DK482088A - Anvendelse af 1,3,7-trisubstituerede purin-2,6-dion-forbindelser til fremstilling af et laegemiddel med interleukin-1-inhiberende virkning - Google Patents

Anvendelse af 1,3,7-trisubstituerede purin-2,6-dion-forbindelser til fremstilling af et laegemiddel med interleukin-1-inhiberende virkning

Info

Publication number: DK482088A
Authority: DK; Denmark
Prior art keywords: interleukin; dion; purin; trisubstituted; medicine
Prior art date: 1986-12-31

Application number

DK482088A

Other languages

Danish (da)

English (en)

Other versions

DK482088D0 (da

Inventor

Gerald L Mandell

Gail W Sullivan

Jr William J Novick

Original Assignee

Hoechst Roussel Pharma

Univ Virginia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-31

Filing date

1988-08-30

Publication date

1988-10-28

1988-08-30 Application filed by Hoechst Roussel Pharma, Univ Virginia filed Critical Hoechst Roussel Pharma

1988-08-30 Publication of DK482088D0 publication Critical patent/DK482088D0/da

1988-10-28 Publication of DK482088A publication Critical patent/DK482088A/da

Links

102000000589 Interleukin-1 Human genes 0.000 title abstract 3
108010002352 Interleukin-1 Proteins 0.000 title abstract 3
230000002401 inhibitory effect Effects 0.000 title abstract 2
-1 1,3,7-TRISUBSTITUTED PURIN-2,6-DION Chemical class 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK482088A 1986-12-31 1988-08-30 Anvendelse af 1,3,7-trisubstituerede purin-2,6-dion-forbindelser til fremstilling af et laegemiddel med interleukin-1-inhiberende virkning DK482088A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US94790586A	1986-12-31	1986-12-31
PCT/US1987/003479 WO1988004928A1 (en)	1986-12-31	1987-12-28	Method of inhibiting interleukin-1 activity

Publications (2)

Publication Number	Publication Date
DK482088D0 DK482088D0 (da)	1988-08-30
DK482088A true DK482088A (da)	1988-10-28

Family

ID=25486973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK482088A DK482088A (da)	1986-12-31	1988-08-30	Anvendelse af 1,3,7-trisubstituerede purin-2,6-dion-forbindelser til fremstilling af et laegemiddel med interleukin-1-inhiberende virkning

Country Status (14)

