-26 2021-02-17 씨4 테라퓨틱스, 인코포레이티드 이카로스의 분해를 위한 세레블론 결합제
CA3101335C (en) 2018-06-13 2024-01-09 Biotheryx, Inc. Fused thiophene compounds
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
CU20210002A7 (es) 2018-07-10 2021-08-06 Novartis Ag Derivados de 3-(5-hidroxi-1-oxoisoindolin-2-il)piperidina-2,6-diona y su uso en el tratamiento de trastornos dependientes de la proteína con dedos de zinc 2 de la familia ikaros (ikzf2)
CN113423701A (zh) * 2018-11-13 2021-09-21 拜欧斯瑞克斯公司 取代的异吲哚啉酮
WO2020128972A1 (en) 2018-12-20 2020-06-25 Novartis Ag Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
BR112021015672A2 (pt) * 2019-02-15 2021-10-05 Novartis Ag Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona substituída e usos dos mesmos
ES3032659T3 (en) * 2019-02-15 2025-07-23 Novartis Ag 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
US20230093099A1 (en) 2019-04-02 2023-03-23 Cullgen (Shanghai), Inc. Compounds and methods of treating cancers
TW202140441A (zh) * 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 經取代之側氧基異吲哚啉化合物

Also Published As

Publication number Publication date
SMT202500281T1 (it) 2025-09-12
US20240376082A1 (en) 2024-11-14
RS66982B1 (sr) 2025-07-31
HUE072309T2 (hu) 2025-11-28
BR112023020077A2 (pt) 2023-11-14
PL4320112T3 (pl) 2025-07-21
EP4320112A1 (en) 2024-02-14
KR20230165815A (ko) 2023-12-05
US11718601B2 (en) 2023-08-08
ES3035755T3 (en) 2025-09-08
TWI867287B (zh) 2024-12-21
IL307343A (en) 2023-11-01
CO2023013321A2 (es) 2023-10-19
SI4320112T1 (sl) 2025-09-30
PT4320112T (pt) 2025-07-07
AR125298A1 (es) 2023-07-05
TW202304881A (zh) 2023-02-01
JP7821197B2 (ja) 2026-02-26
MX2023011715A (es) 2023-10-12
CA3214244A1 (en) 2022-10-13
CL2023002966A1 (es) 2024-02-23
PE20231941A1 (es) 2023-12-05
HRP20250796T1 (hr) 2025-08-29
EP4320112B1 (en) 2025-05-14
LT4320112T (lt) 2025-07-10
WO2022216644A1 (en) 2022-10-13
FI4320112T3 (fi) 2025-07-25
US20230303527A1 (en) 2023-09-28
US20220324840A1 (en) 2022-10-13
AU2022253242A1 (en) 2023-11-23
JP2024515243A (ja) 2024-04-08

Similar Documents

Publication Publication Date Title
DK4165024T3 (da) Cyclobutyldihydroquinolinsulfonamid-forbindelser
EP4129997A4 (en) Octahydropyrazinodiazanaphthyridine dione compounds
EP4186256C0 (en) INTER-AGENCY COMMUNICATION VIA AN AD-HOC NETWORK SLICE
IL310528A (en) Pyrazolopyridinone compounds
EP4293025C0 (en) COMPOSED WITH 4-AMINOQUINAZOLINE
EP4149556C0 (en) PEG LIPIDOIDS COMPOUNDS
EP4137404A4 (en) Multicopter
EP4199925B1 (en) ORETIN RECEPTOR AGONISTS CYCLOPENTAPYRROLE
EP4107782A4 (en) MICROARRAYS
EP4222352A4 (en) BOLTER
EP4272364A4 (en) TA NTN REPORT
EP4223314A4 (en) LIPID NANOPARTICLE
EP4208295C0 (de) Fleischwolf
EP4143199C0 (en) NUCLEOTIDE PROMEDICINAL COMPOUNDS
EP3957265A4 (en) MICROSCOPE COVER
EP4063561C0 (en) REFINER SEGMENT
EP4204218C0 (en) TAPE LAYING HEAD
EP4163277C0 (en) NEW PYRAZOLE DERIVATIVES
EP4274436A4 (en) Combination therapies
EP4192823C0 (en) TRIAZOLES DIFLUOROMETHYL-PYRIDIN-2-YL
EP4154884A4 (en) Anti-sars-cov-2 durg
EP4137402A4 (en) MULTICOPTER
IL313590A (en) Compounds
PT4038149T (pt) Compostos anti-incrustação
EP4228051A4 (en) LEAD STORAGE BATTERY