DK56076A - Fremgansmade til fremstilling af 6-oxo-7,7-disubstitueret - 1,2,7,8-tetrahydro-(og 7,8-didydro)-6h-indeno-(5,4-b)furan-(og thiophen)carboxylsyrer salte estere og amid-derivater deraf - Google Patents

Fremgansmade til fremstilling af 6-oxo-7,7-disubstitueret - 1,2,7,8-tetrahydro-(og 7,8-didydro)-6h-indeno-(5,4-b)furan-(og thiophen)carboxylsyrer salte estere og amid-derivater deraf

Info

Publication number
DK56076A
DK56076A DK56076*#A DK56076A DK56076A DK 56076 A DK56076 A DK 56076A DK 56076 A DK56076 A DK 56076A DK 56076 A DK56076 A DK 56076A
Authority
DK
Denmark
Prior art keywords
didydro
indeno
thiophen
disubstituted
furan
Prior art date
Application number
DK56076*#A
Other languages
English (en)
Other versions
DK143339C (da
DK143339B (da
Inventor
E J Cragoe
O W Woltersdorf
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK56076A publication Critical patent/DK56076A/da
Publication of DK143339B publication Critical patent/DK143339B/da
Application granted granted Critical
Publication of DK143339C publication Critical patent/DK143339C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK56076A 1975-02-24 1976-02-11 Analogifremgangsmaade til fremstilling af 6-oxo-7,7-disubstitueret-1,2,7,8-tetrahydro-6h-indeno(5,4-b)furan-2-carboxylsyrer DK143339C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55240275 1975-02-24
US05/552,402 US3984552A (en) 1975-02-24 1975-02-24 6-Oxo-7-substituted and 7,7-disubstituted-6H-indeno-[5,4-b]furan (and thiophene) carboxylic acids

Publications (3)

Publication Number Publication Date
DK56076A true DK56076A (da) 1976-08-25
DK143339B DK143339B (da) 1981-08-10
DK143339C DK143339C (da) 1981-12-07

Family

ID=24205173

Family Applications (1)

Application Number Title Priority Date Filing Date
DK56076A DK143339C (da) 1975-02-24 1976-02-11 Analogifremgangsmaade til fremstilling af 6-oxo-7,7-disubstitueret-1,2,7,8-tetrahydro-6h-indeno(5,4-b)furan-2-carboxylsyrer

Country Status (15)

Country Link
US (1) US3984552A (da)
JP (1) JPS6154794B2 (da)
AU (1) AU500514B2 (da)
BE (1) BE838828A (da)
CA (1) CA1072972A (da)
CH (1) CH617689A5 (da)
DE (1) DE2607305C2 (da)
DK (1) DK143339C (da)
ES (1) ES445380A1 (da)
FR (1) FR2301246A1 (da)
GB (1) GB1497382A (da)
HU (1) HU177120B (da)
NL (1) NL7601295A (da)
SE (1) SE425605B (da)
ZA (1) ZA761046B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394385A (en) * 1980-11-21 1983-07-19 Merck & Co., Inc. Treatment of gray matter edema
US6890363B1 (en) * 1999-05-24 2005-05-10 Showa Denko K.K. Solid electrolytic capacitor and method for producing the same
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
BR112013032306B1 (pt) 2011-06-16 2021-05-25 Korea Research Institute Of Chemical Technology derivados de indanona, método de preparação dos mesmos, composições farmacêuticas e uso dos mesmos para prevenção ou tratamento de doenças virais
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
ES2863985T3 (es) 2012-12-14 2021-10-13 Korea Res Inst Chemical Tech Nuevo compuesto, sal farmacéuticamente aceptable o isómero óptico del mismo, método para prepararlo y composición farmacéutica para la prevención o el tratamiento de enfermedades virales que lo contienen como ingrediente activo
SG10201708931XA (en) 2012-12-17 2017-12-28 Parion Sciences Inc Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
RU2018138195A (ru) 2012-12-17 2018-12-18 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
JP7592748B2 (ja) 2020-04-20 2024-12-02 ノバルティス アーゲー 抗ウイルス1,3-ジ-オキソ-インデン化合物
US12083092B2 (en) 2020-04-20 2024-09-10 Novartis Ag Antiviral 1,3-di-oxo-indene compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931239A (en) * 1974-04-03 1976-01-06 Merck & Co., Inc. 6-Oxo-7-substituted-6H-indeno-[5,4-b]furan(and thiophene)-carboxylic acids

Also Published As

Publication number Publication date
NL7601295A (nl) 1976-08-26
JPS51110558A (da) 1976-09-30
AU1117976A (en) 1977-08-25
FR2301246B1 (da) 1980-06-20
CA1072972A (en) 1980-03-04
FR2301246A1 (fr) 1976-09-17
AU500514B2 (en) 1979-05-24
HU177120B (en) 1981-07-28
JPS6154794B2 (da) 1986-11-25
DE2607305C2 (de) 1987-04-30
ZA761046B (en) 1977-03-30
ES445380A1 (es) 1977-10-01
US3984552A (en) 1976-10-05
SE425605B (sv) 1982-10-18
CH617689A5 (da) 1980-06-13
BE838828A (fr) 1976-08-23
SE7601422L (sv) 1976-08-25
GB1497382A (en) 1978-01-12
DK143339C (da) 1981-12-07
DE2607305A1 (de) 1976-09-02
DK143339B (da) 1981-08-10

Similar Documents

Publication Publication Date Title
DK156575C (da) Fremgangsmaade til fremstilling af 3-hydroxy-3-cephem- eller 3-oxo-cepham-carboxylsyrederivater
DK139676C (da) Analogifremgangsmaade til fremstilling af carboxylsyreamidderivater
DK346276A (da) Fremgangsmade til fremstilling af alfa-phenylbenzylidenderivater af aminosyrer
SE429961B (sv) Forfarande for framstellning av mjolksyra
DK56076A (da) Fremgansmade til fremstilling af 6-oxo-7,7-disubstitueret - 1,2,7,8-tetrahydro-(og 7,8-didydro)-6h-indeno-(5,4-b)furan-(og thiophen)carboxylsyrer salte estere og amid-derivater deraf
SE7608808L (sv) Forfarande for framstellning av nya derivat av tiazolo/3,4-b/isokinolin
SE426065B (sv) Forfarande for framstellning av nikotinsyraamid
DK381277A (da) Fremgangsmaade til fremstilling af acylerede heterocyclylcarboxylsyrer
IT1116695B (it) Procedimento per la preparazione di ammidi di acidi da corrispondenti nitrili
SE431205B (sv) Forfarande for framstellning av estrar av 3-aminometylen-6,7-dimetoxi-2-metyl-4-oxo-1,2,3,4-tetrahydro-1-kinolinkarboxylsyra
DK43476A (da) Fremgangsmade til fremstilling af cephemcarboxylsyrer
DK374576A (da) Fremgangsmade til fremstilling af 7beta-(d-2-amino-2-(lavalkylsulfonylamino-phenyl)-acetylamino)-3-r-cephem-4-carboxylsyrer eller salte deraf
SE439159B (sv) Forfarnde for framstellning av nya 5-fluoropyrimidin-4-on-derivat
BG27366A3 (bg) Метод за непрекъснато получаване на органични разтвори на перкарбонови киселини
SE409701B (sv) Forfarande for framstellning av aminosyror
SE7606815L (sv) Forfarande for framstellning av nya naftacenderivat
DK281576A (da) Fremgangsmade til fremstilling af substituerede phenylalkylcarboxylsyrer eller salte deraf
SE7604669L (sv) Forfarande for framstellning av estrar av tiokarbamidsyror
DK153554C (da) Fremgangsmaade til fremstilling af 7-aminocephalosporansyrederivater
DK155001C (da) Fremgangsmaade til fremstilling af umaettede carboxylsyrer
SE7604940L (sv) Forfarande for framstellning av sulfamylbensoesyror
AR219072A1 (es) Procedimiento para preparar nuevos derivados de(piridil-3-imino)-3-tetrahidro 1,5,10,10a-tiazol(3,4-b)-isoquinoleina
DK269876A (da) Fremgangsmade til fremstilling af karboxylsyrederivater
DK156576A (da) Fremgangsmade til fremstilling af clavulansyrederivater
SE7601884L (sv) Nytt forfarande for framstellning av 7-metyl-4-oxo-1,4-dihydro-1,8-naftyridin-3-karboxylsyror

Legal Events

Date Code Title Description
PBP Patent lapsed