DK582789A - Knoglemarvundertrykkende middel - Google Patents

Knoglemarvundertrykkende middel

Info

Publication number: DK582789A
Authority: DK; Denmark
Prior art keywords: bone marrow; suppressing; objective substances; holmium; samarium
Prior art date: 1988-12-19

Application number

DK582789A

Other languages

English (en)

Other versions

DK175607B1 (da

DK582789D0 (da

Inventor

Jaime Simon

Joseph R Garlich

David A Wilson

Kenneth Mcmillan

Original Assignee

Dow Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-19

Filing date

1989-11-20

Publication date

1990-06-20

1989-11-20 Application filed by Dow Chemical Co filed Critical Dow Chemical Co

1989-11-20 Publication of DK582789D0 publication Critical patent/DK582789D0/da

1990-06-20 Publication of DK582789A publication Critical patent/DK582789A/da

2004-12-27 Application granted granted Critical

2004-12-27 Publication of DK175607B1 publication Critical patent/DK175607B1/da

Links

239000000126 substance Substances 0.000 title 1
210000001185 bone marrow Anatomy 0.000 abstract 2
QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical group C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 abstract 1
UIWYJDYFSGRHKR-NJFSPNSNSA-N gadolinium-159 Chemical compound [159Gd] UIWYJDYFSGRHKR-NJFSPNSNSA-N 0.000 abstract 1
KJZYNXUDTRRSPN-OUBTZVSYSA-N holmium-166 Chemical compound [166Ho] KJZYNXUDTRRSPN-OUBTZVSYSA-N 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical compound NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
KZUNJOHGWZRPMI-AKLPVKDBSA-N samarium-153 Chemical compound [153Sm] KZUNJOHGWZRPMI-AKLPVKDBSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Optics & Photonics (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Steroid Compounds (AREA)

DK198905827A 1988-12-19 1989-11-20 Knoglemarvsundertrykkende middel DK175607B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/284,875 US4882142A (en)	1988-12-19	1988-12-19	Bone marrow suppressing agents
US28487588		1988-12-19

Publications (3)

Publication Number	Publication Date
DK582789D0 DK582789D0 (da)	1989-11-20
DK582789A true DK582789A (da)	1990-06-20
DK175607B1 DK175607B1 (da)	2004-12-27

Family

ID=23091850

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198905827A DK175607B1 (da)	1988-12-19	1989-11-20	Knoglemarvsundertrykkende middel

Country Status (17)

Country	Link
US (1)	US4882142A (da)
EP (1)	EP0374501B1 (da)
JP (1)	JP2795934B2 (da)
KR (1)	KR0142907B1 (da)
AT (1)	ATE92339T1 (da)
AU (1)	AU625644B2 (da)
CA (1)	CA2003326C (da)
DE (1)	DE68908125T2 (da)
DK (1)	DK175607B1 (da)
FI (1)	FI895516A0 (da)
HK (1)	HK152395A (da)
IE (1)	IE69049B1 (da)
IL (1)	IL92373A (da)
NZ (1)	NZ231474A (da)
PH (1)	PH26086A (da)
PT (1)	PT92362B (da)
ZA (1)	ZA898866B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5064633A (en) *	1984-06-04	1991-11-12	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes, their formulations and use
US5059412A (en) *	1984-06-04	1991-10-22	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US4976950A (en) *	1988-12-19	1990-12-11	The Dow Chemical Company	Bone marrow suppressing agents
WO1991016075A1 (en) *	1990-04-20	1991-10-31	Australian Nuclear Science & Technology Organisation	Bone marrow treatments
MC2260A1 (fr) *	1990-06-18	1993-04-26	Dow Chemical Co	Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
US5133956A (en) *	1991-05-30	1992-07-28	The Dow Chemical Company	Radiolabeled metal-binding protein for the treatment of arthritis
US5320829A (en) *	1991-12-10	1994-06-14	The Dow Chemical Company	Oral compositions for inhibiting plaque formation
TR200002243T2 (tr) *	1997-11-10	2000-12-21	Memorial Sloan-Kettering Cancer Center	Arsenik trioksitin hazırlanması için işlem ve bunların kanser tedavisi için kullanımı.
CA2318471A1 (en) *	1998-01-06	1999-07-15	Alexander V. Kirichenko	Nuclear scintigraphic assessment of mucosal function
US7205404B1 (en)	1999-03-05	2007-04-17	Metabasis Therapeutics, Inc.	Phosphorus-containing prodrugs
JP2003501488A (ja) *	1999-06-11	2003-01-14	ネオルックスコーポレイション	骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) *	1999-07-11	2006-08-22	Neorx Corporation	Skeletal-targeted radiation to treat bone-associated pathologies
US6794371B1 (en) *	1999-10-18	2004-09-21	The Dow Chemical Company	Aminoalkylenephosphonates for treatment of bone disorders
US6565828B2 (en) *	2000-04-07	2003-05-20	Bristol-Myers Squibb Company	Macrocyclic chelants for metallopharmaceuticals
NO313180B1 (no) *	2000-07-04	2002-08-26	Anticancer Therapeutic Inv Sa	Bensökende alfapartikkel emitterende radiofarmasöytika
US6440389B1 (en)	2000-07-19	2002-08-27	The General Hospital Corporation	Fluorescent agents for real-time measurement of organ function
EP1390081A2 (en)	2001-01-08	2004-02-25	Neorx Corporation	Therapeutic and diagnostic compounds, compositions, and methods
US6776977B2 (en) *	2001-01-09	2004-08-17	Bristol-Myers Squibb Pharma Company	Polypodal chelants for metallopharmaceuticals
US20030215391A1 (en) *	2001-07-19	2003-11-20	Carlos Rabito	Fluorescent agents for real-time measurement of organ function
WO2003051403A1 (en)	2001-12-13	2003-06-26	Dow Global Technologies Inc.	Treatment of osteomyelitis with radiopharmaceuticals
US20030228256A1 (en) *	2002-06-11	2003-12-11	Inverardi Luca A.	Methods of achieving transplantation tolerance through radioablation of hemolymphopoietic cell populations
CA2509328A1 (en) *	2002-12-10	2004-06-24	University Of Miami	Radioablation of hemolymphopoietic cell populations
WO2007126730A1 (en) *	2006-03-29	2007-11-08	Isotherapeautics Group Llc	Radionuclide therapy for urinary bladder cancer
US10172965B2 (en) *	2013-10-07	2019-01-08	Igl Pharma, Inc.	High purity therapeutic bone agents
AU2015217221A1 (en)	2014-02-13	2016-08-11	Ligand Pharmaceuticals, Inc.	Prodrug compounds and their uses
CN106687118A (zh)	2014-07-02	2017-05-17	配体药物公司	前药化合物及其用途
WO2016191413A1 (en) *	2015-05-25	2016-12-01	Iso Therapeutics Group, Llc	Dotmp kit formulations for radioisotopes
EP3573619A4 (en)	2017-01-27	2020-10-28	SignalRX Pharmaceuticals, Inc.	THIENOPYRANONES AND FURANOPYRANONES AS KINASE, BROMODOMAIN AND CHECKPOINT INHIBITORS
CA3087932A1 (en)	2018-01-09	2019-07-18	Ligand Pharmaceuticals, Inc.	Acetal compounds and therapeutic uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4508625A (en) *	1982-10-18	1985-04-02	Graham Marshall D	Magnetic separation using chelated magnetic ions
DE164843T1 (de) *	1984-06-04	1989-12-07	The Dow Chemical Co., Midland, Mich.	Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren.
US4678667A (en) *	1985-07-02	1987-07-07	501 Regents of the University of California	Macrocyclic bifunctional chelating agents

1988
- 1988-12-19 US US07/284,875 patent/US4882142A/en not_active Expired - Lifetime
1989
- 1989-11-20 IL IL9237389A patent/IL92373A/en not_active IP Right Cessation
- 1989-11-20 FI FI895516A patent/FI895516A0/fi not_active Application Discontinuation
- 1989-11-20 DK DK198905827A patent/DK175607B1/da not_active IP Right Cessation
- 1989-11-20 CA CA002003326A patent/CA2003326C/en not_active Expired - Lifetime
- 1989-11-21 PH PH39563A patent/PH26086A/en unknown
- 1989-11-21 EP EP89121564A patent/EP0374501B1/en not_active Expired - Lifetime
- 1989-11-21 JP JP1300943A patent/JP2795934B2/ja not_active Expired - Fee Related
- 1989-11-21 ZA ZA898866A patent/ZA898866B/xx unknown
- 1989-11-21 AT AT89121564T patent/ATE92339T1/de not_active IP Right Cessation
- 1989-11-21 DE DE89121564T patent/DE68908125T2/de not_active Expired - Lifetime
- 1989-11-21 PT PT92362A patent/PT92362B/pt not_active IP Right Cessation
- 1989-11-21 KR KR1019890016866A patent/KR0142907B1/ko not_active Expired - Fee Related
- 1989-11-21 IE IE371489A patent/IE69049B1/en not_active IP Right Cessation
- 1989-11-22 AU AU45440/89A patent/AU625644B2/en not_active Expired
- 1989-12-18 NZ NZ231474A patent/NZ231474A/en unknown
1995
- 1995-09-21 HK HK152395A patent/HK152395A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2795934B2 (ja)	1998-09-10
CA2003326C (en)	1999-01-19
KR900009080A (ko)	1990-07-02
ZA898866B (en)	1991-07-31
ATE92339T1 (de)	1993-08-15
PH26086A (en)	1992-02-06
IE69049B1 (en)	1996-08-07
DE68908125D1 (de)	1993-09-09
JPH02237936A (ja)	1990-09-20
NZ231474A (en)	1992-06-25
EP0374501B1 (en)	1993-08-04
DK175607B1 (da)	2004-12-27
DE68908125T2 (de)	1994-03-03
HK152395A (en)	1995-09-29
FI895516A0 (fi)	1989-11-20
US4882142A (en)	1989-11-21
IL92373A (en)	1995-08-31
AU625644B2 (en)	1992-07-16
IE893714L (en)	1990-06-19
CA2003326A1 (en)	1990-06-19
PT92362B (pt)	1995-09-12
PT92362A (pt)	1990-06-29
AU4544089A (en)	1990-06-21
EP0374501A1 (en)	1990-06-27
DK582789D0 (da)	1989-11-20
KR0142907B1 (ko)	1998-07-15

Legal Events

Date	Code	Title	Description
2009-12-07	PUP	Patent expired

Publication	Publication Date	Title
DK582789A (da)	1990-06-20	Knoglemarvundertrykkende middel
ATE212846T1 (de)	2002-02-15	Bisphosphonat und anti-resorption agentien, enthaltende zusammensetzungen zur hemmung der knochenschwund
IT8485554A0 (it)	1984-04-06	Sacca contenente due o piu'sostanze per infusione ad uso medicale, poste in scomparti separati, comprendente mezzi atti a consentire la miscelazione di tali sostanze solo al momento dell'uso.
DE3874250D1 (de)	1992-10-08	Anaesthesiemittel enthaltende kaugummi-zusammensetzungen.
FI910276A7 (fi)	1991-07-19	Makrosyklisiä yhdisteitä, joissa on 3,6,9,15-tetra-atsabisyklo/9.3.1/pentadekaanirakenne, niiden käyttö NMR-, röntgen- tai radiodiagnostiikkaan käytettävissä koostumuksissa ja tällaiset koostumukset
GB8826066D0 (en)	1988-12-14	New use of 11 28-dioxa-4-azatricyclo(22 3 1 0 4.9)octacos-18-ene derivatives & pharmaceutical compositions
IE791203L (en)	1979-12-28	Radioactive scanning agents with hydroquinone as stabilizer
IL84944A (en)	1992-02-16	Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation
NZ235499A (en)	1993-04-28	Radiolabelled hirudin analogues, pharmaceutical compositions and in vitro and in vivo detection of thrombin
GR3002605T3 (en)	1993-01-25	Pharmaceutical compositions containing a derivative of 3-hydroxy-butanoic acid chosen among oligomers of this acid and among esters of this acid or of these oligomers with 1,3-butane-diol
IL86423A0 (en)	1988-11-15	Pharmaceutical compositions for the treatment of alzheimer's disease
DE3370935D1 (en)	1987-05-21	Stable radiographic imaging agents
ZA94186B (en)	1994-08-18	Agents for vascular diseases
IL84844A0 (en)	1988-06-30	Pharmaceutical compositions comprising a certain carbazolone derivative or a salt thereof
GB8411021D0 (en)	1984-06-06	Treating athlete's foot by laser beam
OA09192A (en)	1992-06-30	"Stabilized sulfur dissolving compositions".
ATE130289T1 (de)	1995-12-15	1,3-diphenyl-2-propin-1-one.
NZ231636A (en)	1993-03-26	Anticoagulant peptides analogus to hirudins' active site
KR880013576A (ko)	1988-12-21	골수억제 조성물 및 이의 용도
IL103856A0 (en)	1993-04-04	Aminoalkyl-substituted 5,6-dihydro-dibenz(b,e)azepin-6,11-dione-11-oximes,their preparation and pharmaceutical compositions containing them
FR2609388B1 (fr)	1997-04-04	Inserts de courbes d'arcades dentaires
IT8464285V0 (it)	1984-04-06	Sacca contenente due o piu'sostanze per infusione ad uso medicale, poste in scomparti separati, comprendente mezzi atti a consentire la miscelazione di tali sostanze solo al momento dell'uso.
EP0301352A3 (en)	1989-04-26	Olefinic diphosphonic acids, process for their preparation and their use as threshold agents, as well as complexant compositions containing olefinic diphosphonic acids
CS804388A2 (en)	1990-08-14	Agent for plants' anthers sterilization
CS804488A2 (en)	1990-08-14	Agent for plants' anthers sterilization