DK599788A - Fremstilling af proteiner - Google Patents
Fremstilling af proteinerInfo
- Publication number
- DK599788A DK599788A DK599788A DK599788A DK599788A DK 599788 A DK599788 A DK 599788A DK 599788 A DK599788 A DK 599788A DK 599788 A DK599788 A DK 599788A DK 599788 A DK599788 A DK 599788A
- Authority
- DK
- Denmark
- Prior art keywords
- dna sequence
- polypeptide
- defect
- disclosed
- sequence encoding
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000007547 defect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 150000002482 oligosaccharides Polymers 0.000 abstract 1
- 230000003204 osmotic effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Electrotherapy Devices (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11609587A | 1987-10-29 | 1987-10-29 | |
| US07/189,547 US5135854A (en) | 1987-10-29 | 1988-05-03 | Methods of regulating protein glycosylation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK599788D0 DK599788D0 (da) | 1988-10-28 |
| DK599788A true DK599788A (da) | 1989-04-30 |
Family
ID=26813889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK599788A DK599788A (da) | 1987-10-29 | 1988-10-28 | Fremstilling af proteiner |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0314096B1 (de) |
| JP (1) | JPH02419A (de) |
| AT (1) | ATE100142T1 (de) |
| AU (1) | AU625392B2 (de) |
| CA (1) | CA1325781C (de) |
| DE (1) | DE3887082T2 (de) |
| DK (1) | DK599788A (de) |
| FI (1) | FI100408B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2022108A1 (en) * | 1989-07-31 | 1991-02-01 | Cheryl A. Schulman | Enhanced growth and expression of heterologous proteins in recombinant hosts containing mutations in cell wall and/or plasma membrane biosynthesis |
| CA2022109A1 (en) * | 1989-07-31 | 1991-02-01 | Cheryl A. Schulman | Enhanced expression of heterologous proteins in recombinant hosts in a non-growth media |
| AU8106091A (en) * | 1990-06-08 | 1991-12-31 | Zymogenetics Inc. | Barrier protease |
| IL101653A0 (en) * | 1991-04-29 | 1992-12-30 | Merck & Co Inc | Multiple hepatitis b virus surface proteins which form particles |
| IL101651A0 (en) * | 1991-04-29 | 1992-12-30 | Merck & Co Inc | Hepatitis b virus surface proteins with reduced host carbohydrate content |
| WO1994001132A1 (en) * | 1992-07-07 | 1994-01-20 | Merck & Co., Inc. | VACCINE COMPRISING MIXED preS1+preS2+S AND CORE PARTICLE |
| DE4301932A1 (de) * | 1992-08-07 | 1994-02-10 | Boehringer Mannheim Gmbh | Hefewirtsstämme mit Defekten in der N-Glycosylierung |
| SE9301583D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Yeast strain and methods for expressing heterologous proteins in yeast |
| EP2028275A3 (de) | 2000-06-30 | 2009-05-06 | VIB vzw | Modifikation der Proteinglycosylierung in Pichia Pastoris |
| JP4464269B2 (ja) * | 2002-04-26 | 2010-05-19 | 協和発酵キリン株式会社 | 哺乳類型糖鎖生産メチロトロフ酵母 |
| US7507573B2 (en) | 2003-11-14 | 2009-03-24 | Vib, Vzw | Modification of protein glycosylation in methylotrophic yeast |
| WO2006026992A1 (en) * | 2004-09-07 | 2006-03-16 | Novozymes A/S | Altered structure of n-glycans in a fungus |
| CN100351381C (zh) * | 2005-09-02 | 2007-11-28 | 中山大学 | 一种新的类凝血酶基因及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3537176C2 (de) * | 1984-10-18 | 1994-06-09 | Zymogenetics Inc | Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung |
-
1988
- 1988-10-26 AU AU24356/88A patent/AU625392B2/en not_active Ceased
- 1988-10-26 AT AT88117834T patent/ATE100142T1/de not_active IP Right Cessation
- 1988-10-26 EP EP88117834A patent/EP0314096B1/de not_active Expired - Lifetime
- 1988-10-26 DE DE88117834T patent/DE3887082T2/de not_active Expired - Fee Related
- 1988-10-28 CA CA000581625A patent/CA1325781C/en not_active Expired - Fee Related
- 1988-10-28 DK DK599788A patent/DK599788A/da not_active Application Discontinuation
- 1988-10-28 FI FI884991A patent/FI100408B/fi not_active IP Right Cessation
- 1988-10-29 JP JP63272004A patent/JPH02419A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3887082D1 (de) | 1994-02-24 |
| DE3887082T2 (de) | 1994-04-28 |
| AU625392B2 (en) | 1992-07-09 |
| AU2435688A (en) | 1989-05-11 |
| FI884991L (fi) | 1989-04-30 |
| EP0314096B1 (de) | 1994-01-12 |
| ATE100142T1 (de) | 1994-01-15 |
| DK599788D0 (da) | 1988-10-28 |
| JPH02419A (ja) | 1990-01-05 |
| FI100408B (fi) | 1997-11-28 |
| CA1325781C (en) | 1994-01-04 |
| EP0314096A2 (de) | 1989-05-03 |
| FI884991A0 (fi) | 1988-10-28 |
| EP0314096A3 (en) | 1989-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |