DK99588A - 2-(aminoalkythio)methyl-1,4-dihydropyridin-forbindelser, en fremgangsmaade til deres fremstilling og farmaceutiske midler indeholdende dem - Google Patents
2-(aminoalkythio)methyl-1,4-dihydropyridin-forbindelser, en fremgangsmaade til deres fremstilling og farmaceutiske midler indeholdende demInfo
- Publication number
- DK99588A DK99588A DK099588A DK99588A DK99588A DK 99588 A DK99588 A DK 99588A DK 099588 A DK099588 A DK 099588A DK 99588 A DK99588 A DK 99588A DK 99588 A DK99588 A DK 99588A
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical agents
- aminoalkythio
- methyl
- procedure
- preparation
- Prior art date
Links
- 239000008177 pharmaceutical agent Substances 0.000 title abstract 2
- ZKIJTTNWOULCBY-UHFFFAOYSA-N 1-methyl-4h-pyridine Chemical class CN1C=CCC=C1 ZKIJTTNWOULCBY-UHFFFAOYSA-N 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2096586 | 1986-06-27 | ||
| IT20965/86A IT1204421B (it) | 1986-06-27 | 1986-06-27 | 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono |
| EP8700335 | 1987-06-25 | ||
| PCT/EP1987/000335 WO1988000187A1 (en) | 1986-06-27 | 1987-06-25 | 2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK99588D0 DK99588D0 (da) | 1988-02-25 |
| DK99588A true DK99588A (da) | 1988-02-25 |
| DK164051B DK164051B (da) | 1992-05-04 |
| DK164051C DK164051C (da) | 1992-09-28 |
Family
ID=11174716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK099588A DK164051C (da) | 1986-06-27 | 1988-02-25 | 2-(aminoalkylthio)methyl-1,4-dihydropyridin-forbindelser samt farmaceutisk middel indeholdende en saadan forbindelse |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5047414A (da) |
| EP (2) | EP0254064B1 (da) |
| JP (1) | JPH0832686B2 (da) |
| KR (1) | KR950002154B1 (da) |
| AU (1) | AU603595B2 (da) |
| CA (1) | CA1322753C (da) |
| DK (1) | DK164051C (da) |
| ES (1) | ES2037029T3 (da) |
| FI (1) | FI91149C (da) |
| GR (1) | GR3004954T3 (da) |
| HU (1) | HU201305B (da) |
| IT (1) | IT1204421B (da) |
| MX (1) | MX7134A (da) |
| NZ (1) | NZ220868A (da) |
| PH (1) | PH23208A (da) |
| PL (1) | PL156170B1 (da) |
| RU (1) | RU1816282C (da) |
| WO (1) | WO1988000187A1 (da) |
| ZA (1) | ZA874636B (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213555B (it) * | 1986-12-11 | 1989-12-20 | Boehringer Biochemia Srl | 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS228917B2 (en) * | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
| IL68604A0 (en) * | 1982-05-21 | 1983-09-30 | Haessle Ab | Processes for preparing therapeutically active dihydropyridines and intermediates for the processes |
| PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
| PL140069B1 (en) * | 1982-12-21 | 1987-03-31 | Pfizer | Method of obtaining new derivatives of dihydropiridine |
| GB8306666D0 (en) * | 1983-03-10 | 1983-04-13 | Pfizer Ltd | Therapeutic agents |
| GR851819B (da) * | 1984-08-17 | 1985-11-26 | Wyeth John & Brother Ltd | |
| EP0233228A1 (en) * | 1985-08-06 | 1987-08-26 | Boehringer Mannheim Italia S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
-
1986
- 1986-06-27 IT IT20965/86A patent/IT1204421B/it active
-
1987
- 1987-06-25 AU AU76969/87A patent/AU603595B2/en not_active Ceased
- 1987-06-25 ES ES198787109116T patent/ES2037029T3/es not_active Expired - Lifetime
- 1987-06-25 WO PCT/EP1987/000335 patent/WO1988000187A1/en not_active Ceased
- 1987-06-25 JP JP62504184A patent/JPH0832686B2/ja not_active Expired - Lifetime
- 1987-06-25 HU HU873824A patent/HU201305B/hu not_active IP Right Cessation
- 1987-06-25 EP EP87109116A patent/EP0254064B1/en not_active Expired - Lifetime
- 1987-06-25 EP EP87904520A patent/EP0312541B1/en not_active Expired - Lifetime
- 1987-06-25 CA CA000540555A patent/CA1322753C/en not_active Expired - Fee Related
- 1987-06-25 KR KR1019880700205A patent/KR950002154B1/ko not_active Expired - Fee Related
- 1987-06-26 PH PH35467A patent/PH23208A/en unknown
- 1987-06-26 ZA ZA874636A patent/ZA874636B/xx unknown
- 1987-06-26 NZ NZ220868A patent/NZ220868A/xx unknown
- 1987-06-27 PL PL1987266481A patent/PL156170B1/pl unknown
- 1987-06-29 MX MX713487A patent/MX7134A/es unknown
-
1988
- 1988-02-25 DK DK099588A patent/DK164051C/da not_active IP Right Cessation
- 1988-12-21 FI FI885930A patent/FI91149C/fi not_active IP Right Cessation
- 1988-12-26 RU SU884613190A patent/RU1816282C/ru active
-
1990
- 1990-12-21 US US07/638,131 patent/US5047414A/en not_active Expired - Fee Related
-
1992
- 1992-06-18 GR GR920401276T patent/GR3004954T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL266481A1 (en) | 1988-09-01 |
| EP0312541B1 (en) | 1992-08-26 |
| HU201305B (en) | 1990-10-28 |
| DK164051C (da) | 1992-09-28 |
| IT1204421B (it) | 1989-03-01 |
| KR880701228A (ko) | 1988-07-26 |
| MX7134A (es) | 1993-10-01 |
| ES2037029T3 (es) | 1993-06-16 |
| FI885930L (fi) | 1988-12-21 |
| FI91149B (fi) | 1994-02-15 |
| IT8620965A0 (it) | 1986-06-27 |
| PL156170B1 (pl) | 1992-02-28 |
| HUT49572A (en) | 1989-10-30 |
| AU603595B2 (en) | 1990-11-22 |
| DK164051B (da) | 1992-05-04 |
| US5047414A (en) | 1991-09-10 |
| DK99588D0 (da) | 1988-02-25 |
| JPH01503065A (ja) | 1989-10-19 |
| ZA874636B (en) | 1988-03-30 |
| AU7696987A (en) | 1988-01-29 |
| FI91149C (fi) | 1994-05-25 |
| PH23208A (en) | 1989-06-06 |
| EP0254064B1 (en) | 1992-06-17 |
| WO1988000187A1 (en) | 1988-01-14 |
| KR950002154B1 (ko) | 1995-03-14 |
| NZ220868A (en) | 1989-10-27 |
| EP0254064A1 (en) | 1988-01-27 |
| GR3004954T3 (da) | 1993-04-28 |
| CA1322753C (en) | 1993-10-05 |
| JPH0832686B2 (ja) | 1996-03-29 |
| RU1816282C (ru) | 1993-05-15 |
| EP0312541A1 (en) | 1989-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |