|
US5691181A
(en)
*
|
1984-08-21 |
1997-11-25 |
Celltech Limited |
DNA encoding lipase from human gastric mucosal tissue
|
|
EP0193112A3
(en)
*
|
1985-02-22 |
1987-02-25 |
The Trustees Of Columbia University In The City Of New York |
Cdna encoding mammalian insulin-like growth factor ii
|
|
US5242811A
(en)
*
|
1985-03-26 |
1993-09-07 |
Biogen, Inc. |
Production of human somatomedin C
|
|
ES2000859A6
(es)
*
|
1985-08-12 |
1988-03-16 |
Syntex Inc |
Un metodo para producir un vector de expresion bacteriana para la expresion de proteinas de fusion
|
|
EP0213472A1
(en)
*
|
1985-08-12 |
1987-03-11 |
Syntex (U.S.A.) Inc. |
Method for producing fusion proteins
|
|
DK382886A
(da)
*
|
1985-08-12 |
1987-02-13 |
Syntex Inc |
Fremgangsmaade til fremstilling af hormonfaktorderivater
|
|
US5496924A
(en)
*
|
1985-11-27 |
1996-03-05 |
Hoechst Aktiengesellschaft |
Fusion protein comprising an interleukin-2 fragment ballast portion
|
|
US5359035A
(en)
*
|
1985-12-21 |
1994-10-25 |
Hoechst Aktiengesellschaft |
Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
|
|
US4861757A
(en)
*
|
1986-11-14 |
1989-08-29 |
Institute Of Molecular Biology |
Wound healing and bone regeneration using PDGF and IGF-I
|
|
US5019559A
(en)
*
|
1986-11-14 |
1991-05-28 |
President And Fellows Of Harvard College |
Wound healing using PDGF and IGF-II
|
|
US5270180A
(en)
*
|
1986-12-31 |
1993-12-14 |
Lucky, Ltd. |
Method for the production of salmon growth hormone using a synthetic gene
|
|
US5200509A
(en)
*
|
1987-04-06 |
1993-04-06 |
Celtrix Pharmaceuticals, Inc. |
Human somatomedin carrier protein subunits and process for producing them; recombinant DNA molecules, hosts, processes and human somatomedin carrier protein-like polypeptides
|
|
US5084384A
(en)
*
|
1987-04-23 |
1992-01-28 |
Monsanto Company |
Secretion of insulin-like growth factor-I
|
|
US5256644A
(en)
*
|
1988-05-20 |
1993-10-26 |
Institute Of Molecular Biology, Inc. |
Wound healing using IGF-II and TGF
|
|
US4983581A
(en)
*
|
1988-05-20 |
1991-01-08 |
Institute Of Molecular Biology, Inc. |
Wound healing composition of IGF-I and TGF-β
|
|
DE3834079A1
(de)
*
|
1988-10-06 |
1990-04-12 |
Biotechnolog Forschung Gmbh |
Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren
|
|
IL92816A0
(en)
*
|
1988-12-22 |
1990-09-17 |
Biogrowth Inc |
Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides
|
|
JPH0722517B2
(ja)
*
|
1989-08-24 |
1995-03-15 |
株式会社三和化学研究所 |
モチリン様ポリペプチドの製法並びにそのための組換えdna及び発現用プラスミド
|
|
WO1990010069A1
(fr)
*
|
1989-02-28 |
1990-09-07 |
Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr |
ADN pAA 1213-23 ET pAC 262-33 DE PLASMIDE DE RECOMBINAISON CODANT POUR LA SYNTHESE D'INTERLEUKINE-2 HUMAINE, LEUR PROCEDE DE CONSTRUCTION ET SOUCHE DE BACTERIES ESCHERICHIA COLI RRI/pAC 262-33 EN TANT QUE PRODUCTEUR D'INTERLEUKINE-2 HUMAINE
|
|
US5171670A
(en)
*
|
1989-05-12 |
1992-12-15 |
The General Hospital Corporation |
Recombinant dna method for production of parathyroid hormone
|
|
USRE37919E1
(en)
|
1989-05-12 |
2002-12-03 |
The General Hospital Corporation |
Recombinant DNA method for production of parathyroid hormone
|
|
GB8927008D0
(en)
*
|
1989-11-29 |
1990-01-17 |
Ciba Geigy |
Novel process for the production of unfused protein in e.coli
|
|
CA2082420C
(en)
*
|
1990-05-30 |
2004-07-20 |
Harry N. Antoniades |
Wound healing composition comprising purified igf-i or igf-ii and a purified tgf-.beta.
|
|
ATE158816T1
(de)
|
1990-11-26 |
1997-10-15 |
Genetics Inst |
Expression von pace in wirtszellen und verfahren zu dessen verwendung
|
|
SE9100099D0
(sv)
*
|
1991-01-11 |
1991-01-11 |
Kabi Pharmacia Ab |
Use of growth factor
|
|
US5977070A
(en)
*
|
1992-07-14 |
1999-11-02 |
Piazza; Christin Teresa |
Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
|
|
US5589452A
(en)
*
|
1992-07-14 |
1996-12-31 |
Syntex (U.S.A.) Inc. |
Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
|
|
US5464934A
(en)
*
|
1993-05-14 |
1995-11-07 |
Mallinckrodt Medical, Inc. |
Metal chelates as spacer compounds in biologically active peptides
|
|
US5663304A
(en)
*
|
1993-08-20 |
1997-09-02 |
Genentech, Inc. |
Refolding of misfolded insulin-like growth factor-I
|
|
US5407810A
(en)
*
|
1993-08-20 |
1995-04-18 |
Genentech, Inc. |
Aqueous multiple-phase isolation of polypeptide
|
|
US5446024A
(en)
*
|
1993-12-17 |
1995-08-29 |
Genentech, Inc. |
Purification of insulin-like growth factor
|
|
US5629167A
(en)
*
|
1994-04-19 |
1997-05-13 |
Biocine S.P.A. |
Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
|
|
EP0779927A1
(en)
*
|
1994-09-08 |
1997-06-25 |
Chiron Corporation |
A method of improved production of insulin-like growth factor
|
|
US5728676A
(en)
*
|
1994-09-08 |
1998-03-17 |
Ciba-Geigy Corporation |
Use of insulin-like growth factors I and II for inhibition of inflammatory response
|
|
KR20000068934A
(ko)
*
|
1996-11-08 |
2000-11-25 |
스티븐 로쓰 |
개선된 발현 벡터
|
|
AU729459B2
(en)
*
|
1996-11-15 |
2001-02-01 |
Genentech Inc. |
Purification of neurotrophins
|
|
US6265542B1
(en)
|
1997-10-24 |
2001-07-24 |
Genentech, Inc. |
Purification of molecules
|
|
CA2671261A1
(en)
|
1997-11-06 |
1999-05-20 |
Novartis Vaccines And Diagnostics S.R.L. |
Neisserial antigens
|
|
EP1047784B2
(en)
|
1998-01-14 |
2015-03-18 |
Novartis Vaccines and Diagnostics S.r.l. |
Neissera meningitidis antigens
|
|
GB9808932D0
(en)
|
1998-04-27 |
1998-06-24 |
Chiron Spa |
Polyepitope carrier protein
|
|
EP2261338A3
(en)
|
1998-05-01 |
2012-01-04 |
Novartis Vaccines and Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
|
WO2000066741A2
(en)
|
1999-04-30 |
2000-11-09 |
Chiron S.P.A. |
Conserved neisserial antigens
|
|
GB9911683D0
(en)
|
1999-05-19 |
1999-07-21 |
Chiron Spa |
Antigenic peptides
|
|
GB9916529D0
(en)
|
1999-07-14 |
1999-09-15 |
Chiron Spa |
Antigenic peptides
|
|
JP2004508801A
(ja)
|
1999-10-29 |
2004-03-25 |
カイロン ソチエタ ア レスポンサビリタ リミタータ |
ナイセリア抗原性ペプチド
|
|
PT2289545T
(pt)
|
2000-01-17 |
2016-09-06 |
Glaxosmithkline Biologicals Sa |
Vacina de omv suplementada contra meningococos
|
|
FR2810675B1
(fr)
*
|
2000-06-22 |
2002-09-27 |
Pf Medicament |
Construction modifiee en aval du codon d'initiation pour la surexpression de proteines recombinantes
|
|
KR20030057529A
(ko)
*
|
2000-09-08 |
2003-07-04 |
그리폰 테라퓨틱스, 인코포레이티드 |
합성 적혈구생성 자극 단백질
|
|
CA2881568C
(en)
|
2000-10-27 |
2019-09-24 |
Novartis Vaccines And Diagnostics, Inc. |
Nucleic acids and proteins from streptococcus groups a & b
|
|
DK1332222T3
(da)
|
2000-11-03 |
2009-07-06 |
Genentech Inc |
Stofskifteændringer i fermenteringer der udtrykker rekombinante proteiner
|
|
GB0107658D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Streptococcus pneumoniae
|
|
GB0107661D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Staphylococcus aureus
|
|
ATE469915T1
(de)
|
2001-07-27 |
2010-06-15 |
Novartis Vaccines & Diagnostic |
Antikörper gegen das meningokokken adhäsin app
|
|
RU2331435C2
(ru)
|
2001-12-12 |
2008-08-20 |
Чирон Срл. |
Иммунизация против chlamydia trachomatis
|
|
CA2485701A1
(en)
*
|
2002-05-24 |
2003-12-04 |
Fred W. Wagner |
Method for enzymatic production of glp-1 (7-36) amide peptides
|
|
AU2003243316A1
(en)
*
|
2002-05-24 |
2003-12-12 |
Nps Allelix Corp. |
Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
|
|
DK1521767T3
(da)
|
2002-05-24 |
2010-04-12 |
Medtronic Inc |
Fremgangsmåder og konstrukter til ekspression af clostripain med højt udbytte
|
|
WO2003100022A2
(en)
*
|
2002-05-24 |
2003-12-04 |
Restoragen, Inc. |
Methods and dna constructs for high yield production of polypeptides
|
|
CA2485695A1
(en)
*
|
2002-05-24 |
2003-12-04 |
Fred W. Wagner |
Method for universal enzymatic production of bioactive peptides
|
|
EP1562982B1
(en)
|
2002-11-15 |
2010-05-05 |
Novartis Vaccines and Diagnostics S.r.l. |
Unexpected surface proteins in neisseria meningitidis
|
|
GB0227346D0
(en)
|
2002-11-22 |
2002-12-31 |
Chiron Spa |
741
|
|
GB0308198D0
(en)
|
2003-04-09 |
2003-05-14 |
Chiron Srl |
ADP-ribosylating bacterial toxin
|
|
US7348420B2
(en)
|
2003-04-25 |
2008-03-25 |
North Carolina State University |
Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
|
|
EP1651750B1
(en)
|
2003-06-23 |
2011-04-06 |
North Carolina State University |
Lactobacillus acidophilus nucleic acids encoding fructo-oligosaccharide utilization compounds and uses thereof
|
|
HRP20120315T1
(hr)
*
|
2003-11-21 |
2012-05-31 |
Nps Pharmaceuticals |
Proizvodnja peptida 2 nalik glukagonu i analoga
|
|
BRPI0507169A
(pt)
*
|
2004-02-02 |
2007-06-26 |
Ambrx Inc |
polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
|
|
US7459289B2
(en)
|
2004-03-08 |
2008-12-02 |
North Carolina State University |
Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
|
|
US7632924B2
(en)
*
|
2004-06-18 |
2009-12-15 |
Ambrx, Inc. |
Antigen-binding polypeptides and their uses
|
|
WO2006091231A2
(en)
*
|
2004-07-21 |
2006-08-31 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
BRPI0519430A2
(pt)
|
2004-12-22 |
2009-02-10 |
Ambrx Inc |
hormânio do crescimento humano modificado
|
|
EP2290087A3
(en)
*
|
2004-12-22 |
2011-06-15 |
Genentech, Inc. |
Methods for producing soluble multi-membrane-spanning proteins
|
|
EP2399893B1
(en)
|
2004-12-22 |
2018-08-15 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
EP1836298B1
(en)
*
|
2004-12-22 |
2012-01-18 |
Ambrx, Inc. |
COMPOSITIONS OF AMINOACYL-tRNA SYNTHETASE AND USES THEREOF
|
|
EP1836316A4
(en)
|
2004-12-22 |
2009-07-22 |
Ambrx Inc |
PROCESS FOR EXPRESSION AND CLEANING OF RECOMBINANT HUMAN GROWTH HORMONE
|
|
CN103520735B
(zh)
*
|
2004-12-22 |
2015-11-25 |
Ambrx公司 |
包含非天然编码的氨基酸的人生长激素配方
|
|
EP1871868A2
(en)
|
2005-04-15 |
2008-01-02 |
North Carolina State University |
Methods and compositions to modulate adhesion and stress tolerance in bacteria
|
|
AU2006255122B2
(en)
*
|
2005-06-03 |
2010-10-21 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
|
AU2005335491B2
(en)
*
|
2005-08-18 |
2010-11-25 |
Ambrx, Inc. |
Compositions of tRNA and uses thereof
|
|
CN101400646A
(zh)
*
|
2005-11-08 |
2009-04-01 |
Ambrx公司 |
用于修饰非天然氨基酸和非天然氨基酸多肽的促进剂
|
|
DK2339014T3
(da)
*
|
2005-11-16 |
2015-07-20 |
Ambrx Inc |
Fremgangsmåder og sammensætninger omfattende ikke-naturlige aminosyrer
|
|
GB0524066D0
(en)
|
2005-11-25 |
2006-01-04 |
Chiron Srl |
741 ii
|
|
WO2007070659A2
(en)
*
|
2005-12-14 |
2007-06-21 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
PT2054431E
(pt)
|
2006-06-09 |
2011-11-03 |
Novartis Ag |
Confórmeros de adesinas bacterianas
|
|
WO2008005533A2
(en)
*
|
2006-07-06 |
2008-01-10 |
Aaron Thomas Tabor |
Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
|
|
CN106008699A
(zh)
*
|
2006-09-08 |
2016-10-12 |
Ambrx公司 |
经修饰的人类血浆多肽或Fc骨架和其用途
|
|
EP2064333B1
(en)
*
|
2006-09-08 |
2014-02-26 |
Ambrx, Inc. |
Suppressor trna transcription in vertebrate cells
|
|
JP5399906B2
(ja)
*
|
2006-09-08 |
2014-01-29 |
アンブルックス,インコーポレイテッド |
脊椎動物細胞用のハイブリッドサプレッサーtrna
|
|
CN107501407B
(zh)
|
2007-03-30 |
2022-03-18 |
Ambrx公司 |
经修饰fgf-21多肽和其用途
|
|
US8114630B2
(en)
*
|
2007-05-02 |
2012-02-14 |
Ambrx, Inc. |
Modified interferon beta polypeptides and their uses
|
|
MX2010005317A
(es)
|
2007-11-20 |
2010-06-02 |
Ambrx Inc |
Polipeptidos de insulina modificados y sus usos.
|
|
MX344166B
(es)
|
2008-02-08 |
2016-12-07 |
Ambrx Inc |
Leptina-polipeptidos modificados y sus usos.
|
|
CN102356089B
(zh)
|
2008-02-21 |
2014-02-19 |
诺华股份有限公司 |
脑膜炎球菌fHBP多肽
|
|
CN102159230A
(zh)
|
2008-07-23 |
2011-08-17 |
Ambrx公司 |
经修饰的牛g-csf多肽和其用途
|
|
AU2009296267B2
(en)
*
|
2008-09-26 |
2013-10-31 |
Ambrx, Inc. |
Non-natural amino acid replication-dependent microorganisms and vaccines
|
|
BR122012024318A2
(pt)
|
2008-09-26 |
2019-07-30 |
Ambrx, Inc. |
Polipeptídeos modificados de eritropoetina animal e seus usos
|
|
WO2011008904A1
(en)
|
2009-07-17 |
2011-01-20 |
Tabor Aaron T |
Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
|
|
CN102596240B
(zh)
|
2009-08-27 |
2015-02-04 |
诺华股份有限公司 |
包括脑膜炎球菌fHBP序列的杂交多肽
|
|
CA2779816A1
(en)
|
2009-10-27 |
2011-05-05 |
Novartis Ag |
Modified meningococcal fhbp polypeptides
|
|
BR112012015597A2
(pt)
|
2009-12-21 |
2017-01-31 |
Ambrx Inc |
peptídeos de somatotropina suínos modificados e seus usos
|
|
MX349301B
(es)
|
2009-12-21 |
2017-07-21 |
Ambrx Inc |
Polipéptidos de somatotropina bovina modificados y sus usos.
|
|
CN103221420A
(zh)
|
2010-05-19 |
2013-07-24 |
北卡罗莱纳州立大学 |
用于递送治疗性肽的组合物和方法
|
|
EA030886B1
(ru)
|
2010-08-17 |
2018-10-31 |
Амбркс, Инк. |
Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
WO2015059690A1
(en)
|
2013-10-24 |
2015-04-30 |
Yeda Research And Development Co. Ltd. |
Polynucleotides encoding brex system polypeptides and methods of using s ame
|
|
CN114805532A
(zh)
|
2014-10-24 |
2022-07-29 |
百时美施贵宝公司 |
修饰的fgf-21多肽及其用途
|
|
US10590426B2
(en)
|
2016-08-22 |
2020-03-17 |
Board Of Trustees Of Michigan State University |
Genetic control of cell size
|
|
IL250479A0
(en)
|
2017-02-06 |
2017-03-30 |
Sorek Rotem |
Genetically engineered cells expressing a disarm system that confers resistance to phages and methods for their production
|
|
PE20191716A1
(es)
|
2017-02-08 |
2019-12-05 |
Bristol Myers Squibb Co |
Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos
|
|
IL258467A
(en)
|
2018-03-29 |
2018-07-04 |
Ilana Kolodkin Gal |
Methods of disrupting a biofilm and/or preventing formation of same
|
|
CA3111576A1
(en)
|
2018-09-11 |
2020-03-19 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and their uses
|
|
WO2020202142A2
(en)
|
2019-03-31 |
2020-10-08 |
Yeda Research And Development Co. Ltd. |
Anti-viral and anti-tumoral compounds
|
|
EP4117732A1
(en)
|
2020-03-11 |
2023-01-18 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
|
EP4228656A4
(en)
|
2020-08-18 |
2024-09-04 |
Yeda Research and Development Co. Ltd |
ANTI-VIRAL AND ANTI-TUMOR COMPOUNDS
|
|
IL288680A
(en)
|
2021-12-05 |
2023-07-01 |
Yeda Res & Dev |
Genetically modified phages and their use
|
|
WO2025215636A1
(en)
|
2024-04-08 |
2025-10-16 |
Yeda Research And Development Co. Ltd. |
Anti-defense system polypeptides and uses thereof
|