DK672788A - Rekombinant-dna-vektorer til direkte udtrykkelse af aktiveret humant protein c - Google Patents
Rekombinant-dna-vektorer til direkte udtrykkelse af aktiveret humant protein cInfo
- Publication number
- DK672788A DK672788A DK672788A DK672788A DK672788A DK 672788 A DK672788 A DK 672788A DK 672788 A DK672788 A DK 672788A DK 672788 A DK672788 A DK 672788A DK 672788 A DK672788 A DK 672788A
- Authority
- DK
- Denmark
- Prior art keywords
- humant
- protein
- activated
- recombinant dna
- direct expression
- Prior art date
Links
- 108020004511 Recombinant DNA Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/129,027 US4992373A (en) | 1987-12-04 | 1987-12-04 | Vectors and compounds for direct expression of activated human protein C |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK672788D0 DK672788D0 (da) | 1988-12-02 |
| DK672788A true DK672788A (da) | 1989-07-28 |
Family
ID=22438133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK672788A DK672788A (da) | 1987-12-04 | 1988-12-02 | Rekombinant-dna-vektorer til direkte udtrykkelse af aktiveret humant protein c |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4992373A (da) |
| EP (1) | EP0319312B1 (da) |
| JP (1) | JP2749083B2 (da) |
| KR (1) | KR970009081B1 (da) |
| CN (1) | CN1035527A (da) |
| AR (1) | AR245217A1 (da) |
| AT (1) | ATE96840T1 (da) |
| AU (1) | AU610301B2 (da) |
| CA (1) | CA1339938C (da) |
| DE (1) | DE3885419T2 (da) |
| DK (1) | DK672788A (da) |
| ES (1) | ES2059538T3 (da) |
| HU (1) | HU209587B (da) |
| IE (1) | IE61627B1 (da) |
| IL (1) | IL88559A (da) |
| MX (1) | MX166847B (da) |
| NZ (1) | NZ227177A (da) |
| PT (1) | PT89135B (da) |
| RU (1) | RU1830081C (da) |
| ZA (1) | ZA889033B (da) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6437298A (en) * | 1987-08-04 | 1989-02-07 | Hiroshi Okamoto | Production of c-terminal amidated peptide |
| EP0485504B1 (en) * | 1989-08-11 | 1993-12-01 | Zymogenetics, Inc. | Cell culture methods for producing activated protein c |
| JP3270462B2 (ja) * | 1989-12-29 | 2002-04-02 | ザイモジェネティクス，インコーポレイティド | ハイブリッドプロテインｃ |
| US5270178A (en) * | 1990-02-23 | 1993-12-14 | Eli Lilly And Company | Vectors and compounds for expression of zymogen forms of human protein C |
| IL97312A (en) * | 1990-02-23 | 1999-01-26 | Lilly Co Eli | A method of generating a polypeptide in an eukaryotic vector AND recombinant surrogate cell containing an enhanced transcriptional control unit based on the primary late adenovirus coefficient |
| IL97311A0 (en) * | 1990-02-23 | 1992-05-25 | Lilly Co Eli | Vectors and compounds for expression of glycosylation mutants of human protein c |
| US5326700A (en) * | 1990-11-06 | 1994-07-05 | Eli Lilly And Company | DNA sequences encoding t-PA derivatives with cleavable sites |
| EP0785273A1 (en) * | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Paired basic amino acid converting enzyme and DNA sequence encoding it |
| ATE211177T1 (de) * | 1991-01-11 | 2002-01-15 | American Nat Red Cross | Expression von aktivem menschlichem protein c im milchdrüsengewebe transgener tiere |
| US5965789A (en) * | 1991-01-11 | 1999-10-12 | American Red Cross | Engineering protein posttranslational modification by PACE/furin in transgenic non-human mammals |
| US6262336B1 (en) | 1991-01-11 | 2001-07-17 | American Red Cross | Expression of a heterologous protein C in mammary tissue of transgenic animals using a long whey acidic protein promoter |
