DK487586A - 2-substitueret quinolin og farmaceutisk praeparat indeholdende en saadan forbindelse - Google Patents

2-substitueret quinolin og farmaceutisk praeparat indeholdende en saadan forbindelse Download PDF

Info

Publication number: DK487586A
Authority: DK; Denmark
Prior art keywords: substituted; alkyl; unsubstituted; radical; benzyl
Prior art date: 1985-10-16

Application number

DK487586A

Other languages

Danish (da)

English (en)

Other versions

DK487586D0 (da

Inventor

Robert N Young

Robert Zamboni

Serge Leger

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-16

Filing date

1986-10-13

Publication date

1987-04-17

1986-10-13 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

1986-10-13 Publication of DK487586D0 publication Critical patent/DK487586D0/da

1987-04-17 Publication of DK487586A publication Critical patent/DK487586A/da

Links

-1 2-SUBSTITUTED QUINOLINE Chemical class 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 3
125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 3
125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
239000004215 Carbon black (E152) Substances 0.000 abstract 1
125000002015 acyclic group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000001120 cytoprotective effect Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000002617 leukotrienes Chemical class 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
150000003536 tetrazoles Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

DK487586A 1985-10-16 1986-10-13 2-substitueret quinolin og farmaceutisk praeparat indeholdende en saadan forbindelse DK487586A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US78794285A	1985-10-16	1985-10-16

Publications (2)

Publication Number	Publication Date
DK487586D0 DK487586D0 (da)	1986-10-13
DK487586A true DK487586A (da)	1987-04-17

Family

ID=25142975

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK487586A DK487586A (da)	1985-10-16	1986-10-13	2-substitueret quinolin og farmaceutisk praeparat indeholdende en saadan forbindelse

Country Status (7)

Country	Link
EP (1)	EP0219308B1 (de)
JP (1)	JPS6293277A (de)
AT (1)	ATE68789T1 (de)
CA (1)	CA1298838C (de)
DE (1)	DE3682160D1 (de)
DK (1)	DK487586A (de)
ES (1)	ES2002037A6 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4962203A (en) *	1985-06-18	1990-10-09	Merck Frost Canada, Inc.	2-substituted quinolines useful as leukotriene antagonists
EP0271287A3 (de) *	1986-12-11	1990-06-13	Merck Frosst Canada Inc.	Chinolindicarbonsäuren und ihre Amide
JPH01502755A (ja) *	1987-03-18	1989-09-21	アメリカン・ホーム・プロダクツ・コーポレイション	スルホニルカルボキシアミド
JPS63258854A (ja) *	1987-04-16	1988-10-26	Mitsubishi Kasei Corp	カルボキシスチレン誘導体およびそれを有効成分とする薬剤
US4920131A (en) *	1987-11-03	1990-04-24	Rorer Pharmaceutical Corp.	Quinoline derivatives and use thereof as antagonists of leukotriene D4
GB8728051D0 (en) *	1987-12-01	1988-01-06	Leo Pharm Prod Ltd	Chemical compounds
DE3916663A1 (de) *	1989-05-23	1990-11-29	Bayer Ag	Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5304563A (en) *	1991-02-22	1994-04-19	Bayer Aktiengesellschaft	2-substituted quinolines, and their use in medicaments
US5385912A (en) *	1991-03-08	1995-01-31	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
US5157040A (en) *	1991-04-05	1992-10-20	Merck & Co., Inc.	Substituted quinolines as angiotensin ii antagonists
US5455260A (en) *	1993-05-21	1995-10-03	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Aliphatic amino bis-aryl squalene synthase inhibitors
US5508408A (en) *	1993-09-10	1996-04-16	Ciba-Geigy Corporation	Quinoline compound
US5561143A (en) *	1995-01-25	1996-10-01	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Aliphatic amino bis-aryl squalene synthase inhibitors
TWI311133B (en) *	2001-04-20	2009-06-21	Eisai R&D Man Co Ltd	Carboxylic acid derivativeand the salt thereof
US7371777B2 (en)	2001-08-17	2008-05-13	Eisai Co., Ltd.	Cyclic compound and PPAR agonist

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB321738A (en) *	1928-08-21	1929-11-21	Ig Farbenindustrie Ag	Process for the manufacture of phenylcarboxylic acid compounds
DE2735919A1 (de) *	1977-08-10	1979-02-22	Boehringer Sohn Ingelheim	Neue 2-pyridyl- und 2-pyrimidylaminobenzoesaeuren
CA1134828A (en) *	1978-12-28	1982-11-02	Tadao Tanouchi	Pyridine derivatives
US4325959A (en) *	1979-08-09	1982-04-20	The Dow Chemical Company	Hypoglycemic 4-(((1,3,4, thiadiazolyl)thio)methyl)benzoic acids, ester and amides
US4464533A (en) *	1982-11-08	1984-08-07	Ppg Industries, Inc.	Herbicidally active quinoline or quinoxaline benzoate derivatives
IE56702B1 (en) *	1982-12-01	1991-11-06	Usv Pharma Corp	Antiinflammatory antiallergic compounds
NZ213986A (en) *	1984-10-30	1989-07-27	Usv Pharma Corp	Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
IE58870B1 (en) *	1985-03-08	1993-11-17	Leo Pharm Prod Ltd	Pyridine derivatives
US4839369A (en) *	1985-04-16	1989-06-13	Rorer Pharmaceutical Corporation	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
JPH06752B2 (ja) *	1985-04-24	1994-01-05	正木長谷川	非対称ジオレフイン化合物

1986
- 1986-10-08 AT AT86307785T patent/ATE68789T1/de active
- 1986-10-08 DE DE8686307785T patent/DE3682160D1/de not_active Expired - Lifetime
- 1986-10-08 EP EP86307785A patent/EP0219308B1/de not_active Expired - Lifetime
- 1986-10-13 DK DK487586A patent/DK487586A/da not_active Application Discontinuation
- 1986-10-15 CA CA000520525A patent/CA1298838C/en not_active Expired - Lifetime
- 1986-10-15 ES ES8602615A patent/ES2002037A6/es not_active Expired
- 1986-10-16 JP JP61244299A patent/JPS6293277A/ja active Pending

Also Published As

Publication number	Publication date
JPS6293277A (ja)	1987-04-28
ATE68789T1 (de)	1991-11-15
EP0219308B1 (de)	1991-10-23
CA1298838C (en)	1992-04-14
DE3682160D1 (de)	1991-11-28
DK487586D0 (da)	1986-10-13
EP0219308A2 (de)	1987-04-22
EP0219308A3 (en)	1987-10-14
ES2002037A6 (es)	1988-07-01

Legal Events

Date	Code	Title	Description
1993-10-25	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK487586A (da)	1987-04-17	2-substitueret quinolin og farmaceutisk praeparat indeholdende en saadan forbindelse
IE861607L (en)	1986-12-18	2-substituted quinolines
SE448874B (sv)	1987-03-23	Derivat av 4-amino-5-alkylsulfonyl-orto-anisamider, farmakologisk komposition och sett att framstella amiderna
AU8194891A (en)	1992-02-18	Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene b4 antagonist activity, their preparation and use in pharmaceutical compositions
AU518569B2 (en)	1981-10-08	4-benzyl- and 4-benzoyl imidazole derivatives
FI904659A0 (fi)	1990-09-21	Nya benzimidazolfoereningar och deras anvaendning.
ES8107224A1 (es)	1981-10-01	Un procedimiento para la preparacion de derivados acidos penem-carboxilicos
FI823871L (fi)	1983-06-05	Foerfarande foer framstaellning av substituerade imidazolderivat
Schmelkes et al.	1944	Substituted p-aminobenzoic acids
SE8601825D0 (sv)	1986-04-21	7-amino-3-propenylcephalosporanic acid and esters thereof
DK407885A (da)	1986-03-13	7-(2-(dialkylamino)ethyl)-4-hydroxy-1,3-benzimidazol-2-oner
SE8703886L (sv)	1987-10-08	Nya mellanprodukter anvendbara for framstellning av 4-hydroxi-3-kinolinkarboxylsyraderivat
ES8202554A1 (es)	1982-02-01	Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2)sustituidas
MX5687E (es)	1983-12-09	Procedimiento para la preparacion de derivados imidazo(1,2-alpha)-imidazol substituidos
JPS5692873A (en)	1981-07-27	Imidazoline compound
CH610877A5 (en)	1979-05-15	Process for the preparation of o-(2,6-dichloroanilino)phenylacetic acid and of the addition salts of this acid
JPS5690067A (en)	1981-07-21	Novel heterocyclic ring substituted phenylacetic acid derivative
GB930477A (en)	1963-07-03	Anthranilic acid derivatives and methods for producing same
JPS55151555A (en)	1980-11-26	Proline derivatives and their production
TH2974A (th)	1985-12-02	อนุพันธ์ควิโนโลนคาร์บอกซิลิคแอซิด
ES8307812A1 (es)	1983-08-01	Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulawilo.
ES489925A1 (es)	1980-10-01	Procedimiento para la preparacion de n,n'-difenil-monohidra-zida de acido 2-(3-metil-3-butenil)-malonico
ATE41663T1 (de)	1989-04-15	Verfahren zur herstellung von oxazolinen.
JPS5572186A (en)	1980-05-30	Dibenzothiepin derivative and its preparation