DK513480A - N-adamantansubstituerede tetrapeptidamider eller farmakologisk acceptable salte deraf og fremgangsmaade til deres fremstilling - Google Patents

N-adamantansubstituerede tetrapeptidamider eller farmakologisk acceptable salte deraf og fremgangsmaade til deres fremstilling

Info

Publication number
DK513480A
DK513480A DK513480A DK513480A DK513480A DK 513480 A DK513480 A DK 513480A DK 513480 A DK513480 A DK 513480A DK 513480 A DK513480 A DK 513480A DK 513480 A DK513480 A DK 513480A
Authority
DK
Denmark
Prior art keywords
tetrapeptidamids
adamantan
substituted
procedure
preparation
Prior art date
Application number
DK513480A
Other languages
English (en)
Inventor
R H Mazur
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of DK513480A publication Critical patent/DK513480A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK513480A 1979-12-03 1980-12-02 N-adamantansubstituerede tetrapeptidamider eller farmakologisk acceptable salte deraf og fremgangsmaade til deres fremstilling DK513480A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/099,765 US4273704A (en) 1979-12-03 1979-12-03 N-Adamantane-substituted tetrapeptide amides

Publications (1)

Publication Number Publication Date
DK513480A true DK513480A (da) 1981-07-09

Family

ID=22276513

Family Applications (1)

Application Number Title Priority Date Filing Date
DK513480A DK513480A (da) 1979-12-03 1980-12-02 N-adamantansubstituerede tetrapeptidamider eller farmakologisk acceptable salte deraf og fremgangsmaade til deres fremstilling

Country Status (16)

Country Link
US (1) US4273704A (da)
JP (1) JPS5692847A (da)
AU (1) AU6499080A (da)
BE (1) BE886472A (da)
CA (1) CA1151642A (da)
DE (1) DE3044793A1 (da)
DK (1) DK513480A (da)
ES (2) ES8205753A1 (da)
FR (1) FR2476073A1 (da)
GB (1) GB2066262B (da)
IT (1) IT1127930B (da)
NL (1) NL8006586A (da)
NO (1) NO803640L (da)
PT (1) PT72141B (da)
SE (1) SE8008428L (da)
ZA (1) ZA807513B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404135A (en) * 1981-07-20 1983-09-13 G. D. Searle & Co. Enkephalin derivatives
US4407746A (en) * 1981-12-14 1983-10-04 G. D. Searle & Co. Cyclohexyl and phenyl substituted enkephalins
CS231221B1 (en) * 1982-06-29 1984-10-15 Martin Flegel L-alanyl-d-isoglutamine adamantylamide
DE3485587D1 (de) * 1983-08-16 1992-04-23 Univ Georgia Res Found Herstellung von aminocyclopropancarbonsaeuren und von peptiden.
US4629784A (en) * 1983-08-16 1986-12-16 The University Of Georgia Research Foundation, Inc. Synthesis of cyclopropane amino acids
US4510085A (en) * 1984-04-12 1985-04-09 G.D. Searle & Co. Antihypertensive tetrapeptide amides
US4514332A (en) * 1984-04-16 1985-04-30 G. D. Searle & Co. Tetrapeptide adamantyl amides
FR2572399B1 (fr) * 1984-10-31 1987-01-16 Panmedica Sa Nouveaux derives de l'adamantanamine, leurs procedes de preparation et medicaments les contenant
US4880829A (en) * 1985-08-14 1989-11-14 G. D. Searle And Company Substituted dipeptide amides #3
US4822775A (en) * 1986-02-14 1989-04-18 G. D. Searle & Co. Phenyl substituted dipeptide amides
US4758675A (en) * 1986-07-14 1988-07-19 G. D. Searle & Co. 3-thiophene-substituted tyrosyl dipeptide amides
US5652335A (en) * 1990-02-28 1997-07-29 Teikoku Seiyaku Kabushiki Kaisha Physiologically active substance well capable of permeating biomembrane
DE69130489T2 (de) * 1990-02-28 1999-05-12 Teikoku Seiyaku K.K., Kagawa Physiologisch aktive Substanz die fähig ist Biomembran zu permeieren
EP1574495A1 (en) 1997-01-14 2005-09-14 Daicel Chemical Industries, Ltd. Adamantane derivatives
US7795468B2 (en) * 2001-01-19 2010-09-14 Chevron U.S.A. Inc. Functionalized higher diamondoids
US20050245534A1 (en) * 2004-04-29 2005-11-03 Link James T Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US20100222316A1 (en) 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8415354B2 (en) * 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20050261302A1 (en) * 2004-04-29 2005-11-24 Hoff Ethan D Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application
US7880001B2 (en) * 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
WO2006010362A1 (de) * 2004-07-23 2006-02-02 Justus-Liebig-Universität Giessen Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung
EP1812407A2 (en) * 2004-11-02 2007-08-01 Pfizer, Inc. Novel compounds of substituted and unsubstituted adamantyl amides
KR101496190B1 (ko) 2005-01-05 2015-02-26 애브비 인코포레이티드 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제로서의 아다만틸 유도체
US8198331B2 (en) * 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
HRP20050242B1 (en) * 2005-03-15 2010-09-30 Institut Ruđer Bošković Synthetic peptides containing unnatural adamantane related amino acids for use as antitumour drugs
JP5736098B2 (ja) * 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド 中枢神経系障害を治療するための医薬組成物
EP2399926A1 (en) * 2010-06-22 2011-12-28 Justus-Liebig-Universität Giessen Peptides incorporating 3-aminoadamantane carboxylic acids enhance synaptic plasticity and act as neurogenic agents
CN112552374B (zh) * 2019-09-10 2024-06-04 西藏海思科制药有限公司 一种肽酰胺类化合物及其中间体的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2732451A1 (de) * 1976-07-27 1978-02-02 Reckitt & Colmann Prod Ltd Peptidverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate

Also Published As

Publication number Publication date
ES8300087A1 (es) 1982-10-01
IT1127930B (it) 1986-05-28
FR2476073A1 (fr) 1981-08-21
ES497353A0 (es) 1982-06-16
PT72141A (en) 1981-01-01
GB2066262A (en) 1981-07-08
DE3044793A1 (de) 1981-06-19
IT8050294A0 (it) 1980-12-02
GB2066262B (en) 1983-05-11
JPS5692847A (en) 1981-07-27
NO803640L (no) 1981-06-04
AU6499080A (en) 1981-06-11
NL8006586A (nl) 1981-07-01
ZA807513B (en) 1982-07-28
SE8008428L (sv) 1981-06-04
CA1151642A (en) 1983-08-09
ES508060A0 (es) 1982-10-01
ES8205753A1 (es) 1982-06-16
US4273704A (en) 1981-06-16
PT72141B (en) 1981-10-28
BE886472A (fr) 1981-06-03

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