DK81290A - Rekombinante bakterier og malariavaccine indeholdende disse - Google Patents
Rekombinante bakterier og malariavaccine indeholdende disse Download PDFInfo
- Publication number
- DK81290A DK81290A DK081290A DK81290A DK81290A DK 81290 A DK81290 A DK 81290A DK 081290 A DK081290 A DK 081290A DK 81290 A DK81290 A DK 81290A DK 81290 A DK81290 A DK 81290A
- Authority
- DK
- Denmark
- Prior art keywords
- bacteries
- recombinant
- vaccine containing
- malaria vaccine
- malaria
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title 1
- 229940124735 malaria vaccine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/879—Salmonella
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/104,735 US5112749A (en) | 1987-10-02 | 1987-10-02 | Vaccines for the malaria circumsporozoite protein |
| PCT/US1988/003376 WO1989002924A1 (en) | 1987-10-02 | 1988-09-30 | Vaccines for malaria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK81290D0 DK81290D0 (da) | 1990-03-30 |
| DK81290A true DK81290A (da) | 1990-05-14 |
Family
ID=22302087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK081290A DK81290A (da) | 1987-10-02 | 1990-03-30 | Rekombinante bakterier og malariavaccine indeholdende disse |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5112749A (da) |
| EP (1) | EP0383833A4 (da) |
| JP (1) | JPH03500246A (da) |
| AU (1) | AU2813589A (da) |
| DK (1) | DK81290A (da) |
| OA (1) | OA09200A (da) |
| WO (1) | WO1989002924A1 (da) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT92511A (pt) * | 1988-12-07 | 1990-06-29 | Univ Leicester | Processo de preparacao de um hospedeiro transformado e de proteinas de fusao da subunidade b de toxina labil ao calor |
| SE8904100D0 (sv) * | 1989-12-05 | 1989-12-05 | Astra Ab | New analysis method |
| NZ233255A (en) * | 1989-04-11 | 1993-02-25 | Chiron Corp | Plasmodium cs protein analogues lacking one or more of the repeat epitopes, and containing at least one nonrepeat flanking epitope |
| FR2645877B1 (fr) * | 1989-04-12 | 1991-07-05 | Pasteur Institut | Molecules comportant au moins une sequence peptidique porteuse d'un, ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum au niveau du stade sporozoite et dans les hepatocytes |
| DE69005572T2 (de) * | 1989-09-08 | 1994-04-07 | Takeda Chemical Industries Ltd | Fusionsproteine und Herstellung davon. |
| US5260198A (en) * | 1990-03-31 | 1993-11-09 | Mitsui Toatsu Chemicals, Inc. | Cloned tyrosine phenol-lyase gene, recombinant plasmid containing the same and escherichia coli transformed with the same |
| US5241053A (en) * | 1990-09-05 | 1993-08-31 | Takeda Chemical Industries, Ltd. | Fused proteins comprising glycoprotein gD of HSV-1 and LTB |
| TW201794B (da) * | 1991-05-03 | 1993-03-11 | American Cyanamid Co | |
| US6169171B1 (en) * | 1992-02-27 | 2001-01-02 | Smithkline Beecham Biologicals (S.A.) | Hybrid protein between CS from plasmodium and HBSAG |
| US5928902A (en) * | 1992-02-27 | 1999-07-27 | Smithkline Beecham Biologicals (S.A.) | Hybrid protein between CS from plasmodium and HBsAg |
| FR2697022B1 (fr) | 1992-10-19 | 1994-12-16 | Pasteur Institut | Antigènes de Plasmodium falciparum capables d'induire des anticorps protecteurs à large spectre - Application à la vaccination. |
| CA2156191A1 (en) * | 1993-02-22 | 1994-09-01 | Stephen B. Calderwood | Heterologous antigens in live cell vaccine strains |
| AU6705594A (en) * | 1993-04-15 | 1994-11-08 | Washington University | Compositions of antigen containing recombinant salmonella, their use in anti-malarial vaccines and method for their preparation |
| US5821074A (en) * | 1993-12-21 | 1998-10-13 | Abbott Laboratories | Method and compositions for enhancing aminolevulinic acid dehydratase assay |
| US5565327A (en) * | 1994-03-25 | 1996-10-15 | Duke University | Methods of diagnosing parasitic infections and of testing drug susceptibility of parasites |
| US7223739B1 (en) * | 1995-06-07 | 2007-05-29 | Powderject Vaccines, Inc. | Adjuvanted genetic vaccines |
| US7045336B1 (en) * | 1995-09-06 | 2006-05-16 | The United States Of America As Represented By The Secretary Of The Army | Bacterial delivery system |
| WO1998023763A1 (en) * | 1996-11-29 | 1998-06-04 | The General Hospital Corporation | Heterologous antigens in live cell v. cholerae strains |
| US7189402B1 (en) * | 1998-02-06 | 2007-03-13 | Research Development Foundation | Live vaccine for human immunodeficiency virus |
| ATE512231T1 (de) | 1998-02-27 | 2011-06-15 | Univ Pennsylvania | Impfstoffe, immuntherapeutika und verfahren zur anwendung derselben |
| EP1168918A4 (en) * | 1999-03-03 | 2002-08-21 | Univ Pennsylvania | VACCINE AND GENE THERAPY COMPOSITIONS AND METHOD FOR THEIR PRODUCTION AND USE |
| US7446189B1 (en) | 1999-04-30 | 2008-11-04 | Institut De Recherches Cliniques De Montreal | Nucleic acids encoding mutant human CD80 and compositions comprising the same |
| KR100815888B1 (ko) * | 2000-07-14 | 2008-03-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Hiv 보조 단백질을 암호화하는 dna 백신 |
| AU2002211490A1 (en) * | 2000-10-04 | 2002-04-15 | The Trustees Of The University Of Pennsylvania | Compositions and methods of using capsid protein from flaviviruses and pestiviruses |
| MXPA05006522A (es) * | 2002-12-23 | 2006-02-17 | Bristol Myers Squibb Co | Mejora en la calidad de producto en procesos de cultivo en celulas de mamiferos para la produccion de proteina. |
| NZ570709A (en) | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| EP1633372B1 (en) | 2003-06-13 | 2011-11-30 | The Trustees of The University of Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
| WO2007050095A2 (en) | 2004-11-19 | 2007-05-03 | The Trustees Of The University Of Pennsylvania | Improved vaccines and methods for using the same |
| ES2374458T3 (es) | 2006-01-13 | 2012-02-16 | The Trustees Of The University Of Pennsylvania | Vacunas y agentes inmunoterapéuticos que utilizan il-15 optimizada en codones, y métodos para utilización de los mismos. |
| US9259463B2 (en) | 2006-01-16 | 2016-02-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Chlamydia vaccine |
| CA3057039C (en) | 2006-07-28 | 2023-02-28 | The Trustees Of The University Of Pennsylvania | Hiv consensus envelope sequences and methods for using same |
| KR101652767B1 (ko) * | 2008-04-04 | 2016-08-31 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Il-28을 이용한 백신 및 면역치료제, 및 그를 사용하는 방법 및 조성물 |
| CA2720166A1 (en) * | 2008-04-04 | 2009-10-08 | David B. Weiner | Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same |
| JP4797050B2 (ja) * | 2008-09-09 | 2011-10-19 | 前田製品販売株式会社 | 高さ調整機構付コンクリート製品 |
| WO2010050939A1 (en) | 2008-10-29 | 2010-05-06 | The Trustees Of The University Of Pennsylvania | Improved hcv vaccines and methods for using the same |
| US8921536B2 (en) | 2008-10-29 | 2014-12-30 | The Trustees Of The University Of Pennsylvania | HCV vaccines and methods for using the same |
| CA2653478A1 (en) * | 2009-01-23 | 2010-07-23 | Gregg Martin | Automated wash system for industrial vehicles |
| US9050287B2 (en) | 2009-01-23 | 2015-06-09 | The Trustees Of The University Of Pennsylvania | Vaccines for human papilloma virus and methods for using the same |
| US9119815B2 (en) | 2009-05-05 | 2015-09-01 | Cadila Healthcare Limited | Combined measles-malaria vaccine |
| WO2011032179A1 (en) | 2009-09-14 | 2011-03-17 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same |
| KR102138780B1 (ko) | 2009-11-02 | 2020-07-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 구제역 바이러스(fmdv) 공통 단백질, 이를 위한 코딩 서열 및 이로부터 만들어진 백신 |
| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| EP2539354B1 (en) | 2010-02-08 | 2017-04-05 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same |
| JP6077450B2 (ja) | 2010-11-12 | 2017-02-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| EA033467B1 (ru) | 2011-01-31 | 2019-10-31 | Univ Pennsylvania | Молекула нуклеиновой кислоты для индукции иммунного ответа против герпесвируса и ее применение |
| US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
| EA032364B1 (ru) | 2011-02-11 | 2019-05-31 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Молекула нуклеиновой кислоты, кодирующая коровый белок вируса гепатита в, и вакцина, содержащая указанную молекулу |
| ES2873233T3 (es) * | 2011-06-24 | 2021-11-03 | Realco | Kit y procedimiento de detección de biopelículas |
| KR102314421B1 (ko) | 2011-07-11 | 2021-10-19 | 이노비오 파마수티컬즈, 인크. | 교차-보호성 아레나바이러스 백신 및 이의 사용 방법 |
| MX360449B (es) | 2011-10-12 | 2018-11-01 | Univ Pennsylvania | Vacunas para el virus del papiloma humano y metodos para su uso. |
| EP2771035B1 (en) | 2011-10-24 | 2018-04-11 | The Trustees Of The University Of Pennsylvania | Improved hcv vaccines and methods for using the same |
| JP6333730B2 (ja) | 2011-12-12 | 2018-05-30 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 改善されたil−12遺伝子構築物を含む組成物、及びそれを用いたワクチン、免疫治療剤及び方法 |
| JP6407028B2 (ja) | 2011-12-12 | 2018-10-17 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | MRSAのPBP2a及びその断片を含むタンパク質、それをコードする核酸、並びにMRSA感染を予防する及び治療するための組成物及びそれらの使用 |
| HK1210479A1 (en) | 2012-04-10 | 2016-04-22 | The Trustees Of The University Of Pennsylvania | Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
| ES2776429T3 (es) * | 2012-12-07 | 2020-07-30 | Elanco Tiergesundheit Ag | Preparación de vacunas vivas |
| AU2014248535B2 (en) | 2013-03-12 | 2017-03-30 | Inovio Pharmaceuticals, Inc. | Improved vaccines for human papilloma virus and methods for using the same |
| CN105338998B (zh) | 2013-03-15 | 2021-12-14 | 宾夕法尼亚大学理事会 | 口蹄疫病毒(fmdv)共有蛋白、其编码序列以及由其制造的疫苗 |
| KR20150130284A (ko) | 2013-03-15 | 2015-11-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암 백신 및 이를 이용한 치료 방법 |
| KR102668476B1 (ko) | 2017-12-13 | 2024-05-23 | 이노비오 파마수티컬즈, 인크. | Boris를 표적으로 하는 암 백신 및 이의 용도 |
| WO2019118760A1 (en) | 2017-12-13 | 2019-06-20 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting mesothelin and uses thereof |
| WO2019118764A1 (en) | 2017-12-13 | 2019-06-20 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting muc16 and uses thereof |
| CA3083532C (en) | 2017-12-13 | 2023-09-05 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting prame and uses thereof |
| CN112457411B (zh) * | 2020-11-25 | 2022-11-01 | 中国药科大学 | 一种幽门螺杆菌多表位串联融合蛋白lhuc及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6114889A (ja) * | 1984-06-29 | 1986-01-23 | フアナツク株式会社 | 内圧防爆構造の電動式産業用ロボツト |
| US4550081A (en) * | 1980-05-19 | 1985-10-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Non-reverting salmonella |
| US4735801A (en) * | 1982-09-07 | 1988-04-05 | Board Of Trustees Of Leland Stanford Jr. University | Novel non-reverting salmonella live vaccines |
| US4837151A (en) * | 1980-05-19 | 1989-06-06 | The Board Of Trustees Of The Leland Stanford Junior University, Stanford University | Live vaccines comprising two mutations and foreign antigen |
| US4761372A (en) * | 1981-01-12 | 1988-08-02 | New York University | Mutant enterotoxin of E. coli |
| US4411888A (en) * | 1981-06-22 | 1983-10-25 | The University Of Rochester | Composition of a novel immunogen for protection against diarrheal disease caused by enterotoxigenic Escherichia coli |
| US4632830A (en) * | 1981-07-31 | 1986-12-30 | The United States Of America As Represented By The Secretary Of The Army | Oral vaccine for immunization against enteric disease |
| US4758655A (en) * | 1983-01-03 | 1988-07-19 | Scripps Clinic And Research Foundation | Synthetic polypeptide corresponding to a portion of the heat-labile enterotoxin of escherichia coli, compositions and methods of therewith |
| GB8314645D0 (en) * | 1983-05-26 | 1983-06-29 | Wellcome Found | Bivalent vaccines |
| IL69558A (en) * | 1983-08-23 | 1988-06-30 | Yeda Res & Dev | Synthetic cholera vaccine |
| US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| IL78775A (en) * | 1985-05-15 | 1992-06-21 | Biotech Australia Pty Ltd | Oral vaccines |
| CA1331355C (en) * | 1986-04-21 | 1994-08-09 | Bioenterprises Pty. Ltd | Immunopotentation |
| EP0249449A1 (en) * | 1986-06-11 | 1987-12-16 | Enterovax Research Pty. Ltd. | Bacterial strain for live vaccines |
| JPH0284172A (ja) * | 1988-07-21 | 1990-03-26 | Smithkline Beckman Corp | 異種遺伝子の発現能を有し、組換え型ワクチンとして有用なサルモネラ形質転換体 |
-
1987
- 1987-10-02 US US07/104,735 patent/US5112749A/en not_active Expired - Fee Related
-
1988
- 1988-09-30 AU AU28135/89A patent/AU2813589A/en active Granted
- 1988-09-30 JP JP1500257A patent/JPH03500246A/ja active Pending
- 1988-09-30 WO PCT/US1988/003376 patent/WO1989002924A1/en not_active Ceased
- 1988-09-30 EP EP19890900389 patent/EP0383833A4/en not_active Ceased
-
1990
- 1990-03-29 OA OA59758A patent/OA09200A/xx unknown
- 1990-03-30 DK DK081290A patent/DK81290A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| OA09200A (en) | 1992-06-30 |
| EP0383833A1 (en) | 1990-08-29 |
| AU2813589A (en) | 1989-04-18 |
| US5112749A (en) | 1992-05-12 |
| DK81290D0 (da) | 1990-03-30 |
| EP0383833A4 (en) | 1990-11-07 |
| JPH03500246A (ja) | 1991-01-24 |
| WO1989002924A1 (en) | 1989-04-06 |
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