DK531282A - Fremgangsmaade til fremstilling af substituerede imidazolderivater eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af substituerede imidazolderivater eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf Download PDF

Info

Publication number: DK531282A
Authority: DK; Denmark
Prior art keywords: sub; hydrogen; compounds; acid addition; acceptable acid
Prior art date: 1981-12-04

Application number

DK531282A

Other languages

English (en)

Other versions

DK157926C (da

DK157926B (da

Inventor

Kauko Oiva Antero Kurkela

Arto Johannes Karjalainen

Original Assignee

Farmos Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-12-04

Filing date

1982-11-30

Publication date

1983-06-05

1982-11-30 Application filed by Farmos Oy filed Critical Farmos Oy

1983-06-05 Publication of DK531282A publication Critical patent/DK531282A/da

1990-03-05 Publication of DK157926B publication Critical patent/DK157926B/da

1990-08-06 Application granted granted Critical

1990-08-06 Publication of DK157926C publication Critical patent/DK157926C/da

Links

150000003839 salts Chemical class 0.000 title abstract 3
239000002253 acid Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
231100000614 poison Toxicity 0.000 title 1
230000007096 poisonous effect Effects 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
-1 chloro, bromo, fluoro, methyl Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Catalysts (AREA)

DK531282A 1981-12-04 1982-11-30 Analogifremgangsmaade til fremstilling af 4-(substitueret aminometyl)-imidazoler eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf DK157926C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB08136646A GB2110663B (en)	1981-12-04	1981-12-04	Imidazole derivatives
GB8136646		1981-12-04

Publications (3)

Publication Number	Publication Date
DK531282A true DK531282A (da)	1983-06-05
DK157926B DK157926B (da)	1990-03-05
DK157926C DK157926C (da)	1990-08-06

Family

ID=10526383

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK531282A DK157926C (da)	1981-12-04	1982-11-30	Analogifremgangsmaade til fremstilling af 4-(substitueret aminometyl)-imidazoler eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf

Country Status (15)

Country	Link
US (1)	US4517198A (da)
EP (1)	EP0081324B1 (da)
JP (1)	JPS58105970A (da)
AT (1)	ATE21246T1 (da)
AU (1)	AU552908B2 (da)
CA (1)	CA1184183A (da)
DE (1)	DE3272478D1 (da)
DK (1)	DK157926C (da)
FI (1)	FI76569C (da)
GB (1)	GB2110663B (da)
IE (1)	IE54243B1 (da)
IL (1)	IL67381A (da)
NO (1)	NO158017C (da)
NZ (1)	NZ202649A (da)
ZA (1)	ZA828803B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2548183B1 (fr) *	1983-07-01	1985-10-31	Synthelabo	Diphenylazomethines portant un radical imidazolyle, leur preparation et leur application en therapeutique
FR2575470B1 (fr) *	1984-12-27	1987-02-13	Synthelabo	Derives amines de n-imidazolylmethyl-diphenylazomethines, leur preparation et leur application en therapeutique
FR2575469B1 (fr) *	1984-12-27	1987-01-23	Synthelabo	N-imidazolylmethyl-diphenylazomethines, leur preparation et leur application en therapeutique
US4996221A (en) *	1987-01-13	1991-02-26	The Board Of Trustees Of The Leland Stanford Junior University	Histamine derivatives as immune modulators
JPH032168A (ja) *	1989-03-30	1991-01-08	Farmos Yhtymae Oy	アロマターゼ阻害活性を有する新規な４（５）―イミダゾール
NZ238688A (en) *	1990-06-28	1992-05-26	Smithkline Beecham Corp	Substituted histidines: pharmaceutical compositions, preparation and uses thereof
US5159083A (en) *	1990-12-28	1992-10-27	Neurogen Corporation	Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
GB9127304D0 (en) *	1991-12-23	1992-02-19	Boots Co Plc	Therapeutic agents
USRE37303E1 (en) *	1992-01-10	2001-07-31	Institut National Del La Sante Et De La Recherche Medicale	Imidazole compounds and their therapeutic applications
FR2686084B1 (fr) *	1992-01-10	1995-12-22	Bioprojet Soc Civ	Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
FR2689508B1 (fr) *	1992-04-01	1994-06-17	Fournier Ind & Sante	Derives de l'imidazole, leur procede de preparation et leur application en therapeutique.
GB9312893D0 (en) *	1993-06-22	1993-08-04	Boots Co Plc	Therapeutic agents
AU7275894A (en) *	1993-08-04	1995-02-28	Yamanouchi Pharmaceutical Co., Ltd.	Imidazolylalkylamine derivative and pharmaceutical composition thereof
CA2222099A1 (en) *	1995-05-30	1996-12-05	Gliatech, Inc.	1h-4(5)-substituted imidazole derivatives
US6448282B1 (en)	1995-05-30	2002-09-10	Gliatech, Inc.	1H-4(5)-substituted imidazole derivatives
US20060167269A1 (en) *	2001-07-11	2006-07-27	Hamilton Andrew D	Compounds and methods for the inhibition of compounds cruzi
US20030152747A1 (en) *	2002-01-11	2003-08-14	The Garland Company, Inc., An Ohio Corporation	Roofing materials
MX2009003801A (es) *	2006-10-19	2009-04-22	Hoffmann La Roche	Aminometil-4-imidazoles.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE276541C (da) *
GB1341375A (en) *	1969-11-19	1973-12-19	Smith Kline French Lab	Aminoalkylimidazoles and process for their production
DE2842280A1 (de) *	1978-09-28	1980-04-10	Bayer Ag	N-(1,3-azolyl)-alkyl-halogenacetanilide, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives

1981
- 1981-12-04 GB GB08136646A patent/GB2110663B/en not_active Expired
1982
- 1982-11-11 FI FI823871A patent/FI76569C/fi not_active IP Right Cessation
- 1982-11-25 DE DE8282306295T patent/DE3272478D1/de not_active Expired
- 1982-11-25 EP EP82306295A patent/EP0081324B1/en not_active Expired
- 1982-11-25 CA CA000416315A patent/CA1184183A/en not_active Expired
- 1982-11-25 AT AT82306295T patent/ATE21246T1/de not_active IP Right Cessation
- 1982-11-29 AU AU90957/82A patent/AU552908B2/en not_active Ceased
- 1982-11-29 NZ NZ202649A patent/NZ202649A/en unknown
- 1982-11-30 DK DK531282A patent/DK157926C/da not_active IP Right Cessation
- 1982-11-30 ZA ZA828803A patent/ZA828803B/xx unknown
- 1982-12-01 IL IL67381A patent/IL67381A/xx not_active IP Right Cessation
- 1982-12-03 JP JP57213236A patent/JPS58105970A/ja active Granted
- 1982-12-03 IE IE2877/82A patent/IE54243B1/en not_active IP Right Cessation
- 1982-12-03 NO NO824062A patent/NO158017C/no unknown
- 1982-12-03 US US06/446,717 patent/US4517198A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0081324A2 (en)	1983-06-15
GB2110663B (en)	1985-08-07
NO158017C (no)	1988-06-29
NZ202649A (en)	1985-04-30
NO824062L (no)	1983-06-06
FI76569B (fi)	1988-07-29
EP0081324B1 (en)	1986-08-06
IL67381A0 (en)	1983-05-15
US4517198A (en)	1985-05-14
AU9095782A (en)	1983-06-09
ATE21246T1 (de)	1986-08-15
JPH0344072B2 (da)	1991-07-04
JPS58105970A (ja)	1983-06-24
AU552908B2 (en)	1986-06-26
IL67381A (en)	1986-08-31
NO158017B (no)	1988-03-21
ZA828803B (en)	1983-09-28
DK157926C (da)	1990-08-06
CA1184183A (en)	1985-03-19
FI823871A0 (fi)	1982-11-11
DK157926B (da)	1990-03-05
IE822877L (en)	1983-06-04
DE3272478D1 (en)	1986-09-11
FI76569C (fi)	1988-11-10
EP0081324A3 (en)	1983-12-07
IE54243B1 (en)	1989-08-02
GB2110663A (en)	1983-06-22
FI823871L (fi)	1983-06-05

Legal Events

Date	Code	Title	Description
1997-07-21	PBP	Patent lapsed

Publication	Publication Date	Title
DK157491C (da)	1990-06-25	Analogifremgangsmaade til fremstilling af 4-benzylsubstituerede imidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK57281A (da)	1981-08-14	Fremgangsmaade til fremstilling af substituerede imidazolderivater eller syreadditionssalte deraf
AU552908B2 (en)	1986-06-26	4 n-phenyl benzyl-aminomethyl-imidazole
DK158351C (da)	1990-10-08	Analogifremgangsmaade til fremstilling af substituerede 4-fenylalkylimidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK630486A (da)	1986-12-29	Analogifremgangsmaade til fremstilling af substituerede 4-fenylalkyl- eller 4-fenylalkenylimidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf