DK453089A - Farmaceutisk middel med afslappende virkning indeholdende en nitratester som aktiv forbindelse - Google Patents

Farmaceutisk middel med afslappende virkning indeholdende en nitratester som aktiv forbindelse Download PDF

Info

Publication number
DK453089A
DK453089A DK453089A DK453089A DK453089A DK 453089 A DK453089 A DK 453089A DK 453089 A DK453089 A DK 453089A DK 453089 A DK453089 A DK 453089A DK 453089 A DK453089 A DK 453089A
Authority
DK
Denmark
Prior art keywords
tester
nitrate
active compound
pharmaceutical agent
relaxing effect
Prior art date
Application number
DK453089A
Other languages
English (en)
Other versions
DK453089D0 (da
Inventor
Jan Bron
Geert Jan Sterk
Jan Fetze Van Der Werf
Hendrik Timmerman
Original Assignee
Cedona Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedona Pharm Bv filed Critical Cedona Pharm Bv
Publication of DK453089D0 publication Critical patent/DK453089D0/da
Publication of DK453089A publication Critical patent/DK453089A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/08—Esters of nitric acid having nitrate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK453089A 1988-09-15 1989-09-14 Farmaceutisk middel med afslappende virkning indeholdende en nitratester som aktiv forbindelse DK453089A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8802276A NL8802276A (nl) 1988-09-15 1988-09-15 Geneesmiddel met relaxerende werking, dat als aktieve stof een nitraatester bevat.

Publications (2)

Publication Number Publication Date
DK453089D0 DK453089D0 (da) 1989-09-14
DK453089A true DK453089A (da) 1990-03-16

Family

ID=19852906

Family Applications (1)

Application Number Title Priority Date Filing Date
DK453089A DK453089A (da) 1988-09-15 1989-09-14 Farmaceutisk middel med afslappende virkning indeholdende en nitratester som aktiv forbindelse

Country Status (13)

Country Link
US (1) US5049694A (da)
EP (1) EP0359335A3 (da)
JP (1) JPH02134316A (da)
KR (1) KR900004331A (da)
AU (1) AU638413B2 (da)
DK (1) DK453089A (da)
FI (1) FI894349L (da)
IL (1) IL91602A0 (da)
NL (1) NL8802276A (da)
NO (1) NO171904C (da)
NZ (1) NZ230631A (da)
PT (1) PT91701B (da)
ZA (1) ZA896982B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
US5646181A (en) * 1992-07-02 1997-07-08 Research Foundation Of State University Of New York Method and compositions for treating impotence
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
WO1994021248A1 (de) * 1993-03-15 1994-09-29 Byk Nederland Bv Verwendung von substituierten alkylnitraten zur behandlung des krankhaft erhöhten augeninnendruckes
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
CA2173582C (en) * 1993-10-06 2006-11-28 Piero Del Soldato Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
CN1143950A (zh) * 1994-01-19 1997-02-26 比克荷兰有限公司 含硝酰基的苄胺衍生物及其在治疗心血管疾病和治疗升高眼压中的应用
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
US7115661B1 (en) 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
US6310052B1 (en) 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
IL120531A (en) * 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
RU2125040C1 (ru) * 1997-04-23 1999-01-20 Институт химической физики в Черноголовке РАН Производные янтарной кислоты, способ их получения, промежуточные соединения для их синтеза и способ получения промежуточных соединений
RU2146243C1 (ru) * 1998-04-22 2000-03-10 Институт химической физики в Черноголовке РАН Нитраты спиртов, содержащие амидную, динитрометиленовую и нитроаминную группы, способ их получения, 3-(ациламинодинитроалкил)-тетрагидро-1,3-оксазолы и - оксазины, способ их получения
US6056966A (en) * 1998-05-18 2000-05-02 Baker Norton Pharmaceuticals, Inc. Method and compositions for treating impotence
EP1508042A4 (en) * 2002-05-02 2008-04-02 Bio Rad Laboratories BIOCHIPS WITH HYDROGELS POLYSACCHARIDBASIS COATED SURFACES
JP4891982B2 (ja) * 2008-12-15 2012-03-07 スガツネ工業株式会社 ２軸ヒンジ装置及び携帯機器
CN103739499B (zh) * 2011-10-24 2016-09-07 尼科斯科学爱尔兰公司 醌基一氧化氮供体化合物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2139364A (en) * 1937-03-22 1938-12-06 Shell Dev Alpha-substituted glycerol nitrates
NL49919C (da) * 1938-02-10
US2294849A (en) * 1938-08-20 1942-09-01 Sharples Chemicals Inc Manufacture of nitric acid esters
US2549687A (en) * 1947-11-21 1951-04-17 Duriron Co Heat exchanger
GB713329A (en) * 1951-01-08 1954-08-11 Nat Res Dev Improvements in or relating to production of nitric acid esters of higher alcohols and glycols
US2683164A (en) * 1951-12-21 1954-07-06 Trojan Powder Co Preparation of 1, 2, 6-hexanetriol trinitrate
US2742492A (en) * 1954-07-29 1956-04-17 Ethyl Corp Nitrate formulations
NL98269C (da) * 1956-02-24
NL110701C (da) * 1960-03-14
US3428667A (en) * 1962-09-20 1969-02-18 Aerojet General Co N,n-dinitramines of certain organic compounds and process
US3419571A (en) * 1966-04-06 1968-12-31 Warner Lambert Pharmaceutical Method for relieving coronary insufficiency
US3409620A (en) * 1967-02-06 1968-11-05 Mario Biazzi Sa Dr Ing Continuous manufacture in vacuum of nitric esters and/or organic nitro compounds
US3470231A (en) * 1967-05-29 1969-09-30 Us Navy Method of stabilizing nitric acid esters
US3853891A (en) * 1971-06-16 1974-12-10 Sandoz Ag N-(n-(cyanoalkyl)-n-nitroso)amino-aminoalcohol
US4336408A (en) * 1977-11-25 1982-06-22 Thiokol Corporation 2-Hydroxymethyl-1,3-propanediol preparation
JPS56113748A (en) * 1980-02-13 1981-09-07 Kowa Co Aminoethanol derivative and its preparation
US4417903A (en) * 1982-10-15 1983-11-29 Ethyl Corporation Diesel fuel composition
DE3305690A1 (de) * 1983-02-18 1984-08-30 Heinrich Mack Nachf., 7918 Illertissen Glycerinmononitrate zur behandlung der angina pectoris
US4479905A (en) * 1983-09-19 1984-10-30 Ethyl Corporation Nitration process
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3512627A1 (de) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
PT91701A (pt) 1990-03-30
EP0359335A3 (en) 1991-03-06
FI894349A7 (fi) 1990-03-16
NO893686L (no) 1990-03-16
NO893686D0 (no) 1989-09-14
KR900004331A (ko) 1990-04-12
NO171904B (no) 1993-02-08
AU638413B2 (en) 1993-07-01
US5049694A (en) 1991-09-17
EP0359335A2 (en) 1990-03-21
NO171904C (no) 1993-05-19
IL91602A0 (en) 1990-04-29
NZ230631A (en) 1993-01-27
AU4133089A (en) 1990-03-22
DK453089D0 (da) 1989-09-14
NL8802276A (nl) 1990-04-02
ZA896982B (en) 1990-06-27
JPH02134316A (ja) 1990-05-23
PT91701B (pt) 1995-06-30
FI894349L (fi) 1990-03-16
FI894349A0 (fi) 1989-09-14

Similar Documents

Publication Publication Date Title
DK453089A (da) Farmaceutisk middel med afslappende virkning indeholdende en nitratester som aktiv forbindelse
DK0497794T3 (da) Mikroperoxidasepræparat indeholdende et hemopeptid som en aktiv bestanddel
DK494186D0 (da) Thiazolderivater og leukotrienantagonist indeholdende disse som aktiv bestanddel
NO891663D0 (no) Sjampo med lav ph som inneholder climbazol.
DK50191A (da) Orale farmaceutiske praeparater med colonselektiv afgivelse
LV10573A (lv) Panemiens farmaceitiska sastava iegusanai
DE69007592D1 (de) Transdermal absorbierbare Dopaminderivate enthaltende Arzneizubereitungen.
PT100928A (pt) Derivados de ciclopentano e ciclopenteno, composicoes farmaceuticas contendo estes compostos e seu uso
IT1231012B (it) Composizione farmaceutica per uso orale contenente nac.
AT399878B (de) Kristallines cephalosporinsalz und dieses enthaltendes pharmazeutisches mittel
NO934196D0 (no) N,N-disubstituerte arylcykloalkylaminer, deres salter, legemidler inneholdende disse forbindelser, deres anvendelseog fremgangsm}te for deres fremstilling
DK246984D0 (da) Dihydrobenzopyrrolobenzodiazepiner en fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
FI890853A0 (fi) Farmaceutiskt preparat som tryggar transdermal absorption av den aktiva bestaondsdelen och foerfarande foer framstaellning daerav.
DK674589A (da) Benzenderivater og fremgangsmaade til fresmtilling deraf samt farmaceutiske midler indeholdende derivaterne
DK234489D0 (da) Farmaceutisk praeparat indeholdende et immunosuppressivt middel
DK681887A (da) Azolderivat, fremgangsmaade til fresmtilling heraf samt landburgsmaessigt/havebrugsmaessigt fungicid indeholdende derivatet som aktiv bestanddel
DK401988A (da) 11-substituerede 5-aryl-5h,11h-pyrrolo(2,1-c)-(1,4)benzoxazepiner, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK256689D0 (da) 1,2-dithiol-3-thion-s-oxid-forbindelser til anven delse som laegemidler
DK102988A (da) Middel med antidepressiv virkning
IT8822558A0 (it) Soluzione farmaceutica acquosa per uso oftalmico.
DK225189A (da) Hydrazinocarbonyloxylabdaner, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK444389A (da) Makrocycliske forbindelser, fremgangsmaade til deres fremstilling samt deres anvendelse som mikrobicider
DK162631C (da) Forbindelse, betegnet fr-900216, til anvendelse som terapeutisk aktivt stof, farmaceutisk praeparat indeholdende forbindelsen samt anvendelse af forbindelsen
DK165789C (da) 4-oxo-4h-pyrimidooe2,1,aaaisoquinolinderivater, analogifremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse samt derivaterne til anvendelse som antiallergisk middel
DK444489A (da) Makrocycliske forbindelser, fremgangsmaade til deres fremstilling samt deres anvendelse som mikrobicider

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment