DK573687A - 9-chlorprostaglandinderivater samt fertilitetsmodvirkende middel, der indeholder dem. - Google Patents

9-chlorprostaglandinderivater samt fertilitetsmodvirkende middel, der indeholder dem.

Info

Publication number: DK573687A
Authority: DK; Denmark
Prior art keywords: substituted; aryl; alpha; group; hydrocarbon
Prior art date: 1979-12-10

Application number

DK573687A

Other languages

English (en)

Other versions

DK573687D0 (da

Inventor

Werner Skuballa

Bernd Raduechel

Helmut Vorbrueggen

Walter Elger

Olaf Loge

Ekkehard Schillinger

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-12-10

Filing date

1987-11-02

Publication date

1987-11-02

1987-11-02 Application filed by Schering Ag filed Critical Schering Ag

1987-11-02 Publication of DK573687D0 publication Critical patent/DK573687D0/da

1987-11-02 Publication of DK573687A publication Critical patent/DK573687A/da

Links

239000000126 substance Substances 0.000 title 1
-1 hydrocarbon carboxylic Chemical class 0.000 abstract 4
239000004215 Carbon black (E152) Substances 0.000 abstract 3
229930195733 hydrocarbon Natural products 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002430 hydrocarbons Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrane Compounds (AREA)

DK573687A 1979-12-10 1987-11-02 9-chlorprostaglandinderivater samt fertilitetsmodvirkende middel, der indeholder dem. DK573687A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19792950027 DE2950027A1 (de)	1979-12-10	1979-12-10	9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel

Publications (2)

Publication Number	Publication Date
DK573687D0 DK573687D0 (da)	1987-11-02
DK573687A true DK573687A (da)	1987-11-02

Family

ID=6088285

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK526080A DK153944C (da)	1979-12-10	1980-12-10	Analogifremgangsmaade til fremstilling af 9-chlorprostaglandinderivater
DK573687A DK573687A (da)	1979-12-10	1987-11-02	9-chlorprostaglandinderivater samt fertilitetsmodvirkende middel, der indeholder dem.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK526080A DK153944C (da)	1979-12-10	1980-12-10	Analogifremgangsmaade til fremstilling af 9-chlorprostaglandinderivater

Country Status (14)

Country	Link
US (2)	US4444788A (da)
EP (1)	EP0030377B1 (da)
JP (1)	JPS5692860A (da)
AT (1)	ATE6364T1 (da)
AU (1)	AU543797B2 (da)
CA (1)	CA1196327A (da)
CS (1)	CS226419B2 (da)
DE (2)	DE2950027A1 (da)
DK (2)	DK153944C (da)
ES (1)	ES8200336A1 (da)
HU (1)	HU183263B (da)
IE (1)	IE51212B1 (da)
IL (1)	IL61669A (da)
SU (1)	SU1026652A3 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5204371A (en) *	1979-12-10	1993-04-20	Schering Aktiengesellschaft	Pharmaceutically active 9-chloroprostaglandins
DE2950027A1 (de) *	1979-12-10	1981-06-11	Schering Ag Berlin Und Bergkamen, 1000 Berlin	9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE3126924A1 (de) *	1981-07-03	1983-01-20	Schering Ag, 1000 Berlin Und 4619 Bergkamen	9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE3148743A1 (de) *	1981-12-04	1983-06-09	Schering Ag, 1000 Berlin Und 4619 Bergkamen	9-brom-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3325175A1 (de) *	1983-07-08	1985-01-17	Schering AG, 1000 Berlin und 4709 Bergkamen	11-halogen-prostanderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3337450A1 (de) *	1983-10-12	1985-04-25	Schering AG, 1000 Berlin und 4709 Bergkamen	Prostaglandine und antigestagene fuer den schwangerschaftsabbruch
DE3347128A1 (de) *	1983-12-22	1985-07-11	Schering AG, 1000 Berlin und 4709 Bergkamen	9-halogen-(delta)(pfeil hoch)2(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3414509A1 (de) *	1984-04-13	1985-10-24	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue 9-halogen-prostaglandine
DE3504044A1 (de) *	1985-02-04	1986-08-07	Schering AG, Berlin und Bergkamen, 1000 Berlin	9-halogenprostaglandin-clathrate und ihre verwendung als arzneimittel
DE3510978A1 (de) *	1985-03-22	1986-09-25	Schering AG, Berlin und Bergkamen, 1000 Berlin	Neue 9-halogenprostaglandine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3608088C2 (de) *	1986-03-07	1995-11-16	Schering Ag	Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
AU624078B2 (en) *	1987-07-17	1992-06-04	Schering Aktiengesellschaft Berlin Und Bergkamen	9-halogen-(z)-prostaglandin derivatives, process for manufacturing them, and their use as drugs
DE3724190A1 (de) *	1987-07-17	1989-01-26	Schering Ag	9-halogen-3-oxa-(z)-(delta)(pfeil hoch)5(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3724189A1 (de) *	1987-07-17	1989-01-26	Schering Ag	9-halogen-(z)-(delta)(pfeil hoch)4(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel
US5891910A (en) *	1987-07-17	1999-04-06	Schering Aktiengesellschaft	9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents
JP2716986B2 (ja) *	1987-07-17	1998-02-18	シエーリングアクチエンゲゼルシヤフト	９‐ハロゲン‐（ｚ）‐プロスタグランジン誘導体、その製法及び薬剤としてのその使用
DE4036140A1 (de) *	1990-11-09	1992-05-14	Schering Ag	9-halogen-11ss-hydroxy-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
KR100266834B1 (ko) *	1992-07-24	2000-09-15	우에하라 아끼라	프로스타글란딘 유도체
DE4229050A1 (de) *	1992-08-31	1994-03-03	Schering Ag	Neue 9-Chlor-Prostaglandin-Ester und -amide
DE4229048A1 (de) *	1992-08-31	1994-03-03	Schering Ag	Ester von 9-Chlor-Prostaglandinen, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
DE59308617D1 (de) *	1992-08-31	1998-07-02	Schering Ag	9-chlor-prostaglandin-ester und -amide und ihre verwendung für die herstellung von arzneimitteln
US5972991A (en) *	1992-09-21	1999-10-26	Allergan	Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
IT1257479B (it) *	1992-12-01	1996-01-25		Derivati prostaglandinici aventi effetti radioprotettivi
DE4330177A1 (de) *	1993-08-31	1995-03-02	Schering Ag	Neue 9-Chlor-prostaglandin-derivate
US5721273A (en)	1993-12-15	1998-02-24	Alcon Laboratories, Inc.	Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension
US5807892A (en) *	1994-09-30	1998-09-15	Alcon Laboratories, Inc.	Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US6235780B1 (en)	1998-07-21	2001-05-22	Ono Pharmaceutical Co., Ltd.	ω-cycloalkyl-prostaglandin E1 derivatives
US7563924B2 (en) *	2005-11-21	2009-07-21	Schering Aktiengesellschaft	9-chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments
DE602005005355T2 (de) *	2005-11-21	2009-03-26	Bayer Schering Pharma Ag	9-Chloro-15-deoxyprostaglandinderivate, Verfahren zu ihrer Herstellung und deren Verwendung als Medikamente

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2517773A1 (de) *	1975-04-18	1976-10-28	Schering Ag	Neue 11-oxo-prostaglandin-derivate und verfahren zu ihrer herstellung
US4163016A (en) *	1977-07-05	1979-07-31	Hoffmann-La Roche Inc.	16-Substituted prostaglandins
US4192799A (en) *	1977-09-21	1980-03-11	The Upjohn Company	Conjugates formed by reacting a prostaglandin mimic compound with a carrier molecule
DE2950027A1 (de) *	1979-12-10	1981-06-11	Schering Ag Berlin Und Bergkamen, 1000 Berlin	9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel

1979
- 1979-12-10 DE DE19792950027 patent/DE2950027A1/de not_active Withdrawn
1980
- 1980-12-05 EP EP80107657A patent/EP0030377B1/de not_active Expired
- 1980-12-05 DE DE8080107657T patent/DE3066726D1/de not_active Expired
- 1980-12-05 AT AT80107657T patent/ATE6364T1/de not_active IP Right Cessation
- 1980-12-09 HU HU802949A patent/HU183263B/hu not_active IP Right Cessation
- 1980-12-09 CS CS808647A patent/CS226419B2/cs unknown
- 1980-12-09 CA CA000366408A patent/CA1196327A/en not_active Expired
- 1980-12-09 IL IL61669A patent/IL61669A/xx not_active IP Right Cessation
- 1980-12-09 SU SU803221450A patent/SU1026652A3/ru active
- 1980-12-09 AU AU65190/80A patent/AU543797B2/en not_active Ceased
- 1980-12-09 IE IE2572/80A patent/IE51212B1/en not_active IP Right Cessation
- 1980-12-10 DK DK526080A patent/DK153944C/da not_active IP Right Cessation
- 1980-12-10 ES ES497589A patent/ES8200336A1/es not_active Expired
- 1980-12-10 JP JP17447980A patent/JPS5692860A/ja active Granted
1982
- 1982-06-10 US US06/387,140 patent/US4444788A/en not_active Expired - Fee Related
1987
- 1987-09-08 US US07/096,232 patent/US5079259A/en not_active Expired - Fee Related
- 1987-11-02 DK DK573687A patent/DK573687A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
US5079259A (en)	1992-01-07
ES497589A0 (es)	1981-11-16
IE802572L (en)	1981-06-10
DK573687D0 (da)	1987-11-02
DK153944B (da)	1988-09-26
AU6519080A (en)	1981-06-18
HU183263B (en)	1984-04-28
DK526080A (da)	1981-06-11
ES8200336A1 (es)	1981-11-16
JPS5692860A (en)	1981-07-27
EP0030377A1 (de)	1981-06-17
DE3066726D1 (en)	1984-03-29
AU543797B2 (en)	1985-05-02
US4444788A (en)	1984-04-24
DK153944C (da)	1989-02-20
EP0030377B1 (de)	1984-02-22
IL61669A (en)	1986-08-31
SU1026652A3 (ru)	1983-06-30
JPS6224422B2 (da)	1987-05-28
ATE6364T1 (de)	1984-03-15
DE2950027A1 (de)	1981-06-11
CS226419B2 (en)	1984-03-19
IL61669A0 (en)	1981-01-30
IE51212B1 (en)	1986-11-12
CA1196327A (en)	1985-11-05

Legal Events

Date	Code	Title	Description
1989-06-19	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK573687D0 (da)	1987-11-02	9-chlorprostaglandinderivater samt fertilitetsmodvirkende middel, der indeholder dem.
ATE12094T1 (de)	1985-03-15	Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
AU559449B2 (en)	1987-03-12	9-fluoroprostaglandin analogs
NO154921C (no)	1987-01-14	Fremgangsmaate ved fremstilling av en kationbyttermembran.
PT72131A (en)	1980-12-01	Novel fluorinated copolymer and preparation thereof
SE7604409L (sv)	1976-10-19	Nya prostaglandin-acetylenanaloger och sett att framstella desamma
ES457745A1 (es)	1978-07-16	Procedimiento para la preparacion de nuevas fluoracil-resor-cinas sustituidas.
KR830005092A (ko)	1983-07-23	시클로프로판 카르복실산의 새로운 유도체
ES504702A0 (es)	1982-08-16	Procedimiento de fabricacion y de aplicacion de derivados iridoides reactivos
IT1032763B (it)	1979-06-20	Procedimento per la preparazione di alcoli primari con ramificazione alchilica sul secondo atomo di carbonio
ES536649A0 (es)	1985-07-16	Procedimiento para la preparacion de derivados de estrano y androstano
SE7706245L (sv)	1977-12-16	Forfarande for framstellning av prostacyklinderivat
KR830007693A (ko)	1983-11-04	7-아미노 세펨 화합물을 제조하는 개량방법
CH609682A5 (en)	1979-03-15	Process for the preparation of compounds analogous to prostaglandins
ATE8259T1 (de)	1984-07-15	Neue prostacyclinderivate und ihre herstellung.
AU561813B2 (en)	1987-05-21	9-bromoprostane derivatives
GB911600A (en)	1962-11-28	Derivatvies of 17-epi-oestriol and process for the preparation thereof
SE419562B (sv)	1981-08-10	Forfarande for ytlimmning av papper med ett salt av en sampolymer av styren och en neutraliserad monoolefiniskt omtvettad karbonsyraester som innehaller tertiera eller kvarternera kveveatomer
LU79181A1 (fr)	1979-10-29	Procede d'amelioration de la mise-au-mille du combustible de haut fourneau
JPS51137115A (en)	1976-11-26	Closing system for a tank with pontoon roof
JPS53132069A (en)	1978-11-17	Production of fluorine-containing membrane