Country	Link
EP (1)	EP0279079B1 (ja)
JP (1)	JP2507012B2 (ja)
KR (1)	KR960015726B1 (ja)
AT (1)	ATE151290T1 (ja)
AU (1)	AU668982B2 (ja)
CA (1)	CA1313137C (ja)
DE (1)	DE3752048T2 (ja)
DK (1)	DK482088A (ja)
ES (1)	ES2103255T3 (ja)
GR (1)	GR3024054T3 (ja)
IE (1)	IE873554L (ja)
IL (7)	IL100535A (ja)
WO (1)	WO1988004928A1 (ja)
ZA (1)	ZA879754B (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5272153A (en) *	1986-12-31	1993-12-21	Hoechst-Roussel Pharmaceuticals, Inc.	Method of inhibiting the activity of leukocyte derived cytokines
US4965271A (en) *	1986-12-31	1990-10-23	Hoechst Roussel Pharmaceuticals, Inc.	Method of inhibiting the activity of leukocyte derived cytokines
US5196430A (en) *	1986-12-31	1993-03-23	Hoechst-Roussel Pharmaceuticals Inc.	Method of inhibiting the activity of leukocyte derived cytokines
US5196429A (en) *	1986-12-31	1993-03-23	Hoechst-Roussel Pharmaceuticals Inc.	Method of inhibiting the activity of leukocyte derived cytokines
KR920702606A (ko) *	1989-06-13	1992-10-06	스튜어트 알. 슈터	모노킨(Monokine)의 활성저해
DD298051A5 (de) *	1989-08-16	1992-02-06	��@��@��k��	Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten
EP0493682A3 (en) *	1990-11-30	1992-11-19	Hoechst-Roussel Pharmaceuticals Incorporated	Use of xanthines for the preparation of a medicament effective for inhibiting the effects of allograft reaction in humans
EP0490181A1 (en) *	1990-11-30	1992-06-17	Hoechst-Roussel Pharmaceuticals Incorporated	Use of xanthines for preparation of a medicament having immunosuppressing activity
US6420374B1 (en)	1990-11-30	2002-07-16	Fred Hutchinson Cancer Research Center	Use of xanthines as immunosuppressants and to inhibit allograft reactions
WO1992021344A2 (en) *	1991-05-24	1992-12-10	Fred Hutchinson Cancer Research Center	Modulation of cellular response to external stimuli
EP0518263A1 (en) *	1991-06-10	1992-12-16	Hoechst-Roussel Pharmaceuticals Incorporated	Micropellets and a process for their manufacture
WO1993003728A1 (en) *	1991-08-27	1993-03-04	Temple University Of The Commonwealth System Of	Xanthine suppression of antigen activation of t- or b-cells
WO1993008819A1 (en) *	1991-10-31	1993-05-13	The Victoria University Of Manchester	Treatment of neurological conditions by an interleukin-1 inhibiting compound
AU3539795A (en) *	1994-08-25	1996-03-14	Medical University Of South Carolina	Methods of treating cold symptoms using pentoxifylline
US5856330A (en) *	1996-07-31	1999-01-05	Hoechst Aktiengesellschaft	Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US5981536A (en) *	1996-07-31	1999-11-09	Hoechst Aktiengesellschaft	Use of xanthine derivatives for the modulation of apoptosis
JP3830115B2 (ja) *	1997-10-06	2006-10-04	シャープ株式会社	液晶表示素子
TW561297B (en) *	1997-11-25	2003-11-11	Toshiba Corp	Electrode wiring board subjected to counter measure against static electricity and display device using the same
JP3019053B2 (ja) *	1997-12-25	2000-03-13	日本電気株式会社	液晶表示装置及びその製造方法
KR20100121527A (ko)	2008-02-29	2010-11-17	콘서트 파마슈티컬즈, 인크.	치환된 잔틴 유도체
US20110053961A1 (en)	2009-02-27	2011-03-03	Concert Pharmaceuticals, Inc.	Substituted xanthine derivatives
MX2012002704A (es)	2009-09-02	2012-03-21	Concert Pharmaceuticals Inc	Derivados de xantina sustituidos.
EP2611807A2 (en)	2010-09-01	2013-07-10	Concert Pharmaceuticals Inc.	Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purine-2,6(3h,7h)dione
WO2013013052A1 (en)	2011-07-19	2013-01-24	Concert Pharmaceuticals, Inc.	Substituted xanthine derivatives
IN2014DN08443A (ja)	2012-04-13	2015-05-08	Concert Pharmaceuticals Inc
WO2013159006A1 (en)	2012-04-20	2013-10-24	Concert Pharmaceuticals, Inc.	Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3,7-dimethyl-1h-purine-2,6(3h,7h)-dione

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0005015B1 (en) *	1978-04-22	1986-10-29	BEECHAM - WUELFING GmbH & Co. KG	Use of a xanthine derivate in the manufacture of a medicament
US4567183A (en) *	1983-03-11	1986-01-28	Analgesic Associates	Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
US4636507A (en) *	1984-04-30	1987-01-13	Hoechst-Roussel Pharmaceuticals Inc.	Host defense mechanism enhancement
GB8418430D0 (en) *	1984-07-19	1984-08-22	Beecham Wuelfing Gmbh & Co Kg	Treatment

1987
- 1987-12-23 IL IL10053587A patent/IL100535A/en not_active IP Right Cessation
- 1987-12-23 IL IL10685487A patent/IL106854A/en not_active IP Right Cessation
- 1987-12-23 IL IL10685987A patent/IL106859A/en not_active IP Right Cessation
- 1987-12-23 IL IL10053387A patent/IL100533A/en not_active IP Right Cessation
- 1987-12-23 IL IL10053687A patent/IL100536A/en not_active IP Right Cessation
- 1987-12-23 IL IL8493487A patent/IL84934A/en not_active IP Right Cessation
- 1987-12-23 IL IL10686187A patent/IL106861A/xx not_active IP Right Cessation
- 1987-12-28 KR KR1019880701056A patent/KR960015726B1/ko not_active Expired - Fee Related
- 1987-12-28 JP JP63501103A patent/JP2507012B2/ja not_active Expired - Lifetime
- 1987-12-28 WO PCT/US1987/003479 patent/WO1988004928A1/en not_active Ceased
- 1987-12-30 AT AT87119377T patent/ATE151290T1/de not_active IP Right Cessation
- 1987-12-30 DE DE3752048T patent/DE3752048T2/de not_active Expired - Fee Related
- 1987-12-30 IE IE873554A patent/IE873554L/xx unknown
- 1987-12-30 ES ES87119377T patent/ES2103255T3/es not_active Expired - Lifetime
- 1987-12-30 ZA ZA879754A patent/ZA879754B/xx unknown
- 1987-12-30 CA CA000555613A patent/CA1313137C/en not_active Expired - Fee Related
- 1987-12-30 EP EP87119377A patent/EP0279079B1/en not_active Expired - Lifetime
1988
- 1988-08-30 DK DK482088A patent/DK482088A/da not_active Application Discontinuation
1993
- 1993-08-27 AU AU46027/93A patent/AU668982B2/en not_active Ceased
1997
- 1997-07-09 GR GR970401709T patent/GR3024054T3/el unknown

Also Published As

Publication number	Publication date
EP0279079A3 (en)	1990-06-13
AU619732B2 (en)	1992-02-06
EP0279079B1 (en)	1997-04-09
DE3752048T2 (de)	1997-10-02
DK482088D0 (da)	1988-08-30
IL100533A (en)	1994-05-30
ATE151290T1 (de)	1997-04-15
CA1313137C (en)	1993-01-26
AU668982B2 (en)	1996-05-23
IE873554L (en)	1988-06-30
AU637542B2 (en)	1993-05-27
IL106859A (en)	1996-10-16
GR3024054T3 (en)	1997-10-31
IL100535A (en)	1994-05-30
DE3752048D1 (de)	1997-05-15
IL84934A (en)	1994-08-26
KR960015726B1 (ko)	1996-11-20
IL106854A (en)	1996-05-14
KR890700347A (ko)	1989-04-24
IL100536A (en)	1994-05-30
JPH02501829A (ja)	1990-06-21
AU1291892A (en)	1992-05-14
JP2507012B2 (ja)	1996-06-12
IL106861A (en)	1997-02-18
ZA879754B (en)	1989-07-26
EP0279079A2 (en)	1988-08-24
ES2103255T3 (es)	1997-09-16
AU1150588A (en)	1988-07-27
AU4602793A (en)	1993-11-18
WO1988004928A1 (en)	1988-07-14

Legal Events

Date	Code	Title	Description
2000-07-31	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK482088D0 (da)	1988-08-30	Anvendelse af 1,3,7-trisubstituerede purin-2,6-dion-forbindelser til fremstilling af et laegemiddel med interleukin-1-inhiberende virkning
AU652094B2 (en)	1994-08-11	Method of inhibiting the activity of leukocyte derived cytokines
FI870421A7 (fi)	1987-07-31	Analogiamenetelmä alkueläintenvastaisesti vaikuttavien 5,6-dihydro-2-(substituoitu fenyyli)-1,2,4-triatsiini-3,5(2H,4H)-dionijohdannaisten valmistamiseksi
ATE46332T1 (de)	1989-09-15	Spiro-imidazolidine als aldose-reduktaseinhibitoren.
NO166039C (no)	1991-05-29	Analogifremgangsmaate for fremstilling av steroido(3,2-c)pyrazoler med antiandrogen virkning.
ES517779A0 (es)	1983-08-16	Procedimiento de preparacion de nuevos derivados de 2-fenilmorfolina.
DE68910165D1 (de)	1993-12-02	Antihypertensive Sulfonanilide.
ATE53004T1 (de)	1990-06-15	Pharmazeutische zusammensetzungen mit inhalt von 5-phenyl-1,3-dioxoalkenylverbindungen.
DE69029069D1 (de)	1996-12-12	Verwendung von Xanthinderivaten gegen Magengeschwüre
DK210488A (da)	1988-04-18	Dopamin-beta-hydroxylase-inhibitorer
IT8622875A0 (it)	1986-12-24	Composizione per regolare la crescita delle piante.
EP0264951A3 (en)	1988-09-14	Procaterol-derivatives
ES2039270T3 (es)	1993-09-16	Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
IT8653048V0 (it)	1986-02-28	Dado di tipo perfezionato
LV5359A3 (lv)	1994-03-10	Panemiens nevelamu augu apkarosanai
LV5155A3 (lv)	1993-10-10	Panemiens nevelamu augu apkarosanai
SE8403465D0 (sv)	1984-06-29	Lock till olika typer av toilettstolar
IT213440Z2 (it)	1989-11-27	Tronchesina per alvorazioni su componenti elettronici, il cui angolo di apertura massima e'determinato dalla opportuna profilatura delle due branche
NO924242L (no)	1988-10-26	Fremgangsmaate for fremstilling av nye glykopeptider med enkefalinase-hemmende virkning