DK645189D0 - Sulfonsyresubstituerede, aromatiske steroider, farmaceutiske midler indeholdende disse samt deres anvendelse - Google Patents

Sulfonsyresubstituerede, aromatiske steroider, farmaceutiske midler indeholdende disse samt deres anvendelse

Info

Publication number: DK645189D0
Authority: DK; Denmark
Prior art keywords: sulphonic acid; pharmaceutical agents; agents containing; acid substituted; aromatic steroids
Prior art date: 1988-12-23

Application number

DK645189A

Other languages

English (en)

Other versions

DK645189A (da

Inventor

Dennis Alan Holt

Mark Alan Levy

Brian Walter Metcalf

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-23

Filing date

1989-12-19

Publication date

1989-12-19

1989-12-19 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1989-12-19 Publication of DK645189D0 publication Critical patent/DK645189D0/da

1990-06-24 Publication of DK645189A publication Critical patent/DK645189A/da

Links

239000008177 pharmaceutical agent Substances 0.000 title 1
150000003431 steroids Chemical class 0.000 title 1
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 title 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK645189A 1988-12-23 1989-12-19 Sulfonsyresubstituerede, aromatiske steroider, farmaceutiske midler indeholdende disse samt deres anvendelse DK645189A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/290,020 US4970205A (en)	1988-12-23	1988-12-23	Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase

Publications (2)

Publication Number	Publication Date
DK645189D0 true DK645189D0 (da)	1989-12-19
DK645189A DK645189A (da)	1990-06-24

Family

ID=23114202

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK645189A DK645189A (da)	1988-12-23	1989-12-19	Sulfonsyresubstituerede, aromatiske steroider, farmaceutiske midler indeholdende disse samt deres anvendelse

Country Status (14)

Country	Link
US (1)	US4970205A (da)
EP (1)	EP0375347B1 (da)
JP (1)	JPH02225494A (da)
CN (1)	CN1051181A (da)
AT (1)	ATE115960T1 (da)
AU (2)	AU627528B2 (da)
CA (1)	CA2005215A1 (da)
DE (1)	DE68920128T2 (da)
DK (1)	DK645189A (da)
ES (1)	ES2066003T3 (da)
GR (1)	GR3015476T3 (da)
IE (1)	IE894108L (da)
PT (1)	PT92719A (da)
ZA (1)	ZA899669B (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5138063A (en) *	1984-02-27	1992-08-11	Merck & Co., Inc.	17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
US5571817A (en) *	1984-02-27	1996-11-05	Merck & Co., Inc.	Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
US5151430A (en) *	1990-06-20	1992-09-29	Merck & Co., Inc.	Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5061802A (en) *	1990-06-20	1991-10-29	Merck & Co. Inc.	17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
US5162332A (en) *	1990-06-20	1992-11-10	Merck & Co., Inc.	Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
US5098908A (en) *	1990-06-20	1992-03-24	Merck & Co., Inc.	17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5300294A (en) *	1990-06-27	1994-04-05	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
US5091380A (en) *	1990-06-28	1992-02-25	Merck & Co., Inc.	N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
IL101243A (en) *	1991-03-20	1999-12-22	Merck & Co Inc	Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
IL104303A0 (en) *	1992-01-06	1993-05-13	Smithkline Beecham Corp	Process
ATE195129T1 (de) *	1992-05-20	2000-08-15	Merck & Co Inc	4-azasteroide als 5-alpha-reduktase
CZ283894A3 (en) *	1992-05-20	1995-09-13	Merck & Co Inc	7beta-substituted 4-aza-5alpha-cholestanones, their use for the preparation of pharmaceutical preparations and pharmaceutical compositions containing thereof
CA2135173A1 (en) *	1992-05-20	1993-11-25	Bruce E. Witzel	Ester derivatives of 4-aza-steroids
US5237064A (en) *	1992-05-20	1993-08-17	Merck & Co., Inc.	Process for producing 7β-substituted-aza-5αandrostan-3-ones
EP0641204B1 (en) *	1992-05-20	2000-08-16	Merck & Co. Inc.	17-ethers and thioethers of 4-aza-steroids
DE69326008T2 (de) *	1992-05-20	2000-03-02	Merck & Co., Inc.	17-amino-substituierte 4-azasteroide als 5-alpha-reductase inhibitoren
JPH07506575A (ja) *	1992-05-21	1995-07-20	アンドルシェルシュ・インコーポレイテッド	テストステロン５α−レダクターゼ活性の阻害剤
JPH0641038A (ja)	1992-07-17	1994-02-15	Mitsubishi Kasei Corp	カルボン酸誘導体
US5324734A (en) *	1992-09-15	1994-06-28	Merck & Co., Inc.	Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione
US5278159A (en) *	1992-10-06	1994-01-11	Merck & Co., Inc.	Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
US5359071A (en) *	1993-03-12	1994-10-25	Merck & Co., Inc.	15-substituted 4-azasteroids
US5621104A (en) *	1993-03-24	1997-04-15	Merck & Co., Inc.	Substituted 3-phenanthridinone derivatives as 5-alpha-reductase inhibitors
FR2706454B1 (fr) *	1993-06-17	1995-09-15	Roussel Uclaf	Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant.
DE69405760T2 (de) *	1993-06-28	1998-04-09	Merck & Co Inc	4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5637310A (en) *	1993-12-20	1997-06-10	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
DE4447714C2 (de) *	1994-08-09	1998-02-05	Jenapharm Gmbh	Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
ES2347027T3 (es)	1998-05-22	2010-10-22	The Board Of Trustees Of The Leland Stanford Junior University	Moleculas bifuncionales y terapias basadas en las mismas.
EP2671507A3 (en)	2005-04-28	2014-02-19	Proteus Digital Health, Inc.	Pharma-informatics system
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
CN100355772C (zh) *	2005-12-28	2007-12-19	天津大学	具有5α－还原酶抑制活性的甾体化合物及其制备方法
CA2752373C (en)	2009-02-20	2017-10-10	To-Bbb Holding B.V.	Glutathione-based drug delivery system
IL255113B (en)	2009-05-06	2022-09-01	Laboratory Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2555579A (en) *	1950-05-24	1951-06-05	Ayerst Mckenna & Harrison	P-aminobenzoyl-diethyl aminoethanol salts of steroids 3-monosulphates
DE1107664B (de) *	1959-11-05	1961-05-31	Schering Ag	Verfahren zur Herstellung neuer in 3-Stellung substituierter OEstratriene
FR1521896A (fr) *	1966-05-04	1968-04-19	Ohio State University Represen	Procédé de transformation de thioncarbamates en thiolcarbamates
FR2022104A1 (da) *	1968-07-24	1970-07-31	Farmaceutici Italia
US4179453A (en) *	1978-04-13	1979-12-18	Merck & Co., Inc.	Process for preparing 17β-carboxy-5-androsten-3-ones
US4377584A (en) *	1978-04-13	1983-03-22	Merck & Co., Inc.	4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4191759A (en) *	1978-04-13	1980-03-04	Merck & Co., Inc.	N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors
US4317817A (en) *	1979-08-27	1982-03-02	Richardson-Merrell Inc.	Novel steroid 5α-reductase inhibitors
DK465481A (da) *	1980-11-21	1982-05-22	Hoffmann La Roche	Fremgangsmaade til fremstilling af d-homostemoider
JPS5953417A (ja) *	1982-09-21	1984-03-28	Shiseido Co Ltd	皮膚外用剤
JPS60116657A (ja) *	1983-11-30	1985-06-24	Ono Pharmaceut Co Ltd	アニリン誘導体
JPS60142941A (ja) *	1983-12-28	1985-07-29	Ono Pharmaceut Co Ltd	ケトン化合物
JPS60146855A (ja) *	1984-01-11	1985-08-02	Ono Pharmaceut Co Ltd	アニリン誘導体
CA1261835A (en) *	1984-08-20	1989-09-26	Masaaki Toda	(fused) benz(thio)amides
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors

1988
- 1988-12-23 US US07/290,020 patent/US4970205A/en not_active Expired - Fee Related
1989
- 1989-10-24 CN CN89108217A patent/CN1051181A/zh active Pending
- 1989-12-12 CA CA002005215A patent/CA2005215A1/en not_active Abandoned
- 1989-12-18 ZA ZA899669A patent/ZA899669B/xx unknown
- 1989-12-19 DK DK645189A patent/DK645189A/da not_active Application Discontinuation
- 1989-12-19 DE DE68920128T patent/DE68920128T2/de not_active Expired - Fee Related
- 1989-12-19 ES ES89313260T patent/ES2066003T3/es not_active Expired - Lifetime
- 1989-12-19 EP EP89313260A patent/EP0375347B1/en not_active Expired - Lifetime
- 1989-12-19 AT AT89313260T patent/ATE115960T1/de not_active IP Right Cessation
- 1989-12-20 AU AU47005/89A patent/AU627528B2/en not_active Ceased
- 1989-12-20 JP JP1330927A patent/JPH02225494A/ja active Pending
- 1989-12-20 IE IE894108A patent/IE894108L/xx unknown
- 1989-12-22 PT PT92719A patent/PT92719A/pt not_active Application Discontinuation
1992
- 1992-11-24 AU AU29602/92A patent/AU655691B2/en not_active Ceased
1995
- 1995-03-20 GR GR950400607T patent/GR3015476T3/el unknown

Also Published As

Publication number	Publication date
ES2066003T3 (es)	1995-03-01
CN1051181A (zh)	1991-05-08
AU627528B2 (en)	1992-08-27
DE68920128D1 (de)	1995-02-02
EP0375347B1 (en)	1994-12-21
CA2005215A1 (en)	1990-06-23
JPH02225494A (ja)	1990-09-07
IE894108L (en)	1990-06-23
EP0375347A1 (en)	1990-06-27
AU2960292A (en)	1993-01-21
ATE115960T1 (de)	1995-01-15
GR3015476T3 (en)	1995-06-30
AU655691B2 (en)	1995-01-05
PT92719A (pt)	1990-06-29
ZA899669B (en)	1990-11-28
US4970205A (en)	1990-11-13
AU4700589A (en)	1990-06-28
DE68920128T2 (de)	1995-05-11
DK645189A (da)	1990-06-24

Legal Events

Date	Code	Title	Description
1997-08-25	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK645189A (da)	1990-06-24	Sulfonsyresubstituerede, aromatiske steroider, farmaceutiske midler indeholdende disse samt deres anvendelse
ATE114666T1 (de)	1994-12-15	Phosphonsäure-derivate von aromatischen steroiden als 5-alpha-reduktase-inhibitoren.
DE68921174D1 (de)	1995-03-23	Phosphinsäure-Derivate von aromatischen Steroiden als 5-alpha Reduktase-Inhibitoren.
DK645389A (da)	1990-06-24	Phosphinsyresubstituerede steroider, farmaceutiske midler indeholdende disse samt deres anvendelse
DK37388A (da)	1988-07-29	Steroid-5-alfa-reduktaseinhibitorer
IT8667371A1 (it)	1987-11-06	Composizioni topiche per il trattamento della pelle a base di derivati dell'acido salicilico.
NO881940D0 (no)	1988-05-04	4-aminokinolin-derivater og deres anvendelse som legemidler.
PT773022E (pt)	2002-06-28	Preparacao farmaceutica para o tratamento de rinites agudas contendo simpaticomimeticos e pantotenol e/ou acido pantotenico
ATE110736T1 (de)	1994-09-15	Phosphonsäure-derivate von steroiden als hemmstoffe der 5-alpha-reduktase.
FI895046A0 (fi)	1989-10-24	4-amino-3-acylkinolinderivat samt deras anvaendning saosom inhibitorer av sekretion av matsmaeltningsvaetskor.
DK163185C (da)	1992-06-29	1h-imidazol-1-ethanol og estere deraf og deres farmaceutisk acceptable syreadditionssalte til anvendelse som talgsyntesehaemmende midler samt farmaceutiske praeparater indeholdende saadanne forbindelser
IT1197289B (it)	1988-11-30	Sale di lisina dell'acido 4-bifenilacetico e sue composizioni oftalmiche
DK192487D0 (da)	1987-04-14	Carbiovasculaere farmaceutiske praeparater, som er egnet til topisk indgivning