DK52685A - N,3-diacyl-2-oxindol-1-carboxamid-forbindelser og mellemprodukter ved deres fremstilling samt farmaceutisk praeparat - Google Patents
N,3-diacyl-2-oxindol-1-carboxamid-forbindelser og mellemprodukter ved deres fremstilling samt farmaceutisk praeparat Download PDFInfo
- Publication number
- DK52685A DK52685A DK52685A DK52685A DK52685A DK 52685 A DK52685 A DK 52685A DK 52685 A DK52685 A DK 52685A DK 52685 A DK52685 A DK 52685A DK 52685 A DK52685 A DK 52685A
- Authority
- DK
- Denmark
- Prior art keywords
- intermediates
- oxindol
- diacyl
- preparation
- pharmaceutical preparations
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- CVICEEPAFUYBJG-UHFFFAOYSA-N 5-chloro-2,2-difluoro-1,3-benzodioxole Chemical group C1=C(Cl)C=C2OC(F)(F)OC2=C1 CVICEEPAFUYBJG-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 150000005623 oxindoles Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57790384A | 1984-02-07 | 1984-02-07 | |
| US57790384 | 1984-02-07 | ||
| US61986184A | 1984-06-12 | 1984-06-12 | |
| US61986184 | 1984-06-12 | ||
| US06/670,697 US4721712A (en) | 1984-06-12 | 1984-11-13 | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents |
| US67069784 | 1984-11-13 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK52685D0 DK52685D0 (da) | 1985-02-06 |
| DK52685A true DK52685A (da) | 1985-09-20 |
| DK162839B DK162839B (da) | 1991-12-16 |
| DK162839C DK162839C (da) | 1992-05-04 |
Family
ID=27416285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK052685A DK162839C (da) | 1984-02-07 | 1985-02-06 | N,3-diacyl-2-oxindol-1-carboxamid-forbindelser og 3-acyl-2-oxindol-forbindelser til anvendelse som mellemprodukter ved deres fremstilling |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP0153818B1 (da) |
| AT (2) | ATE63543T1 (da) |
| DE (2) | DE3568776D1 (da) |
| DK (1) | DK162839C (da) |
| GR (1) | GR850310B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686224A (en) * | 1984-10-31 | 1987-08-11 | Pfizer Inc. | Oxindole antiinflammatory agents |
| US5036099A (en) * | 1987-02-02 | 1991-07-30 | Pfizer Inc. | Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide |
| HU215112B (hu) * | 1989-01-10 | 1998-12-28 | Pfizer Inc. | Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására |
| WO1990008146A1 (en) * | 1989-01-10 | 1990-07-26 | Pfizer Inc. | Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides |
| WO1994018194A1 (en) * | 1993-02-09 | 1994-08-18 | Pfizer Inc. | Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as intiinflammatory agents |
| HUP9600855A3 (en) * | 1996-04-03 | 1998-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing tenidap |
| JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
| US8217051B2 (en) | 2009-02-17 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| ES2472447B1 (es) | 2012-11-30 | 2015-07-09 | Abengoa Solar New Technologies S.A. | Plataforma portátil de mezcla para la producción de un fluido caloportador y procedimiento de producción del mismo |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
| US3767653A (en) * | 1971-06-28 | 1973-10-23 | Squibb & Sons Inc | Thiazines |
| IE57741B1 (en) * | 1984-03-19 | 1993-03-24 | Pfizer | Process for making 2-oxindole-1-carboxamides and intermediates therefor |
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
| US4690943A (en) * | 1984-09-19 | 1987-09-01 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
-
1985
- 1985-02-04 EP EP85300724A patent/EP0153818B1/en not_active Expired
- 1985-02-04 DE DE8585300724T patent/DE3568776D1/de not_active Expired
- 1985-02-04 AT AT87201673T patent/ATE63543T1/de not_active IP Right Cessation
- 1985-02-04 AT AT85300724T patent/ATE41420T1/de not_active IP Right Cessation
- 1985-02-04 DE DE8787201673T patent/DE3582890D1/de not_active Expired - Lifetime
- 1985-02-04 GR GR850310A patent/GR850310B/el not_active IP Right Cessation
- 1985-02-04 EP EP87201673A patent/EP0276500B1/en not_active Expired
- 1985-02-06 DK DK052685A patent/DK162839C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3582890D1 (de) | 1991-06-20 |
| EP0276500A2 (en) | 1988-08-03 |
| EP0153818A3 (en) | 1986-01-29 |
| ATE41420T1 (de) | 1989-04-15 |
| ATE63543T1 (de) | 1991-06-15 |
| EP0153818B1 (en) | 1989-03-15 |
| EP0276500A3 (en) | 1989-04-12 |
| GR850310B (da) | 1985-06-05 |
| EP0153818A2 (en) | 1985-09-04 |
| DK162839C (da) | 1992-05-04 |
| DK52685D0 (da) | 1985-02-06 |
| DK162839B (da) | 1991-12-16 |
| EP0276500B1 (en) | 1991-05-15 |
| DE3568776D1 (en) | 1989-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK197685D0 (da) | N,3-disubstituerede-2-oxindol-1-carboxamid-derivater og farmaceutiskepraeparater indeholdende saadanne derivater samt mellemprodukter til brug ved fremstillingen deraf | |
| NO892892L (no) | Substituerte aminometyltetraliner, samt deres heterocykliske analoger. | |
| DK172089D0 (da) | 1,3-dioxolanderivater samt fremgangsmaade til fremstilling deraf | |
| SE8505112D0 (sv) | Novel pharmacological compounds | |
| DK506587A (da) | Imidderivater | |
| NO882939L (no) | Forbedring av fliskutter. | |
| SE8404065D0 (sv) | Novel biologically active compounds | |
| DK52685A (da) | N,3-diacyl-2-oxindol-1-carboxamid-forbindelser og mellemprodukter ved deres fremstilling samt farmaceutisk praeparat | |
| DK451588D0 (da) | Heterocycliske forbindelser, deres fremstilling og laegemidler indeholdende forbindelserne | |
| DE68906707D1 (de) | 3-substituierte 2-oxindol-1-carboxamid-derivate zur hemmung der aktivitaet der t-zellen. | |
| DK297485D0 (da) | Carbapenemer med kvaternaere heteroarylalkylthio 2-substituenter samt laegemiddel indeholdende saadanne forbindelser | |
| DK425788D0 (da) | 1,4-disubstituerede 1-azolyl-3,3-dimethylbutanderivater, fremgangsmaade til deres anvendelse samt deres anvendelse | |
| DE3584652D1 (de) | 2,2,6,6-tetramethyl-4-piperidinyl-derivate und ihre verwendung als lichtstabilisatoren. | |
| ATE83481T1 (de) | Fuenfgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen. | |
| DK360888A (da) | 3',4'-dinitrogen-substituerede epipodophyllotoxinglucosidderivater | |
| IL76345A0 (en) | Proline derivatives and antihypertensive and anti-glaucoma pharmaceutical preparations containing the same | |
| ES2125849T3 (es) | 1-dimetilcarbamoil-3-sustituido-5-sustituido-1h-1,2,4-triazoles. | |
| ES2053808T3 (es) | Nuevos compuestos azolicos. | |
| NO905063D0 (no) | Fremgangsmaate for fremstilling samt anvendelse av pyridin-2-4- og 2,5- dikarboksylsyrediamider. | |
| IT8523158A0 (it) | Composti eterociclici dotati di attivita' terapeutica. | |
| DE3884014D1 (de) | Mono- und Diepoxidderivate von 23-Deoxy-LL-F28249-Verbindungen. | |
| FI905922A0 (fi) | Antagonister foer a-adrenerga receptorer. | |
| DE3772926D1 (de) | Verfahren zur stabilisierung von procaterol. | |
| ATE84794T1 (de) | Aminosaeure-derivate als antihypertensive. | |
| IT8423967A0 (it) | Composti eterociclici dotati di attivita' terapeutica. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |