DK90683A - Fremgangsmaade til udvinding af insulin fra et insulin-protamin-kompleks - Google Patents

Fremgangsmaade til udvinding af insulin fra et insulin-protamin-kompleks Download PDF

Info

Publication number: DK90683A
Authority: DK; Denmark
Prior art keywords: insulin; complex; protamin; recovery; procedure
Prior art date: 1982-02-26

Application number

DK90683A

Other languages

English (en)

Other versions

DK90683D0 (da

Inventor

Denise Louise Grimes

Charles Stephen Hollinden

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-02-26

Filing date

1983-02-25

Publication date

1983-08-27

1983-02-25 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1983-02-25 Publication of DK90683D0 publication Critical patent/DK90683D0/da

1983-08-27 Publication of DK90683A publication Critical patent/DK90683A/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 8
102000004877 Insulin Human genes 0.000 title abstract 4
108090001061 Insulin Proteins 0.000 title abstract 4
229940125396 insulin Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title 1
238000011084 recovery Methods 0.000 title 1
239000012736 aqueous medium Substances 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229940048914 protamine Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK90683A 1982-02-26 1983-02-25 Fremgangsmaade til udvinding af insulin fra et insulin-protamin-kompleks DK90683A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/352,725 US4459226A (en)	1982-02-26	1982-02-26	Process for recovering insulin

Publications (2)

Publication Number	Publication Date
DK90683D0 DK90683D0 (da)	1983-02-25
DK90683A true DK90683A (da)	1983-08-27

Family

ID=23386223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90683A DK90683A (da)	1982-02-26	1983-02-25	Fremgangsmaade til udvinding af insulin fra et insulin-protamin-kompleks

Country Status (7)

Country	Link
US (1)	US4459226A (da)
EP (1)	EP0087932B1 (da)
AT (1)	ATE19390T1 (da)
AU (1)	AU551740B2 (da)
DE (2)	DE87932T1 (da)
DK (1)	DK90683A (da)
GB (1)	GB2115428B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5032109A (en) *	1987-02-10	1991-07-16	Drug Delivery Systems Inc.	Electrolytic transdermal delivery of polypeptides
US4878892A (en) *	1987-02-10	1989-11-07	Drug Delivery Systems Inc.	Electrolytic transdermal delivery of polypeptides
US4940456A (en) *	1987-02-10	1990-07-10	Dan Sibalis	Electrolytic transdermal delivery of proteins
US4992418A (en) *	1987-07-17	1991-02-12	Mount Sinai School Of Medicine	Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
DE3726655A1 (de) *	1987-08-11	1989-02-23	Hoechst Ag	Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
US5208217A (en) *	1989-04-20	1993-05-04	Mount Sinai School Of Medicine Of The City University Of New York	Hepatospecific insulin analogues
AU7678196A (en) *	1995-11-13	1997-06-05	Minimed, Inc.	Methods and compositions for the delivery of monomeric proteins
US6956021B1 (en) *	1998-08-25	2005-10-18	Advanced Inhalation Research, Inc.	Stable spray-dried protein formulations
US7678364B2 (en)	1999-08-25	2010-03-16	Alkermes, Inc.	Particles for inhalation having sustained release properties
US20080248999A1 (en) *	2007-04-04	2008-10-09	Biodel Inc.	Amylin formulations
US20080090753A1 (en)	2004-03-12	2008-04-17	Biodel, Inc.	Rapid Acting Injectable Insulin Compositions
EP2106790B1 (en) *	2004-03-12	2012-10-24	Biodel, Inc.	Rapid acting drug delivery compositions
US20080096800A1 (en) *	2004-03-12	2008-04-24	Biodel, Inc.	Rapid mucosal gel or film insulin compositions
US20080085298A1 (en) *	2004-03-12	2008-04-10	Biodel, Inc.	Rapid Mucosal Gel or Film Insulin Compositions
US8084420B2 (en) *	2005-09-29	2011-12-27	Biodel Inc.	Rapid acting and long acting insulin combination formulations
US7713929B2 (en) *	2006-04-12	2010-05-11	Biodel Inc.	Rapid acting and long acting insulin combination formulations
CA2649109A1 (en) *	2006-04-12	2007-10-25	Biodel, Inc.	Rapid acting and long acting insulin combination formulations
WO2009089181A1 (en) *	2008-01-04	2009-07-16	Blodel, Inc.	Insulin formulations for insulin release as a function of tissue glucose levels
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB797959A (en) *	1955-02-09	1958-07-09	Vitrum Apoteksvar	Improvements in or relating to the preparation of insulin
US3069323A (en) *	1959-09-14	1962-12-18	Armour Pharma	Insulin recovery process
US3221008A (en) *	1962-01-30	1965-11-30	Merck & Co Inc	Ion exchange process for the recovery of ionic organic substances
GB1140353A (en) *	1965-02-22	1969-01-15	Wellcome Found	Improvements in and relating to the preparation of insulin
GB1054523A (da) *	1965-11-17	1900-01-01
US3907676A (en) *	1970-07-28	1975-09-23	Novo Terapeutisk Labor As	Process for purifying insulin
DE2212695A1 (de) *	1972-03-16	1973-09-20	Hoechst Ag	Verfahren zur reinigung von insulin und insulinderivaten
US3876623A (en) *	1973-05-09	1975-04-08	Lilly Co Eli	Process for purifying insulin
US3878186A (en) *	1973-05-09	1975-04-15	Lilly Co Eli	Process for purifying insulin
DK140801B (da) *	1975-01-15	1979-11-19	Nordisk Insulinlab	Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.
US4183849A (en) *	1975-01-15	1980-01-15	Nordisk Insulinlaboratorium	Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect
GB1581824A (en) *	1976-01-16	1980-12-31	Leo Sa Lab	Preparation of insulin
DE2629568C3 (de) *	1976-07-01	1981-09-10	Hoechst Ag, 6000 Frankfurt	Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
AU5397579A (en) *	1978-12-26	1980-07-03	Eli Lilly And Company	Purifying insulin
JPS649263A (en) *	1987-07-02	1989-01-12	Asahi Chemical Ind	Antistatic polyester composition

1982
- 1982-02-26 US US06/352,725 patent/US4459226A/en not_active Expired - Lifetime
1983
- 1983-02-24 AT AT83300979T patent/ATE19390T1/de active
- 1983-02-24 AU AU11813/83A patent/AU551740B2/en not_active Ceased
- 1983-02-24 DE DE198383300979T patent/DE87932T1/de active Pending
- 1983-02-24 EP EP83300979A patent/EP0087932B1/en not_active Expired
- 1983-02-24 GB GB08305128A patent/GB2115428B/en not_active Expired
- 1983-02-24 DE DE8383300979T patent/DE3363140D1/de not_active Expired
- 1983-02-25 DK DK90683A patent/DK90683A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
GB8305128D0 (en)	1983-03-30
GB2115428B (en)	1985-09-11
US4459226A (en)	1984-07-10
ATE19390T1 (de)	1986-05-15
AU1181383A (en)	1983-09-01
EP0087932A1 (en)	1983-09-07
GB2115428A (en)	1983-09-07
AU551740B2 (en)	1986-05-08
DE3363140D1 (en)	1986-05-28
DE87932T1 (de)	1984-01-05
DK90683D0 (da)	1983-02-25
EP0087932B1 (en)	1986-04-23

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Legal Events

Date	Code	Title	Description
1995-04-24	ARF	Application refused