DK434085A - Fremgangsmaade til isolering og rensning af podophyllotoxin - Google Patents

Fremgangsmaade til isolering og rensning af podophyllotoxin Download PDF

Info

Publication number: DK434085A
Authority: DK; Denmark
Prior art keywords: podophyl; lotoxin; insulating; cleaning; procedure
Prior art date: 1984-09-26

Application number

DK434085A

Other languages

English (en)

Other versions

DK434085D0 (da

DK169385B1 (da

Inventor

Ole Buchardt

Original Assignee

Pharma Medica As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-09-26

Filing date

1985-09-25

Publication date

1986-03-27

1985-09-25 Application filed by Pharma Medica As filed Critical Pharma Medica As

1985-09-25 Publication of DK434085D0 publication Critical patent/DK434085D0/da

1986-03-27 Publication of DK434085A publication Critical patent/DK434085A/da

1994-10-17 Application granted granted Critical

1994-10-17 Publication of DK169385B1 publication Critical patent/DK169385B1/da

Links

YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 title abstract 4
YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 title abstract 4
229960001237 podophyllotoxin Drugs 0.000 title abstract 4
YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
238000004140 cleaning Methods 0.000 title 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
239000007787 solid Substances 0.000 abstract 2
239000007858 starting material Substances 0.000 abstract 2
150000001491 aromatic compounds Chemical class 0.000 abstract 1
150000002390 heteroarenes Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK434085A 1984-09-26 1985-09-25 Fremgangsmåde til fremstilling af renset podophyllotoxin DK169385B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8424269		1984-09-26
GB848424269A GB8424269D0 (en)	1984-09-26	1984-09-26	Isolation and purification of podophyllotoxin

Publications (3)

Publication Number	Publication Date
DK434085D0 DK434085D0 (da)	1985-09-25
DK434085A true DK434085A (da)	1986-03-27
DK169385B1 DK169385B1 (da)	1994-10-17

Family

ID=10567263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK434085A DK169385B1 (da)	1984-09-26	1985-09-25	Fremgangsmåde til fremstilling af renset podophyllotoxin

Country Status (13)

Country	Link
US (1)	US4680399A (da)
EP (1)	EP0197219B1 (da)
AT (1)	ATE48427T1 (da)
CA (2)	CA1268709A (da)
DE (2)	DE3574595D1 (da)
DK (1)	DK169385B1 (da)
ES (2)	ES8702395A1 (da)
FI (1)	FI84557C (da)
GB (1)	GB8424269D0 (da)
IS (1)	IS3039A7 (da)
NO (1)	NO164658C (da)
PL (1)	PL147999B1 (da)
PT (1)	PT81190B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0207124B1 (en) *	1984-12-28	1991-10-09	Conpharm Ab	Use of podophyllotoxin and derivatives thereof
US5057616A (en) *	1989-09-29	1991-10-15	Oclassen Pharmaceuticals, Inc.	Podophyllotoxin purification process
US5315016A (en) *	1992-10-13	1994-05-24	Nycomed Dak A/S	Process for preparing pure podophyllotoxin
US5589106A (en) *	1995-02-14	1996-12-31	Nalco Chemical Company	Carbon steel corrosion inhibitors
US7087251B2 (en)	1998-06-01	2006-08-08	Albemarle Corporation	Control of biofilm
US6348219B1 (en)	1998-06-01	2002-02-19	Albemarle Corporation	Processes for preparing concentrated aqueous liquid biocidal compositions
US6511682B1 (en)	1998-06-01	2003-01-28	Albemarle Corporation	Concentrated aqueous bromine solutions and their preparation
US8414932B2 (en)	1998-06-01	2013-04-09	Albemarie Corporation	Active bromine containing biocidal compositions and their preparation
US8293795B1 (en)	1998-06-01	2012-10-23	Albemarle Corporation	Preparation of concentrated aqueous bromine solutions and biocidal applications thereof
US6068861A (en)	1998-06-01	2000-05-30	Albemarle Corporation	Concentrated aqueous bromine solutions and their preparation
US6652889B2 (en)	1998-06-01	2003-11-25	Albemarle Corporation	Concentrated aqueous bromine solutions and their preparation and use
US6352725B1 (en)	1998-06-01	2002-03-05	Albemarle Corporation	Continuous processes for preparing concentrated aqueous liquid biocidal composition
US6299909B1 (en)	1998-06-01	2001-10-09	Albemarle Corporation	Concentrated aqueous bromine solutions and their preparation
US6506418B1 (en)	1999-09-24	2003-01-14	Albemarle Corporation	Concentrated aqueous bromine solutions and their preparation
US6375991B1 (en)	2000-09-08	2002-04-23	Albemarle Corporation	Production of concentrated biocidal solutions
WO2003011033A1 (en) *	2001-06-28	2003-02-13	Solution Biosciences, Inc.	Microbiological control in animal processing
US6986910B2 (en)	2001-06-28	2006-01-17	Albemarle Corporation	Microbiological control in poultry processing
US6919364B2 (en)	2001-06-28	2005-07-19	Solution Biosciences, Inc.	Microbiological control in animal processing
US7901276B2 (en) *	2003-06-24	2011-03-08	Albemarle Corporation	Microbiocidal control in the processing of meat-producing four-legged animals
WO2006029354A1 (en) *	2004-09-07	2006-03-16	Albemarle Corporation	Concentrated aqueous bromine solutions and their preparation
WO2006071215A1 (en) *	2004-12-23	2006-07-06	Albemarle Corporation	Microbiocidal control in the processing of meat-producing four-legged animals
JP2009518014A (ja)	2005-12-01	2009-05-07	ソリユーシヨン・バイオサイエンシズ・インコーポレーテツド	食肉用四足動物の処理における殺菌剤コントロール
US20090130017A1 (en) *	2007-11-19	2009-05-21	Searete Llc	Targeted short-lived drug delivery
CN104098583B (zh) *	2013-04-09	2018-02-02	中国医学科学院药物研究所	鬼臼毒素晶x型物质及制备方法和其药物组合物与用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2984674A (en) *	1958-06-02	1961-05-16	Sandoz Ag	Amides of podophyllic acid and picropodophyllic acid
US4122092A (en) *	1977-08-25	1978-10-24	University Of Rochester	Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone

1984
- 1984-09-26 GB GB848424269A patent/GB8424269D0/en active Pending
1985
- 1985-09-09 US US06/773,929 patent/US4680399A/en not_active Expired - Lifetime
- 1985-09-10 IS IS3039A patent/IS3039A7/is unknown
- 1985-09-24 EP EP85306787A patent/EP0197219B1/en not_active Expired
- 1985-09-24 ES ES547248A patent/ES8702395A1/es not_active Expired
- 1985-09-24 DE DE8585306787T patent/DE3574595D1/de not_active Expired - Fee Related
- 1985-09-24 NO NO853743A patent/NO164658C/no not_active IP Right Cessation
- 1985-09-24 AT AT85306787T patent/ATE48427T1/de not_active IP Right Cessation
- 1985-09-24 DE DE8888120946T patent/DE3583043D1/de not_active Expired - Fee Related
- 1985-09-25 FI FI853690A patent/FI84557C/fi not_active IP Right Cessation
- 1985-09-25 DK DK434085A patent/DK169385B1/da not_active IP Right Cessation
- 1985-09-25 PT PT81190A patent/PT81190B/pt not_active IP Right Cessation
- 1985-09-25 CA CA000491564A patent/CA1268709A/en not_active Expired - Lifetime
- 1985-09-26 PL PL1985255527A patent/PL147999B1/pl unknown
1986
- 1986-05-16 ES ES555039A patent/ES8900110A1/es not_active Expired
1989
- 1989-02-22 CA CA000591830A patent/CA1276110C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES547248A0 (es)	1987-01-01
ES555039A0 (es)	1988-12-16
FI84557C (fi)	1991-12-27
EP0197219A1 (en)	1986-10-15
NO853743L (no)	1986-04-01
NO164658C (no)	1990-10-31
IS3039A7 (is)	1986-01-21
ATE48427T1 (de)	1989-12-15
DK434085D0 (da)	1985-09-25
US4680399A (en)	1987-07-14
DE3574595D1 (de)	1990-01-11
ES8900110A1 (es)	1988-12-16
FI853690L (fi)	1986-03-27
FI84557B (fi)	1991-09-13
DK169385B1 (da)	1994-10-17
PT81190A (en)	1985-10-01
ES8702395A1 (es)	1987-01-01
DE3583043D1 (de)	1991-07-04
EP0197219B1 (en)	1989-12-06
CA1268709A (en)	1990-05-08
NO164658B (no)	1990-07-23
CA1276110C (en)	1990-11-13
PT81190B (pt)	1987-09-30
FI853690A0 (fi)	1985-09-25
PL255527A1 (en)	1986-07-15
GB8424269D0 (en)	1984-10-31
PL147999B1 (en)	1989-09-30

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Legal Events

Date	Code	Title	Description
2005-10-17	PUP	Patent expired