DK668687A - Indolcarboxamidderivater, deres fremstilling samt laegemidler med indhold deraf - Google Patents

Indolcarboxamidderivater, deres fremstilling samt laegemidler med indhold deraf

Info

Publication number: DK668687A
Authority: DK; Denmark
Prior art keywords: image; preparation; double bond; indolcarboxamide; derivatives
Prior art date: 1986-12-19

Application number

DK668687A

Other languages

English (en)

Other versions

DK668687D0 (da

DK169328B1 (da

Inventor

Francois Clemence

Jacques Guillaume

Gilles Hamon

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-19

Filing date

1987-12-18

Publication date

1988-06-20

1986-12-19 Priority claimed from FR868617810A external-priority patent/FR2608601B2/fr

1987-12-18 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1987-12-18 Publication of DK668687D0 publication Critical patent/DK668687D0/da

1988-06-20 Publication of DK668687A publication Critical patent/DK668687A/da

1994-10-10 Application granted granted Critical

1994-10-10 Publication of DK169328B1 publication Critical patent/DK169328B1/da

Links

VFHUJFBEFDVZPJ-UHFFFAOYSA-N 1h-indole-2-carboxamide Chemical class C1=CC=C2NC(C(=O)N)=CC2=C1 VFHUJFBEFDVZPJ-UHFFFAOYSA-N 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
239000003416 antiarrhythmic agent Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
238000002483 medication Methods 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Hematology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK668687A 1986-12-19 1987-12-18 Indolcarboxamidderivater, deres fremstilling samt farmaceutiske præparater med indhold deraf DK169328B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR868617810A FR2608601B2 (fr)	1985-07-11	1986-12-19	Nouveaux derives de l'indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
FR8617810		1986-12-19

Publications (3)

Publication Number	Publication Date
DK668687D0 DK668687D0 (da)	1987-12-18
DK668687A true DK668687A (da)	1988-06-20
DK169328B1 DK169328B1 (da)	1994-10-10

Family

ID=9342092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK668687A DK169328B1 (da)	1986-12-19	1987-12-18	Indolcarboxamidderivater, deres fremstilling samt farmaceutiske præparater med indhold deraf

Country Status (12)

Country	Link
EP (1)	EP0275762B1 (da)
JP (1)	JPS63233972A (da)
KR (1)	KR880007459A (da)
AT (1)	ATE97403T1 (da)
AU (1)	AU617094B2 (da)
DE (1)	DE3788207T2 (da)
DK (1)	DK169328B1 (da)
ES (1)	ES2059402T3 (da)
FI (1)	FI85139C (da)
HU (1)	HU199792B (da)
IE (1)	IE61987B1 (da)
ZA (1)	ZA879523B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4908367A (en) *	1985-07-11	1990-03-13	Roussel Uclaf	N-(1H-indole-4-yl)-benzamides
FR2584713B1 (fr) *	1985-07-11	1988-09-09	Roussel Uclaf	Nouveaux derives de l'indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
FR2609464B1 (fr) *	1987-01-09	1990-12-07	Roussel Uclaf	Nouveaux derives du n-(1h-indol 4-yl) benzamide ainsi que leurs sels, leur application a titre de medicaments, et les compositions les renfermant
JP2004529110A (ja)	2001-03-06	2004-09-24	アストラゼネカアクチボラグ	脈管損傷活性を有するインドール誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2528043A1 (fr) *	1982-06-03	1983-12-09	Roussel Uclaf	Nouveaux derives de la 1,3-dihydro 4-/1-hydroxy-2-amino-ethyl/2h-indol-2-one, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2558158B1 (fr) *	1984-01-13	1986-05-16	Roussel Uclaf	Derives de l'indole ethenyl phenol, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires
US4853408A (en) *	1985-04-23	1989-08-01	Roussel Uclaf	4-phenylpropyl-indoles having antiarythmic activity
FR2583047B1 (fr) *	1985-06-05	1988-01-08	Roussel Uclaf	Procede de preparation de derives du 4-phenylpropyl indole, et intermediaires
JP2950710B2 (ja) *	1992-07-15	1999-09-20	小島プレス工業株式会社	シフトレバー装置

1987
- 1987-12-17 ES ES87402892T patent/ES2059402T3/es not_active Expired - Lifetime
- 1987-12-17 EP EP87402892A patent/EP0275762B1/fr not_active Expired - Lifetime
- 1987-12-17 DE DE87402892T patent/DE3788207T2/de not_active Expired - Fee Related
- 1987-12-17 AT AT87402892T patent/ATE97403T1/de not_active IP Right Cessation
- 1987-12-18 DK DK668687A patent/DK169328B1/da not_active IP Right Cessation
- 1987-12-18 FI FI875586A patent/FI85139C/fi not_active IP Right Cessation
- 1987-12-18 AU AU82805/87A patent/AU617094B2/en not_active Ceased
- 1987-12-18 HU HU875870A patent/HU199792B/hu not_active IP Right Cessation
- 1987-12-18 JP JP62319123A patent/JPS63233972A/ja active Pending
- 1987-12-18 ZA ZA879523A patent/ZA879523B/xx unknown
- 1987-12-18 IE IE344187A patent/IE61987B1/en not_active IP Right Cessation
- 1987-12-19 KR KR870014617A patent/KR880007459A/ko not_active Ceased

Also Published As

Publication number	Publication date
AU8280587A (en)	1988-06-23
FI85139B (fi)	1991-11-29
AU617094B2 (en)	1991-11-21
KR880007459A (ko)	1988-08-27
EP0275762A1 (fr)	1988-07-27
ATE97403T1 (de)	1993-12-15
FI875586A0 (fi)	1987-12-18
DK668687D0 (da)	1987-12-18
IE873441L (en)	1988-06-19
EP0275762B1 (fr)	1993-11-18
ES2059402T3 (es)	1994-11-16
HU199792B (en)	1990-03-28
DE3788207T2 (de)	1994-03-31
ZA879523B (en)	1989-02-22
HUT47245A (en)	1989-02-28
JPS63233972A (ja)	1988-09-29
DK169328B1 (da)	1994-10-10
DE3788207D1 (de)	1993-12-23
FI85139C (fi)	1992-03-10
IE61987B1 (en)	1994-12-14
FI875586A7 (fi)	1988-06-20

Legal Events

Date	Code	Title	Description
1994-10-10	B1	Patent granted (law 1993)
1995-08-28	PBP	Patent lapsed

Publication	Publication Date	Title
ES2017611T3 (es)	1995-05-01	Tiazoles sustituidos y su uso como fungicidas.
NO2005015I2 (no)	2007-10-01	Terapeutisk aktiv forbindelse preparat inneholdende forbindelsen samt den anvendelse
IL89921A (en)	1993-08-18	1,3-dioxolane derivatives and pharmaceutical compositions containing the same
DK183386D0 (da)	1986-04-21	Sucralfatsuspension
DE3777763D1 (de)	1992-04-30	Dimethylpolysiloxan-mikroemulsionen enthaltende kosmetische zusammensetzungen.
NO934300D0 (no)	1993-11-26	Pyrrolidin- og tiazolidinderivater, deres fremstilling samt medikamenter inneholdende forbindelsene
FI870457A0 (fi)	1987-02-03	Farmaceutiska preparatformer foer stabilisering av interferon- .
ES2167463T3 (es)	2002-05-16	Componentes de un compuesto medicinal que comprenden derivados n-sustituidos de la o-toluidina y preparacion percutaneamente absorbible.
ATE94869T1 (de)	1993-10-15	Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika.
DE69321875D1 (de)	1998-12-10	Benzimidezolderivate mit antidiabetischer und Anti-Plättchenklumpungswirkung
ATE108437T1 (de)	1994-07-15	Substituierte diaminophthalimide und analoga.
MX9203243A (es)	1992-07-01	Oxazolidinonas y composiciones farmaceuticas que las contienen.
DK668687D0 (da)	1987-12-18	Indolcarboxamidderivater, deres fremstilling samt laegemidler med indhold deraf
ES2058572T3 (es)	1994-11-01	Nuevos derivados de ureileno-2,4,6-triamino-pirimidina-3-oxido, su preparacion y su empleo en cosmetica y dermofarmacia.
ATE78693T1 (de)	1992-08-15	Ein dideoxynukleosid enthaltendes arzneimittel.
ATE198890T1 (de)	2001-02-15	Antidepressiva
DK0617035T3 (da)	1998-07-27	Hetero-tricyclisk-substituerede phenyl-cyclohexan-carboxylsyrederivater.
MX9207395A (es)	1993-07-01	Tiazoles novedosos.
DE69432000D1 (de)	2003-02-20	Verwendung von Tetrahydropyridinderivaten zur Herstellung von Kardioprotektiven Medikamenten
DK0578535T3 (da)	1996-12-09	Hidtil ukendt peptid-derivater, der er aktive i celleadhæsionsprocesser, fremgangsmåde til deres fremstilling samt farmaceutiske sammensætninger indeholdende derivarerne
DK324987D0 (da)	1987-06-25	3-substituerede 1-(2-halogenalkoxy-benzen-sulfonyl)-3-heteroaryl-(thio)urinstoffer, fremgangsmaader til deres fremstilling samt deres anvendelse som herbicider
DK181089D0 (da)	1989-04-14	1-dimethylcarbamoyl-3-substituerede-5-substituerede-1h-1,2,4-triazoler
DE3767940D1 (de)	1991-03-14	Pyranderivate.
ES2036577T3 (es)	1993-06-01	Procedimiento de preparacion de bencensulfonamidas utiles como agentes anti-arritmicos.
IL105599A0 (en)	1993-09-22	Enantiomers derived from(s)-2-amino-2(3,4-dichlorobenzyl)-1-propanol and pharmaceutical compositions containing same