DK447786A - Fremgangsmaade til udvinding af insulin-forloebere fra reaktionsblandingen, der fremkommer ved foldning af insulin-forloebere ud fra de tilsvarende s-sulfonater - Google Patents

Fremgangsmaade til udvinding af insulin-forloebere fra reaktionsblandingen, der fremkommer ved foldning af insulin-forloebere ud fra de tilsvarende s-sulfonater Download PDF

Info

Publication number: DK447786A
Authority: DK; Denmark
Prior art keywords: insulin; chain; pct; reaction mixture; folding
Prior art date: 1985-01-19

Application number

DK447786A

Other languages

English (en)

Other versions

DK172712B1 (da

DK447786D0 (da

Inventor

Ulrich Grau

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-19

Filing date

1986-09-18

Publication date

1986-09-18

1986-09-18 Application filed by Hoechst Ag filed Critical Hoechst Ag

1986-09-18 Publication of DK447786A publication Critical patent/DK447786A/da

1986-09-18 Publication of DK447786D0 publication Critical patent/DK447786D0/da

1999-06-14 Application granted granted Critical

1999-06-14 Publication of DK172712B1 publication Critical patent/DK172712B1/da

Links

102000004877 Insulin Human genes 0.000 title abstract 8
108090001061 Insulin Proteins 0.000 title abstract 8
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 8
229940125396 insulin Drugs 0.000 title abstract 4
239000011541 reaction mixture Substances 0.000 title abstract 4
238000000605 extraction Methods 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 2
239000002243 precursor Substances 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002244 precipitate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
External Artificial Organs (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Steroid Compounds (AREA)

DK198604477A 1985-01-19 1986-09-18 Fremgangsmåde til udvinding af insulin-forløbere fra reaktionsblandinger, der fremkommer ved foldning af insulin-forløbere DK172712B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE3501641		1985-01-19
DE19853501641 DE3501641A1 (de)	1985-01-19	1985-01-19	Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
EP8600008		1986-01-11
PCT/EP1986/000008 WO1986004335A1 (fr)	1985-01-19	1986-01-11	Procede de preparation de precurseurs d'insuline contenus dans des melanges de reaction resultant de la preparation de precurseurs d'insuline par pliage des sulfones-s correspondants

Publications (3)

Publication Number	Publication Date
DK447786A true DK447786A (da)	1986-09-18
DK447786D0 DK447786D0 (da)	1986-09-18
DK172712B1 DK172712B1 (da)	1999-06-14

Family

ID=6260194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198604477A DK172712B1 (da)	1985-01-19	1986-09-18	Fremgangsmåde til udvinding af insulin-forløbere fra reaktionsblandinger, der fremkommer ved foldning af insulin-forløbere

Country Status (9)

Country	Link
US (1)	US4801684A (da)
EP (1)	EP0245267B1 (da)
JP (1)	JPS62501501A (da)
AT (1)	ATE58741T1 (da)
AU (1)	AU579710B2 (da)
DE (2)	DE3501641A1 (da)
DK (1)	DK172712B1 (da)
HU (1)	HU200611B (da)
WO (1)	WO1986004335A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3901718A1 (de) *	1989-01-21	1990-07-26	Hoechst Ag	Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DE3901719A1 (de) *	1989-01-21	1990-07-26	Hoechst Ag	Verfahren zur herstellung eines insulinvorlaeufers
US5492936A (en) *	1990-11-30	1996-02-20	Allergan, Inc.	Bimodal molecular weight hyaluronate formulations and methods for using same
ATE148710T1 (de) *	1992-12-02	1997-02-15	Hoechst Ag	Verfahren zur gewinnung von proinsulin mit korrekt verbundenen cystinbrücken
US6001604A (en) *	1993-12-29	1999-12-14	Bio-Technology General Corp.	Refolding of proinsulins without addition of reducing agents
DE19735711C2 (de) *	1997-08-18	2001-04-26	Aventis Pharma Gmbh	Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
KR100253916B1 (ko) *	1997-12-29	2000-05-01	김충환	사람 인슐린 전구체의 제조방법
WO2002067969A2 (en)	2001-02-21	2002-09-06	Medtronic Minimed, Inc.	Stabilized insulin formulations
WO2012152439A1 (en)	2011-05-10	2012-11-15	Glucometrix Ag	Comprehensive buffer system for renaturing human proinsulin or proinsulin derivatives
KR20170036643A (ko) *	2015-09-24	2017-04-03	한미약품 주식회사	인슐린의 제조 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2428412A1 (de) *	1974-06-12	1976-01-15	Hoechst Ag	Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DE2923787A1 (de) *	1979-06-12	1980-12-18	Max Planck Gesellschaft	Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
PL127843B1 (en) *	1980-03-27	1983-11-30	Lilly Co Eli	Process for preparing insulin precursor
ZA811970B (en) *	1980-03-27	1982-11-24	Lilly Co Eli	Process for producing an insulin
US4421685A (en) *	1980-03-27	1983-12-20	Eli Lilly And Company	Process for producing an insulin
ZA811972B (en) *	1980-03-27	1982-11-24	Lilly Co Eli	Process for producing an insulin precursor
US4430266A (en) *	1980-11-28	1984-02-07	Eli Lilly And Company	Process for producing an insulin precursor
US4654324A (en) *	1981-08-27	1987-03-31	Eli Lilly And Company	Human proinsulin pharmaceutical formulations
DE3326472A1 (de) *	1983-07-22	1985-02-14	Hoechst Ag, 6230 Frankfurt	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus

1985
- 1985-01-19 DE DE19853501641 patent/DE3501641A1/de not_active Withdrawn
1986
- 1986-01-11 EP EP86900761A patent/EP0245267B1/de not_active Expired - Lifetime
- 1986-01-11 US US06/924,850 patent/US4801684A/en not_active Expired - Lifetime
- 1986-01-11 WO PCT/EP1986/000008 patent/WO1986004335A1/de not_active Ceased
- 1986-01-11 AT AT86900761T patent/ATE58741T1/de not_active IP Right Cessation
- 1986-01-11 HU HU861143A patent/HU200611B/hu not_active IP Right Cessation
- 1986-01-11 JP JP61500688A patent/JPS62501501A/ja active Pending
- 1986-01-11 DE DE8686900761T patent/DE3675936D1/de not_active Expired - Lifetime
- 1986-01-11 AU AU53568/86A patent/AU579710B2/en not_active Ceased
- 1986-09-18 DK DK198604477A patent/DK172712B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPS62501501A (ja)	1987-06-18
EP0245267A1 (de)	1987-11-19
WO1986004335A1 (fr)	1986-07-31
EP0245267B1 (de)	1990-11-28
ATE58741T1 (de)	1990-12-15
DE3675936D1 (de)	1991-01-10
HUT46041A (en)	1988-09-28
DK172712B1 (da)	1999-06-14
AU5356886A (en)	1986-08-13
DE3501641A1 (de)	1986-07-24
HU200611B (en)	1990-07-28
US4801684A (en)	1989-01-31
AU579710B2 (en)	1988-12-08
DK447786D0 (da)	1986-09-18

Legal Events

Date	Code	Title	Description
1999-06-14	B1	Patent granted (law 1993)
2006-01-30	PUP	Patent expired

Publication	Publication Date	Title
DK447786A (da)	1986-09-18	Fremgangsmaade til udvinding af insulin-forloebere fra reaktionsblandingen, der fremkommer ved foldning af insulin-forloebere ud fra de tilsvarende s-sulfonater
YU53290A (sh)	1992-12-21	Postupak za dobijanje novih jedinjenja insulina
PT83278A (en)	1986-09-01	Process for the preparation of insulin analogues and of injectable insulin solutions containing the same
DE3482470D1 (de)	1990-07-19	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate, diese enthaltende mittel und ihre verwendung.
ATE114142T1 (de)	1994-12-15	Verfahren zur herstellung von basischen aluminiumverbindungen.
DK390689A (da)	1990-02-11	Fremgangsmaade til fremstilling af des-b30-insuliner og des-b30-insulinderivater
HUT35002A (en)	1985-05-28	Process for preparing insuline derivatives
DK117883D0 (da)	1983-03-11	Fremgangsmade til fremstilling af insuliner ud fra praeproinsulinanaloge
DK1179593T3 (da)	2008-04-28	Fremgangsmåde til fremstilling af rekombinant insulin fra nyt fusionsprotein
EP0249412A3 (en)	1989-02-22	C-terminal alpha-amidating enzyme and process for production and use thereof
ATE73818T1 (de)	1992-04-15	Verfahren zur herstellung von peptiden unter der verwendung von perchloraten.
Chu et al.	1987	Possible involvement of the A20-A21 peptide bond in the expression of the biological activity of insulin. 2.[21-Asparagine diethylamide-A] insulin
PH26896A (en)	1992-12-03	GRF analogs V
Ramshaw et al.	1976	The amino acid sequence of plastocyanin from Lactuca sativa (lettuce)
CA1304192C (en)	1992-06-23	Grf analogs vi
TOMETSKO	1964	Synthetic Studies on Insulin