DK627687A - Hirudinvariant - Google Patents

Hirudinvariant

Info

Publication number: DK627687A
Authority: DK; Denmark
Prior art keywords: hirudin; amino acid; hirudine; variants; natural form
Prior art date: 1986-12-01

Application number

DK627687A

Other languages

English (en)

Other versions

DK627687D0 (da

DK173247B1 (da

Inventor

Michael Courtney

Eric Degryse

Gerard Loison

Yves Lemoine

Original Assignee

Transgene Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-01

Filing date

1987-11-30

Publication date

1988-06-02

1987-11-30 Application filed by Transgene Sa filed Critical Transgene Sa

1987-11-30 Publication of DK627687D0 publication Critical patent/DK627687D0/da

1988-06-02 Publication of DK627687A publication Critical patent/DK627687A/da

2000-05-22 Application granted granted Critical

2000-05-22 Publication of DK173247B1 publication Critical patent/DK173247B1/da

Links

102000007625 Hirudins Human genes 0.000 title 1
108010007267 Hirudins Proteins 0.000 title 1
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title 1
229940006607 hirudin Drugs 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Tropical Medicine & Parasitology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Cosmetics (AREA)

DK198706276A 1986-12-01 1987-11-30 Varianter af hirudin HV2, disse varianter til anvendelse som lægemiddel, specielt som thrombinihibitorer, et præparat til a DK173247B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8616723		1986-12-01
FR868616723A FR2607517B2 (fr)	1986-12-01	1986-12-01	Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu

Publications (3)

Publication Number	Publication Date
DK627687D0 DK627687D0 (da)	1987-11-30
DK627687A true DK627687A (da)	1988-06-02
DK173247B1 DK173247B1 (da)	2000-05-22

Family

ID=9341393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198706276A DK173247B1 (da)	1986-12-01	1987-11-30	Varianter af hirudin HV2, disse varianter til anvendelse som lægemiddel, specielt som thrombinihibitorer, et præparat til a

Country Status (24)

Country	Link
US (1)	US5650301A (da)
EP (1)	EP0273800B1 (da)
JP (1)	JP2567263B2 (da)
KR (1)	KR960011918B1 (da)
AT (1)	ATE73462T1 (da)
AU (1)	AU617989B2 (da)
BG (1)	BG49719A3 (da)
CA (1)	CA1341416C (da)
CS (1)	CS276245B6 (da)
DE (1)	DE3777367D1 (da)
DK (1)	DK173247B1 (da)
ES (1)	ES2032465T3 (da)
FI (1)	FI99211C (da)
FR (1)	FR2607517B2 (da)
GR (1)	GR3004556T3 (da)
HU (1)	HU213871B (da)
IE (1)	IE60544B1 (da)
MC (1)	MC1884A1 (da)
NO (1)	NO177500C (da)
PL (1)	PL157254B1 (da)
PT (1)	PT86233B (da)
RO (1)	RO106890B1 (da)
SU (1)	SU1687032A3 (da)
ZA (1)	ZA879011B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2628429B1 (fr) *	1988-03-08	1990-12-28	Transgene Sa	Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
GB8817161D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Modified proteins
GB8817160D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Novel proteins
US5284768A (en) *	1988-08-24	1994-02-08	Sanofi	Signal peptide, DNA sequences coding for the latter, expression vectors carrying one of these sequences, gram-negative bacteria transformed by these vectors, and process for the periplasmic production of a polypeptide
US5879926A (en) *	1989-03-31	1999-03-09	Transgene S.A.	Yeast strains for the production of mature heterologous proteins, especially hirudin
FR2645175B1 (fr) *	1989-03-31	1994-02-18	Transgene Sa	Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche
FR2645174B1 (fr) *	1989-03-31	1994-01-07	Transgene Sa	Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant
FR2646437B1 (fr) *	1989-04-28	1991-08-30	Transgene Sa	Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
FR2656531B1 (fr) *	1989-12-29	1992-04-24	Sanofi Sa	Promoteur artificiel pour l'expression de proteines dans le levure.
US5118790A (en) *	1990-07-24	1992-06-02	Sri International	Analogs of hirudin
ATE176500T1 (de) *	1990-11-08	1999-02-15	Japan Energy Corp	Sekretionsvektor, diesen enthaltene transformierte mikroorganismen und herstellung von produkten durch obigen mikroorganismus
US5837808A (en) *	1991-08-20	1998-11-17	Baxter International Inc.	Analogs of hirudin
US5407822A (en) *	1991-10-02	1995-04-18	Sanofi	Artificial promoter for the expression of proteins in yeast
US12466852B2 (en)	2019-04-16	2025-11-11	Sungen Bioscience Co., Ltd.	Method for extraction and purification of hirudin mutant and use thereof
WO2025262265A1 (en)	2024-06-21	2025-12-26	Etablissement Francais Du Sang	Chimeric molecules comprising an anti-fibrin antibody and an antithrombotic molecule

