DK8091D0 - Kontrastmidler indeholdende stabile friradikaler - Google Patents

Kontrastmidler indeholdende stabile friradikaler

Info

Publication number
DK8091D0
DK8091D0 DK008091A DK8091A DK8091D0 DK 8091 D0 DK8091 D0 DK 8091D0 DK 008091 A DK008091 A DK 008091A DK 8091 A DK8091 A DK 8091A DK 8091 D0 DK8091 D0 DK 8091D0
Authority
DK
Denmark
Prior art keywords
contrast agents
friradicals
agents containing
containing stable
stable
Prior art date
Application number
DK008091A
Other languages
English (en)
Other versions
DK8091A (da
Inventor
Ib Leunback
Original Assignee
Hafslund Nycomed Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hafslund Nycomed Innovation filed Critical Hafslund Nycomed Innovation
Publication of DK8091D0 publication Critical patent/DK8091D0/da
Publication of DK8091A publication Critical patent/DK8091A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
DK008091A 1988-07-19 1991-01-17 Kontrastmidler indeholdende stabile friradikaler DK8091A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888817137A GB8817137D0 (en) 1988-07-19 1988-07-19 Compositions
PCT/EP1989/000832 WO1990000904A1 (en) 1988-07-19 1989-07-17 Stable free radical containing contrast media

Publications (2)

Publication Number Publication Date
DK8091D0 true DK8091D0 (da) 1991-01-17
DK8091A DK8091A (da) 1991-01-17

Family

ID=10640699

Family Applications (1)

Application Number Title Priority Date Filing Date
DK008091A DK8091A (da) 1988-07-19 1991-01-17 Kontrastmidler indeholdende stabile friradikaler

Country Status (13)

Country Link
US (1) US5322065A (da)
EP (1) EP0351919B1 (da)
JP (1) JPH03506028A (da)
AT (1) ATE77755T1 (da)
AU (1) AU622692B2 (da)
DE (1) DE68901958T2 (da)
DK (1) DK8091A (da)
ES (1) ES2033077T3 (da)
GB (1) GB8817137D0 (da)
GR (1) GR3005234T3 (da)
PH (1) PH27247A (da)
WO (1) WO1990000904A1 (da)
ZA (1) ZA895468B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819753D0 (en) * 1988-08-19 1988-09-21 Nycomed As Apparatus
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
GB8929300D0 (en) * 1989-12-29 1990-02-28 Instrumentarium Corp Apparatus
GB9024528D0 (en) * 1990-11-12 1991-01-02 Instrumentarium Corp Improvements in and relating to magnetic resonance imaging
US5264204A (en) * 1992-04-30 1993-11-23 Mallinckrodt Medical, Inc. Hydrophilic free radicals for magnetic resonance imaging
DE4328639C2 (de) * 1993-08-23 2002-10-24 Lancaster Group Gmbh Verfahren zur Messung des antioxidativen Potentials der Haut
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
AU1208697A (en) * 1995-12-28 1997-07-28 Daiichi Radioisotope Laboratories, Ltd. Diagnostic drugs
US5978694A (en) * 1997-02-27 1999-11-02 Uri Rapoport Method and apparatus for detecting a magnetically responsive substance
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6185444B1 (en) * 1998-03-13 2001-02-06 Skelscan, Inc. Solid-state magnetic resonance imaging
US6503478B2 (en) * 1999-01-13 2003-01-07 Lightouch Medical, Inc. Chemically specific imaging of tissue
US6574496B1 (en) * 1999-05-19 2003-06-03 Amersham Health As Magnetic resonance imaging
US7574248B2 (en) * 2002-05-17 2009-08-11 General Hospital Corporation Method and apparatus for quantitative bone matrix imaging by magnetic resonance imaging
AU2005267668B2 (en) 2004-07-30 2011-10-20 Ge Healthcare As Method of producing a composition, composition and its use
US20070025918A1 (en) * 2005-07-28 2007-02-01 General Electric Company Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization
WO2007038626A2 (en) * 2005-09-28 2007-04-05 President And Fellows Of Harvard College Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging
EP1954321B1 (en) 2005-12-01 2011-11-23 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
WO2007066247A2 (en) 2005-12-08 2007-06-14 Koninklijke Philips Electronics, N.V. System and method for monitoring in vivo drug release using overhauser-enhanced nmr
AU2006326596A1 (en) * 2005-12-10 2007-06-21 The President And Fellows Of Harvard College In situ hyperpolarization of imaging agents
US20090252686A1 (en) * 2006-01-11 2009-10-08 President And Fellows Of Harvard College Ex Vivo Hyperpolarization of Imaging Agents
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
DE102008064400A1 (de) * 2008-06-02 2009-12-03 Rohde & Schwarz Gmbh & Co. Kg Mikrowellenuntersuchung mit einem Kontrastmittel
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
EP2476009A1 (en) 2009-09-10 2012-07-18 GE Healthcare UK Limited 13c-mr detection using hyperpolarised 13c-fructose
JP5758982B2 (ja) 2010-04-08 2015-08-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 過分極基質の製造方法およびｍｒｉのための方法
EP2766050B1 (en) 2011-10-12 2018-09-05 Bracco Imaging S.p.A Process for the preparation of hyperpolarized derivatives for use in mri analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
EP2833924B1 (en) 2012-04-02 2019-05-08 Bracco Imaging S.p.A Hyperpolarized amino acids

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2154857A5 (en) * 1971-09-28 1973-05-18 Commissariat Energie Atomique Deuterated nitroxide radical - tetra methyl 2,2,5,5-aza -1-cyclopentane oxa-3-oxyl-1
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4516075A (en) * 1983-01-04 1985-05-07 Wisconsin Alumni Research Foundation NMR scanner with motion zeugmatography
DE3328365A1 (de) * 1983-08-03 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Neue diagnostische mittel
US4615879A (en) * 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
GB8522535D0 (en) * 1985-09-11 1985-10-16 Amersham Int Plc Contrast agent
US4834964A (en) * 1986-03-07 1989-05-30 M.R.I., Inc. Use of charged nitroxides as NMR image enhancing agents for CSF
US4719425A (en) * 1986-04-15 1988-01-12 Scientific Innovations, Inc. NMR imaging method and apparatus
US4984573A (en) * 1987-06-23 1991-01-15 Hafslund Nycomed Innovation Ab Method of electron spin resonance enhanced magnetic resonance imaging
US5167948A (en) * 1987-08-07 1992-12-01 Mallinckrodt Medical, Inc. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
US5042488A (en) * 1987-09-29 1991-08-27 The Washington University Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ
US4893627A (en) * 1988-05-26 1990-01-16 The United States Of America As Represented By The United States Department Of Energy Method for nuclear magnetic resonance imaging using deuterum as a contrast agent

Also Published As

Publication number Publication date
JPH03506028A (ja) 1991-12-26
GB8817137D0 (en) 1988-08-24
DE68901958D1 (de) 1992-08-06
US5322065A (en) 1994-06-21
WO1990000904A1 (en) 1990-02-08
ES2033077T3 (es) 1993-03-01
DE68901958T2 (de) 1992-12-10
AU3867889A (en) 1990-02-19
PH27247A (en) 1993-05-03
EP0351919A1 (en) 1990-01-24
ATE77755T1 (de) 1992-07-15
DK8091A (da) 1991-01-17
GR3005234T3 (da) 1993-05-24
EP0351919B1 (en) 1992-07-01
ZA895468B (en) 1990-04-25
AU622692B2 (en) 1992-04-16

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