DK66389A - 2',3'-dideoxy-2',2'-diflour-nucleosider og fremgangsmaade til fremstilling heraf - Google Patents

2',3'-dideoxy-2',2'-diflour-nucleosider og fremgangsmaade til fremstilling heraf

Info

Publication number
DK66389A
DK66389A DK066389A DK66389A DK66389A DK 66389 A DK66389 A DK 66389A DK 066389 A DK066389 A DK 066389A DK 66389 A DK66389 A DK 66389A DK 66389 A DK66389 A DK 66389A
Authority
DK
Denmark
Prior art keywords
diflour
dideoxy
nucleosides
procedures
preparing
Prior art date
Application number
DK066389A
Other languages
Danish (da)
English (en)
Other versions
DK66389D0 (da
Inventor
Larry Wayne Hertel
Cora Sue Grossman
Julian Stanley Kroin
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK66389D0 publication Critical patent/DK66389D0/da
Publication of DK66389A publication Critical patent/DK66389A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK066389A 1988-02-16 1989-02-13 2',3'-dideoxy-2',2'-diflour-nucleosider og fremgangsmaade til fremstilling heraf DK66389A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15611688A 1988-02-16 1988-02-16

Publications (2)

Publication Number Publication Date
DK66389D0 DK66389D0 (da) 1989-02-13
DK66389A true DK66389A (da) 1989-08-17

Family

ID=22558157

Family Applications (1)

Application Number Title Priority Date Filing Date
DK066389A DK66389A (da) 1988-02-16 1989-02-13 2',3'-dideoxy-2',2'-diflour-nucleosider og fremgangsmaade til fremstilling heraf

Country Status (16)

Country Link
EP (1) EP0329348B1 (de)
JP (1) JP3142128B2 (de)
KR (1) KR890013049A (de)
CN (1) CN1035117A (de)
AU (1) AU607840B2 (de)
CA (1) CA1312599C (de)
DE (1) DE68923387T2 (de)
DK (1) DK66389A (de)
ES (1) ES2075040T3 (de)
HU (1) HU203363B (de)
IL (1) IL89258A0 (de)
MX (1) MX14910A (de)
NZ (1) NZ227960A (de)
PH (1) PH25381A (de)
PT (1) PT89705B (de)
ZA (1) ZA891076B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
FI95384C (fi) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
AU629988B2 (en) * 1989-10-11 1992-10-15 Merrell Dow Pharmaceuticals Inc. Inosine/guanosine derivatives as antineoplastic agents
CA2073063A1 (en) * 1989-11-06 1991-05-07 Jo Klaveness Nucleoside derivatives
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
KR927003044A (ko) * 1990-01-11 1992-12-17 크리스토퍼 케이. 미라벨리 Rna 활성과 유전자 발현을 검출하고 조절하는 조성물 및 그 방법
WO1991015498A2 (en) * 1990-04-04 1991-10-17 Nycomed Imaging As Nucleoside derivatives
ZA914894B (en) * 1990-07-02 1992-04-29 Squibb & Sons Inc Purinyl and pyrimidinyl tetrahydrofurans
US6262241B1 (en) 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
AU4134793A (en) * 1992-06-22 1993-12-23 Eli Lilly And Company 2'-deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
US6013790A (en) * 1996-09-25 2000-01-11 Board Of Regents University Of Nebraska-Lincoln Heavily fluorinated sugar analogs
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
US7176237B2 (en) 2002-01-15 2007-02-13 The Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
WO2004041203A2 (en) 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP2094651A1 (de) 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthese und biologische wirkungen neuer tricyclischer bis-enone (tbes)
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
KR20100102107A (ko) * 2007-11-06 2010-09-20 파마이센시아 코퍼레이션 β-뉴클레오시드의 새로운 합성 방법
BRPI0907423A2 (pt) 2008-01-11 2020-10-27 Reata Pharmaceuticals, Inc. composto triterpenoide sintético para uso em um método de melhoria da função renal em um indivíduo, e uso do referido composto
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
KR101713140B1 (ko) 2008-04-18 2017-03-08 리타 파마슈티컬스 잉크. Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체
JP5529851B2 (ja) 2008-04-18 2014-06-25 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体
WO2009146218A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
MX2010011439A (es) 2008-04-18 2011-01-25 Reata Pharmaceuticals Inc Moduladores de inflamacion antioxidantes: derivados del acido oleanolico homologacion c-17.
CN108686203A (zh) 2012-04-04 2018-10-23 哈洛齐梅公司 使用抗透明质酸剂和肿瘤靶向紫杉烷的组合疗法
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
EP0184365B1 (de) * 1984-12-04 1993-08-04 Eli Lilly And Company Tumorbehandlung bei Säugetieren
PT86377B (pt) * 1986-12-24 1990-11-20 Lilly Co Eli Processo para a preparacao de conjugados de imunoglobulinas com um difluoronucleosideo acilado

Also Published As

Publication number Publication date
PH25381A (en) 1991-06-03
ES2075040T3 (es) 1995-10-01
KR890013049A (ko) 1989-09-21
AU607840B2 (en) 1991-03-14
HUT49366A (en) 1989-09-28
EP0329348B1 (de) 1995-07-12
IL89258A0 (en) 1989-09-10
MX14910A (es) 1993-11-01
JP3142128B2 (ja) 2001-03-07
EP0329348A3 (en) 1990-09-12
CA1312599C (en) 1993-01-12
EP0329348A2 (de) 1989-08-23
PT89705B (pt) 1994-04-29
ZA891076B (en) 1990-10-31
DK66389D0 (da) 1989-02-13
NZ227960A (en) 1990-11-27
DE68923387T2 (de) 1996-01-25
HU203363B (en) 1991-07-29
AU2992689A (en) 1989-08-17
JPH01249797A (ja) 1989-10-05
PT89705A (pt) 1989-10-04
DE68923387D1 (de) 1995-08-17
CN1035117A (zh) 1989-08-30

Similar Documents

Publication Publication Date Title
DK66389D0 (da) 2',3'-dideoxy-2',2'-diflour-nucleosider og fremgangsmaade til fremstilling heraf
DK297089A (da) Pyrimidinderivater og fremgangsmaade til fremstilling deraf
DK381485A (da) 1,2-benzisothiazol-3-yl-piperazinderivater og fremgangsmaade til fremstilling deraf
DK577084D0 (da) 2,2'iminobisethanol-derivater og fremgangsmaade til fremstilling deraf
DK11992A (da) Epipodophyllotoxinglycosid-4'-phosphatderivater, deres fremstilling og anvendelse
NO891866D0 (no) Kromanderivater og fremgangsmaate for fremstilling derav.
NO875358D0 (no) 6-benzoksazinyl- og 6-benzotiazinyl-2,3,4,5-tetrahydropyridazin-3-oner og fremgangsmaate for deres fremstilling.
NO870512L (no) 1,4-benzoksazinderivater og fremgangsmaate for deres fremstilling.
DK582489D0 (da) Substituerede 2'-deoxy-4'-azido-nucleosider, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende samme
NO892494D0 (no) Kromanderivater og fremgangsmaate for fremstilling derav.
DK165952C (da) 1,3-oxazolidin-2-on-derivater og fremgangsmaade til fremstilling heraf
DK69989D0 (da) Benzodioxolderivater og fremgangsmaade til fremstilling deraf
DK1693D0 (da) Pyranobenzoxadiazolderivat og fremgangsmaade til fremstilling deraf
NO894103D0 (no) Kromanderivater og fremgangsmaate for fremstilling derav.
DK202989A (da) Antitumormidler og fremgangsmaade til fremstilling deraf
DK530689A (da) Adenylcyclasederivater, fremgangsmaade til fremstilling deraf og deres anvendelse
DK603788D0 (da) Purinderivater og fremgangsmaade til fremstilling deraf
DK477287A (da) Pyrido-benzoxadiazin-derivater og fremgangsmaade til fremstilling deraf
DK103889A (da) Benzimidazooe1,2-caachinazoliner og fremgangsmaade til fremstilling heraf
DK217388D0 (da) 1,3-dioxaner og fremgangsmaade til fremstilling deraf
DK34491D0 (da) Ekstruderet, biaksialt strakt skumplastroer og fremgangsmaade til fremstilling deraf
NO900252D0 (no) Cefasporinderivater og fremgangsmaate for fremstilling derav.
NO893963D0 (no) 3-aryloksymetyl-cefalosporinderivater og fremgangsmaate til fremstilling derav.
DK129689D0 (da) Ifosfamid-mesna-lyofilisat og fremgangsmaade til fremstilling deraf
NO872885L (no) 1,3,5-tritianderivater og fremgangsmŸte for deres fremstilling.

Legal Events

Date Code Title Description
ATS Application withdrawn