DK480489A - Anvendelse af pteridinforbindelser til forebyggelse af primaer og sekundaer resistens ved kemoterapi, og laegemidler indeholdende disse forbindelser - Google Patents

Anvendelse af pteridinforbindelser til forebyggelse af primaer og sekundaer resistens ved kemoterapi, og laegemidler indeholdende disse forbindelser Download PDF

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Publication number
DK480489A
DK480489A DK480489A DK480489A DK480489A DK 480489 A DK480489 A DK 480489A DK 480489 A DK480489 A DK 480489A DK 480489 A DK480489 A DK 480489A DK 480489 A DK480489 A DK 480489A
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DK
Denmark
Prior art keywords
compounds
group
pteridines
chemotherapy
pteridic
Prior art date
Application number
DK480489A
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English (en)
Other versions
DK480489D0 (da
Inventor
Armin Heckel
Joerg Lebsanft
Uwe Bamberger
Avner Ramu
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK480489D0 publication Critical patent/DK480489D0/da
Publication of DK480489A publication Critical patent/DK480489A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK480489A 1988-10-01 1989-09-29 Anvendelse af pteridinforbindelser til forebyggelse af primaer og sekundaer resistens ved kemoterapi, og laegemidler indeholdende disse forbindelser DK480489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3833393A DE3833393A1 (de) 1988-10-01 1988-10-01 Verwendung von pteridinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
DK480489D0 DK480489D0 (da) 1989-09-29
DK480489A true DK480489A (da) 1990-04-02

Family

ID=6364156

Family Applications (1)

Application Number Title Priority Date Filing Date
DK480489A DK480489A (da) 1988-10-01 1989-09-29 Anvendelse af pteridinforbindelser til forebyggelse af primaer og sekundaer resistens ved kemoterapi, og laegemidler indeholdende disse forbindelser

Country Status (19)

Country Link
EP (1) EP0362645B1 (da)
JP (1) JPH02256676A (da)
KR (1) KR910006289A (da)
AT (1) ATE106728T1 (da)
AU (1) AU620645B2 (da)
DD (1) DD299062A5 (da)
DE (2) DE3833393A1 (da)
DK (1) DK480489A (da)
ES (1) ES2056174T3 (da)
FI (1) FI92699C (da)
HU (1) HU205761B (da)
IL (1) IL91814A (da)
MX (1) MX9203034A (da)
NO (1) NO175979C (da)
NZ (1) NZ230833A (da)
PT (1) PT91836B (da)
SU (1) SU1720491A3 (da)
UA (1) UA8028A1 (da)
ZA (1) ZA897414B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU770551B2 (en) * 1998-12-28 2004-02-26 4-Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
DE10202468A1 (de) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
PL1663244T3 (pl) * 2003-09-12 2008-01-31 4 Aza Ip Nv Pochodne pterydyny do leczenia chorób związanych z TNF-alfa
PT1673092E (pt) * 2003-10-17 2007-11-23 4 Aza Ip Nv ''derivados de pteridina substituídos com heterociclos e sua utilização em terapia''
RU2447074C2 (ru) * 2005-05-12 2012-04-10 Тиботек Фармасьютикалз Лтд. Птеридины, полезные в качестве ингибиторов hcv, и способы получения птеридинов
WO2008009079A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
SG11201606876RA (en) 2015-03-04 2016-10-28 Gilead Sciences Inc Toll like receptor modulator compounds
KR20160003575A (ko) 2015-11-09 2016-01-11 정민시 발전기용 동력전달장치
SI3507276T1 (sl) 2016-09-02 2022-01-31 Gilead Sciences, Inc. Spojine modulatorja toličnih receptorjev
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574206A (en) * 1965-04-15 1971-04-06 Boehringer Sohn Ingelheim 2,7-dimorpholino-4-amino-6-phenyl-pteridines
NL129630C (da) * 1966-10-14
DE1617336C2 (de) * 1966-11-25 1982-07-01 C.H. Boehringer Sohn, 6507 Ingelheim Arzneimittel gegen Angina pectoris
DE1795515A1 (de) * 1967-08-18 1972-03-30 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen Pteridinen
DE1795516A1 (de) * 1967-12-15 1972-01-27 Thomae Gmbh Dr K 4-AEthanolisopropanolamino-2-(2'-methylmorpholino)-7-morpholino-6-phenyl-pteridin
DE1921308A1 (de) * 1969-04-25 1971-01-07 Boehringer Sohn Ingelheim Herzwirksame Zubereitungen
US4767761A (en) * 1987-11-04 1988-08-30 Dana-Farber Cancer Institute, Inc. Ornithine derivatives and their use as methotrexate-resistant cell inhibitors

Also Published As

Publication number Publication date
IL91814A0 (en) 1990-06-10
AU620645B2 (en) 1992-02-20
KR910006289A (ko) 1991-04-29
HU205761B (en) 1992-06-29
NO893879L (no) 1990-04-02
FI894615A7 (fi) 1990-04-02
ATE106728T1 (de) 1994-06-15
JPH02256676A (ja) 1990-10-17
MX9203034A (es) 1992-07-01
PT91836B (pt) 1995-07-18
UA8028A1 (uk) 1995-12-26
NZ230833A (en) 1991-05-28
DE58907824D1 (de) 1994-07-14
FI92699C (fi) 1994-12-27
NO175979C (no) 1995-01-11
FI894615A0 (fi) 1989-09-29
AU4174989A (en) 1990-04-05
DD299062A5 (de) 1992-03-26
EP0362645A2 (de) 1990-04-11
DE3833393A1 (de) 1990-04-05
DK480489D0 (da) 1989-09-29
PT91836A (pt) 1990-04-30
SU1720491A3 (ru) 1992-03-15
NO175979B (no) 1994-10-03
EP0362645B1 (de) 1994-06-08
EP0362645A3 (de) 1992-03-25
FI92699B (fi) 1994-09-15
IL91814A (en) 1994-02-27
ES2056174T3 (es) 1994-10-01
NO893879D0 (no) 1989-09-29
ZA897414B (en) 1991-06-26
HUT52504A (en) 1990-07-28

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