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3586333T2 (de) *	1984-03-27	1992-12-10	Transgene Sa	Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin.
DE3583361D1 (de) *	1984-06-14	1991-08-08	Ucp Gen Pharma Ag	Verfahren zur herstellung von thrombin-inhibitoren.
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
EP0209061B1 (de) *	1985-07-17	1994-01-12	Hoechst Aktiengesellschaft	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel

1986
- 1986-12-01 FR FR868616723A patent/FR2607517B2/fr not_active Expired
1987
- 1987-11-25 NO NO874905A patent/NO177500C/no not_active IP Right Cessation
- 1987-11-27 IE IE323987A patent/IE60544B1/en not_active IP Right Cessation
- 1987-11-27 AU AU81880/87A patent/AU617989B2/en not_active Expired
- 1987-11-27 PT PT86233A patent/PT86233B/pt unknown
- 1987-11-30 DE DE8787402696T patent/DE3777367D1/de not_active Expired - Lifetime
- 1987-11-30 DK DK198706276A patent/DK173247B1/da not_active IP Right Cessation
- 1987-11-30 EP EP87402696A patent/EP0273800B1/fr not_active Expired - Lifetime
- 1987-11-30 AT AT87402696T patent/ATE73462T1/de not_active IP Right Cessation
- 1987-11-30 ES ES198787402696T patent/ES2032465T3/es not_active Expired - Lifetime
- 1987-11-30 CA CA000553153A patent/CA1341416C/fr not_active Expired - Fee Related
- 1987-11-30 SU SU874203831A patent/SU1687032A3/ru active
- 1987-11-30 RO RO130679A patent/RO106890B1/ro unknown
- 1987-12-01 CS CS878732A patent/CS276245B6/cs not_active IP Right Cessation
- 1987-12-01 ZA ZA879011A patent/ZA879011B/xx unknown
- 1987-12-01 FI FI875295A patent/FI99211C/fi not_active IP Right Cessation
- 1987-12-01 JP JP62305504A patent/JP2567263B2/ja not_active Expired - Lifetime
- 1987-12-01 PL PL1987269164A patent/PL157254B1/pl unknown
- 1987-12-01 KR KR1019870013708A patent/KR960011918B1/ko not_active Expired - Fee Related
- 1987-12-01 BG BG082035A patent/BG49719A3/xx unknown
- 1987-12-01 HU HU875394A patent/HU213871B/hu unknown
- 1987-12-01 MC MC871932A patent/MC1884A1/fr unknown
1992
- 1992-05-12 GR GR920400903T patent/GR3004556T3/el unknown
1995
- 1995-06-07 US US08/480,511 patent/US5650301A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3777367D1 (de)	1992-04-16
HUT45564A (en)	1988-07-28
SU1687032A3 (ru)	1991-10-23
EP0273800B1 (fr)	1992-03-11
ZA879011B (en)	1988-05-27
CS276245B6 (en)	1992-05-13
FI99211B (fi)	1997-07-15
CS8708732A2 (en)	1991-07-16
DK627687D0 (da)	1987-11-30
RO106890B1 (ro)	1993-07-30
PT86233B (pt)	1990-11-07
PL157254B1 (pl)	1992-05-29
NO177500B (no)	1995-06-19
KR960011918B1 (ko)	1996-09-04
NO177500C (no)	1995-09-27
NO874905D0 (no)	1987-11-25
EP0273800A2 (fr)	1988-07-06
BG49719A3 (bg)	1992-01-15
MC1884A1 (fr)	1989-01-24
US5650301A (en)	1997-07-22
ES2032465T3 (es)	1993-02-16
ATE73462T1 (de)	1992-03-15
FI99211C (fi)	1997-10-27
JPS63152987A (ja)	1988-06-25
CA1341416C (fr)	2003-01-21
DK173247B1 (da)	2000-05-22
FR2607517A2 (fr)	1988-06-03
AU617989B2 (en)	1991-12-12
JP2567263B2 (ja)	1996-12-25
PT86233A (fr)	1987-12-01
GR3004556T3 (da)	1993-04-28
IE873239L (en)	1988-06-01
NO874905L (no)	1988-06-02
FI875295L (fi)	1988-06-02
FI875295A0 (fi)	1987-12-01
EP0273800A3 (en)	1988-07-20
HU213871B (en)	1997-11-28
FR2607517B2 (fr)	1989-12-22
IE60544B1 (en)	1994-07-27
PL269164A1 (en)	1988-08-18
AU8188087A (en)	1988-06-02
KR880007729A (ko)	1988-08-29

Legal Events

Date	Code	Title	Description
2000-05-22	B1	Patent granted (law 1993)
2007-12-17	PUP	Patent expired

Publication	Publication Date	Title
DK340088D0 (da)	1988-06-21	Aminosyrederivater
DK627687D0 (da)	1987-11-30	Hirudinvariant
DK565987A (da)	1988-05-01	Substituerede aminosyrer
ATE82857T1 (de)	1992-12-15	Interleukin-2-zusammensetzungen.
ATE140962T1 (de)	1996-08-15	Dns-klone von menschlichem thrombomodulin
ATE86490T1 (de)	1993-03-15	Tracheobronchodilatator.
DK131087A (da)	1987-09-15	1,2,3,4-tetrahydro-6-substitueret-4-aryl-(eller -heterocyclo-)-3-substitueret-2-thioxo-/eller -oxo)-5-pyrimidincarboxylsyrer og estere
NO871053L (no)	1987-10-02	Anvendelse av substituerte n-triklormetyltiodikarboksimider i kombinasjon med n,n[-substituerte bis-(2,4-diamino-s-triazin-6-yl)-oligosulfider i vulkaniserbare kautsjukblandinger og slike kautsjukblandinger.
DK523288D0 (da)	1988-09-20	Aminosyrederivater
DE3787657D1 (de)	1993-11-11	Aminosäure-Derivate.
NO883960D0 (no)	1988-09-06	Arylcyklobutenylamidoalkensyrer og salter derav.
ATE81134T1 (de)	1992-10-15	Peptide.
IT8619594A0 (it)	1986-02-28	Acid 8-osso-2-ossa-1-azabiciclo 4.2.0 ottano-3-carbossilici.
TR23134A (tr)	1989-04-10	(2-siyano-2-(fenil veya naftil)-2-ikaameli-etil)pirazinler ve pridazinler
KR870008000U (ko)	1987-06-10	때밀이구
RO94121A2 (ro)	1988-03-30	Compozitie stabilizatoare emulsionabila pe baza de alchilarilfenoli
SE8700089D0 (sv)	1987-01-13	"klubbor"
KR870006196U (ko)	1987-05-06	어린이용 실내화
FI871626L (fi)	1988-10-15	Gjuten haestsko.
KR860012959U (ko)	1986-11-08	때밀이구
TR23120A (tr)	1989-04-03	Ensektisid olarak kullanilabilen n'-suebstituee edilmis-n-asil-n'-hidrazinler
KR880009390U (ko)	1988-07-22	때밀이구
KR890017172U (ko)	1989-09-06	때밀이구
ATE95518T1 (de)	1993-10-15	Aminosaeure-derivate.