DK630487A - Pyrrolderivater, deres fremstilling og farmaceutiske praeparater deraf - Google Patents

Pyrrolderivater, deres fremstilling og farmaceutiske praeparater deraf

Info

Publication number: DK630487A
Authority: DK; Denmark
Prior art keywords: alkyl; pyrrolidinyl; substituted; piperidyl; piperazinyl
Prior art date: 1986-12-02

Application number

DK630487A

Other languages

English (en)

Other versions

DK169969B1 (da

DK630487D0 (da

Inventor

Jean-Dominique Bourzat

Marc Capet

Claude Cotrel

Richard Labaudiniere

Philippe Pitchen

Gerard Roussel

Original Assignee

Rhone Poulenc Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-02

Filing date

1987-12-01

Publication date

1988-06-03

1987-12-01 Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante

1987-12-01 Publication of DK630487D0 publication Critical patent/DK630487D0/da

1988-06-03 Publication of DK630487A publication Critical patent/DK630487A/da

1995-04-18 Application granted granted Critical

1995-04-18 Publication of DK169969B1 publication Critical patent/DK169969B1/da

Links

GSSXLFACIJSBOM-UHFFFAOYSA-N 2h-pyran-2-ol Chemical compound OC1OC=CC=C1 GSSXLFACIJSBOM-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
-1 2-piperazinyl Chemical group 0.000 abstract 9
125000000217 alkyl group Chemical group 0.000 abstract 3
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
GSIQLKOFXMCKNK-UHFFFAOYSA-N 6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine Chemical compound C1=CN=C2CNCC2=N1 GSIQLKOFXMCKNK-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000005117 dialkylcarbamoyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical compound C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 abstract 1
150000003951 lactams Chemical group 0.000 abstract 1
125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
125000005936 piperidyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003233 pyrroles Chemical class 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Indole Compounds (AREA)
Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
Rolls And Other Rotary Bodies (AREA)

DK630487A 1986-12-02 1987-12-01 Isoindolinonderivater, fremgangsmåder til deres fremstilling og farmaceutiske præparater deraf DK169969B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8616796		1986-12-02
FR8616796A FR2607504B1 (fr)	1986-12-02	1986-12-02	Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number	Publication Date
DK630487D0 DK630487D0 (da)	1987-12-01
DK630487A true DK630487A (da)	1988-06-03
DK169969B1 DK169969B1 (da)	1995-04-18

Family

ID=9341443

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK630487A DK169969B1 (da)	1986-12-02	1987-12-01	Isoindolinonderivater, fremgangsmåder til deres fremstilling og farmaceutiske præparater deraf

Country Status (23)

Country	Link
EP (1)	EP0271404B1 (da)
JP (1)	JPS63154682A (da)
KR (1)	KR880007517A (da)
AT (1)	ATE66219T1 (da)
AU (1)	AU594215B2 (da)
CA (1)	CA1298295C (da)
DE (1)	DE3772172D1 (da)
DK (1)	DK169969B1 (da)
ES (1)	ES2038687T3 (da)
FI (1)	FI84723C (da)
FR (1)	FR2607504B1 (da)
GR (1)	GR3002490T3 (da)
HU (1)	HU197573B (da)
IE (1)	IE61089B1 (da)
IL (1)	IL84658A (da)
MA (1)	MA21118A1 (da)
MX (1)	MX9558A (da)
NO (1)	NO166037C (da)
NZ (1)	NZ222752A (da)
OA (1)	OA08696A (da)
PT (1)	PT86261B (da)
SU (3)	SU1616515A3 (da)
ZA (1)	ZA879001B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2607503B1 (fr) *	1986-12-02	1989-02-24	Rhone Poulenc Sante	Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2607506B1 (fr) *	1986-12-02	1989-01-06	Rhone Poulenc Sante	Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
CZ309617B6 (cs) *	2019-04-05	2023-05-24	Ústav organické chemie a biochemie AV ČR, v. v. i	3α5ß-Neuroaktivní steroidy pro léčbu epilepsie a záchvatových onemocnění

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2101081B1 (da) *	1970-08-19	1974-01-11	Rhone Poulenc Sa
OA04285A (fr) *	1972-01-07	1979-12-31	Rhone Poulenc Sa	Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
AR207555A1 (es) *	1972-12-04	1976-10-15		Procedimiento para preparar aril-6-piperazinocarboniloxi-5 oxo-7 tetrahidro-2,3,6,7 ditiino(1,4)(2,3-c)pirroles
ZA756953B (en) *	1974-11-07	1976-10-27	Rhone Poulenc Ind	1,4-oxathiino(2,3-c)pyrrole derivatives
AR208414A1 (es) *	1974-11-07	1976-12-27	Rhone Poulenc Ind	Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
DE3378763D1 (en) *	1982-04-02	1989-02-02	Takeda Chemical Industries Ltd	Condensed pyrrolinone derivatives, and their production
FR2559484B2 (fr) *	1983-07-06	1986-09-26	Provesan Sa	Nouveau derive 7-(pyrrol-1-yl) de l'acide 1-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridin)-3-carboxylique, sa preparation et son application en tant que medicament
CS274601B2 (en) *	1983-07-27	1991-09-15	Dainippon Pharmaceutical Co	Method of 1,8-naphthyridine derivative production
JPS6169773A (ja) *	1984-09-14	1986-04-10	Takeda Chem Ind Ltd	イソインドリノン誘導体
US4657913A (en) *	1985-04-18	1987-04-14	Warner-Lambert Company	Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
FR2607503B1 (fr) *	1986-12-02	1989-02-24	Rhone Poulenc Sante	Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2607506B1 (fr) *	1986-12-02	1989-01-06	Rhone Poulenc Sante	Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent

1986
- 1986-12-02 FR FR8616796A patent/FR2607504B1/fr not_active Expired
1987
- 1987-11-27 MA MA21359A patent/MA21118A1/fr unknown
- 1987-11-29 IL IL84658A patent/IL84658A/xx unknown
- 1987-11-30 IE IE325287A patent/IE61089B1/en not_active IP Right Cessation
- 1987-11-30 ZA ZA879001A patent/ZA879001B/xx unknown
- 1987-11-30 NZ NZ222752A patent/NZ222752A/xx unknown
- 1987-11-30 AU AU81936/87A patent/AU594215B2/en not_active Ceased
- 1987-12-01 KR KR870013649A patent/KR880007517A/ko not_active Ceased
- 1987-12-01 AT AT87402708T patent/ATE66219T1/de not_active IP Right Cessation
- 1987-12-01 NO NO875012A patent/NO166037C/no unknown
- 1987-12-01 FI FI875299A patent/FI84723C/fi not_active IP Right Cessation
- 1987-12-01 CA CA000553252A patent/CA1298295C/fr not_active Expired - Lifetime
- 1987-12-01 ES ES198787402708T patent/ES2038687T3/es not_active Expired - Lifetime
- 1987-12-01 MX MX955887A patent/MX9558A/es unknown
- 1987-12-01 DK DK630487A patent/DK169969B1/da not_active IP Right Cessation
- 1987-12-01 DE DE8787402708T patent/DE3772172D1/de not_active Expired - Fee Related
- 1987-12-01 SU SU874203799A patent/SU1616515A3/ru active
- 1987-12-01 EP EP87402708A patent/EP0271404B1/fr not_active Expired - Lifetime
- 1987-12-01 HU HU875398A patent/HU197573B/hu not_active IP Right Cessation
- 1987-12-02 PT PT86261A patent/PT86261B/pt not_active IP Right Cessation
- 1987-12-02 JP JP62305512A patent/JPS63154682A/ja active Pending
- 1987-12-02 OA OA59236A patent/OA08696A/xx unknown
1988
- 1988-11-04 SU SU884356873A patent/SU1685264A3/ru active
- 1988-11-04 SU SU884356916A patent/SU1657056A3/ru active
1991
- 1991-08-16 GR GR91400274T patent/GR3002490T3/el unknown

Also Published As

Publication number	Publication date
EP0271404B1 (fr)	1991-08-14
FI875299A0 (fi)	1987-12-01
NZ222752A (en)	1989-10-27
FI84723B (fi)	1991-09-30
PT86261B (pt)	1990-11-07
GR3002490T3 (en)	1992-12-30
MA21118A1 (fr)	1988-07-01
NO166037B (no)	1991-02-11
NO166037C (no)	1991-05-22
HU197573B (en)	1989-04-28
EP0271404A3 (en)	1989-04-05
PT86261A (fr)	1988-01-01
OA08696A (fr)	1989-03-31
EP0271404A2 (fr)	1988-06-15
ATE66219T1 (de)	1991-08-15
FR2607504A1 (fr)	1988-06-03
FR2607504B1 (fr)	1989-01-27
IE873252L (en)	1988-06-02
KR880007517A (ko)	1988-08-27
NO875012D0 (no)	1987-12-01
IL84658A0 (en)	1988-04-29
SU1616515A3 (ru)	1990-12-23
CA1298295C (fr)	1992-03-31
ES2038687T3 (es)	1993-08-01
HUT46007A (en)	1988-09-28
DK169969B1 (da)	1995-04-18
JPS63154682A (ja)	1988-06-27
DK630487D0 (da)	1987-12-01
SU1657056A3 (ru)	1991-06-15
FI84723C (fi)	1992-01-10
SU1685264A3 (ru)	1991-10-15
NO875012L (no)	1988-06-03
AU8193687A (en)	1988-06-02
IL84658A (en)	1992-01-15
DE3772172D1 (de)	1991-09-19
AU594215B2 (en)	1990-03-01
MX9558A (es)	1993-11-01
IE61089B1 (en)	1994-09-21
ZA879001B (en)	1988-06-01
FI875299A7 (fi)	1988-06-03

Legal Events

Date	Code	Title	Description
1995-04-18	B1	Patent granted (law 1993)
1996-08-19	PBP	Patent lapsed

Publication	Publication Date	Title
DK630687A (da)	1988-06-03	Pyrrolderivater, deres fremstilling og farmaceutiske praeparater deraf
DK630487A (da)	1988-06-03	Pyrrolderivater, deres fremstilling og farmaceutiske praeparater deraf
DK630587D0 (da)	1987-12-01	Pyrrolderivater, deres fremstilling og farmaceutiske praeparater deraf