DOP2002000519A - PROCEDURE FOR THE PREPARATION OF SUBSTITUTED BICYCLE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH - Google Patents

PROCEDURE FOR THE PREPARATION OF SUBSTITUTED BICYCLE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH

Info

Publication number
DOP2002000519A
DOP2002000519A DO2002000519A DO2002000519A DOP2002000519A DO P2002000519 A DOP2002000519 A DO P2002000519A DO 2002000519 A DO2002000519 A DO 2002000519A DO 2002000519 A DO2002000519 A DO 2002000519A DO P2002000519 A DOP2002000519 A DO P2002000519A
Authority
DO
Dominican Republic
Prior art keywords
treatment
procedure
preparation
cellular growth
abnormal cellular
Prior art date
Application number
DO2002000519A
Other languages
Spanish (es)
Inventor
David Harold Brown Ripin
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of DOP2002000519A publication Critical patent/DOP2002000519A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/027Organoboranes and organoborohydrides

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a procedimientos para preparar compuestos de formula. Y a sales, pro fármacos y solvatos farmacéuticamente aceptables de los mismos, en la que R1, R3, R4, R5, R11, m y p son como se han definido en este documento. Los compuestos de formula 1 son útiles en el tratamiento del crecimiento celular anormal en mamíferos por la administración de composiciones farmacéuticas.The invention relates to processes for preparing compounds of formula. And pharmaceutically acceptable salts, pro drugs and solvates thereof, wherein R1, R3, R4, R5, R11, m and p are as defined herein. The compounds of formula 1 are useful in the treatment of abnormal cell growth in mammals by the administration of pharmaceutical compositions.

DO2002000519A 2001-11-30 2002-11-21 PROCEDURE FOR THE PREPARATION OF SUBSTITUTED BICYCLE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH DOP2002000519A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33464701P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
DOP2002000519A true DOP2002000519A (en) 2003-05-31

Family

ID=23308141

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2002000519A DOP2002000519A (en) 2001-11-30 2002-11-21 PROCEDURE FOR THE PREPARATION OF SUBSTITUTED BICYCLE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH

Country Status (29)

Country Link
US (1) US20030144506A1 (en)
EP (1) EP1448551B1 (en)
JP (1) JP4220388B2 (en)
KR (1) KR20040054813A (en)
CN (1) CN1639149A (en)
AR (1) AR037591A1 (en)
AT (1) ATE377009T1 (en)
AU (1) AU2002337428A1 (en)
BR (1) BR0214606A (en)
CA (1) CA2462149C (en)
DE (1) DE60223279T2 (en)
DO (1) DOP2002000519A (en)
ES (1) ES2295409T3 (en)
GT (1) GT200200245A (en)
HN (1) HN2002000334A (en)
HU (1) HUP0500117A3 (en)
IL (1) IL160971A0 (en)
MX (1) MXPA04005157A (en)
PA (1) PA8558601A1 (en)
PE (1) PE20030643A1 (en)
PL (1) PL370911A1 (en)
PY (1) PY0229003A (en)
RS (1) RS44004A (en)
RU (1) RU2004116345A (en)
SV (1) SV2004001419A (en)
TN (1) TNSN02096A1 (en)
TW (1) TW200300691A (en)
WO (1) WO2003045939A1 (en)
ZA (1) ZA200402054B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054585A1 (en) * 2002-12-18 2004-07-01 Pfizer Products Inc. 4-anilino quinazoline derivatives for the treatment of abnormal cell growth
JP2006512355A (en) * 2002-12-19 2006-04-13 ファイザー・プロダクツ・インク E-2-methoxy-N- (3- {4- [3-methyl-4- (6-methylpyridin-3-yloxy) -phenylamino] -quinazolin-6-yl} -allyl) -acetamide complex , Their manufacturing method and use
RS20050652A (en) * 2003-04-09 2007-11-15 Pfizer Products Inc., Process for the preparation of n- (((pyridinyloxy)- phenylamino)quinazolinyl)- alyl)acetamide derivatives and related compounds as well as intermediates of such processes and processes for the preparation of such intermediates
NZ544472A (en) 2003-07-03 2009-04-30 Myriad Genetics Inc Compounds and therapeutical use thereof
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
US20050192298A1 (en) * 2004-02-27 2005-09-01 Pfizer Inc Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide
CN1972688B (en) * 2004-05-06 2012-06-27 沃尼尔·朗伯有限责任公司 4-phenylamino-quinazolin-6-yl-amides
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
CA2635837A1 (en) * 2005-12-02 2007-06-28 The Paper Products Limited Holographic flexible tube laminate for packaging and method of making the same
AU2019346550A1 (en) 2018-09-25 2021-04-22 Black Diamond Therapeutics, Inc. Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use
EP4013749B1 (en) 2019-08-15 2026-03-11 Black Diamond Therapeutics, Inc. Alkynyl quinazoline compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW321649B (en) * 1994-11-12 1997-12-01 Zeneca Ltd
DE19501481A1 (en) * 1995-01-19 1996-07-25 Bayer Ag 2,8-disubstituted quinazolinones
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
HRP20021005A2 (en) * 2000-06-22 2004-02-29 Pfizer Prod Inc Substituted bicyclic derivatives for the treatment of abnormal cell growth

Also Published As

Publication number Publication date
AR037591A1 (en) 2004-11-17
AU2002337428A1 (en) 2003-06-10
WO2003045939A1 (en) 2003-06-05
HUP0500117A2 (en) 2005-05-30
JP2005515986A (en) 2005-06-02
JP4220388B2 (en) 2009-02-04
DE60223279D1 (en) 2007-12-13
BR0214606A (en) 2004-09-14
DE60223279T2 (en) 2008-05-29
IL160971A0 (en) 2004-08-31
RS44004A (en) 2006-10-27
CN1639149A (en) 2005-07-13
MXPA04005157A (en) 2004-08-11
RU2004116345A (en) 2005-03-27
HUP0500117A3 (en) 2008-03-28
EP1448551A1 (en) 2004-08-25
ATE377009T1 (en) 2007-11-15
EP1448551B1 (en) 2007-10-31
ES2295409T3 (en) 2008-04-16
PL370911A1 (en) 2005-05-30
PA8558601A1 (en) 2003-06-30
PY0229003A (en) 2004-06-01
CA2462149C (en) 2010-06-22
GT200200245A (en) 2003-09-24
CA2462149A1 (en) 2003-06-05
TW200300691A (en) 2003-06-16
SV2004001419A (en) 2004-02-24
US20030144506A1 (en) 2003-07-31
PE20030643A1 (en) 2003-07-23
KR20040054813A (en) 2004-06-25
HN2002000334A (en) 2003-02-21
TNSN02096A1 (en) 2005-12-23
ZA200402054B (en) 2005-05-23

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