DK633189A - Anvendelse af peptidisostere som retrovirale proteasehaemmere - Google Patents

Anvendelse af peptidisostere som retrovirale proteasehaemmere Download PDF

Info

Publication number
DK633189A
DK633189A DK633189A DK633189A DK633189A DK 633189 A DK633189 A DK 633189A DK 633189 A DK633189 A DK 633189A DK 633189 A DK633189 A DK 633189A DK 633189 A DK633189 A DK 633189A
Authority
DK
Denmark
Prior art keywords
peptidisosters
protease inhibitors
retroviral protease
retroviral
inhibitors
Prior art date
Application number
DK633189A
Other languages
English (en)
Other versions
DK633189D0 (da
Inventor
Alexander Faessler
Ernst Hungerbuehler
Johannes Roesel
Heinrich Rueeger
Peter Schneider
Jeanette Wood
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK633189D0 publication Critical patent/DK633189D0/da
Publication of DK633189A publication Critical patent/DK633189A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/553—Renin inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK633189A 1988-12-15 1989-12-14 Anvendelse af peptidisostere som retrovirale proteasehaemmere DK633189A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH464188 1988-12-15

Publications (2)

Publication Number Publication Date
DK633189D0 DK633189D0 (da) 1989-12-14
DK633189A true DK633189A (da) 1990-06-16

Family

ID=4279922

Family Applications (1)

Application Number Title Priority Date Filing Date
DK633189A DK633189A (da) 1988-12-15 1989-12-14 Anvendelse af peptidisostere som retrovirale proteasehaemmere

Country Status (7)

Country Link
EP (1) EP0374097A3 (da)
JP (1) JPH02212434A (da)
AU (1) AU4678589A (da)
CA (1) CA2005337A1 (da)
DK (1) DK633189A (da)
IL (1) IL92671A0 (da)
ZA (1) ZA899559B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
DE4001236A1 (de) * 1990-01-18 1991-07-25 Bayer Ag Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren
CA2036413C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
CA2036398C (en) * 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
CA2036397C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
IL98260A0 (en) * 1990-06-01 1992-06-21 Ciba Geigy Ag Hiv protease inhibiting oligopeptides,process for their preparation and pharmaceutical compositions containing them
HU221816B1 (hu) 1991-10-11 2003-01-28 Bristol-Myers Squibb Pharma Company Gyűrűs karbonil vegyületek, és ezeket tartalmazó gyógyászati készítmények
AU3240493A (en) * 1991-12-12 1993-07-19 Schering Corporation Compounds and compositions for treating HIV infections
CA2091151A1 (en) * 1992-03-13 1993-09-14 Kwan Y. Hui Retroviral protease inhibitors
TW217410B (da) * 1992-04-01 1993-12-11 Ciba Geigy
AU4253193A (en) * 1992-05-20 1993-12-13 G.D. Searle & Co. Urea-containing hydroxyethylamine compounds as retroviral protease inhibitors
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
ES2124327T3 (es) * 1993-02-09 1999-02-01 Bayer Ag Derivados de sulfonamida aminometileno como inmunosupresores.
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
AU6491294A (en) * 1993-03-26 1994-10-24 Warner-Lambert Company Inhibitors of endothelin converting enzyme
DE4332395A1 (de) * 1993-09-23 1995-04-13 Horst Dr Lindhofer Inhibitoren zur Hemmung der zymogenähnlichen Freispaltung der HIV-1 Protease
PT708085E (pt) * 1994-10-19 2002-11-29 Novartis Ag Eteres antivirais de isosteros de substrato de aspartato protease
CA2191924A1 (en) * 1995-12-05 1997-06-06 Kevin Felsenstein 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
US5703129A (en) * 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
FR2614533A1 (fr) * 1987-04-23 1988-11-04 Sandoz Sa Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments

Also Published As

Publication number Publication date
JPH02212434A (ja) 1990-08-23
IL92671A0 (en) 1990-09-17
ZA899559B (en) 1990-08-29
EP0374097A3 (de) 1991-06-12
AU4678589A (en) 1990-06-21
CA2005337A1 (en) 1990-06-15
EP0374097A2 (de) 1990-06-20
DK633189D0 (da) 1989-12-14

Similar Documents

Publication Publication Date Title
DK633189D0 (da) Anvendelse af peptidisostere som retrovirale proteasehaemmere
FI950650L (fi) Retrovirusproteaasi-inhibiittoreina käyttökelpoisia hydroksietyyliaminosulfoniamideja
FI950651L (fi) Retrovirusproteaasi-inhibiittoreina käyttökelpoisia sulfonyylialkanoyyliaminohydroksietyyliaminosulfoniamideja
FI964835L (fi) Retrovirusperäisten proteaasi-inhibbiittoreiden yhdistelmiä
DK674387D0 (da) Proteaseinhibitorer
MX9100119A (es) Inhibidores de proteasa retroviral
FI950841L (fi) Retrovirusproteaasi-inhibiittoreina käyttökelpoisia N-(alkanoyyliamino-2-hydroksipropyyli)-sulfoniamideja
ATE241602T1 (de) Sulfonamide inhibitore von hiv-aspartyl protease
DK486686D0 (da) Anvendelse af benzamidderivater
DK363887A (da) Anvendelse af bromcruptin
DK633289D0 (da) Retrovirale proteasehaemmere
DK0391171T3 (da) Anvendelse af di-styryl-phenyl-triglycolether som krystallisationsinhibitor
DK453789D0 (da) Fremgangsmaade til paavirkning af azopigmenters triboelektriske effekt
MX9100120A (es) Inhibidores de proteasas retrovirales
DK226989D0 (da) Fremgangsmaade til plasma-rensning af overflader
DK273089A (da) Anvendelse af peptidderivater
DK4687A (da) Anvendelse af esterforbindelser som temporaert mikrobicid
DK301585D0 (da) Anvendelse af actinonin som immunpotentiator
DK316289A (da) Anvendelse af difluormethyl-thiadiazolyl-oxyeddikesyreamider som selektive herbicider
DK80990D0 (da) Sulfonylderivater af thien-triazol-diazepin
FI906140A7 (fi) Retroviraalisten proteaasien inhibiittoreita
DK104389A (da) Anvendelse af imidazolderivater
DK130390A (da) Praeparat af i prokaryonter udtrykt plasminogenaktivator
DK369686D0 (da) Fremgangsmaade til oprensning af vaevsplasminogenaktivator
DK562289A (da) Anvendelse af somatostatiner

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
AHS Application shelved for other reasons than non-payment