DK8386A - Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme - Google Patents

Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme Download PDF

Info

Publication number
DK8386A
DK8386A DK008386A DK8386A DK8386A DK 8386 A DK8386 A DK 8386A DK 008386 A DK008386 A DK 008386A DK 8386 A DK8386 A DK 8386A DK 8386 A DK8386 A DK 8386A
Authority
DK
Denmark
Prior art keywords
carbamoyltetrahydroisoquinolines
benzyl
procedures
substituted
preparation
Prior art date
Application number
DK008386A
Other languages
English (en)
Other versions
DK8386D0 (da
Inventor
Chavdar Borissov Ivanov
Donka Minkova Mondeshka
Nikolina Dimitrova Berova
Rossitza Stefanova Rakovska
Yordanka Tzolova Panova
Marko Tzonev Markov
Radi Georgiev Ovcharov
Petko Dimitrov Usunov
Orhideya Boncheva Zabunova
Original Assignee
Tpo Pharmachim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tpo Pharmachim filed Critical Tpo Pharmachim
Publication of DK8386D0 publication Critical patent/DK8386D0/da
Publication of DK8386A publication Critical patent/DK8386A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK008386A 1986-01-15 1986-01-08 Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme DK8386A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP86300241A EP0232569B1 (en) 1986-01-15 1986-01-15 1-benzyl-2-(n-substituted)-carbamoyl-tetrahydroisoquinolines and method for the preparation thereof

Publications (2)

Publication Number Publication Date
DK8386D0 DK8386D0 (da) 1986-01-08
DK8386A true DK8386A (da) 1987-07-09

Family

ID=8195851

Family Applications (1)

Application Number Title Priority Date Filing Date
DK008386A DK8386A (da) 1986-01-15 1986-01-08 Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme

Country Status (5)

Country Link
US (1) US4678853A (da)
EP (1) EP0232569B1 (da)
JP (1) JPS62198666A (da)
DE (1) DE3669507D1 (da)
DK (1) DK8386A (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
US5087214A (en) * 1991-05-21 1992-02-11 United Technologies Automotive, Inc. Battery terminal connector
GB9127306D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US5919795A (en) * 1995-06-07 1999-07-06 Pfizer Inc. Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion
US6858147B2 (en) * 2001-08-03 2005-02-22 Dispersion Technology, Inc. Method for the removal of heavy metals from aqueous solution by means of silica as an adsorbent in counter-flow selective dialysis
ES2580108T3 (es) * 2005-07-11 2016-08-19 Aerie Pharmaceuticals, Inc Compuestos de isoquinolina
EP2526948A1 (en) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO kinase inhibitors
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
WO2010126626A2 (en) 2009-05-01 2010-11-04 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
ES2776199T3 (es) 2013-03-15 2020-07-29 Aerie Pharmaceuticals Inc Conjugados de compuestos de isoquinolina y prostaglandinas
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
WO2017086941A1 (en) 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
WO2018045091A1 (en) 2016-08-31 2018-03-08 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
CA3057872A1 (en) 2017-03-31 2018-10-04 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725388A (en) * 1970-06-25 1973-04-03 Boehringer Sohn Ingelheim N-acyl-7-(n{41 -cycloalkyl-ureido-n{40 -sulfonyl)-isoquinolines and -benzazepines and alkali metal salts thereof
US3875167A (en) * 1972-05-26 1975-04-01 Research Corp Synthesis of thalicarpine
US3905982A (en) * 1973-07-23 1975-09-16 Searle & Co 1-Aryl-n-dialkylaminoalkyl-3,4-dihydro-2(1H)-isoquinolinecarboxamides and related compounds

Also Published As

Publication number Publication date
US4678853A (en) 1987-07-07
EP0232569A1 (en) 1987-08-19
JPS62198666A (ja) 1987-09-02
EP0232569B1 (en) 1990-03-14
DK8386D0 (da) 1986-01-08
DE3669507D1 (de) 1990-04-19

Similar Documents

Publication Publication Date Title
DK195587D0 (da) Phenylpiperazinderivater og deres anvendelse til fremstilling af antiarrytmi-laegemidler
DK288785D0 (da) Benzensulfonamido-derivater til terapeutisk anvendelse og fremgangsmaade til fremstilling af saadanne derivater
DK8386D0 (da) Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme
DK559387D0 (da) Fremgangsmaade og mellemprodukt til fremstilling af 3-pyrrolidinoler
DK94686D0 (da) Nye oxadiazolylimidazobenzodiazepinderivater og fremgangsmaader til fremstilling af samme
DK549087D0 (da) Gangliosidbeslaegtede forbindelser og fremgangsmaade til fremstilling af samme
DK448887D0 (da) Hidtil ukendt amylaseenzym og fremgangsmaade til fremstilling af samme
DK537687D0 (da) Fremgangsmaade til fremstilling af n-substituerede piperazinoner
DK38493D0 (da) Fremgangsmaade til fremstilling af alkoxymethylether- og alkoxymethylesterderivater af glyceroler
DK169386D0 (da) Fremgangsmaade til fremstilling af azetidinderivater og mellemprodukter dertil
DK367683D0 (da) Fremgangsmade til fremstilling af n-substituerede 1-oxido-nicotinamider og salte deraf
DK251087A (da) Dopamin-beta-hydrolaseinhibitorer og fremgangsmaade til fremstilling deraf
DK102387A (da) Fremgangsmaade til fremstilling af biscarbamater og nye biscarbamater
DK525187A (da) Imidazooe4,5-baapyridinon-2-derivater, fremgangsmaade til fremstilling af og laegemidler indeholdende saadanne derivater
DK243885A (da) Fremgangsmaade til fremstilling af stoebeforme og maskine til udoevelse af fremgangsmaaden
DK436887A (da) Fremgangsmaade til fremstilling af triazol-tetrahydrofuran-derivater og mellemprodukter til anvendelse herved
DK355786D0 (da) Fremgangsmaade og precursorer til fremstilling af methyl-9-oxo-11alfa,16-dihydroxy-16-vinyl-5-cis-transprostadienoater
DK585686D0 (da) Form iii krystaller af n-alfa-(((s)-4-oxo-2-azetidinyl)carbonyl)-l-histidyl-l-prolinamid og fremgangsmaade til fremstilling af krystallerne
NO854925L (no) Fremgangsmaate for fremstilling av akrylamid og n-substituerte akrylamider.
DK558487A (da) Fremgangsmaade til fremstilling af moertel
DK84183A (da) Benzyletherderivater af pentiter og fremgangsmaade til fremstilling deraf
DK670588A (da) Farmaceutisk praeparat til behandling af phlebektasi og fremgangsmaade til fremstilling af praeparatet
DK508689A (da) Organofluorider af tin og fremgangsmaade til fremstilling heraf
DK505286A (da) Quinazolinonforbindelser og fremgangsmaader til fremstilling af saadanne forbindelser
DK130992A (da) Fremgangsmaade til fremstilling af angiotenxinomdannende enzyminhibitorer

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment