DK43884A - 3-PYRROLIDINE PROPIOPHENON DERIVATIVES AND PROCEDURES FOR THE PREPARATION OF THE SAME - Google Patents
3-PYRROLIDINE PROPIOPHENON DERIVATIVES AND PROCEDURES FOR THE PREPARATION OF THE SAME Download PDFInfo
- Publication number
- DK43884A DK43884A DK43884A DK43884A DK43884A DK 43884 A DK43884 A DK 43884A DK 43884 A DK43884 A DK 43884A DK 43884 A DK43884 A DK 43884A DK 43884 A DK43884 A DK 43884A
- Authority
- DK
- Denmark
- Prior art keywords
- pyrrolidine
- derivatives
- formula
- image
- propiophenon
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- KFGDCSJIJKJNGH-UHFFFAOYSA-N 1-phenyl-3-pyrrolidin-3-ylpropan-1-one Chemical class N1CC(CC1)CCC(=O)C1=CC=CC=C1 KFGDCSJIJKJNGH-UHFFFAOYSA-N 0.000 abstract 1
- 206010008531 Chills Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 229960002715 nicotine Drugs 0.000 abstract 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
- KRIOVPPHQSLHCZ-UHFFFAOYSA-N propiophenone Chemical class CCC(=O)C1=CC=CC=C1 KRIOVPPHQSLHCZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Novel 3-pyrrolidinepropiophenone derivatives of the formula: <IMAGE> in which R denotes an ethyl, propyl, isopropyl, butyl or isobutyl group or a cycloalkyl group having 5-7 carbon atoms, and pharmaceutically acceptable acid addition salts thereof, are prepared by reacting a propiophenone derivative of the formula: <IMAGE> in which R has the previously mentioned meaning, with a formaldehyde, or an equivalent thereto, and pyrrolidine, or a salt thereof. The novel compounds possess improved muscle-relaxing activity and greatly inhibit nicotine-induced convulsions and oxotremor-induced shivering. The compounds are of low toxicity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK43884A DK156832C (en) | 1984-01-31 | 1984-01-31 | 3-PYRROLIDINE PROPIOPHENON DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK43884A DK156832C (en) | 1984-01-31 | 1984-01-31 | 3-PYRROLIDINE PROPIOPHENON DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME |
| DK43884 | 1984-01-31 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK43884D0 DK43884D0 (en) | 1984-01-31 |
| DK43884A true DK43884A (en) | 1985-08-01 |
| DK156832B DK156832B (en) | 1989-10-09 |
| DK156832C DK156832C (en) | 1990-03-12 |
Family
ID=8093542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK43884A DK156832C (en) | 1984-01-31 | 1984-01-31 | 3-PYRROLIDINE PROPIOPHENON DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME |
Country Status (1)
| Country | Link |
|---|---|
| DK (1) | DK156832C (en) |
-
1984
- 1984-01-31 DK DK43884A patent/DK156832C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK156832B (en) | 1989-10-09 |
| DK156832C (en) | 1990-03-12 |
| DK43884D0 (en) | 1984-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |