DK434587A - Heparinderivater, farmaceutisk praeparat, der indeholder dem og anvendelsen af derivaterne - Google Patents

Heparinderivater, farmaceutisk praeparat, der indeholder dem og anvendelsen af derivaterne

Info

Publication number: DK434587A
Authority: DK; Denmark
Prior art keywords: derivatives; heparin; activity; molecular weight; low molecular
Prior art date: 1986-08-20

Application number

DK434587A

Other languages

English (en)

Other versions

DK434587D0 (da

DK175087B1 (da

Inventor

Kevin Michael Foley

Charles Campbell Griffin

Original Assignee

Univ Miami

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-20

Filing date

1987-08-20

Publication date

1988-02-21

1986-08-20 Priority claimed from US06/898,130 external-priority patent/US4745105A/en

1986-08-20 Priority claimed from US06/898,127 external-priority patent/US4745108A/en

1986-08-20 Priority claimed from US06/898,124 external-priority patent/US4745107A/en

1986-08-20 Priority claimed from US06/898,431 external-priority patent/US4942156A/en

1986-08-20 Priority claimed from US06/898,436 external-priority patent/US4745106A/en

1987-08-20 Application filed by Univ Miami filed Critical Univ Miami

1987-08-20 Publication of DK434587D0 publication Critical patent/DK434587D0/da

1988-02-21 Publication of DK434587A publication Critical patent/DK434587A/da

2004-05-24 Application granted granted Critical

2004-05-24 Publication of DK175087B1 publication Critical patent/DK175087B1/da

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 4
239000000825 pharmaceutical preparation Substances 0.000 title 1
239000003055 low molecular weight heparin Substances 0.000 abstract 3
229940127215 low-molecular weight heparin Drugs 0.000 abstract 3
230000001858 anti-Xa Effects 0.000 abstract 2
230000001455 anti-clotting effect Effects 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
230000001747 exhibiting effect Effects 0.000 abstract 2
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical class CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 1
-1 ester derivatives of heparin Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
239000002628 heparin derivative Substances 0.000 abstract 1
125000001165 hydrophobic group Chemical group 0.000 abstract 1
230000014508 negative regulation of coagulation Effects 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
230000035699 permeability Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)

DK198704345A 1986-08-20 1987-08-20 Alkanoylestere af heparin, farmaceutisk præparat, der indeholder dem og anvendelse deraf DK175087B1 (da)

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date	Title
US89812486		1986-08-20
US89812786		1986-08-20
US06/898,130 US4745105A (en)	1986-08-20	1986-08-20	Low molecular weight heparin derivatives with improved permeability
US89843686		1986-08-20
US89813086		1986-08-20
US06/898,127 US4745108A (en)	1986-08-20	1986-08-20	Heparin derivatives having decreased anti-Xa specificity
US06/898,124 US4745107A (en)	1986-08-20	1986-08-20	Heparin derivatives with improved permeability
US06/898,431 US4942156A (en)	1986-08-20	1986-08-20	Low molecular weight heparin derivatives having improved anti-Xa specificity
US06/898,436 US4745106A (en)	1986-08-20	1986-08-20	Heparin derivatives having improved anti-Xa specificity
US89843186		1986-08-20

Publications (3)

Publication Number	Publication Date
DK434587D0 DK434587D0 (da)	1987-08-20
DK434587A true DK434587A (da)	1988-02-21
DK175087B1 DK175087B1 (da)	2004-05-24

Family

ID=27542290

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198704345A DK175087B1 (da)	1986-08-20	1987-08-20	Alkanoylestere af heparin, farmaceutisk præparat, der indeholder dem og anvendelse deraf

Country Status (8)

Country	Link
EP (1)	EP0256880B1 (da)
JP (1)	JP2643950B2 (da)
AT (1)	ATE122059T1 (da)
CA (1)	CA1312861C (da)
DE (1)	DE3751275T2 (da)
DK (1)	DK175087B1 (da)
ES (1)	ES2071608T3 (da)
NO (1)	NO172803C (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3821271A1 (de) *	1988-06-23	1989-12-28	Solco Basel Ag	Derivatisiertes heparin, verfahren zu dessen herstellung und arzneimittel, welches dieses enthaelt
US5011919A (en) *	1989-01-30	1991-04-30	Ajorca S.A.	Modified heparins and obtention process
IT1243300B (it) *	1990-12-20	1994-05-26	Fidia Spa	Derivati dell'eparina
IT1286510B1 (it) *	1996-11-29	1998-07-15	Cooperativa Centro Ricerche Po	Esteri butirrici ad attivita' antiproliferativa e composizioni farmaceutiche che li contengono
JP4964577B2 (ja) *	2006-12-15	2012-07-04	有限会社応用糖質化学研究所	親脂質性ヘパリン修飾体、その製造方法及び毛髪成長促進剤
CN102516416A (zh) *	2011-12-28	2012-06-27	蚌埠医学院	一种肝素酯化物的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1355036A (en) *	1970-04-14	1974-06-05	Ici Ltd	Articles of plastic film
JPS52111983A (en) *	1976-03-18	1977-09-20	Teijin Ltd	Preparation of heparin derivatives
JPS55158055A (en) *	1979-05-25	1980-12-09	Teijin Ltd	Preparation of antithrombus medical material
US4331697A (en) *	1980-09-02	1982-05-25	Teijin Limited	Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative
ZA829463B (en) *	1982-07-19	1983-10-26	Hepar Ind Inc	Process for manufacturing low molecular weight heparins by depolymerization of normal heparin

1987
- 1987-08-18 EP EP87307292A patent/EP0256880B1/en not_active Expired - Lifetime
- 1987-08-18 ES ES87307292T patent/ES2071608T3/es not_active Expired - Lifetime
- 1987-08-18 DE DE3751275T patent/DE3751275T2/de not_active Expired - Lifetime
- 1987-08-18 AT AT87307292T patent/ATE122059T1/de not_active IP Right Cessation
- 1987-08-19 NO NO87873501A patent/NO172803C/no not_active IP Right Cessation
- 1987-08-20 DK DK198704345A patent/DK175087B1/da not_active IP Right Cessation
- 1987-08-20 JP JP62207359A patent/JP2643950B2/ja not_active Expired - Lifetime
- 1987-08-21 CA CA000545111A patent/CA1312861C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2643950B2 (ja)	1997-08-25
NO172803C (no)	1993-09-08
ATE122059T1 (de)	1995-05-15
NO873501L (no)	1988-02-22
EP0256880B1 (en)	1995-05-03
EP0256880A2 (en)	1988-02-24
DE3751275D1 (de)	1995-06-08
CA1312861C (en)	1993-01-19
NO873501D0 (no)	1987-08-19
DK434587D0 (da)	1987-08-20
DE3751275T2 (de)	1995-09-07
DK175087B1 (da)	2004-05-24
NO172803B (no)	1993-06-01
EP0256880A3 (en)	1988-12-14
JPS6366202A (ja)	1988-03-24
ES2071608T3 (es)	1995-07-01

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Legal Events

Date	Code	Title	Description
2007-09-10	PUP	Patent expired