| US5831141A (en) * | 1991-01-11 | 1998-11-03 | United States Of America As Represented By The Department Of Health And Human Services | Expression of a heterologous polypeptide in mammary tissue of transgenic non-human mammals using a long whey acidic protein promoter |
| MY110664A (en) * | 1992-05-21 | 1999-01-30 | Lilly Co Eli | Protein c derivatives |
| US5464934A (en) * | 1993-05-14 | 1995-11-07 | Mallinckrodt Medical, Inc. | Metal chelates as spacer compounds in biologically active peptides |
| US5618714A (en) * | 1993-12-15 | 1997-04-08 | Eli Lilly And Company | Methods for producing protein C |
| US5698444A (en) * | 1993-12-23 | 1997-12-16 | Eli Lilly And Company | Serotonin receptor protein and related nucleic acid compounds |
| US6017697A (en) | 1994-11-14 | 2000-01-25 | Eli Lilly And Company | Excitatory amino acid receptor protein and related nucleic acid compounds |
| US5723755A (en) * | 1995-05-16 | 1998-03-03 | Francis E. Lefaivre | Large scale production of human or animal proteins using plant bioreactors |
| WO1997020043A1 (en) * | 1995-11-30 | 1997-06-05 | Zymogenetics, Inc. | Protein c production in transgenic animals |
| US5905185A (en) * | 1995-11-30 | 1999-05-18 | Ppl Therapeutics | Protein C production in non-human transgenic mammals |
| ZA983496B (en) * | 1997-04-28 | 1999-10-25 | Lilly Co Eli | Methods for processing activated protein C. |
| US6630137B1 (en) * | 1997-04-28 | 2003-10-07 | Eli Lilly And Company | Activated protein C formulations |
| BR9809932A (pt) * | 1997-06-05 | 2000-08-01 | Lilly Co Eli | Métodos para tratamento de distúrbios trombóticos |
| HUP0001237A3 (en) * | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| US6103524A (en) * | 1998-07-30 | 2000-08-15 | Eli Lilly And Company | Metabotropic glutamate receptor protein and nucleic acid |
| US6815533B1 (en) | 1998-07-31 | 2004-11-09 | Eli Lilly And Company | Cryogranulation of activated protein C |
| CN1324244A (zh) | 1998-10-22 | 2001-11-28 | 伊莱利利公司 | 治疗脓毒症的方法 |
| DE69930419T2 (de) | 1998-11-13 | 2006-09-07 | Eli Lilly And Co., Indianapolis | Verwendung von menschliche protein c zur herstellung eines arzneimittels zur behandlung von heparininduzierter thrombozytopenie |
| ATE235915T1 (de) | 1998-11-20 | 2003-04-15 | Lilly Co Eli | Behandlung von hämorrhagischem virusfieber mit protein c |
| BR9915572A (pt) | 1998-11-23 | 2001-08-14 | Lilly Co Eli | Processo de tratamento de doença de célula falciforme e talassemia |
| US6998122B1 (en) | 1999-04-30 | 2006-02-14 | Eli Lilly And Company | Protein C derivatives |
| CA2372907A1 (en) * | 1999-04-30 | 2000-11-09 | Andrew Darrow | Zymogen activation system |
| US6420157B1 (en) * | 1999-04-30 | 2002-07-16 | Ortho-Mcneil Pharmaceutical, Inc. | Zymogen activation system |
| EP1237917A2 (en) * | 1999-11-19 | 2002-09-11 | Eli Lilly And Company | Protein c derivatives |
| US6841371B2 (en) | 2000-02-02 | 2005-01-11 | Eli Lilly And Company | Protein C derivatives |
| JP2003521938A (ja) | 2000-02-11 | 2003-07-22 | イーライ・リリー・アンド・カンパニー | プロテインｃ誘導体 |
| US7204981B2 (en) * | 2000-03-28 | 2007-04-17 | Eli Lilly And Company | Methods of treating diseases with activated protein C |
| EP1289543A2 (en) | 2000-05-24 | 2003-03-12 | Eli Lilly And Company | Formulations and methods for treating hypercoagulable states |
