DK549189A - Galanthamin-analoge samt anvendelse af disse til fremstilling af laegemidler til behandling af alzheimer's syge - Google Patents

Galanthamin-analoge samt anvendelse af disse til fremstilling af laegemidler til behandling af alzheimer's syge

Info

Publication number: DK549189A
Authority: DK; Denmark
Prior art keywords: disease; alzheimer; medicinals; galanthamine; analogue
Prior art date: 1987-05-04

Application number

DK549189A

Other languages

English (en)

Other versions

DK549189D0 (da

DK175839B1 (da

Inventor

Bonnie Davis

Madeleine Joullie

Original Assignee

Bonnie Davis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-04

Filing date

1989-11-03

Publication date

1990-01-03

1989-11-03 Application filed by Bonnie Davis filed Critical Bonnie Davis

1989-11-03 Publication of DK549189D0 publication Critical patent/DK549189D0/da

1990-01-03 Publication of DK549189A publication Critical patent/DK549189A/da

2005-03-21 Application granted granted Critical

2005-03-21 Publication of DK175839B1 publication Critical patent/DK175839B1/da

Links

208000024827 Alzheimer disease Diseases 0.000 title abstract 2
ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical class O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Processing Of Meat And Fish (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Compression Or Coding Systems Of Tv Signals (AREA)
Eye Examination Apparatus (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

DK198905491A 1987-05-04 1989-11-03 Forbindelser af typen 6H-benzfuro[3a,3,-ef][2]benzazepin samt anvendelse af disse til behandling af Alzheimer's syge DK175839B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US4652287A	1987-05-04	1987-05-04
US4652287		1987-05-04
US8801542		1988-05-04
PCT/US1988/001542 WO1988008708A1 (en)	1987-05-04	1988-05-04	Compounds for the treatment of alzheimer's disease
CA569641		1988-06-16
CA000569641A CA1338326C (en)	1987-05-04	1988-06-16	Compounds for the treatment of alzheimer's disease

Publications (3)

Publication Number	Publication Date
DK549189D0 DK549189D0 (da)	1989-11-03
DK549189A true DK549189A (da)	1990-01-03
DK175839B1 DK175839B1 (da)	2005-03-21

Family

ID=42046403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198905491A DK175839B1 (da)	1987-05-04	1989-11-03	Forbindelser af typen 6H-benzfuro[3a,3,-ef][2]benzazepin samt anvendelse af disse til behandling af Alzheimer's syge

Country Status (10)

Country	Link
EP (1)	EP0363415B1 (da)
JP (1)	JP2755403B2 (da)
KR (1)	KR100195399B1 (da)
AT (1)	ATE411026T1 (da)
AU (1)	AU632458B2 (da)
CA (1)	CA1338326C (da)
DE (1)	DE3856594D1 (da)
DK (1)	DK175839B1 (da)
FI (1)	FI102756B (da)
WO (1)	WO1988008708A1 (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5336675A (en) *	1991-05-14	1994-08-09	Ernir Snorrason	Method of treating mania in humans
DE69229781T2 (de) *	1991-05-14	2000-01-05	Ernir Snorrason	Behandlung des ermüdungssyndroms mit cholinesteraseinhibitoren
US5153193A (en)	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US6316439B1 (en) *	1993-10-15	2001-11-13	Aventis Pharamaceuticals Inc.	Galanthamine derivatives as acetylcholinesterase inhibitors
US6323195B1 (en) *	1993-10-15	2001-11-27	Aventis Pharmaceuticals Inc.	Galanthamine derivatives as acetylcholinesterase inhibitors
US6323196B1 (en) *	1993-10-15	2001-11-27	Aventis Pharmaceuticals Inc.	Galanthamine derivatives as acetylcholinesterase inhibitors
US6407229B1 (en)	1994-10-21	2002-06-18	Sanochemia Pharmazeutika Ag	Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine
AT401058B (de) *	1994-10-21	1996-06-25	Waldheim Pharmazeutika Gmbh	Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins
EP0787115B1 (de) *	1994-10-21	2000-01-05	Sanochemia Pharmazeutika AG	VERFAHREN ZUM HERSTELLEN VON DERIVATEN DES 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO[3a,3,2-ef][2]BENZAZEPINS
GB9506843D0 (en)	1995-04-03	1995-05-24	Chiroscience Ltd	Oxidative process and products thereof
GB9514821D0 (en) *	1995-07-19	1995-09-20	Sod Conseils Rech Applic	Galanthamine derivatives
GB9519267D0 (en) *	1995-09-21	1995-11-22	Chiroscience Ltd	Preparation of alkaloids
AT403803B (de) *	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
AU2004242546B2 (en) *	1998-11-23	2008-05-15	Bonnie Davis	Dosage formulations for acetylcholinesterase inhibitors
WO2000030446A1 (en) *	1998-11-23	2000-06-02	Bonnie Davis	Dosage formulations for acetylcholinesterase inhibitors
EP1140105B1 (en)	1998-12-24	2003-10-22	Janssen Pharmaceutica N.V.	Controlled release galantamine composition
AU780012B2 (en)	1999-12-10	2005-02-24	Bonnie Davis	Analogs of galanthamine and lycoramine as modulators of nicotinic receptors
CN1380883A (zh)	2000-03-31	2002-11-20	萨诺化学药物股份公司	雪花胺的新衍生物和类似物
US20030162770A1 (en)	2002-02-22	2003-08-28	Davis Bonnie M.	Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
ATE473219T1 (de) *	2005-09-22	2010-07-15	Galantos Pharma Gmbh	Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen
EP1777222A1 (en) *	2005-09-22	2007-04-25	Galantos Pharma GmbH	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP2137192B8 (en)	2008-04-14	2014-06-11	Neurodyn Life Sciences Inc.	Derivatives of galantamine as pro-drugs for the treatment of human brain diseases
US9625475B2 (en)	2008-09-29	2017-04-18	Abbvie Inc.	Indole and indoline derivatives and methods of use thereof
TW201018694A (en)	2008-09-29	2010-05-16	Abbott Lab	Indole and indoline derivatives and methods of use thereof
EP2533645B1 (en)	2010-02-09	2016-07-27	The Johns Hopkins University	Methods and compositions for improving cognitive function
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
US9211288B2 (en)	2012-12-13	2015-12-15	H. Lundbeck A/S	Compositions comprising vortioxetine and donepezil
US10806717B2 (en)	2013-03-15	2020-10-20	The Johns Hopkins University	Methods and compositions for improving cognitive function
CA2904767C (en)	2013-03-15	2022-06-21	Agenebio, Inc.	Methods and compositions for improving cognitive function
EA034167B8 (ru)	2015-05-22	2021-04-27	Эйджинбайо, Инк.	Фармацевтические композиции леветирацетама пролонгированного высвобождения

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3673177A (en) *	1970-05-04	1972-06-27	American Cyanamid Co	Substituted 4-(anilinomethylene)-3-galanthamaninones
PL122665B1 (en) *	1978-11-21	1982-08-31	Edinen Zentar Chim	Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) *	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
NL8800350A (nl) *	1988-02-12	1989-09-01	Stichting Biomedical Research	Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.

1988
- 1988-05-04 DE DE3856594T patent/DE3856594D1/de not_active Expired - Lifetime
- 1988-05-04 EP EP88905083A patent/EP0363415B1/en not_active Expired - Lifetime
- 1988-05-04 WO PCT/US1988/001542 patent/WO1988008708A1/en not_active Ceased
- 1988-05-04 KR KR1019880701794A patent/KR100195399B1/ko not_active Expired - Lifetime
- 1988-05-04 AT AT88905083T patent/ATE411026T1/de not_active IP Right Cessation
- 1988-05-04 AU AU18084/88A patent/AU632458B2/en not_active Expired
- 1988-05-04 JP JP63504783A patent/JP2755403B2/ja not_active Expired - Fee Related
- 1988-06-16 CA CA000569641A patent/CA1338326C/en not_active Expired - Lifetime
1989
- 1989-11-02 FI FI895213A patent/FI102756B/fi not_active IP Right Cessation
- 1989-11-03 DK DK198905491A patent/DK175839B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0363415A1 (en)	1990-04-18
CA1338326C (en)	1996-05-14
JP2755403B2 (ja)	1998-05-20
EP0363415B1 (en)	2008-10-15
FI102756B1 (fi)	1999-02-15
JPH02503794A (ja)	1990-11-08
KR100195399B1 (ko)	1999-06-15
AU632458B2 (en)	1993-01-07
FI895213A0 (fi)	1989-11-02
DE3856594D1 (de)	2008-11-27
DK549189D0 (da)	1989-11-03
ATE411026T1 (de)	2008-10-15
DK175839B1 (da)	2005-03-21
AU1808488A (en)	1988-12-06
EP0363415A4 (en)	1993-03-17
FI102756B (fi)	1999-02-15
KR890701107A (ko)	1989-12-19
WO1988008708A1 (en)	1988-11-17

Legal Events

Date	Code	Title	Description
2008-05-19	PUP	Patent expired

Publication	Publication Date	Title
DK549189D0 (da)	1989-11-03	Galanthamin-analoge samt anvendelse af disse til fremstilling af laegemidler til behandling af alzheimer's syge
DE10199020I2 (de)	2004-05-06	Galanthamin oder dessen Analoge zur Behandlung derAlzheimerschen Krankheit.
FI933946A7 (fi)	1994-03-11	Hypoglykeemisinä aineina ja Alzheimerin taudin hoidossa käyttökelpoisia yhdisteitä
NO892270L (no)	1989-12-04	Fremgangsmaate for fremstilling av preparater for anvendelse ved behandlingen av alkoholisme.
NO911952L (no)	1991-07-05	Behandling av tilstander og sykdommer samt midler derfor.
FI98762B (fi)	1997-04-30	Säiliön viimeistelyn tarkastus
FI962557A7 (fi)	1996-08-22	PLA2-inhibiittoreiden käyttö Alzheimerin taudin hoidossa
NO990542L (no)	1999-02-05	K-252a-derivater og anvendelse av K-252a-derivater
FI891986A7 (fi)	1989-04-26	Farmaseuttiset koostumukset psoriasiksen hoitoon
NO892505D0 (no)	1989-06-16	Behandling av vandige dispersjoner.
DK325289D0 (da)	1989-06-29	Strontiumsalt, fremgangsmaade til fremstilling heraf samt farmaceutiske midler indeholdende saltet
NO913117D0 (no)	1991-08-09	Fremgangsmaate for behandling av benoedeleggende sykdommer.
LV10391A (lv)	1995-02-20	Alkilfosforskabes savienojumu izmantosana psoriazes tipa slimibu arstesanai
FI844645A0 (fi)	1984-11-27	1,7-difenyl-3-metylaza-7-cyan-8 -metyl-nonan foer anvaendning vid bekaempning av sjukdomar.
KR890700684A (ko)	1989-04-26	습식공법들에서 피혁류의 처리를 위한 장치
ATE142503T1 (de)	1996-09-15	Arzneimittelzubereitung bei der behandlung von tonsillitis
DK131188A (da)	1988-09-12	3-(2-halogenalkyl)-1,4-oxathiiner og 2(2-halogenalkyl)-1,4-dithiiner, samt farmaceutiske praeparater indeholdende disse til behandling af leukaemi og tumorer
NO920524D0 (no)	1992-02-10	Kynurensyrederivater, deres fremstilling og farmasoeytiskeblandinger inneholdende disse
SE8802323D0 (sv)	1988-06-21	8alfa-acylaminoergoline, its preparation and pharmaceutical compositions containing it
SE8900564D0 (sv)	1989-02-17	Novel medicinal use
DE68914886D1 (de)	1994-06-01	Mittel zur Behandlung von Raynaud's Krankheit.
DE3776662D1 (de)	1992-03-19	Pharmazeutische zusammensetzungen zur behandlung von hyperproliferativer hautkrankheit.
ATE89727T1 (de)	1993-06-15	Optisch reines dexniguldipin und dessen derivate zur behandlung von tumorerkrankungen.
DK585389A (da)	1991-05-22	Praeparat til behandling af hudsygdomme samt anvendelse af artemisinin og derivater heraf til fremstilling af et saadant praeparat
IT8222416A1 (it)	1984-01-16	Procedimento per l'estrazione del cromo e delle proteine dagli scarti delle pelli conciate al cromo