DK565683A - Fremgangsmaade til fremstilling af isotretinoin - Google Patents

Fremgangsmaade til fremstilling af isotretinoin Download PDF

Info

Publication number: DK565683A
Authority: DK; Denmark
Prior art keywords: palladium; rhodium; compound; isotretinoin; producing
Prior art date: 1982-12-10

Application number

DK565683A

Other languages

English (en)

Other versions

DK170945B1 (da

DK565683D0 (da

Inventor

Robert Lucci

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-10

Filing date

1983-12-08

Publication date

1984-06-11

1983-12-08 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1983-12-08 Publication of DK565683D0 publication Critical patent/DK565683D0/da

1984-06-11 Publication of DK565683A publication Critical patent/DK565683A/da

1996-03-25 Application granted granted Critical

1996-03-25 Publication of DK170945B1 publication Critical patent/DK170945B1/da

Links

SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 title abstract 2
229960005280 isotretinoin Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 6
229910052763 palladium Inorganic materials 0.000 abstract 3
229910052703 rhodium Inorganic materials 0.000 abstract 2
239000010948 rhodium Substances 0.000 abstract 2
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 2
XRNPHZPFAWLRNJ-UHFFFAOYSA-N 2-hydroxy-3-methyl-2h-furan-5-one Chemical compound CC1=CC(=O)OC1O XRNPHZPFAWLRNJ-UHFFFAOYSA-N 0.000 abstract 1
XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 abstract 1
150000003284 rhodium compounds Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Catalysts (AREA)

DK565683A 1982-12-10 1983-12-08 Fremgangsmåde til fremstilling af 13-cisretinsyre og fremgangsmåde til fremstilling af en palladiumkatalysator til brug ved fremgangsmåden DK170945B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US44866082A	1982-12-10	1982-12-10
US44866082		1982-12-10

Publications (3)

Publication Number	Publication Date
DK565683D0 DK565683D0 (da)	1983-12-08
DK565683A true DK565683A (da)	1984-06-11
DK170945B1 DK170945B1 (da)	1996-03-25

Family

ID=23781154

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK565683A DK170945B1 (da)	1982-12-10	1983-12-08	Fremgangsmåde til fremstilling af 13-cisretinsyre og fremgangsmåde til fremstilling af en palladiumkatalysator til brug ved fremgangsmåden

Country Status (5)

Country	Link
EP (1)	EP0111325B1 (da)
JP (1)	JPS59116263A (da)
AT (1)	ATE32217T1 (da)
DE (1)	DE3375480D1 (da)
DK (1)	DK170945B1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4313089A1 (de) *	1993-04-22	1994-10-27	Basf Ag	Verfahren zur Herstellung von 13-(Z)-Retinsäure
US5534261A (en) *	1995-01-17	1996-07-09	University Of Southern California	Retinoid-based compositions and method for preventing adhesion formation using the same
IT1274494B (it) *	1995-05-12	1997-07-17	Lab Mag Spa	Procedimento fotochimico per la preparazione dell'acido 13-cis-retinoico
US6124485A (en) *	1998-03-25	2000-09-26	Abbott Laboratories	Process for producing 13-cis retinoic acid
EP1564209A1 (en) *	2004-02-17	2005-08-17	Helsinn Advanced Synthesis SA	Process for the preparation of 13-cis-retinoic acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4051174A (en) *	1973-08-21	1977-09-27	Hoffmann-La Roche Inc.	Isomerization process

1983
- 1983-12-08 AT AT83112376T patent/ATE32217T1/de not_active IP Right Cessation
- 1983-12-08 DK DK565683A patent/DK170945B1/da not_active IP Right Cessation
- 1983-12-08 DE DE8383112376T patent/DE3375480D1/de not_active Expired
- 1983-12-08 EP EP83112376A patent/EP0111325B1/de not_active Expired
- 1983-12-09 JP JP58231628A patent/JPS59116263A/ja active Granted

Also Published As

Publication number	Publication date
DK170945B1 (da)	1996-03-25
JPH0425263B2 (da)	1992-04-30
DK565683D0 (da)	1983-12-08
EP0111325B1 (de)	1988-01-27
JPS59116263A (ja)	1984-07-05
EP0111325A3 (en)	1985-07-03
ATE32217T1 (de)	1988-02-15
DE3375480D1 (en)	1988-03-03
EP0111325A2 (de)	1984-06-20

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Legal Events

Date	Code	Title	Description
1996-03-25	B1	Patent granted (law 1993)
2002-08-05	PBP	Patent lapsed