DOP2002000460A - 2,5-diamidoindoles sustituidos y su utilizacion. - Google Patents
2,5-diamidoindoles sustituidos y su utilizacion.Info
- Publication number
- DOP2002000460A DOP2002000460A DO2002000460A DO2002000460A DOP2002000460A DO P2002000460 A DOP2002000460 A DO P2002000460A DO 2002000460 A DO2002000460 A DO 2002000460A DO 2002000460 A DO2002000460 A DO 2002000460A DO P2002000460 A DOP2002000460 A DO P2002000460A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- disorders
- obesity
- nitrogen
- diseases
- disease
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 208000008589 Obesity Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 235000020824 obesity Nutrition 0.000 abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 208000004350 Strabismus Diseases 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000029078 coronary artery disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 201000006316 hypertropia Diseases 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010003497 Asphyxia Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010006482 Bronchospasm Diseases 0.000 abstract 1
- 208000032841 Bulimia Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 206010007556 Cardiac failure acute Diseases 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010014418 Electrolyte imbalance Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000017228 Gastrointestinal motility disease Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 201000005569 Gout Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020112 Hirsutism Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 201000001431 Hyperuricemia Diseases 0.000 abstract 1
- 206010058359 Hypogonadism Diseases 0.000 abstract 1
- 206010021133 Hypoventilation Diseases 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 208000008930 Low Back Pain Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 208000005107 Premature Birth Diseases 0.000 abstract 1
- 206010036590 Premature baby Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 206010042434 Sudden death Diseases 0.000 abstract 1
- 206010047163 Vasospasm Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 230000007885 bronchoconstriction Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 230000027288 circadian rhythm Effects 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000002357 endometrial effect Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 231100000502 fertility decrease Toxicity 0.000 abstract 1
- 208000020694 gallbladder disease Diseases 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 210000004392 genitalia Anatomy 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 201000010066 hyperandrogenism Diseases 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- 208000000509 infertility Diseases 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 231100000535 infertility Toxicity 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 206010027175 memory impairment Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 abstract 1
- 230000001850 reproductive effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 230000036299 sexual function Effects 0.000 abstract 1
- 201000002859 sleep apnea Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
- 230000002861 ventricular Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con un compuesto de la fórmula (I): (en donde A. B. C y D son independientemente nitrógeno u opcionalmente metino substituido; E es nitrógeno, metino o metino substituido con hidróxi; n es O o 1; T, U, V y W son independientemente nitrógeno u opcionalmente metino substituido; X es -N(S02R4)-, -N(COR5)- o -CO-; ¥ es -C(R6)(R7)-, -O- o -N(R8)-, siempre que el compuesto (I) es excluido cuando E es nitrógeno, n es O, X es -CO-, e Y es -O-) y similares, eI cual es útil como un agente para el tratamiento de varias enfermedades relacionadas con el NPY, por ejemplo. desórdenes cardiovasculares tales como angina. insuficiencia cardiaca aguda o congestiva. infarto miocárdico. hipertensión, nefropatía, anormalidad de electrólitos. vasospasmo. arteriosclerosis, etc.; desórdenes del sistema nervioso central tales corno la bulimia. depresión, ansiedad. acceso, epilepsia, demencia, dolor, alcoholismo, síndrome de abstinencia. desórdenes de Ios ritmos circadianos, esquizofrenia, deterioro de la memoria, desórdenes del sueño. deterioro cognoscitivo, etc.; enfermedades metabólicas tales como la obesidad. diabetes, anormalidades hormonales, hipercolesterolemia, hiperlipidernia, gota, hígado adiposo, etc.; desórdenes genitales o reproductivos tales como Ia infertilidad. parto prematuro, di sfunción sexual, etc., desórdenes gastrointestinales; desórdenes respiratorios, enfermedades inflamatorias o glaucoma y similares, así como también, por ejemplo. ateroesclerosis. hipogonadismo, hiperandrogenismo, síndrome de ovario poliquístico. hirsutismo. desórdenes de la motilidad gastrointestinal, reflujo gastro-esofágeo relacionado con la obesidad, hipoventilación por obesidad (síndrome de Pickwick), apnea del sueño, inflamación, inflamación sistémica de la vasculatura. osteoartritis, resistencia a Ia insulina, broncoconstricción, preferencia por el alcohol, síndrome metabólico. enfermedad de Alzheimer. hipertropia cardiaca, hipertropia del ventrícu1o izquierdo, hipertrigliceridemia, colesterol HDL bajo; desórdenes cardiovasculares tales como enfermedad coronaria del corazón (CHD), enfermedad cerebrovascular, ataque, enfermedad vascular periférica, muerte repentina, enfermedades de la vesícula biliar, cáncer (de pech~o, del endometrio y del colon), sofocación, hiperuricemia, fertilidad daflada, dolor de la espalda baja, o riesgo anestésico aumentado, y similares
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2002000460A DOP2002000460A (es) | 2002-09-04 | 2002-09-04 | 2,5-diamidoindoles sustituidos y su utilizacion. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2002000460A DOP2002000460A (es) | 2002-09-04 | 2002-09-04 | 2,5-diamidoindoles sustituidos y su utilizacion. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2002000460A true DOP2002000460A (es) | 2003-03-31 |
Family
ID=44261095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2002000460A DOP2002000460A (es) | 2002-09-04 | 2002-09-04 | 2,5-diamidoindoles sustituidos y su utilizacion. |
Country Status (1)
| Country | Link |
|---|---|
| DO (1) | DOP2002000460A (es) |
-
2002
- 2002-09-04 DO DO2002000460A patent/DOP2002000460A/es unknown
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