DK439384A - DERIVATIVES OF 4- (3-ALKYNYLOXY-2-HYDROXYPROPYL) -PIPERAZIN-1-YL-N-PHENYLACETAMIDE, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THESE - Google Patents
DERIVATIVES OF 4- (3-ALKYNYLOXY-2-HYDROXYPROPYL) -PIPERAZIN-1-YL-N-PHENYLACETAMIDE, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THESE Download PDFInfo
- Publication number
- DK439384A DK439384A DK439384A DK439384A DK439384A DK 439384 A DK439384 A DK 439384A DK 439384 A DK439384 A DK 439384A DK 439384 A DK439384 A DK 439384A DK 439384 A DK439384 A DK 439384A
- Authority
- DK
- Denmark
- Prior art keywords
- atoms
- branched
- phenylacetamide
- alkynyloxy
- piperazin
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1. Compounds of the formula : see diagramm : EP0143016,P9,F1 wherein R1 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R2 and R3 represent separately a phenyl radical, an alkyl radical linear or branched having 1-6 C atoms, or together with the carbon atom to which they are bounded a cycloalkyl radical of 5 to 7 C atoms ; R4 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R5 represents an alkyl radical linear or branched having 1-6 C atoms or phenyl radical optionally substituted by a halogen atom ; X represents hydrogen or halogen atom, and pharmaceutically acceptable addition salts thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8314720A FR2552083B1 (en) | 1983-09-15 | 1983-09-15 | (ALKYNYLOXY-3 HYDROXY-2-PROPYL) -4 PIPERAZINYL-1 N-PHENYL ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK439384D0 DK439384D0 (en) | 1984-09-14 |
| DK439384A true DK439384A (en) | 1985-03-16 |
Family
ID=9292262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK439384A DK439384A (en) | 1983-09-15 | 1984-09-14 | DERIVATIVES OF 4- (3-ALKYNYLOXY-2-HYDROXYPROPYL) -PIPERAZIN-1-YL-N-PHENYLACETAMIDE, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THESE |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0143016B1 (en) |
| JP (1) | JPS60142972A (en) |
| KR (1) | KR850002477A (en) |
| AT (1) | ATE28639T1 (en) |
| AU (1) | AU572888B2 (en) |
| DE (1) | DE3465085D1 (en) |
| DK (1) | DK439384A (en) |
| ES (2) | ES8602724A1 (en) |
| FI (1) | FI77243C (en) |
| FR (1) | FR2552083B1 (en) |
| GR (1) | GR80359B (en) |
| HU (1) | HU192994B (en) |
| PT (1) | PT79214B (en) |
| ZA (1) | ZA846937B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451798B2 (en) | 2000-02-22 | 2002-09-17 | Cv Therapeutics, Inc. | Substituted alkyl piperazine derivatives |
| US6552023B2 (en) | 2000-02-22 | 2003-04-22 | Cv Therapeutics, Inc. | Aralkyl substituted piperazine compounds |
| US6677336B2 (en) | 2000-02-22 | 2004-01-13 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| IL151178A0 (en) * | 2000-02-22 | 2003-04-10 | Cv Therapeutics Inc | Substituted piperazine compounds |
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| CA2682384C (en) * | 2007-03-30 | 2016-05-10 | Council Of Scientific And Industrial Research | Benzophenone hybrids as potential anticancer agents and a process for the preparation thereof |
| JP6077344B2 (en) * | 2013-03-12 | 2017-02-08 | 花王株式会社 | Bleach composition comprising a piperazine derivative |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3951979A (en) * | 1972-04-13 | 1976-04-20 | Roland Yves Mauvernary | New amino propanediol derivatives |
| FR2173869B1 (en) * | 1972-04-13 | 1975-12-26 | Cerm Cent Europ Rech Mauvernay | |
| FR2403330A1 (en) * | 1977-06-16 | 1979-04-13 | Fabre Sa Pierre | NEW DERIVATIVES OF BENZOYL-2-CHLORO-4-GLYCINANILIDES SUBSTITUTES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
-
1983
- 1983-09-15 FR FR8314720A patent/FR2552083B1/en not_active Expired
-
1984
- 1984-09-04 ZA ZA846937A patent/ZA846937B/en unknown
- 1984-09-10 AU AU32861/84A patent/AU572888B2/en not_active Ceased
- 1984-09-13 JP JP59192411A patent/JPS60142972A/en active Pending
- 1984-09-13 ES ES535899A patent/ES8602724A1/en not_active Expired
- 1984-09-13 GR GR80359A patent/GR80359B/en unknown
- 1984-09-14 KR KR1019840005613A patent/KR850002477A/en not_active Withdrawn
- 1984-09-14 DK DK439384A patent/DK439384A/en not_active Application Discontinuation
- 1984-09-14 AT AT84401824T patent/ATE28639T1/en not_active IP Right Cessation
- 1984-09-14 EP EP84401824A patent/EP0143016B1/en not_active Expired
- 1984-09-14 DE DE8484401824T patent/DE3465085D1/en not_active Expired
- 1984-09-14 PT PT79214A patent/PT79214B/en unknown
- 1984-09-14 HU HU843473A patent/HU192994B/en not_active IP Right Cessation
- 1984-09-14 FI FI843617A patent/FI77243C/en not_active IP Right Cessation
-
1985
- 1985-07-05 ES ES544919A patent/ES8607265A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI77243B (en) | 1988-10-31 |
| FR2552083B1 (en) | 1986-05-09 |
| FI77243C (en) | 1989-02-10 |
| HU192994B (en) | 1987-08-28 |
| HUT35253A (en) | 1985-06-28 |
| DK439384D0 (en) | 1984-09-14 |
| EP0143016A1 (en) | 1985-05-29 |
| AU572888B2 (en) | 1988-05-19 |
| DE3465085D1 (en) | 1987-09-03 |
| KR850002477A (en) | 1985-05-13 |
| FR2552083A1 (en) | 1985-03-22 |
| FI843617L (en) | 1985-03-16 |
| AU3286184A (en) | 1985-03-21 |
| ES544919A0 (en) | 1986-05-16 |
| ES8607265A1 (en) | 1986-05-16 |
| ATE28639T1 (en) | 1987-08-15 |
| ES535899A0 (en) | 1985-12-01 |
| ZA846937B (en) | 1985-04-24 |
| ES8602724A1 (en) | 1985-12-01 |
| EP0143016B1 (en) | 1987-07-29 |
| PT79214A (en) | 1984-10-01 |
| JPS60142972A (en) | 1985-07-29 |
| FI843617A0 (en) | 1984-09-14 |
| GR80359B (en) | 1985-01-11 |
| PT79214B (en) | 1986-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |