DK614487A - 5-substituerede imidazolidindion-forbindelser og farmaceutiske praeparater indeholdende disse - Google Patents

5-substituerede imidazolidindion-forbindelser og farmaceutiske praeparater indeholdende disse

Info

Publication number: DK614487A
Authority: DK; Denmark
Prior art keywords: compounds; trifluoromethyl; bromine; chlorine; fluorine
Prior art date: 1986-11-24

Application number

DK614487A

Other languages

English (en)

Other versions

DK614487D0 (da

Inventor

Reinhard Sarges

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-24

Filing date

1987-11-23

Publication date

1988-05-25

1987-11-23 Application filed by Pfizer filed Critical Pfizer

1987-11-23 Publication of DK614487D0 publication Critical patent/DK614487D0/da

1988-05-25 Publication of DK614487A publication Critical patent/DK614487A/da

Links

-1 5-SUBSTITUTED IMIDAZOLIDE INDION COMPOUNDS Chemical class 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 3
229910052794 bromium Inorganic materials 0.000 abstract 3
229910052801 chlorine Inorganic materials 0.000 abstract 3
239000000460 chlorine Chemical group 0.000 abstract 3
229910052731 fluorine Inorganic materials 0.000 abstract 3
239000011737 fluorine Chemical group 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000003884 phenylalkyl group Chemical group 0.000 abstract 2
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cosmetics (AREA)
External Artificial Organs (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK614487A 1986-11-24 1987-11-23 5-substituerede imidazolidindion-forbindelser og farmaceutiske praeparater indeholdende disse DK614487A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1986/002514 WO1993013092A1 (en)	1986-11-24	1986-11-24	Imidazolidinedione derivatives

Publications (2)

Publication Number	Publication Date
DK614487D0 DK614487D0 (da)	1987-11-23
DK614487A true DK614487A (da)	1988-05-25

Family

ID=22195719

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK614487A DK614487A (da)	1986-11-24	1987-11-23	5-substituerede imidazolidindion-forbindelser og farmaceutiske praeparater indeholdende disse

Country Status (10)

Country	Link
US (1)	US5011840A (da)
EP (1)	EP0269355B1 (da)
JP (1)	JPS63150278A (da)
AT (1)	ATE62482T1 (da)
DE (1)	DE3769286D1 (da)
DK (1)	DK614487A (da)
ES (1)	ES2031520T3 (da)
GR (1)	GR3001765T3 (da)
PT (1)	PT86183B (da)
WO (1)	WO1993013092A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3120857B2 (ja) *	1990-02-19	2000-12-25	中外製薬株式会社	新規な縮合複素環化合物とこれを用いた抗喘息剤
US5202318A (en) *	1990-05-14	1993-04-13	Syntex (U.S.A.) Inc.	Tricyclic compounds acting at serotonin receptor subtypes
US6555573B2 (en) *	2000-12-21	2003-04-29	The Quigley Corporation	Method and composition for the topical treatment of diabetic neuropathy
US7435725B2 (en) *	2001-11-06	2008-10-14	The Quigly Corporation	Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030105027A1 (en) *	2001-11-06	2003-06-05	Rosenbloom Richard A.	Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
DE10210195B4 (de)	2002-03-07	2005-12-15	Schwarz Pharma Ag	Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
US7083813B2 (en) *	2002-11-06	2006-08-01	The Quigley Corporation	Methods for the treatment of peripheral neural and vascular ailments
US20090018151A1 (en) *	2007-02-23	2009-01-15	Ezekiel Fink	Topical Treatment of Peripheral diabetic complications

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3798224A (en) *	1969-12-30	1974-03-19	Sumitomo Chemical Co	Naphthalimide hydrazinamides
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
US4139532A (en) *	1976-05-14	1979-02-13	Basf Aktiengesellschaft	N-Acylaminonaphthalimides
IE47592B1 (en) *	1977-12-29	1984-05-02	Ici Ltd	Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4209527A (en) *	1979-05-16	1980-06-24	Pfizer Inc.	Benzimidazolone derivatives
US4521416A (en) *	1983-03-22	1985-06-04	Warner-Lambert Company	4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones
EP0169050A3 (en) *	1984-07-17	1986-12-10	Eli Lilly And Company	Pyridazinylimidazolidinone compounds
US4782064A (en) *	1986-07-21	1988-11-01	American Cyanamid Co.	2-heteroaryl-alkyl-1H-benz[de]-isoquinoline-1,3(2H)-diones

1986
- 1986-11-24 WO PCT/US1986/002514 patent/WO1993013092A1/en not_active Ceased
- 1986-11-24 US US07/435,529 patent/US5011840A/en not_active Expired - Lifetime
1987
- 1987-11-18 EP EP87310147A patent/EP0269355B1/en not_active Expired - Lifetime
- 1987-11-18 AT AT87310147T patent/ATE62482T1/de not_active IP Right Cessation
- 1987-11-18 DE DE8787310147T patent/DE3769286D1/de not_active Expired - Lifetime
- 1987-11-18 ES ES198787310147T patent/ES2031520T3/es not_active Expired - Lifetime
- 1987-11-20 PT PT86183A patent/PT86183B/pt not_active IP Right Cessation
- 1987-11-23 DK DK614487A patent/DK614487A/da not_active Application Discontinuation
- 1987-11-24 JP JP62295913A patent/JPS63150278A/ja active Pending
1991
- 1991-04-11 GR GR91400453T patent/GR3001765T3/el unknown

Also Published As

Publication number	Publication date
PT86183A (en)	1987-12-01
DE3769286D1 (de)	1991-05-16
EP0269355B1 (en)	1991-04-10
PT86183B (pt)	1990-11-07
JPS63150278A (ja)	1988-06-22
WO1993013092A1 (en)	1993-07-08
ES2031520T3 (es)	1992-12-16
US5011840A (en)	1991-04-30
DK614487D0 (da)	1987-11-23
GR3001765T3 (en)	1992-11-23
EP0269355A1 (en)	1988-06-01
ATE62482T1 (de)	1991-04-15

Legal Events

Date	Code	Title	Description
1992-07-27	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
NO305987B1 (no)	1999-08-30	Heterosykliske forbindelser med antidiabetisk aktivitet, deres anvendelse og farmasoeytisk preparat inneholdende disse
FI953968A0 (fi)	1995-08-23	Antraniiliset happojohdannaiset
ATE141589T1 (de)	1996-09-15	Alkoxyiminoacetamid-derivate und ihre verwendung als pilztötendes mittel
DK0846686T3 (da)	2002-03-25	1-phenylpyrazolderivater og deres anvendelse som parasiticide midler
FI894066A0 (fi)	1989-08-30	Depressionshaemmande n-substituerade nikotinamidfoereningar.
TR200302047T4 (tr)	2004-01-21	Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri.
DE69028934D1 (de)	1996-11-28	Tetrahydrobenzimidazol-Derivate
ES8505652A1 (es)	1985-06-01	Procedimiento para preparar nuevas 1-bencil-aminoalquil-pirrolidinonas
DK614487D0 (da)	1987-11-23	5-substituerede imidazolidindion-forbindelser og farmaceutiske praeparater indeholdende disse
DE69414019D1 (de)	1998-11-26	Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren
NO892170D0 (no)	1989-05-30	Buten- eller propensyrederivater og fremgangsmaate for deres fremstilling.
DE3776044D1 (de)	1992-02-27	Pyridazinon-derivate.
DK147588A (da)	1988-09-19	Benzoxazinderivat samt fremgangsmaade til fremstilling deraf
ATE504572T1 (de)	2011-04-15	Derivate von aromatische heterocyclen enthaltende integraseinhibitoren
ATE140229T1 (de)	1996-07-15	Benzoxazepinon-verfahren
DE69526413D1 (de)	2002-05-23	Heterocyclische Carboxyalkylderivate
ES2193168T3 (es)	2003-11-01	Nuevos derivados de acido parabanico como inhibidores de aldosa reductasa.
DK0475352T3 (da)	1995-10-16	3-(1H-Indazol-3-yl)-4-pyridinaminer, fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler
ATE71378T1 (de)	1992-01-15	Purin-histamin-h1-antagonisten, ihre herstellung und sie enthaltende pharmazeutische praeparate.