DK595383A - C-3''-alkylerede oleandomycin-derivater og 10- og 4''-epi-derivater deraf samt fremgangsmaade til fremstilling deraf - Google Patents

C-3''-alkylerede oleandomycin-derivater og 10- og 4''-epi-derivater deraf samt fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number: DK595383A
Authority: DK; Denmark
Prior art keywords: derivatives; alkylated; preparing; procedure; oleandomycin
Prior art date: 1982-12-27

Application number

DK595383A

Other languages

English (en)

Other versions

DK595383D0 (da

Inventor

Arthur Adam Nagel

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-27

Filing date

1983-12-23

Publication date

1984-06-28

1983-12-23 Application filed by Pfizer filed Critical Pfizer

1983-12-23 Publication of DK595383D0 publication Critical patent/DK595383D0/da

1984-06-28 Publication of DK595383A publication Critical patent/DK595383A/da

Links

238000000034 method Methods 0.000 title abstract 2
RZPAKFUAFGMUPI-UHFFFAOYSA-N Oleandomycin Natural products O1C(C)C(O)C(OC)CC1OC1C(C)C(=O)OC(C)C(C)C(O)C(C)C(=O)C2(OC2)CC(C)C(OC2C(C(CC(C)O2)N(C)C)O)C1C RZPAKFUAFGMUPI-UHFFFAOYSA-N 0.000 abstract 1
239000004104 Oleandomycin Substances 0.000 abstract 1
230000029936 alkylation Effects 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
239000003242 anti bacterial agent Chemical group 0.000 abstract 1
RZPAKFUAFGMUPI-KGIGTXTPSA-N oleandomycin Chemical group O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C RZPAKFUAFGMUPI-KGIGTXTPSA-N 0.000 abstract 1
229960002351 oleandomycin Drugs 0.000 abstract 1
235000019367 oleandomycin Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK595383A 1982-12-27 1983-12-23 C-3''-alkylerede oleandomycin-derivater og 10- og 4''-epi-derivater deraf samt fremgangsmaade til fremstilling deraf DK595383A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/453,255 US4429116A (en)	1982-12-27	1982-12-27	Alkylated oleandomycin containing compounds

Publications (2)

Publication Number	Publication Date
DK595383D0 DK595383D0 (da)	1983-12-23
DK595383A true DK595383A (da)	1984-06-28

Family

ID=23799805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK595383A DK595383A (da)	1982-12-27	1983-12-23	C-3''-alkylerede oleandomycin-derivater og 10- og 4''-epi-derivater deraf samt fremgangsmaade til fremstilling deraf

Country Status (8)

Country	Link
US (1)	US4429116A (da)
EP (1)	EP0114486B1 (da)
JP (1)	JPS59130898A (da)
AT (1)	ATE47397T1 (da)
DE (1)	DE3380732D1 (da)
DK (1)	DK595383A (da)
GR (1)	GR79138B (da)
IE (1)	IE56567B1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL75908A0 (en) *	1984-08-31	1985-12-31	Abbott Lab	Macrolide alkylation process
US4640910A (en) *	1985-11-12	1987-02-03	Abbott Laboratories	Erythromycin A silylated compounds and method of use
SI9010556B (sl) *	1990-03-21	1998-10-31	Pliva	Oleandomicin oksimi in postopek za njihovo pripravo
JPH0731923U (ja) *	1993-11-18	1995-06-16	株式会社ユタカ装工	支柱連結部における連結構造およびこれを用いた石柱連結構造
US9486467B2 (en)	2006-06-12	2016-11-08	Ramot At Tel-Aviv University Ltd.	Method of treating colorectal cancer that expresses a mutated APC gene by administering erythromycin or tylosin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2757123A (en)	1955-06-29	1956-07-31	Pfizer & Co C	Oleandomycin, its salts and production
US3022219A (en)	1958-03-07	1962-02-20	Pfizer & Co C	Acyl esters of oleandomycin
US3884903A (en)	1973-06-21	1975-05-20	Abbott Lab	4{41 -Deoxy-4{41 -oxoerythromycin B derivatives
US4125705A (en)	1977-02-04	1978-11-14	Pfizer Inc.	Semi-synthetic 4-amino-oleandomycin derivatives
US4180654A (en) *	1978-01-03	1979-12-25	Pfizer Inc.	4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate
US4336368A (en) *	1981-04-20	1982-06-22	Pfizer Inc.	4 Deoxy-4-methylene oleandomycin and derivatives thereof

1982
- 1982-12-27 US US06/453,255 patent/US4429116A/en not_active Expired - Lifetime
1983
- 1983-12-16 DE DE8383307666T patent/DE3380732D1/de not_active Expired
- 1983-12-16 EP EP83307666A patent/EP0114486B1/en not_active Expired
- 1983-12-16 AT AT83307666T patent/ATE47397T1/de active
- 1983-12-22 GR GR73340A patent/GR79138B/el unknown
- 1983-12-23 DK DK595383A patent/DK595383A/da not_active Application Discontinuation
- 1983-12-23 IE IE3065/83A patent/IE56567B1/en not_active IP Right Cessation
- 1983-12-27 JP JP58252428A patent/JPS59130898A/ja active Pending

Also Published As

Publication number	Publication date
EP0114486B1 (en)	1989-10-18
DE3380732D1 (en)	1989-11-23
EP0114486A2 (en)	1984-08-01
IE833065L (en)	1984-06-27
IE56567B1 (en)	1991-09-11
DK595383D0 (da)	1983-12-23
EP0114486A3 (en)	1984-12-12
US4429116A (en)	1984-01-31
JPS59130898A (ja)	1984-07-27
GR79138B (da)	1984-10-02
ATE47397T1 (de)	1989-11-15

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Legal Events

Date	Code	Title	Description
1990-02-26	AHS	Application shelved for other reasons than non-payment