DK588286D0 - Fremgangsmaade til fremstilling af 5-(2,5-dimethylphenoxy)-2,2-dimethylpentansyre - Google Patents

Fremgangsmaade til fremstilling af 5-(2,5-dimethylphenoxy)-2,2-dimethylpentansyre

Info

Publication number: DK588286D0
Authority: DK; Denmark
Prior art keywords: dimethylphenoxy; acid; preparing; dimethylpentanic; alkali metal
Prior art date: 1985-12-09

Application number

DK588286A

Other languages

English (en)

Other versions

DK174496B1 (da

DK588286A (da

Inventor

Francis R Kearney

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-09

Filing date

1986-12-08

Publication date

1986-12-08

1986-12-08 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1986-12-08 Publication of DK588286D0 publication Critical patent/DK588286D0/da

1987-06-10 Publication of DK588286A publication Critical patent/DK588286A/da

2003-04-22 Application granted granted Critical

2003-04-22 Publication of DK174496B1 publication Critical patent/DK174496B1/da

Links

HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 title abstract 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
NKTOLZVEWDHZMU-UHFFFAOYSA-N 2,5-xylenol Chemical compound CC1=CC=C(C)C(O)=C1 NKTOLZVEWDHZMU-UHFFFAOYSA-N 0.000 abstract 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
229910052783 alkali metal Inorganic materials 0.000 abstract 2
-1 alkali metal salt Chemical class 0.000 abstract 2
KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 abstract 2
VEFLKXRACNJHOV-UHFFFAOYSA-N 1,3-dibromopropane Chemical compound BrCCCBr VEFLKXRACNJHOV-UHFFFAOYSA-N 0.000 abstract 1
MFESCIUQSIBMSM-UHFFFAOYSA-N I-BCP Chemical compound ClCCCBr MFESCIUQSIBMSM-UHFFFAOYSA-N 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
229960003627 gemfibrozil Drugs 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000003880 polar aprotic solvent Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Adhesives Or Adhesive Processes (AREA)
Luminescent Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

DK198605882A 1985-12-09 1986-12-08 Fremgangsmåde til fremstilling af 5-(2,5-dimethylphenoxy)-2,2-dimethylpentansyre DK174496B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/806,312 US4665226A (en)	1985-12-09	1985-12-09	Process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
US80631285		1985-12-09

Publications (3)

Publication Number	Publication Date
DK588286D0 true DK588286D0 (da)	1986-12-08
DK588286A DK588286A (da)	1987-06-10
DK174496B1 DK174496B1 (da)	2003-04-22

Family

ID=25193782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198605882A DK174496B1 (da)	1985-12-09	1986-12-08	Fremgangsmåde til fremstilling af 5-(2,5-dimethylphenoxy)-2,2-dimethylpentansyre

Country Status (22)

Country	Link
US (1)	US4665226A (da)
EP (1)	EP0226161B1 (da)
JP (1)	JP2506094B2 (da)
KR (2)	KR870005954A (da)
CN (1)	CN1012896B (da)
AT (1)	ATE47832T1 (da)
AU (1)	AU590358B2 (da)
CA (1)	CA1267155A (da)
DE (1)	DE3666805D1 (da)
DK (1)	DK174496B1 (da)
ES (1)	ES2011245B3 (da)
FI (1)	FI85974C (da)
GR (1)	GR3000216T3 (da)
HK (1)	HK112193A (da)
HU (1)	HU195635B (da)
IE (1)	IE59499B1 (da)
IL (1)	IL80885A (da)
IN (1)	IN166169B (da)
NO (1)	NO164293C (da)
PH (1)	PH24273A (da)
PT (1)	PT83888B (da)
ZA (1)	ZA868893B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU205891B (en) *	1990-05-11	1992-07-28	Gyogyszerkutato Intezet	Process for producing 2,2-dimethyl-5-/2,5-dimethyl-phenoxy/-pentanoic acid
US5235097A (en) *	1990-05-11	1993-08-10	Egis Gyogyszergyar	Process for the preparation of 2,2-dimethyl-5-(2,5-dimethyl-phenoxy)-pentanoic acid, intermediates for preparing this compound and process for preparing the intermediates
US5041640A (en) *	1990-09-20	1991-08-20	Warner-Lambert Company	Process for mono-, di-, trisubstituted acetic acids
BE1007058A3 (fr) *	1992-06-16	1995-03-07	Omnichem Sa	Un procede nouveau pour la preparation de l'acide 5-(2,5-dimethylphenoxy)-2,2-dimethyl pentanoique.
IT1265087B1 (it) *	1993-05-20	1996-10-30	Recordati Chem Pharm	Processo per la preparazione di gemfibrozil
US5412112A (en) *	1994-06-14	1995-05-02	Industrial Technology Research Institute	Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids
US5530145A (en) *	1994-06-14	1996-06-25	Syn-Tech Chem & Pharm Co., Ltd.	Anticholesteremic compounds
EP1627069A4 (en) *	2002-08-08	2010-06-02	Glaxosmithkline Llc	PROCESS FOR THE ISOLATION AND PURIFICATION OF ANSAMITOCINES
CN101440032B (zh) *	2008-11-13	2012-05-23	浙江大学	一种吉非罗齐的多晶型及其制备方法
WO2020212955A1 (en) *	2019-04-18	2020-10-22	Hikal Limited	Process for the preparation of a key intermediate of gemfibrozil

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3674836A (en) *	1968-05-21	1972-07-04	Parke Davis & Co	2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
US3707566A (en) *	1970-03-30	1972-12-26	Parke Davis & Co	Aryloxypentane compounds
US3759986A (en) *	1970-03-30	1973-09-18	Parke Davis & Co	Esters of 2,2-dimethyl-5-(aryloxy)-1-pentanols
GB1422679A (en) *	1972-11-16	1976-01-28	Funai Pharmaceutical Ind Ltd	Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same
GB2024209B (en) *	1978-05-31	1982-09-08	Sori Soc Rech Ind	Phenoxalkylcarboxylic acids
ES533668A0 (es) *	1983-06-24	1985-10-01	Yamanouchi Pharma Co Ltd	Un compuesto fenoxi

1985
- 1985-12-09 US US06/806,312 patent/US4665226A/en not_active Expired - Lifetime
1986
- 1986-11-18 IN IN1005/DEL/86A patent/IN166169B/en unknown
- 1986-11-19 IE IE306086A patent/IE59499B1/en not_active IP Right Cessation
- 1986-11-24 ZA ZA868893A patent/ZA868893B/xx unknown
- 1986-11-24 AU AU65606/86A patent/AU590358B2/en not_active Ceased
- 1986-11-25 CA CA000523753A patent/CA1267155A/en not_active Expired - Fee Related
- 1986-12-01 FI FI864900A patent/FI85974C/fi not_active IP Right Cessation
- 1986-12-03 KR KR860010302A patent/KR870005954A/ko active Granted
- 1986-12-05 IL IL80885A patent/IL80885A/xx unknown
- 1986-12-05 PH PH34561A patent/PH24273A/en unknown
- 1986-12-08 JP JP61290642A patent/JP2506094B2/ja not_active Expired - Fee Related
- 1986-12-08 DE DE8686117076T patent/DE3666805D1/de not_active Expired
- 1986-12-08 NO NO864933A patent/NO164293C/no unknown
- 1986-12-08 EP EP86117076A patent/EP0226161B1/en not_active Expired
- 1986-12-08 DK DK198605882A patent/DK174496B1/da not_active IP Right Cessation
- 1986-12-08 ES ES86117076T patent/ES2011245B3/es not_active Expired - Lifetime
- 1986-12-08 AT AT86117076T patent/ATE47832T1/de not_active IP Right Cessation
- 1986-12-08 HU HU865104A patent/HU195635B/hu not_active IP Right Cessation
- 1986-12-09 PT PT83888A patent/PT83888B/pt not_active IP Right Cessation
- 1986-12-09 CN CN86108472A patent/CN1012896B/zh not_active Expired
1987
- 1987-12-03 KR KR1019860010302Q patent/KR950003120B1/ko not_active Expired - Fee Related
1989
- 1989-11-15 GR GR89400242T patent/GR3000216T3/el unknown
1993
- 1993-10-21 HK HK1121/93A patent/HK112193A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN86108472A (zh)	1987-07-22
IN166169B (da)	1990-03-24
HUT43024A (en)	1987-09-28
DK174496B1 (da)	2003-04-22
FI85974C (fi)	1992-06-25
FI864900L (fi)	1987-06-10
HU195635B (en)	1988-06-28
PT83888B (pt)	1989-05-12
FI85974B (fi)	1992-03-13
NO164293C (no)	1990-09-19
US4665226A (en)	1987-05-12
NO164293B (no)	1990-06-11
EP0226161A1 (en)	1987-06-24
IE59499B1 (en)	1994-03-09
NO864933D0 (no)	1986-12-08
PT83888A (en)	1987-01-01
HK112193A (en)	1993-10-29
JPS62138447A (ja)	1987-06-22
IL80885A (en)	1991-04-15
AU6560686A (en)	1987-06-11
DE3666805D1 (en)	1989-12-14
KR950003120B1 (ko)	1995-04-01
ATE47832T1 (de)	1989-11-15
IL80885A0 (en)	1987-03-31
DK588286A (da)	1987-06-10
PH24273A (en)	1990-05-29
ES2011245B3 (es)	1990-01-01
CA1267155A (en)	1990-03-27
EP0226161B1 (en)	1989-11-08
IE863060L (en)	1987-06-09
CN1012896B (zh)	1991-06-19
JP2506094B2 (ja)	1996-06-12
AU590358B2 (en)	1989-11-02
KR870005954A (ko)	1987-07-08
FI864900A0 (fi)	1986-12-01
ZA868893B (en)	1988-07-27
NO864933L (no)	1987-06-10
GR3000216T3 (en)	1990-12-31

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Legal Events

Date	Code	Title	Description
2004-08-09	PBP	Patent lapsed	Country of ref document: DK