| MXPA03003388A (es) * | 2000-10-18 | 2005-03-07 | Maxygen Aps | Moleculas de proteina c o similares a las de proteina c activadas. |
| US6933367B2 (en) | 2000-10-18 | 2005-08-23 | Maxygen Aps | Protein C or activated protein C-like molecules |
| WO2002085117A1 (en) * | 2001-04-24 | 2002-10-31 | Eisai Co., Ltd. | Methods and compositions for preventing and treating septic shock and endotoxemia |
| EP1453529A4 (en) | 2001-09-19 | 2007-09-26 | Oklahoma Med Res Found | TREATMENT OF SEPSIS WITH TAFI |
| US20030073636A1 (en) * | 2001-09-19 | 2003-04-17 | Oklahoma Medical Research Foundation | Method of treating diabetes |
| FR2831170B1 (fr) * | 2001-10-19 | 2004-03-19 | Inst Nat Sante Rech Med | Proteines c modifiees activables directement par la thrombine |
| US20050143283A1 (en) * | 2002-03-08 | 2005-06-30 | Eli Lilly And Company | Activated protein c formulations |
| US20070142272A1 (en) * | 2003-01-24 | 2007-06-21 | Zlokovic Berislav V | Neuroprotective activity of activated protein c independent of its anticoagulant activity |
| JP2008507561A (ja) * | 2004-07-23 | 2008-03-13 | ザ ユニバーシティ オブ ロチェスター | 活性化プロテインｃによる、脳内のプラスミノゲン活性化因子の不都合な作用の阻害 |
| AU2006250889A1 (en) * | 2005-05-24 | 2006-11-30 | Avesthagen Limited | A process comprising codon optimization for the production of recombinant activated human protein C for the treatment of sepsis |
| US20090148458A1 (en) * | 2005-06-23 | 2009-06-11 | The University Of British Columbia | Coagulation factor iii polymorphisms associated with prediction of subject outcome and response to therapy |
| BRPI0613137A2 (pt) * | 2005-06-24 | 2010-12-21 | Drugrecure Aps | administração em vias aéreas de proteìna c ativada em condições inflamatórias afetando o trato respiratório |
| EP2041338A4 (en) * | 2006-06-09 | 2009-09-30 | Univ British Columbia | INTERFERON GAMMA POLYMORPHISMS AS INDICATORS OF RESULT IN SERIOUSLY SICK SUBJECTS |
| CA2712057A1 (en) * | 2008-01-15 | 2009-07-23 | The University Of British Columbia | Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound |
| RU2469093C2 (ru) * | 2008-12-19 | 2012-12-10 | Общество с ограниченной ответственностью "Лаборатория медицинской биотехнологии" (ООО "ЛМБТ") | ЭКСПРЕССИОННАЯ ПЛАЗМИДНАЯ ДНК pCID-PROC, КОДИРУЮЩАЯ ПРОТЕИН С ЧЕЛОВЕКА, И КЛЕТОЧНАЯ ЛИНИЯ DG-CID-PROC-1, ПРОДУЦИРУЮЩАЯ РЕКОМБИНАНТНЫЙ ПРОТЕИН С ЧЕЛОВЕКА |
| ES2629099T3 (es) | 2008-12-19 | 2017-08-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Derivados de serin proteasa y usos en la prevención o el tratamiento de y trastornos de la coagulación sanguinea |
| EP2199387A1 (en) | 2008-12-19 | 2010-06-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Serine protease derivatives and uses for the prevention and/or the treatment of blood coagulation disorders |
| EP2539448B1 (en) * | 2010-02-26 | 2016-12-14 | The Children's Hospital of Philadelphia | Protein c zymogen and methods of use thereof to prevent cancer metastases |
| WO2012068519A2 (en) | 2010-11-19 | 2012-05-24 | Sirius Genomics Inc. | Markers associated with response to activated protein c administration, and uses thereof |
| US11895994B2 (en) | 2019-10-27 | 2024-02-13 | Shanghai Raas Blood Products Co., Ltd. | Humanized knock-in mouse expressing human Protein C |
| JPWO2023171719A1 (da) * | 2022-03-08 | 2023-09-14 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4769326A (en) * | 1980-02-29 | 1988-09-06 | The Regents Of The University Of California | Expression linkers |
| US4603105A (en) * | 1982-05-27 | 1986-07-29 | Kaplan Donald A | Efficient screening methods for low probability variants |
| GB8327860D0 (en) * | 1983-10-18 | 1983-11-16 | Fujisawa Pharmaceutical Co | Monoclonal antiprotein c antibody |
| US4617265A (en) * | 1984-09-19 | 1986-10-14 | Board Of Regents, University Of Texas System | Colony blot assay for enterotoxigenic bacteria |
| US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
| CA1341228C (en) * | 1985-06-27 | 2001-05-15 | Mark J. Murray | Expression of protein c |
| US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
| GB8728837D0 (en) * | 1987-12-10 | 1988-01-27 | Eaton Corp | Semi-automatic mechanical transmission control and control and control method |
| ZA889497B (en) * | 1987-12-28 | 1990-08-29 | Lilly Co Eli | Vectors and compounds for expression of zymogen forms of human protein c |
-
1987
- 1987-12-04 US US07/129,027 patent/US4992373A/en not_active Expired - Lifetime
-
1988
- 1988-12-01 ZA ZA889033A patent/ZA889033B/xx unknown
- 1988-12-01 IL IL8855988A patent/IL88559A/en not_active IP Right Cessation
- 1988-12-01 HU HU886142A patent/HU209587B/hu not_active IP Right Cessation
- 1988-12-01 AR AR88312611A patent/AR245217A1/es active
- 1988-12-02 AU AU26509/88A patent/AU610301B2/en not_active Ceased
- 1988-12-02 DE DE88311421T patent/DE3885419T2/de not_active Expired - Fee Related
- 1988-12-02 PT PT89135A patent/PT89135B/pt active IP Right Grant
- 1988-12-02 AT AT88311421T patent/ATE96840T1/de not_active IP Right Cessation
- 1988-12-02 JP JP63306784A patent/JP2749083B2/ja not_active Expired - Lifetime
- 1988-12-02 IE IE361288A patent/IE61627B1/en not_active IP Right Cessation
- 1988-12-02 CA CA000584921A patent/CA1339938C/en not_active Expired - Fee Related
- 1988-12-02 MX MX014026A patent/MX166847B/es unknown
- 1988-12-02 RU SU884613088A patent/RU1830081C/ru active
- 1988-12-02 EP EP88311421A patent/EP0319312B1/en not_active Expired - Lifetime
- 1988-12-02 DK DK672788A patent/DK672788A/da not_active Application Discontinuation
- 1988-12-02 NZ NZ227177A patent/NZ227177A/xx unknown
- 1988-12-02 ES ES88311421T patent/ES2059538T3/es not_active Expired - Lifetime
- 1988-12-03 CN CN88108295A patent/CN1035527A/zh active Pending
- 1988-12-03 KR KR88016104A patent/KR970009081B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AR245217A1 (es) | 1993-12-30 |
| RU1830081C (ru) | 1993-07-23 |
| IE61627B1 (en) | 1994-11-16 |
| AU2650988A (en) | 1989-06-08 |
| EP0319312A3 (en) | 1990-09-19 |
| IL88559A0 (en) | 1989-07-31 |
| CA1339938C (en) | 1998-07-07 |
| HU209587B (en) | 1994-08-29 |
| KR970009081B1 (en) | 1997-06-05 |
| IE883612L (en) | 1989-06-04 |
| EP0319312A2 (en) | 1989-06-07 |
| US4992373A (en) | 1991-02-12 |
| CN1035527A (zh) | 1989-09-13 |
| AU610301B2 (en) | 1991-05-16 |
| HUT50497A (en) | 1990-02-28 |
| JPH022372A (ja) | 1990-01-08 |
| MX166847B (es) | 1993-02-09 |
| ES2059538T3 (es) | 1994-11-16 |
| PT89135A (pt) | 1989-12-29 |
| DE3885419T2 (de) | 1994-03-31 |
| DE3885419D1 (de) | 1993-12-09 |
| JP2749083B2 (ja) | 1998-05-13 |
| ATE96840T1 (de) | 1993-11-15 |
| ZA889033B (en) | 1990-08-29 |
| DK672788D0 (da) | 1988-12-02 |
| KR890010199A (ko) | 1989-08-07 |
| IL88559A (en) | 1994-02-27 |
| NZ227177A (en) | 1990-07-26 |
| EP0319312B1 (en) | 1993-11-03 |
| PT89135B (pt) | 1994-04-29 |
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