DK650187A - Hidtil ukendte pyrrolobenzimidazoler, fremgangsmaade til fremstilling deraf samt laegemiddel, der indeholder disse forbindelser - Google Patents

Hidtil ukendte pyrrolobenzimidazoler, fremgangsmaade til fremstilling deraf samt laegemiddel, der indeholder disse forbindelser

Info

Publication number
DK650187A
DK650187A DK650187A DK650187A DK650187A DK 650187 A DK650187 A DK 650187A DK 650187 A DK650187 A DK 650187A DK 650187 A DK650187 A DK 650187A DK 650187 A DK650187 A DK 650187A
Authority
DK
Denmark
Prior art keywords
pyrrolobenzimidazoles
unknown
procedures
compounds
production
Prior art date
Application number
DK650187A
Other languages
English (en)
Other versions
DK650187D0 (da
Inventor
Walter-Gunar Friebe
Alfred Mertens
Klaus Strein
Erwin Boehm
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK650187D0 publication Critical patent/DK650187D0/da
Publication of DK650187A publication Critical patent/DK650187A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK650187A 1986-12-11 1987-12-10 Hidtil ukendte pyrrolobenzimidazoler, fremgangsmaade til fremstilling deraf samt laegemiddel, der indeholder disse forbindelser DK650187A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863642315 DE3642315A1 (de) 1986-12-11 1986-12-11 Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel

Publications (2)

Publication Number Publication Date
DK650187D0 DK650187D0 (da) 1987-12-10
DK650187A true DK650187A (da) 1988-06-12

Family

ID=6315954

Family Applications (1)

Application Number Title Priority Date Filing Date
DK650187A DK650187A (da) 1986-12-11 1987-12-10 Hidtil ukendte pyrrolobenzimidazoler, fremgangsmaade til fremstilling deraf samt laegemiddel, der indeholder disse forbindelser

Country Status (13)

Country Link
US (1) US4863945A (da)
EP (1) EP0271040A3 (da)
JP (1) JPS63162692A (da)
KR (1) KR880007536A (da)
AU (1) AU8245087A (da)
DD (1) DD267047A5 (da)
DE (1) DE3642315A1 (da)
DK (1) DK650187A (da)
FI (1) FI875438A7 (da)
HU (1) HU200339B (da)
IL (1) IL84589A0 (da)
PT (1) PT86331B (da)
ZA (1) ZA879166B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5434163A (en) * 1993-05-14 1995-07-18 The Medical College Of Pennsylvania Treatment of Cryptococcus neoformans infection
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
EP1598353A1 (en) * 2004-05-17 2005-11-23 Boehringer Ingelheim International GmbH Pyrrolobenzimidazolones and their use as antiproliferative agents
US7285569B2 (en) 2004-09-24 2007-10-23 Hoff Hoffmann-La Roche Inc. Tricycles, their manufacture and use as pharmaceutical agents
US20060142247A1 (en) * 2004-12-17 2006-06-29 Guy Georges Tricyclic heterocycles
CA2603204A1 (en) * 2005-04-14 2006-10-19 F. Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
JP2008533181A (ja) * 2005-04-14 2008-08-21 エフ．ホフマン−ラ ロシュ アーゲー 三環式アゾール誘導体、それらの製造及び医薬品としての使用
WO2007068465A1 (en) * 2005-12-15 2007-06-21 F. Hoffmann-La Roche Ag Tricyclic lactam derivatives, their manufacture and use as pharmaceutical agents
KR20080106284A (ko) * 2006-03-23 2008-12-04 에프. 호프만-라 로슈 아게 치환된 인다졸 유도체, 이의 제조 및 약학적 제제로서의 용도
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
CA2738573C (en) 2009-04-03 2013-02-19 F. Hoffmann-La Roche Ag Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
PE20141360A1 (es) 2011-02-07 2014-10-13 Plexxikon Inc Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
WO2026026970A1 (zh) * 2024-08-02 2026-02-05 上海赛默罗生物科技有限公司 稠合环类化合物及其中间体和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR851085B (da) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
FI875438A0 (fi) 1987-12-10
EP0271040A2 (de) 1988-06-15
ZA879166B (en) 1988-06-14
AU8245087A (en) 1988-06-16
KR880007536A (ko) 1988-08-27
PT86331B (pt) 1990-11-07
IL84589A0 (en) 1988-04-29
PT86331A (de) 1988-01-01
HUT47278A (en) 1989-02-28
HU200339B (en) 1990-05-28
DK650187D0 (da) 1987-12-10
US4863945A (en) 1989-09-05
FI875438A7 (fi) 1988-06-12
EP0271040A3 (de) 1989-11-02
DD267047A5 (de) 1989-04-19
JPS63162692A (ja) 1988-07-06
DE3642315A1 (de) 1988-06-23

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Legal Events

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