DK619086A - GM-CSF PROTEIN, DERIVATIVES THEREOF, AND MANUFACTURE AND USE OF SUCH PROTEINS - Google Patents

GM-CSF PROTEIN, DERIVATIVES THEREOF, AND MANUFACTURE AND USE OF SUCH PROTEINS

Info

Publication number
DK619086A
DK619086A DK619086A DK619086A DK619086A DK 619086 A DK619086 A DK 619086A DK 619086 A DK619086 A DK 619086A DK 619086 A DK619086 A DK 619086A DK 619086 A DK619086 A DK 619086A
Authority
DK
Denmark
Prior art keywords
proteins
derivatives
manufacture
csf protein
csf
Prior art date
Application number
DK619086A
Other languages
Danish (da)
Other versions
DK170346B1 (en
DK619086D0 (en
Inventor
Paul Habermann
Hubert Muellner
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK619086D0 publication Critical patent/DK619086D0/en
Publication of DK619086A publication Critical patent/DK619086A/en
Application granted granted Critical
Publication of DK170346B1 publication Critical patent/DK170346B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

CSF proteins which are biologically active are obtained by expression of a gene coding for human granulocyte macrophage colony stimulating factor (CSF) in bacteria. Biologically active derivatives with a modified amino acid sequence are obtained by altering the natural or synthetic gene structure.
DK619086A 1985-12-21 1986-12-19 Granulocyte Macrophage Colony Stimulating Factor (CSF) Proteins, Method for Preparation thereof, Expression Vector and E.coli Cell for Use in This Method and Using These Proteins DK170346B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3545568 1985-12-21
DE19853545568 DE3545568A1 (en) 1985-12-21 1985-12-21 GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE

Publications (3)

Publication Number Publication Date
DK619086D0 DK619086D0 (en) 1986-12-19
DK619086A true DK619086A (en) 1987-06-22
DK170346B1 DK170346B1 (en) 1995-08-07

Family

ID=6289242

Family Applications (1)

Application Number Title Priority Date Filing Date
DK619086A DK170346B1 (en) 1985-12-21 1986-12-19 Granulocyte Macrophage Colony Stimulating Factor (CSF) Proteins, Method for Preparation thereof, Expression Vector and E.coli Cell for Use in This Method and Using These Proteins

Country Status (17)

Country Link
EP (1) EP0228018B1 (en)
JP (1) JP2575367B2 (en)
KR (1) KR940005585B1 (en)
AT (1) ATE71144T1 (en)
AU (2) AU601959B2 (en)
CA (1) CA1341197C (en)
DE (2) DE3545568A1 (en)
DK (1) DK170346B1 (en)
ES (1) ES2055686T3 (en)
FI (1) FI91168C (en)
GR (1) GR3003999T3 (en)
HU (1) HU202584B (en)
IE (1) IE59779B1 (en)
IL (1) IL81020A (en)
NO (1) NO177270C (en)
PT (1) PT83972B (en)
ZA (1) ZA869557B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078996A (en) * 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
EP0238655A4 (en) * 1985-10-03 1989-09-11 Biogen Nv Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells.
DE3712985A1 (en) * 1987-04-16 1988-11-03 Hoechst Ag BIFUNCTIONAL PROTEINS
US5359035A (en) * 1985-12-21 1994-10-25 Hoechst Aktiengesellschaft Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
JP2583770B2 (en) * 1986-09-17 1997-02-19 大塚製薬株式会社 gene
JPS6420097A (en) * 1987-03-02 1989-01-24 Sumitomo Chemical Co Human granulocyte-macrophage colony stimulating factor
PT87133B (en) * 1987-04-02 1992-07-31 Amrad Corp Ltd METHOD OF PURIFICATION OF THE LEUKEMIA INHIBITOR FACTOR (LIF) AND PHARMACEUTICAL COMPOSITIONS CONTAINING POLIPEPTIDES WITH LIF ACTIVITY
AU609128B2 (en) * 1987-04-02 1991-04-26 Amrad Operations Pty. Limited Leukaemia-inhibitory factor
WO1988010310A1 (en) * 1987-06-25 1988-12-29 Immunex Corporation Bovine granulocyte-macrophage colony stimulating factor
EP0318184A1 (en) * 1987-11-12 1989-05-31 Schering Corporation Acceleration of bone formation with GM-CSF
GB2212159B (en) * 1987-11-13 1992-01-22 British Bio Technology Synthetic gene for human granulocyte/macrophage colony stimulating factor.
WO1989010403A1 (en) * 1988-04-21 1989-11-02 Medvet Science Pty. Ltd. Human gm-csf variants
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
JP3115318B2 (en) * 1989-08-22 2000-12-04 イミュネックス・コーポレーション Fusion protein containing GM-CSF and IL-3
NZ236819A (en) * 1990-02-03 1993-07-27 Max Planck Gesellschaft Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions
US5270181A (en) * 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
WO1997012054A1 (en) * 1995-09-28 1997-04-03 Otsuka Pharmaceutical Co., Ltd. Neutrophil chemotactic lymphokine, and drug and kit for the diagnosis of drug hypersensitive granulocytopenia containing the same
RU2144083C1 (en) * 1998-03-13 2000-01-10 Государственный научный центр вирусологии и биотехнологии "Вектор" Method of industrial producing human recombinant granulocyte-macrophage colony-stimulating factor
KR100448021B1 (en) * 2001-12-28 2004-09-08 크레아젠 주식회사 Transgenic Escherichia coli transformed with pGM-CSF vector expressing recombinant mouse granulocyte-macrophage colony stimulating factor and method for mass production of the recombinant protein
US9157084B2 (en) 2009-12-23 2015-10-13 Gradalis, Inc. Furin-knockdown bi-functional RNA
EP2515916B1 (en) * 2009-12-23 2016-03-09 Gradalis, Inc. Furin-knockdown and gm-csf-augmented (fang) cancer vaccine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
SE8300693L (en) * 1983-02-09 1984-08-10 Sven Lofdahl SET TO MAKE AND ISOLATE PROTEINS AND POLYPEPTIDES, AND A HYBRID VECTOR FOR THIS
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of mature human IGF and EGF via prokaryotic recombinant DNA technology
AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
NZ212645A (en) * 1984-07-06 1990-02-26 Sandoz Ltd Method for producing primate granulocyte-macrophage colony stimulating factor (gm-csf)
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
ZA856108B (en) * 1984-10-29 1986-10-29 Immunex Corp Cloning of human granulocyte-macrophage colony simulating factor gene
EP0202300B1 (en) * 1984-11-20 1992-11-11 Schering Biotech Corporation Cdna clones coding for polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity
EP0238655A4 (en) * 1985-10-03 1989-09-11 Biogen Nv Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells.
DE3541856A1 (en) * 1985-11-27 1987-06-04 Hoechst Ag EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS
DE3636903A1 (en) * 1985-12-21 1987-07-02 Hoechst Ag FUSION PROTEINS WITH EUKARYOTIC BALLASTES

Also Published As

Publication number Publication date
NO177270B (en) 1995-05-08
HUT44615A (en) 1988-03-28
FI865186A0 (en) 1986-12-18
ES2055686T3 (en) 1994-09-01
KR870006188A (en) 1987-07-09
KR940005585B1 (en) 1994-06-21
FI91168C (en) 1994-05-25
PT83972A (en) 1987-01-01
NO177270C (en) 1995-08-16
ZA869557B (en) 1987-10-28
IE59779B1 (en) 1994-04-06
GR3003999T3 (en) 1993-03-16
AU6675686A (en) 1987-06-25
DK170346B1 (en) 1995-08-07
JP2575367B2 (en) 1997-01-22
FI865186L (en) 1987-06-22
PT83972B (en) 1989-07-31
IL81020A (en) 1995-11-27
IL81020A0 (en) 1987-03-31
HU202584B (en) 1991-03-28
CA1341197C (en) 2001-03-06
AU6268390A (en) 1990-12-13
AU601959B2 (en) 1990-09-27
EP0228018A2 (en) 1987-07-08
NO865191L (en) 1987-06-22
DE3545568A1 (en) 1987-07-16
DE3683267D1 (en) 1992-02-13
DK619086D0 (en) 1986-12-19
FI91168B (en) 1994-02-15
NO865191D0 (en) 1986-12-19
ATE71144T1 (en) 1992-01-15
EP0228018B1 (en) 1992-01-02
JPS62164695A (en) 1987-07-21
AU637139B2 (en) 1993-05-20
IE863335L (en) 1987-06-21
EP0228018A3 (en) 1987-12-02

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed