DK507188A - Cholecalciferolderivater - Google Patents

Cholecalciferolderivater

Info

Publication number
DK507188A
DK507188A DK507188A DK507188A DK507188A DK 507188 A DK507188 A DK 507188A DK 507188 A DK507188 A DK 507188A DK 507188 A DK507188 A DK 507188A DK 507188 A DK507188 A DK 507188A
Authority
DK
Denmark
Prior art keywords
cholecalciferal
derivatives
cholecalciferal derivatives
Prior art date
Application number
DK507188A
Other languages
English (en)
Other versions
DK507188D0 (da
Inventor
Enrico Giuseppe Baggiolini
Bernard Michael Hennessy
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK507188D0 publication Critical patent/DK507188D0/da
Publication of DK507188A publication Critical patent/DK507188A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK507188A 1987-09-14 1988-09-12 Cholecalciferolderivater DK507188A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/096,981 US4898855A (en) 1987-09-14 1987-09-14 Deuterated analogs of 1,25-dihydroxycholecalciferol

Publications (2)

Publication Number Publication Date
DK507188D0 DK507188D0 (da) 1988-09-12
DK507188A true DK507188A (da) 1989-03-15

Family

ID=22260083

Family Applications (1)

Application Number Title Priority Date Filing Date
DK507188A DK507188A (da) 1987-09-14 1988-09-12 Cholecalciferolderivater

Country Status (7)

Country Link
US (1) US4898855A (da)
EP (1) EP0307786A3 (da)
JP (1) JPH01110667A (da)
AU (1) AU2213188A (da)
DK (1) DK507188A (da)
NZ (1) NZ226131A (da)
ZA (1) ZA886793B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US5206229A (en) * 1988-04-21 1993-04-27 Leo Pharmaceutical Products Ltd Vitamin d analogues
FR2631025B1 (fr) * 1988-05-04 1991-04-12 Ire Medgenix Sa Nouveaux derives de la vitamine d3 et application aux dosages des metabolites de la vitamine d3
JPH075542B2 (ja) * 1988-09-14 1995-01-25 呉羽化学工業株式会社 ビタミンd▲下3▼誘導体及びその製造方法
DE69005897D1 (de) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferolderivate.
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
DE4343838C2 (de) * 1993-12-22 1998-07-09 Lohmann Therapie Syst Lts Deuteriertes Arzneimittel in transdermaler Applikation und Verfahren zu seiner Herstellung
KR100477070B1 (ko) * 1994-03-25 2006-04-21 이소테크니카 인코포레이티드 중수소화작용에의한의약품의효능강화법
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6579630B2 (en) 2000-12-07 2003-06-17 Canon Kabushiki Kaisha Deuterated semiconducting organic compounds used for opto-electronic devices
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
ES2331289B2 (es) 2008-06-27 2010-06-25 Universidade De Santiago De Compostela Compuestos de la vitamina d deuterados.
US20100120756A1 (en) * 2008-09-17 2010-05-13 Auspex Pharmaceuticals, Inc. Phenothiazine modulators of h1 receptors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same
US4424161A (en) * 1979-12-10 1984-01-03 Massachusetts General Hospital 1β3 H! 1α,25 Dihydroxyvitamin D3 and method for its preparation
US4297289A (en) * 1980-07-17 1981-10-27 Wisconsin Alumni Research Foundation Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds

Also Published As

Publication number Publication date
EP0307786A2 (de) 1989-03-22
EP0307786A3 (de) 1989-06-28
DK507188D0 (da) 1988-09-12
JPH01110667A (ja) 1989-04-27
ZA886793B (en) 1989-05-30
AU2213188A (en) 1989-03-16
US4898855A (en) 1990-02-06
NZ226131A (en) 1991-04-26

Similar Documents

Publication Publication Date Title
TR26815A (tr) Azolilmetil-sikropil türevleri
DK263587A (da) Imidazoquinolinyletherderivater
DK82087A (da) Pyrocatecholderivater
DK295288D0 (da) (1h-azol-1-ylmethyl)substituerede benzotriazolderivater
DK69887A (da) Dichloranilinderivater
ATA312487A (de) Tetrahydrocarbazolonderivate
TR24894A (tr) N-FENILPIRAZOL TüREVLERI
DK507188D0 (da) Cholecalciferolderivater
DK693587A (da) Alkansulfonanilidderivater
DK378088D0 (da) Alkenderivater
DK81888D0 (da) Dibenzoxepinderivater
DK49688A (da) Propiolophenonderivater
DK691287D0 (da) 5-floururacilderivater
DK271088A (da) Tienopyridinderivater
DK444687D0 (da) Alfa-substituerede ketonitron-derivater
FI893041A7 (fi) Substituoidut atsasykloheksyylijohdannaiset
DK695788A (da) Naphtalenderivater
DK440687D0 (da) Bicyclooctanderivater
DK229887A (da) Alkenamidderivater
DK619187A (da) Isoindolderivater
FI885063A7 (fi) Uudet 4-demetoksi-antrasykliinijohdannaiset
DK435087D0 (da) Isoprenderivater
DK71488A (da) Dipenylethylen-derivater
DK733688D0 (da) Dioxazocinderivater
DK440787D0 (da) Bicyclooctanderivater

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment