DK567888A - Fremgangsmaade til fremstilling af proteiner - Google Patents

Fremgangsmaade til fremstilling af proteiner

Info

Publication number
DK567888A
DK567888A DK567888A DK567888A DK567888A DK 567888 A DK567888 A DK 567888A DK 567888 A DK567888 A DK 567888A DK 567888 A DK567888 A DK 567888A DK 567888 A DK567888 A DK 567888A
Authority
DK
Denmark
Prior art keywords
acid
protein
production
anhydromevalonolactone
hydroxy
Prior art date
Application number
DK567888A
Other languages
English (en)
Other versions
DK567888D0 (da
DK175411B1 (da
Inventor
Andrea Stecher-Schilling
Rolf-Guenter Werner
William Werz
Hans Zaehner
Axel Zeeck
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873734632 external-priority patent/DE3734632A1/de
Priority claimed from DE19873738649 external-priority patent/DE3738649A1/de
Priority claimed from DE19883801562 external-priority patent/DE3801562A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK567888D0 publication Critical patent/DK567888D0/da
Publication of DK567888A publication Critical patent/DK567888A/da
Application granted granted Critical
Publication of DK175411B1 publication Critical patent/DK175411B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6459Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/36Lipids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK198805678A 1987-10-13 1988-10-12 Fremgangsmåde til fremstilling af proteiner DK175411B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19873734632 DE3734632A1 (de) 1987-10-13 1987-10-13 Verfahren zur herstellung von t-pa
DE3734632 1987-10-13
DE19873738649 DE3738649A1 (de) 1987-11-13 1987-11-13 Verfahren zur herstellung von proteinen
DE3738649 1987-11-13
DE3801562 1988-01-20
DE19883801562 DE3801562A1 (de) 1988-01-20 1988-01-20 Verfahren zur herstellung von proteinen

Publications (3)

Publication Number Publication Date
DK567888D0 DK567888D0 (da) 1988-10-12
DK567888A true DK567888A (da) 1989-04-14
DK175411B1 DK175411B1 (da) 2004-09-27

Family

ID=27196629

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198805678A DK175411B1 (da) 1987-10-13 1988-10-12 Fremgangsmåde til fremstilling af proteiner

Country Status (16)

Country Link
EP (1) EP0315782B1 (da)
JP (1) JP2688222B2 (da)
KR (1) KR890006671A (da)
AT (1) ATE112308T1 (da)
AU (1) AU614999B2 (da)
CA (1) CA1341400C (da)
DE (1) DE3851685D1 (da)
DK (1) DK175411B1 (da)
ES (1) ES2064336T3 (da)
FI (1) FI94963C (da)
HU (1) HU205381B (da)
IE (1) IE65986B1 (da)
IL (1) IL88001A (da)
NO (1) NO174778C (da)
NZ (1) NZ226521A (da)
PT (1) PT88751B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1554592A (en) * 1991-04-18 1992-11-17 Toray Industries, Inc. Interleukin 6 composition and production thereof
DE4113750A1 (de) * 1991-04-26 1992-10-29 Boehringer Mannheim Gmbh Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen
US6309864B1 (en) * 1997-04-03 2001-10-30 Yoshitomi Pharmaceutical Industries, Ltd. Process for producing foreign proteins
WO2003048357A1 (fr) * 2001-12-04 2003-06-12 Mitsubishi Pharma Corporation Procede d'activation de proteine
WO2004056872A1 (ja) * 2002-12-20 2004-07-08 Mitsubishi Pharma Corporation タンパク質のチオール基を保護する方法
TWI601823B (zh) * 2007-04-26 2017-10-11 中外製藥股份有限公司 Cell culture methods using media containing high concentrations of amino acids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0163751B1 (en) * 1984-06-05 1989-09-20 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
GB8606386D0 (en) * 1986-03-14 1986-04-23 Celltech Ltd Production of protein

Also Published As

Publication number Publication date
KR890006671A (ko) 1989-06-15
NO174778C (no) 1994-07-06
ES2064336T3 (es) 1995-02-01
HUT48306A (en) 1989-05-29
FI884652A0 (fi) 1988-10-11
FI94963B (fi) 1995-08-15
JP2688222B2 (ja) 1997-12-08
NO884549L (no) 1989-04-14
PT88751B (pt) 1995-03-01
DK567888D0 (da) 1988-10-12
DK175411B1 (da) 2004-09-27
AU614999B2 (en) 1991-09-19
HU205381B (en) 1992-04-28
NZ226521A (en) 1991-04-26
NO174778B (no) 1994-03-28
CA1341400C (en) 2002-11-19
EP0315782B1 (de) 1994-09-28
EP0315782A3 (en) 1989-09-20
ATE112308T1 (de) 1994-10-15
DE3851685D1 (de) 1994-11-03
PT88751A (pt) 1989-07-31
FI94963C (fi) 1995-11-27
EP0315782A2 (de) 1989-05-17
IL88001A0 (en) 1989-06-30
JPH01231887A (ja) 1989-09-18
IE883079L (en) 1989-04-13
IE65986B1 (en) 1995-11-29
AU2373388A (en) 1989-05-11
NO884549D0 (no) 1988-10-12
FI884652L (fi) 1989-04-14
IL88001A (en) 1996-01-19

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