DK526189A - Laegemiddelkonjugat - Google Patents

Laegemiddelkonjugat

Info

Publication number
DK526189A
DK526189A DK526189A DK526189A DK526189A DK 526189 A DK526189 A DK 526189A DK 526189 A DK526189 A DK 526189A DK 526189 A DK526189 A DK 526189A DK 526189 A DK526189 A DK 526189A
Authority
DK
Denmark
Prior art keywords
drug
prodrug
carrier
stomach
bond
Prior art date
Application number
DK526189A
Other languages
Danish (da)
English (en)
Other versions
DK526189D0 (da
Inventor
Victor E Shashoua
Original Assignee
Victor E Shashoua
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Victor E Shashoua filed Critical Victor E Shashoua
Publication of DK526189D0 publication Critical patent/DK526189D0/da
Publication of DK526189A publication Critical patent/DK526189A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK526189A 1988-02-26 1989-10-24 Laegemiddelkonjugat DK526189A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/160,667 US4939174A (en) 1988-02-26 1988-02-26 Appetite suppression with dopamine-fatty acid conjugates
PCT/US1989/000757 WO1989007938A1 (fr) 1988-02-26 1989-02-24 Conjugue medicamenteux d'acide gras administrant le medicament a travers la barriere vasculaire du cerveau

Publications (2)

Publication Number Publication Date
DK526189D0 DK526189D0 (da) 1989-10-24
DK526189A true DK526189A (da) 1989-12-12

Family

ID=22577881

Family Applications (1)

Application Number Title Priority Date Filing Date
DK526189A DK526189A (da) 1988-02-26 1989-10-24 Laegemiddelkonjugat

Country Status (10)

Country Link
US (1) US4939174A (fr)
EP (1) EP0401301B1 (fr)
JP (1) JP2959784B2 (fr)
KR (1) KR100228456B1 (fr)
AT (1) ATE176152T1 (fr)
AU (1) AU635203B2 (fr)
DE (1) DE68928920T2 (fr)
DK (1) DK526189A (fr)
FI (1) FI904207A7 (fr)
WO (1) WO1989007938A1 (fr)

Families Citing this family (59)

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US5284876A (en) * 1988-02-26 1994-02-08 Neuromedica, Inc. Method of treating tardive dyskinesia using dopaminergic agents of prodrugs of therapeutic agents
US5994392A (en) 1988-02-26 1999-11-30 Neuromedica, Inc. Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid
US6107499A (en) * 1988-02-26 2000-08-22 Neuromedica, Inc. Dopamine analog amide
US5545719A (en) * 1990-05-01 1996-08-13 Neuromedica, Inc. Nerve growth peptides
WO1992020362A1 (fr) * 1991-05-14 1992-11-26 Shashoua Victor E Peptides favorisant le developpement de cellules nerveuses et leurs utilisations
FR2712888B1 (fr) * 1993-11-23 1996-02-09 Bioeurope Utilisation de alpha-D-alkylglucopyranosides et esters de ceux-ci pour la préparation de prodrogues capables de traverser la barrière hématoencéphalique, prodrogues obtenues et précurseurs de celles-ci.
DE4437502A1 (de) * 1993-12-02 1995-06-08 Basf Ag Hirudin-Konjugate aus Hirudin und lipophilen Verbindungen
DE69529054T2 (de) * 1994-02-28 2003-08-21 Nanopharm Ag System zur gezielten wirkstoffzufuhr, verfahren zu seiner herstellung und verwendung
US5716614A (en) * 1994-08-05 1998-02-10 Molecular/Structural Biotechnologies, Inc. Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
AUPM906594A0 (en) * 1994-10-26 1994-11-17 Peptide Technology Limited Synthetic polyunsaturated fatty acid analogues
US5952499A (en) * 1995-01-16 1999-09-14 Commonwealth Scientific And Industrial Research Organisation Therapeutic compound-fatty acid conjugates
US5639858A (en) * 1995-03-22 1997-06-17 Tularik, Inc. Human signal transducer and binding assays
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
WO1997044026A1 (fr) * 1996-05-22 1997-11-27 Neuromedica, Inc. Compositions contenant des conjugues d'acide cis-docosahexanoique et de taxotere
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6589994B1 (en) * 1996-08-30 2003-07-08 Nps Pharmaceuticals, Inc. Treating a variety of pathological conditions, including spasticity and convulsions, by effecting a modulation of CNS activity with isovaleramide, isovaleric acid, or a related compound
US6197764B1 (en) * 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof
US6153653A (en) * 1997-11-26 2000-11-28 Protarga, Inc. Choline compositions and uses thereof
US5977174A (en) * 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US5955459A (en) * 1997-11-26 1999-09-21 Neuromedica, Inc. Fatty acid-antipsychotic compositions and uses thereof
US6225444B1 (en) 1998-02-10 2001-05-01 Protarga, Inc. Neuroprotective peptides and uses thereof
IL125731A (en) * 1998-08-11 2004-06-20 Zvi Yehuda Acylates which are products of neurotransmitters and essential fatty acids, pharmaceutical compositions containing them, use of such acylates in the manufacture of medicaments, and method for treating nervous diseases in non-human animals
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
GB9930026D0 (en) * 1999-12-21 2000-02-09 Univ Sheffield Novel compounds of unsaturated fatty acids
ATE556706T1 (de) * 2001-03-23 2012-05-15 Luitpold Pharm Inc Fettalkohol-arzneimittel-konjugate
AU2002303164A1 (en) * 2001-03-23 2002-10-08 Protarga, Inc. Fatty amine drug conjugates
AU2003217791A1 (en) 2002-02-28 2003-09-16 A And D Bioscience, Inc. Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
CA2477604A1 (fr) 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation de la methylation de proteines et du phosphate des phosphoproteines
WO2003079980A2 (fr) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Glucuronides, glucosamides et glucosides d'acide carboxylique, de quinolones, penicillines et analogues, et leurs utilisations
US20050255038A1 (en) * 2002-04-12 2005-11-17 A And D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof
WO2003094842A2 (fr) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugues comprenant un medicament agissant sur le systeme nerveux central, lequel medicament est lie a un acide glucuronique ou a une glucosamine par l'intermediaire d'une liaison amide, et utilisations correspondantes
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
CA2527024C (fr) * 2003-05-28 2012-08-21 Paul Anziano Compositions et methodes permettant d'inhiber un isoforme de la manganese superoxyde dismutase humaine
WO2005089518A2 (fr) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Expression de uch-l1 et cancerotherapie
US20050272722A1 (en) * 2004-03-18 2005-12-08 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
WO2006084033A1 (fr) 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions et procedes pour l'amelioration de la fonction cognitive
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
US7989499B2 (en) * 2005-02-09 2011-08-02 Mitotek, Llc Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
EP1968591A4 (fr) 2005-12-23 2010-02-17 Link Medicine Corp Traitement de formes de synucleinopathie
JP4745838B2 (ja) * 2006-01-27 2011-08-10 株式会社Ｔａｉｙｏ 電動アクチュエータの制御方法及び装置
WO2009151683A2 (fr) * 2008-03-12 2009-12-17 Link Medicine Corporation Inhibiteurs de quinolinone farnésyl transférase pour le traitement de synucléinopathies et d'autres indications
JP5607025B2 (ja) 2008-04-21 2014-10-15 シグナム バイオサイエンシーズ， インコーポレイテッド 化合物、組成物およびそれらを作製する方法
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
JP2012508768A (ja) * 2008-11-13 2012-04-12 リンク・メディスン・コーポレーション アザキノリノン誘導体及びその使用
US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US10167263B2 (en) 2008-11-20 2019-01-01 Northwestern University Treatment of amyotrophic lateral sclerosis
WO2010063080A1 (fr) * 2008-12-05 2010-06-10 Commonwealth Scientific And Industrial Research Organisation Promédicaments amphiphiles
EP3144299A1 (fr) 2009-05-05 2017-03-22 Cambria Pharmaceuticals, Inc. Pyrimidine-2, 4, 6-triones a utiliser dans le traitement de sclerose laterale amyotrophique
EP2438059A1 (fr) 2009-06-05 2012-04-11 Link Medicine Corporation Dérivés d'aminopyrrolidinone et utilisations de ceux-ci
WO2011059821A2 (fr) 2009-10-29 2011-05-19 Cambria Pharmaceuticals, Inc. Cyclohexane-1,3-diones pour emploi dans le traitement de la sclérose latérale amyotrophique
CN103180297A (zh) 2009-12-11 2013-06-26 基因密码公司 使用gdnf家族配体(gfl)模拟剂或ret信号传导通路活化剂促进神经细胞存活的方法
FR2964866B1 (fr) * 2010-09-22 2013-03-29 Oreal Utilisation comme antipelliculaire de derives ortho-diphenol, nouveaux composes et composition cosmetique les comprenant
WO2012177997A1 (fr) 2011-06-22 2012-12-27 The General Hospital Corporation Traitement de protéinopathies
EP3008167A4 (fr) 2013-06-13 2017-06-07 VeroScience LLC Compositions et méthodes pour le traitement des troubles métaboliques
CA3007641C (fr) 2015-12-09 2023-10-17 Brandeis University Inhibiteurs de la dbh pour le traitement ou la prevention de la perte de memoire
AU2022215936A1 (en) * 2021-02-03 2023-08-24 Consejo Nacional De Investigaciones Científicas Y Técnicas (Conicet) Chemically coupled transporter for low-hydrophobicity bioactive drugs into the central nervous system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT7927748A0 (it) * 1979-11-30 1979-11-30 Simes Derivati dell'acido 6,6'-diapopsi psicarotenedioico e relativi procedimenti di preparazione.
JPS58177953A (ja) * 1982-04-13 1983-10-18 Eisai Co Ltd ポリプレニルカルボン酸アミドおよびその製造方法
US4550109A (en) * 1984-05-31 1985-10-29 The Board Of Regents, The University Of Texas System Lipoidal biopterin compounds

Also Published As

Publication number Publication date
FI904207A0 (fi) 1990-08-24
JPH03503893A (ja) 1991-08-29
EP0401301A4 (en) 1991-09-04
DE68928920D1 (de) 1999-03-11
EP0401301A1 (fr) 1990-12-12
AU3354689A (en) 1989-09-22
JP2959784B2 (ja) 1999-10-06
ATE176152T1 (de) 1999-02-15
DE68928920T2 (de) 1999-07-22
WO1989007938A1 (fr) 1989-09-08
DK526189D0 (da) 1989-10-24
AU635203B2 (en) 1993-03-18
KR100228456B1 (ko) 1999-11-01
FI904207A7 (fi) 1990-08-24
KR900700092A (ko) 1990-08-11
US4939174A (en) 1990-07-03
EP0401301B1 (fr) 1999-01-27

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment